Pharmacologic Substance
triaziquone
Subclass of:
Aziridines
Definitions related to triaziquone:
  • Alkylating antineoplastic agent used mainly for ovarian tumors. It is toxic to skin, gastrointestinal tract, bone marrow and kidneys.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
  • An aziridinylbenzoquinone-based alkylating agent with potential antineoplastic activity. The alkylating group in triaziquone becomes activated upon reduction of quinone to the hydroquinone form. This eventually results in the alkylation and crosslinking of DNA, thereby inhibiting DNA replication followed by an induction of apoptosis. In addition, reactive oxygen species may form during redox cycling which may contribute to this agent's cytotoxic activity.
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
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