Pharmacologic Substance
prednimustine
Definitions related to prednimustine:
  • Ester of CHLORAMBUCIL and PREDNISOLONE used as a combination alkylating agent and synthetic steroid to treat various leukemias and other neoplasms. It causes gastrointestinal and bone marrow toxicity.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
  • The prednisolone ester of chlorambucil and nitrogen mustard alkylating agent with antineoplastic activity. Prednimustine itself is not cytotoxic, however, it becomes cytotoxic upon hydrolysis by serum esterases to chlorambucil. Therefore, the increased potency of prednimustine is linked to the prolonged availability of free chlorambucil.
    NCI
    U.S. National Cancer Institute, 2021
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