Pharmacologic Substance
chlorambucil Audio
chlo·ram·bu·cil [ klaw-ram-byuh-sil, kloh- ]
Brand Names:
Leukeran
Effect:
Decreased DNA Integrity; Decreased DNA Replication
May Treat:
Breast Neoplasms; Choriocarcinoma; Hodgkin Disease; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, Non-Hodgkin; Ovarian Neoplasms; Testicular Neoplasms; Thrombocytosis; Waldenstrom Macroglobulinemia
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to chlorambucil:
  • A drug used to treat several types of leukemias and lymphomas. It blocks cell growth by damaging the cell's DNA and may kill cancer cells. It is a type of alkylating agent.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
  • An orally-active antineoplastic aromatic nitrogen mustard. Chlorambucil alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. (NCI04)
    NCI
    U.S. National Cancer Institute, 2021
  • Nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others; may be a carcinogen.
    CRISP Thesaurus
    National Institutes of Health, 2006
Try this search on: Farlex, Merriam-Webster, Oxford Dictionary, or Wordnik

This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.