Pharmacologic Substance
chlorambucil
chlo·ram·bu·cil [ klaw-ram-byuh-sil, kloh- ]
Brand Names:
Leukeran
Effect:
Decreased DNA Integrity; Decreased DNA Replication
May Treat:
Breast Neoplasms;
Choriocarcinoma;
Hodgkin Disease;
Leukemia, Lymphocytic, Chronic, B-Cell;
Lymphoma, Non-Hodgkin;
Ovarian Neoplasms;
Testicular Neoplasms;
Thrombocytosis;
Waldenstrom Macroglobulinemia
More Information:
Definitions related to chlorambucil:
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A drug used to treat several types of leukemias and lymphomas. It blocks cell growth by damaging the cell's DNA and may kill cancer cells. It is a type of alkylating agent.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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An orally-active antineoplastic aromatic nitrogen mustard. Chlorambucil alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. (NCI04)NCI ThesaurusU.S. National Cancer Institute, 2021
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Nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others; may be a carcinogen.CRISP ThesaurusNational Institutes of Health, 2006
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