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Nihon Naika Gakkai Zasshi. the Journal... Mar 1994
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Clinics in Laboratory Medicine Sep 2019
Topics: Anti-Bacterial Agents; Bacteria; Bacterial Infections; Bacterial Vaccines; Drug Development; Humans
PubMed: 31383273
DOI: 10.1016/j.cll.2019.06.001 -
Epidemiology and Infection Jul 2023Routine blood examination is an easy way to examine infectious diseases. This study is aimed to develop a model to diagnose serious bacterial infections (SBI) in ICU...
Routine blood examination is an easy way to examine infectious diseases. This study is aimed to develop a model to diagnose serious bacterial infections (SBI) in ICU neonates based on routine blood parameters. This was a cross-sectional study, and data were extracted from the Medical Information Mart for Intensive Care III (MIMIC-III). SBI was defined as suffering from one of the following: pyelonephritis, bacteraemia, bacterial meningitis, sepsis, pneumonia, cellulitis, and osteomyelitis. Variables with statistical significance in the univariate logistic regression analysis and log systemic immune-inflammatory index (SII) were used to develop the model. The area under the curve (AUC) was calculated to assess the performance of the model. A total of 1,880 participants were finally included for analysis. Weight, haemoglobin, mean corpuscular volume, white blood cell, monocyte, premature delivery, and log SII were selected to develop the model. The developed model showed a good performance to diagnose SBI for ICU neonates, with an AUC of 0.812 (95% confidence interval (CI): 0.737-0.888). A nomogram was developed to make this model visualise. In conclusion, our model based on routine blood parameters performed well in the diagnosis of neonatal SBI, which may be helpful for clinicians to improve treatment recommendations.
Topics: Humans; Infant, Newborn; Bacterial Infections; Cross-Sectional Studies; Intensive Care Units, Neonatal
PubMed: 37519228
DOI: 10.1017/S0950268823001231 -
Reviews of Infectious Diseases 1985An overview of infections caused by gram-negative bacteria over the past 40 years discloses remarkable changes in their specific etiology and management. These organisms...
An overview of infections caused by gram-negative bacteria over the past 40 years discloses remarkable changes in their specific etiology and management. These organisms were responsible for disease in the preantibiotic era but at a much lower frequency than at present, and fatality rates were generally high. Bacteria such as Pseudomonas and Serratia, now relatively commonly involved in infection, rarely, if ever, caused disease before antibiotics became available. Although often present in surgical wounds, these organisms clearly were colonizers rather than pathogens. It is clear that the use of potent antimicrobial agents has been responsible for a general decrease in the fatality rates associated with gram-negative bacterial infections. However, it is evident that their use has been involved in the development of potentially lethal complications not seen in the past. Factors presently recognized as playing important roles in the problems associated with the treatment of gram-negative bacterial infections are the increasing number of older and sometimes debilitated patients and the longer survival of individuals with tumors or leukemia who, because of immunosuppression due to disease or treatment, are highly susceptible to invasion by almost any organism. Factors that have increased the magnitude of the problem of treatment of gram-negative bacterial infections include an increasing frequency of bacterial resistance to one or more antibiotics and a tendency of physicians to use more than one drug, sometimes as many as three or four, to treat gram-negative bacterial infections, especially in immunosuppressed people. Such polypharmacy is responsible for the development of suprainfections, some of which are caused by organisms very difficult to eradicate.
Topics: Anti-Bacterial Agents; Bacterial Infections; Drug Resistance, Microbial; Gram-Negative Bacteria; History, 20th Century; Humans; Immune Tolerance; Intestines
PubMed: 3909310
DOI: 10.1093/clinids/7.supplement_4.s538 -
Current Gastroenterology Reports Aug 2003Diarrheal illness caused by bacterial pathogens is a global health problem and remains one of the most common complaints prompting patients to seek medical care.... (Review)
Review
Diarrheal illness caused by bacterial pathogens is a global health problem and remains one of the most common complaints prompting patients to seek medical care. Strategies to increase the yield of stool culture and new rapid diagnostic tests can improve diagnostic ability. Emerging antimicrobial resistance among the common bacterial causes of diarrhea has made treatment more challenging. Emerging fluoroquinolone resistance is a particular concern. Recent studies of rifaximin, a nonabsorbed antibiotic for the treatment of bacterial diarrhea, have shown favorable results. Rifaximin may represent a much-needed addition to the armamentarium against bacterial agents.
Topics: Bacterial Infections; Diarrhea; Drug Resistance, Microbial; Humans
PubMed: 12864958
DOI: 10.1007/s11894-003-0065-z -
The National Medical Journal of India 2018
Topics: Anti-Bacterial Agents; Bacterial Infections; Drug Resistance, Multiple, Bacterial; Global Health; Health Care Costs; Humans
PubMed: 31044757
DOI: 10.4103/0970-258X.255752 -
Biomedical and Environmental Sciences :... Jun 2015
Review
Topics: Anti-Bacterial Agents; Bacterial Infections; Breast Implants; Clinical Laboratory Techniques; Early Diagnosis; Humans; Microbiological Techniques
PubMed: 26177911
DOI: 10.3967/bes2015.068 -
Folia Biologica 2004
Review
Topics: Bacterial Infections; Gene Expression Regulation; Humans; Immunity, Cellular; Virus Diseases
PubMed: 15373342
DOI: No ID Found -
Bundesgesundheitsblatt,... May 2018
Topics: Animals; Antimicrobial Stewardship; Bacterial Infections; Drug Resistance, Bacterial; Germany; Health Priorities; Humans; International Cooperation
PubMed: 29637227
DOI: 10.1007/s00103-018-2732-0 -
Progress in Surgery 1979
Review
Topics: Anti-Bacterial Agents; Bacterial Infections; Gangrene; Gas Gangrene; Humans; Penicillin G; Tetanus; Wound Infection
PubMed: 375309
DOI: 10.1159/000402250