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Indian Journal of Dermatology,... 2013
Topics: Adult; Asian People; Bowen's Disease; Family; Female; Humans; Male; Skin; Skin Neoplasms; Young Adult
PubMed: 23974595
DOI: 10.4103/0378-6323.116752 -
The British Journal of Dermatology Mar 1998We describe two Afro-Caribbean women who presented with pigmented Bowen's disease. One, a 44-year-old woman, developed a sharply demarcated, irregularly marginated,...
We describe two Afro-Caribbean women who presented with pigmented Bowen's disease. One, a 44-year-old woman, developed a sharply demarcated, irregularly marginated, hyperpigmented plaque with a velvety surface in the perianal area. The other, a 25-year-old woman, developed a well defined, verrucous, hyperpigmented patch on the umbilicus. Histology showed that both cases were Bowen's disease, and subsequent treatment with 5-fluorouracil and cryotherapy led to complete resolution.
Topics: Adult; Anus Diseases; Black People; Bowen's Disease; Female; Humans; Hyperpigmentation; Skin Neoplasms; Umbilicus
PubMed: 9580811
DOI: 10.1046/j.1365-2133.1998.02136.x -
The Hand Oct 1981
Topics: Bowen's Disease; Carcinoma, Squamous Cell; Humans; Male; Middle Aged; Nail Diseases; Skin Neoplasms
PubMed: 7319333
DOI: 10.1016/s0072-968x(81)80012-5 -
The Pan African Medical Journal 2018We here report the case of a16-year old patient, with no particular past medical history, presenting, with skin swelling at the level of the forefoot evolving for 02...
We here report the case of a16-year old patient, with no particular past medical history, presenting, with skin swelling at the level of the forefoot evolving for 02 years, at the Department of Dermatology. Clinical examination showed hard budding cutaneous mass painless on palpation covering the 2, the 3 and the 4, right toes, measuring 4 cm in large diameter. The remainder of the clinical examination was normal, without adenopathies. Skin biopsy was performed at the level of the tumor and histological examination showed carcinoma in situ. Surgical treatment was recommended. Bowen's disease is a relatively rare squamous intraepithelial carcinoma in situ. It mainly affects adults at any age, with predominance in women. The diagnosis is suspected on the basis of clinical examination, but it is confirmed by the anatomo-pathological examination.
Topics: Adolescent; Biopsy; Bowen's Disease; Female; Foot Diseases; Humans; Skin Neoplasms
PubMed: 29632625
DOI: 10.11604/pamj.2018.29.3.14441 -
Diseases of the Colon and Rectum Jul 1999The aim of this study was to review the literature with regard to perianal Bowen's disease and anal intraepithelial neoplasia. (Review)
Review
PURPOSE
The aim of this study was to review the literature with regard to perianal Bowen's disease and anal intraepithelial neoplasia.
METHODS
A literature review was conducted from 1960 to 1999 using MEDLINE.
RESULTS
Perianal Bowen's disease and anal intraepithelial neoplasia are precursors to squamous carcinoma of the anus. They are analogous to and are associated with cervical and vulvar intraepithelial neoplasia, and have human papillomavirus as a common cause. Biopsy and histopathologic examination is required for diagnosis and to distinguish other perianal dermatoses. Treatment options range from aggressive wide local excision of all disease with negative margins to observation alone for microscopic lesions not visible to the naked eye. The disease has a proclivity for recurrence and recalcitrance.
CONCLUSIONS
Most surgeons caring for patients with perianal Bowen's disease and high-grade anal epithelial neoplasia use wide local excision, with an effort to obtain disease-free margins. Some authors have reported the advantages of ablative procedures such as laser ablation and cryotherapy. Microscopic disease found serendipitously in hemorrhoidectomy specimens can probably be treated conservatively with serial examinations alone. There is a lack of controlled data supporting an optimal treatment strategy. A multicenter controlled study comparing wide local excision with ablative procedures may be warranted.
Topics: Anus Neoplasms; Bowen's Disease; Carcinoma in Situ; Humans; Neoplasm Recurrence, Local; Skin Neoplasms
PubMed: 10411443
DOI: 10.1007/BF02237107 -
The Breast Journal Jun 2020Bowen's disease or squamous cell carcinoma in situ is a precursor malignant neoplasm restricted to the epidermis. Clinically and histologically, Bowen's disease of the... (Review)
Review
INTRODUCTION
Bowen's disease or squamous cell carcinoma in situ is a precursor malignant neoplasm restricted to the epidermis. Clinically and histologically, Bowen's disease of the nipple can resemble Paget's disease. It is crucial to differentiate between the two with immunohistological staining in order to provide the appropriate treatment. This review of Bowen's disease of the nipple will examine the diagnostic and treatment modalities previously used. We also present our own case of Bowen's disease of the nipple and propose a clinical pathway for this rare disease process.
METHODS
A review of published literature using MEDLINE, PubMed, and Google Scholar revealed seven articles were identified with a total of eight cases of Bowen's disease of the nipple.
RESULTS
Treatment modalities varied within the literature. This ranged from photodynamic therapy to simple mastectomy and sentinel lymph node biopsy. Standard surgical margins are inadequate for Bowen's disease of the nipple, as it has been shown to spread along the lactiferous ducts. Our case is of a 57-year-old female with Bowen's disease of her right nipple, confirmed through immunohistological staining. Wide local excision with immediate full-thickness skin graft reconstruction was performed and is now disease-free with a healed graft.
CONCLUSION
There is no accepted management pathway for Bowen's disease of the nipple. We propose a treatment algorithm that involves immunohistological staining to diagnose Bowen's disease of the nipple. This would then be followed by a wide local excision, complete nipple excision including underlying lactiferous ducts and glandular tissue and subsequent reconstruction.
Topics: Bowen's Disease; Breast Neoplasms; Female; Humans; Mastectomy; Middle Aged; Nipples; Skin Neoplasms
PubMed: 32212188
DOI: 10.1111/tbj.13824 -
Praxis Sep 2016
Review
Topics: Bowen's Disease; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Combined Modality Therapy; Cross-Sectional Studies; Diagnosis, Differential; Humans; Keratosis, Actinic; Skin Neoplasms; Sunscreening Agents; Ultraviolet Rays
PubMed: 27606914
DOI: 10.1024/1661-8157/a002459 -
Expert Review of Anticancer Therapy May 2013Dermoscopy has become an integrative part of the clinical examination of skin tumors. This is because it significantly improves the early diagnosis of melanoma and... (Review)
Review
Dermoscopy has become an integrative part of the clinical examination of skin tumors. This is because it significantly improves the early diagnosis of melanoma and non-melanoma skin cancer (NMSC) including basal cell carcinoma and keratinocyte skin cancer compared with the unaided eye. Besides its value in the noninvasive diagnosis of skin cancer, dermoscopy has also gained increased interest in the management of NMSC. Dermoscopy has been used in the preoperative evaluation of tumor margins, monitoring of the outcomes of topical treatments and post-treatment follow-up. This article provides an update on NMSC with special emphasis on dermoscopy in the diagnosis and management of basal cell carcinoma, actinic keratosis, Bowens' disease and squamous cell carcinoma.
Topics: Bowen's Disease; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Dermoscopy; Early Detection of Cancer; Humans; Keratosis, Actinic; Skin Neoplasms; Treatment Outcome
PubMed: 23617346
DOI: 10.1586/era.13.38 -
Giornale Italiano Di Dermatologia E... Dec 2016Keratinocyte skin cancer (KSC) refers to a broad class of tumors with a regrettably rising incidence worldwide. The term KSC stands for different stages of skin cancer... (Review)
Review
Keratinocyte skin cancer (KSC) refers to a broad class of tumors with a regrettably rising incidence worldwide. The term KSC stands for different stages of skin cancer including actinic keratosis (AK), Bowen's Disease (BD) and invasive squamous cell carcinoma (SCC). These tumors tend to grow slow, are unlikely to result in distant metastatic disease and death but they frequently destroy underlying tissues and should therefore be removed at the earliest possible stage. The fact that the cure rate is very high when KSC is detected in early stages emphasizes once more the applicability of dermoscopy as an integrative part of the clinical examination of skin tumors. In the first part of this review article, we summarize key points of the dermoscopic diagnosis of KSC including different stages of AK, BD and SCC. In the second part we want to focus on the progression model of KSC and the role of dermoscopy in the management of keratinocyte skin cancer.
Topics: Bowen's Disease; Carcinoma, Squamous Cell; Dermoscopy; Disease Progression; Humans; Keratinocytes; Keratosis, Actinic; Neoplasm Staging; Skin Neoplasms
PubMed: 27589482
DOI: No ID Found -
The American Journal of Dermatopathology Apr 2023
Topics: Humans; Bowen's Disease; Skin Neoplasms; Melanoma
PubMed: 36921300
DOI: 10.1097/DAD.0000000000002393