-
BMJ Case Reports Sep 2020genus comprises of obligate anaerobic, gram-negative bacteria that are commensal organisms of oral cavity, gut and vaginal mucosa. Although many species have... (Review)
Review
genus comprises of obligate anaerobic, gram-negative bacteria that are commensal organisms of oral cavity, gut and vaginal mucosa. Although many species have well-established pathogenicity with respect to pulmonary infections, rarely has been isolated as a cause of lung abscess. We present a rare case of left lower lobe lung abscess due to identified using next-generation sequencing of microbial cell-free DNA testing. A brief review of the literature regarding species pulmonary infections, use of next-generation cell-free DNA testing early in the evaluation, antibiotic susceptibility and resistance is also a part of this report.
Topics: Adult; Bacteroidaceae Infections; Humans; Lung Abscess; Male; Prevotella
PubMed: 32900736
DOI: 10.1136/bcr-2020-235960 -
International Journal of Environmental... Feb 2020: The management of lung abscess may be a challenge in elderly patients undergoing chemotherapy and/or radiotherapy for previous malignancy. Herein, we reported a case...
: The management of lung abscess may be a challenge in elderly patients undergoing chemotherapy and/or radiotherapy for previous malignancy. Herein, we reported a case series of elderly patients with previous lymphoma undergoing endoscopic treatment followed by pulmonary rehabilitation for lung abscess. : Our study population included a consecutive series of elderly patients with previous lymphoma and lung abscess. Suppurative infection was refractory with specific antibiotic therapy. In all cases, drainage was endoscopically inserted in lung abscess via video-bronchoscopy. This strategy allowed performing daily therapy with the installation of gentamicin directly into the abscess cavity. All patients underwent a respiratory rehabilitation program to speed up convalescence and allow early discharge. : After positioning the catheter through a bronchoscopic route and subsequent washing with gentamicin, all the patients in our study showed an improvement in clinical conditions with resolution of fever within a few days of starting the procedure with normalization of blood tests (mean hospital length 7 ± 0.73 days). A follow-up chest computed tomography scan showed a resolution of lung abscess within a mean of 27 ± 1.53 days. Endoscopic treatment with a rehabilitation program may be a valuable strategy for the management of lung abscess that is refractory to standard antibiotic therapy. Further and larger studiesshould be done to confirm our results.
Topics: Aged; Anti-Bacterial Agents; Bronchoscopy; Female; Humans; Lung Abscess; Lymphoma; Male; Middle Aged; Respiratory Therapy; Tomography, X-Ray Computed
PubMed: 32033391
DOI: 10.3390/ijerph17030997 -
BMC Infectious Diseases Jul 2021Granulicatella adiacens is facultative anaerobic Gram-positive bacteria, which mainly involve bacterial endocarditis and bacteremia, but there are few reports of local...
BACKGROUND
Granulicatella adiacens is facultative anaerobic Gram-positive bacteria, which mainly involve bacterial endocarditis and bacteremia, but there are few reports of local suppurative infection. A case of lung abscess with a coinfection of Granulicatella adiacens and other bacteria in a lung cancer patient will be reported in this paper. To our knowledge, this is the first case report describing lung abscess due to G.adiacens.
CASE PRESENTATION
A 52-year-old Chinese woman was admitted to the hospital, She complained of coughing and expectoration for 1 month, shortness of breath for half a month, and dyspnea for 1 day. After a series of examinations, she was diagnosed with lung abscess, pleural effusion, and bronchogenic carcinoma. Draining pus culture demonstrated Granulicatella adiacens. After more than 5 weeks of antibiotic therapies in total, she gradually recovered to fight against lung cancer.
CONCLUSION
This is the first reported lung abscess caused by G.adiacens. In immunosuppressed hosts, G.adiacens is a virulent pathogen associated with a spectrum of intrathoracic suppurative. Earlier diagnosis and proper drainage surgery with effective antibiotics treatment are very important, and antimicrobial treatment should be more than 5 weeks. When complex pulmonary infection interferes with the CT diagnosis, clinical suspicion of lung cancer should be increased if G.adiacens or Eikenella corrodens is detected from a pulmonary infection.
Topics: Anti-Bacterial Agents; Carnobacteriaceae; Coinfection; Eikenella corrodens; Female; Humans; Lung Abscess; Lung Neoplasms; Middle Aged; Treatment Outcome
PubMed: 34238251
DOI: 10.1186/s12879-021-06191-8 -
Open Respiratory Archives 2021
PubMed: 37497071
DOI: 10.1016/j.opresp.2021.100085 -
Infection and Drug Resistance 2019A lung abscess is an infectious pulmonary disease characterized by pus-filled cavity formation and often an air-fluid level. In this article, we described an indolent...
A lung abscess is an infectious pulmonary disease characterized by pus-filled cavity formation and often an air-fluid level. In this article, we described an indolent community-acquired lung abscess suspected as a tumor previously. A 56-year-old male presented with cough and expectoration for 2 months and hemoptysis for 2 weeks. His physical examinations, whole blood count and C-reactive protein level were normal. The chest computed tomography (CT) scan showed a 40×38×39 mm high-density mass in the right upper pulmonary lobe, with irregular borders. The pathology of a CT-guided percutaneous needle aspiration biopsy showed numerous inflammatory cells and bacteria infiltration without tumor lesions. Bacteriological detection of lung tissue revealed the cause was odontogenic flora. A next-generation sequencing demonstrated the etiologic correlation between lung abscess and periodontitis. After a 2-month pathogen-directed oral antibiotics therapy combined with chlorhexidine gargle oral care, this patient showed a remarkable improvement. Periodontitis can be a cause of a lung abscess, which would be taken into account in the treatment regimes preventing infectious recurrence.
PubMed: 31496760
DOI: 10.2147/IDR.S218921 -
The American Journal of Case Reports 2014Male, 64 FINAL DIAGNOSIS: Lung pleomorphic carcinoma Symptoms: Cough • fever
PATIENT
Male, 64 FINAL DIAGNOSIS: Lung pleomorphic carcinoma Symptoms: Cough • fever
MEDICATION
- Clinical Procedure: - Specialty: Oncology.
OBJECTIVE
Unusual clinical course.
BACKGROUND
The diagnosis of lung cancer is often made based on computed tomography (CT) image findings if it cannot be confirmed on pathological examinations, such as bronchoscopy. However, the CT image findings of cancerous lesions are similar to those of abscesses.We herein report a case of lung cancer that resembled a lung abscess on CT.
CASE REPORT
We herein describe the case of 64-year-old male who was diagnosed with lung cancer using surgery. In this case, it was quite difficult to distinguish between the lung cancer and a lung abscess on CT images, and a lung abscess was initially suspected due to symptoms, such as fever and coughing, contrast-enhanced CT image findings showing a ring-enhancing mass in the right upper lobe and the patient's laboratory test results. However, a pathological diagnosis of lung cancer was confirmed according to the results of a rapid frozen section biopsy of the lesion.
CONCLUSIONS
This case suggests that physicians should not suspect both a lung abscesses and malignancy in cases involving masses presenting as ring-enhancing lesions on contrast-enhanced CT.
PubMed: 24949114
DOI: 10.12659/AJCR.890570 -
European Journal of Case Reports in... 2023Leptospirosis is a zoonotic infection infrequently reported in non-tropical regions. Although classically described as a biphasic illness, unusual clinical...
UNLABELLED
Leptospirosis is a zoonotic infection infrequently reported in non-tropical regions. Although classically described as a biphasic illness, unusual clinical manifestations have been reported, including a previous case of a lung abscess associated with this causative agent. We present the case of a 49-year-old man with a new diagnosis of two liver abscesses associated with leptospirosis.
LEARNING POINTS
Leptospirosis is a zoonosis caused by spirochetes of the genus ; the infection is more commonly reported in tropical regions.Leptospirosis classically manifests as a biphasic illness, the first phase characterized by high fever that coincides with leptospiraemia, followed by a brief period when the patient is afebrile. In the second phase, fever returns, accompanied by jaundice and renal failure.The unusual clinical manifestations of leptospirosis include a previous report of a lung abscess, but despite frequent liver involvement, liver abscess in this context has not previously been described.
PubMed: 36969519
DOI: 10.12890/2023_003783 -
Therapeutic Advances in Respiratory... 2021Pyogenic lung abscesses are rare and poorly described infections. This study aimed to describe their prognostic factors.
BACKGROUND
Pyogenic lung abscesses are rare and poorly described infections. This study aimed to describe their prognostic factors.
METHODS
We retrospectively included all patients hospitalized between 1 January 1998 and 1 June 2018, with an International Classification of Diseases, version 10 (IDC-10) diagnosis of pyogenic lung abscess, from the Diamm based medical records (Micro6, Nancy, France). Parasitic, fungal, or mycobacterial lung abscesses were excluded.
RESULTS
A total of 64 patients were included. Abscesses were associated with immunosuppression in 28 patients, including HIV infection and immunosuppressive therapy for eight and 12 patients, respectively. Bacterial identification was obtained for 36 patients. Nine patients (14%) developed lung abscesses after hematogenous dissemination. They differed from bronchogenic abscesses by their younger age ( = 0.03), the absence of smoking or emphysema ( = 0.05), ( = 0.001) or spp. ( = 0.05) isolation, and the smaller size of their abscess ( = 0.02). Overall, evolution was marked by radiological sequelae (46.9%), relapse (12.5%), and death (4.8%). Radiological sequelae occurred more frequently during the course of bronchogenic abscesses ( = 0.02), particularly when they spontaneously discharged ( = 0.04). Relapses were more frequent in patients with emphysema ( = 0.04) and when was isolated ( = 0.04). In multivariate analysis, poor outcomes, including death, sequelae, and relapse occurred more frequently in patients who had bronchogenic abscess ( = 0.02), and in those who received antibiotics during less than 6 weeks ( = 0.05).
CONCLUSION
A duration of antibiotic treatment of less than 6 weeks and bronchogenic presentation were globally associated with poor outcome of pyogenic lung abscesses. These data should be considered when proposing guidelines for the care of pyogenic lung abscesses..
Topics: Hospital Units; Humans; Liver Abscess, Pyogenic; Retrospective Studies; Risk Factors
PubMed: 34098822
DOI: 10.1177/17534666211003012 -
Interactive Cardiovascular and Thoracic... Jun 2022This study aimed to elucidate the outcomes of emergency salvage surgery following life-threatening events (serious haemorrhage and/or infections) among patients with...
OBJECTIVES
This study aimed to elucidate the outcomes of emergency salvage surgery following life-threatening events (serious haemorrhage and/or infections) among patients with lung cancer who had undergone chemo- and/or radiotherapy.
MATERIALS AND METHODS
We analysed the data of patient from 2015 to 2020, retrospectively. The clinical characteristics, including preoperative treatment, perioperative outcomes and survival time, were analysed.
RESULTS
Of the 862 patients who underwent primary lung cancer surgeries, 10 (1.2%) underwent emergency surgeries. The preoperative clinical characteristics were: median age, 63.7 years [interquartile range (IQR) 55-70.5]; sex (male/female), 9/1; clinical staging before initial treatment (I/II/III/IV), 1/1/3/5; initial treatment (chemoradiotherapy/chemotherapy/proton beam therapy), 5/4/1; and indications for emergency surgery (lung abscess/lung abscess with haemoptysis/haemoptysis/empyema), 5/3/1/1. The selected procedures and results were as follows: lobectomy/bilobectomy/pneumonectomy, 8/1/1 (all open thoracotomies); median operation time, 191.0 min (IQR 151-279); median blood loss, 1071.5 ml (IQR 540-1691.5); postoperative severe complications, 3 (30%); hospital mortality, none; median postoperative hospital stay, 37 days (12-125); control of infection and/or haemoptysis, all the cases; final outcome (alive/dead), 3/7 (all the cancer deaths); median postoperative survival, 9.4 months (IQR 4.3-20.4); and median survival from initial treatment, 19.4 months (IQR 8.0-66.9).
CONCLUSIONS
Emergency salvage lung resection is a technically challenging procedure; however, the results were feasible and acceptable when the surgical indication, procedure and optimal timing were considered carefully by a multidisciplinary team. Although the aim was palliation, some patients who received additional chemotherapy afterwards and, thus, had additional survival time.
Topics: Carcinoma, Non-Small-Cell Lung; Female; Hemoptysis; Humans; Lung; Lung Abscess; Lung Neoplasms; Male; Middle Aged; Neoplasm Staging; Pneumonectomy; Retrospective Studies; Salvage Therapy; Treatment Outcome
PubMed: 35253874
DOI: 10.1093/icvts/ivac043 -
Open Access Macedonian Journal of... Sep 2018The incidence of lung abscess acquired in the community is unknown, but this is a common clinical problem encountered in developing countries. The incidence of lung...
BACKGROUND
The incidence of lung abscess acquired in the community is unknown, but this is a common clinical problem encountered in developing countries. The incidence of lung abscess was high in the pre-antibiotic era but the advent of susceptible antibiotics it has reduced with an equal fall in mortality to 8.7%. With the emerging antibiotic resistance and change in the trends of bacteriological profile causing lung abscess, it is the need of time to reevaluate lung abscess.
AIM
The study aimed to determine the clinical, radiological and bacteriological profile of lung abscess.
MATERIAL AND METHOD
The study was a non-randomized prospective observational study conducted in the department of pulmonary medicine for 18 months. In the study, patients > 15 years of age with clinical features of lung abscess were recruited and were subjected to chest X-ray, routine blood test. Sputum gram stain and culture, as well as antibiotic sensitivity according to the organism, were evaluated. Reports of all investigations along with patient characteristics and risk factors were analysed statistically using SPSS 20.0.
RESULTS
Forty-six cases of lung abscess were included, and the majority of patients were found to be adults with a mean age of 42.9 years with a male to female ratio of 6.6:1. The most common predisposing factor was an unhygienic oral cavity in 28% of cases with alcohol ingestion being the most important risk factor in 22% of cases. The most common organism found in lung abscess cases was , and they were sensitive to ceftazidime.
CONCLUSION
Our study shows that should be considered an important pathogen in community-acquired lung abscesses.
PubMed: 30337980
DOI: 10.3889/oamjms.2018.374