Pharmacologic Substance
risperidone Audio
[ ris-payr-ih-done ]
Brand Names:
Perseris; Risperdal
Effect:
Decreased Dopamine Activity; Decreased Histamine Activity; Decreased Norepinephrine Activity; Decreased Serotonin Activity
May Treat:
Autistic Disorder; Bipolar Disorder; Dementia; Schizophrenia; Tourette Syndrome
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to risperidone:
  • A benzisoxazole derivative with antipsychotic property. Risperidone selectively antagonizes serotonin (5-HT) effects via cortical 5-HT2 receptor, and, to a lesser extent, competes with dopamine at the limbic dopamine D2 receptor. The antagonism leads to decreased psychotic effects, such as hallucinations and delusions. In addition, risperidone has low to moderate affinity for histamine H1, 5-HT1A, 5-HT1C, and 5-HT1D receptors, while it has weak affinity for dopamine D1 and haloperidol-sensitive sigma site receptors.
    NCI
    U.S. National Cancer Institute, 2021
  • A selective blocker of DOPAMINE D2 RECEPTORS and SEROTONIN 5-HT2 RECEPTORS that acts as an atypical antipsychotic agent. It has been shown to improve both positive and negative symptoms in the treatment of SCHIZOPHRENIA.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
  • Selective blocker of dopamine D2 and serotonin-5-HT2 receptors that acts as an atypical antipsychotic agent; has been shown to improve both positive and negative symptoms in the treatment of schizophrenia.
    CRISP Thesaurus
    National Institutes of Health, 2006
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