Organic Chemical
oxylipins
Subclass of:
Fatty Acids, Unsaturated
Definitions related to oxylipins:
  • A family of bioactive lipid metabolites that are produced when polyunsaturated fatty acids (PUFAs) undergo at least one round of dioxygen-dependent oxidation, which is catalyzed by cyclooxygenase (COX), lipoxygenase (LOX) or cytochrome P450 (CYP) epoxygenase family enzymes Oxylipins play an important role in the modulation of the tumor microenvironment (TME) and facilitate tumor cell proliferation, migration and invasion.
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
  • Eighteen-carbon cyclopentyl polyunsaturated fatty acids derived from ALPHA-LINOLENIC ACID via an oxidative pathway analogous to the EICOSANOIDS in animals. Biosynthesis is inhibited by SALICYLATES. A key member, jasmonic acid of PLANTS, plays a similar role to ARACHIDONIC ACID in animals.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
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