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Clinical and Experimental Dermatology Sep 2002Sporotrichosis is a cutaneous fungal infection with a global distribution. The disease has several clinical forms, primarily cutaneous with associated lymphadenopathy.... (Review)
Review
Sporotrichosis is a cutaneous fungal infection with a global distribution. The disease has several clinical forms, primarily cutaneous with associated lymphadenopathy. However, dissemination to osteoarticular structures and viscera may occur, both in healthy and immunosuppressed individuals; such disseminated forms usually follow spread after inhalation of fungal spores. Cutaneous infection is usually associated with trauma during the course of outdoor work, and treatment is required for the majority of patients. Potassium iodide (the treatment of choice in endemic areas) is an effective and inexpensive therapy; however, its adverse effects and complicated dosage regimen often weigh against its use in developed countries, where itraconazole is the antimycotic of choice.
Topics: Antifungal Agents; Diagnosis, Differential; Humans; Potassium Iodide; Sporotrichosis
PubMed: 12372075
DOI: 10.1046/j.1365-2230.2002.01087.x -
Photodiagnosis and Photodynamic Therapy Dec 2018Photodynamic Inactivation (PDI) has recently gained interest as an alternative modality to fight pathogenic entities and its effect can be further enhanced by using... (Comparative Study)
Comparative Study
BACKGROUND
Photodynamic Inactivation (PDI) has recently gained interest as an alternative modality to fight pathogenic entities and its effect can be further enhanced by using certain inorganic salts. Here, the Potassium Iodide (KI)-mediated PDI effect on Enterococcus faecalis using Toluidine Blue Ortho (TBO) as photosensitizer (PS) has been evaluated, and subsequent Biofilm formation extent is accounted for.
METHODS
The comparative photoinactivation of TBO and TBO/KI on E.faecalis was investigated by quantifying surviving bacterial colonies after laser irradiation with 30,60, and 180 s exposure times and different PS/Potentiator concentrations. The biofilm formation capability of E.faecalis was observed by calculating Optical Density (OD) of samples 24,48, and 72 h post-PDI treatment. Scanning Electron Microscopy (SEM) was used as a qualitative measure of bacterial biofilm growth.
RESULTS
More than 4 LOGS of photokilling was obtained for experimental groups with the highest PS/KI concentrations at 180 s exposure time. All KI-potentiated groups showed enhancement in PDI effect when compared to non-potentiated counterparts. The degree of recurring biofilm for laser-treated groups also showed to be much less than that of control group, as confirmed by both OD measurement and SEM imaging.
Topics: Biofilms; Enterococcus faecalis; Photochemotherapy; Photosensitizing Agents; Potassium Iodide; Tolonium Chloride
PubMed: 30278278
DOI: 10.1016/j.pdpdt.2018.09.019 -
Acta Dermato-venereologica 1990We studied the effect of potassium iodide on the chemotaxis of neutrophil in 15 healthy subjects with a modified Boyden chamber method. Orally administered potassium...
We studied the effect of potassium iodide on the chemotaxis of neutrophil in 15 healthy subjects with a modified Boyden chamber method. Orally administered potassium iodide (15 mg/kg/day for 3 days) significantly inhibited the neutrophil chemotaxis in peripheral blood. It is postulated that the therapeutic effect of potassium iodide on erythema nodosum, nodular vasculitis, and Sweet's syndrome might be mediated through the inhibition of neutrophil chemotaxis by this agent.
Topics: Adult; Chemotaxis, Leukocyte; Humans; Leukocyte Count; Male; Middle Aged; Neutrophils; Potassium Iodide
PubMed: 1972841
DOI: No ID Found -
Anais Brasileiros de Dermatologia 2021Sporotrichosis is a subcutaneous mycosis caused by dimorphic fungi of the genus Sporothrix. The authors report a case of fixed cutaneous sporotrichosis with therapeutic...
Sporotrichosis is a subcutaneous mycosis caused by dimorphic fungi of the genus Sporothrix. The authors report a case of fixed cutaneous sporotrichosis with therapeutic failure after 18 months of itraconazole and terbinafine associated with cryosurgery. The patient was cured after the introduction of saturated potassium iodide solution. Sporothrix brasiliensis was the identified species, presenting a susceptibility profile to itraconazole and terbinafine. This fact suggests that therapeutic failure is probably related to the host-fungus interaction rather than drug resistance. It is possible that the immunomodulatory action of the saturated potassium iodide solution may have played an important role in curing this patient.
Topics: Antifungal Agents; Humans; Itraconazole; Potassium Iodide; Sporothrix; Sporotrichosis
PubMed: 33622634
DOI: 10.1016/j.abd.2020.04.013 -
Science (New York, N.Y.) Dec 1982
Topics: Animals; Dose-Response Relationship, Radiation; Humans; Iodine Radioisotopes; Neoplasms, Radiation-Induced; Potassium Iodide; Thyroid Gland; Thyroid Neoplasms
PubMed: 7146900
DOI: 10.1126/science.7146900 -
British Medical Journal Oct 1969
Topics: Adult; Asthma; Child; Female; Humans; Male; Potassium Iodide
PubMed: 5349316
DOI: 10.1136/bmj.4.5677.236 -
American Journal of Ophthalmology Jan 1970
Topics: Animals; Anti-Bacterial Agents; Antifungal Agents; Aspergillosis; Glycolysis; Keratitis; Mycoses; Photometry; Potassium Iodide; Rabbits; Sodium Chloride
PubMed: 5411653
DOI: 10.1016/0002-9394(70)91864-7 -
Journal of the American Academy of... May 1994
Clinical Trial Randomized Controlled Trial
Topics: Administration, Oral; Adolescent; Adult; Aged; Double-Blind Method; Female; Follow-Up Studies; Granuloma Annulare; Humans; Male; Middle Aged; Placebos; Potassium Iodide; Remission Induction
PubMed: 8176023
DOI: 10.1016/s0190-9622(08)81516-2 -
Archives of Internal Medicine Aug 1982A 73-year-old man was initially seen with a 15-year history of intermittent fevers and had been treated for culture-negative subacute bacterial endocarditis. He had been...
A 73-year-old man was initially seen with a 15-year history of intermittent fevers and had been treated for culture-negative subacute bacterial endocarditis. He had been taking potassium iodide as a bronchorrheic agent for approximately the same 15-year period, and, when potassium iodide therapy was discontinued, the fever resolved and has not recurred during 2 1/2 years of observation. The possible mechanisms of fever caused by potassium iodide and current clinical indications for potassium iodide use are described.
Topics: Aged; Fever of Unknown Origin; Humans; Lung Diseases, Obstructive; Male; Potassium Iodide
PubMed: 7103636
DOI: No ID Found -
Methods in Molecular Biology (Clifton,... 2022Antimicrobial photodynamic inactivation (aPDI) involves the use of a nontoxic dye or photosensitizer excited with visible light to produce reactive oxygen species that...
Antimicrobial photodynamic inactivation (aPDI) involves the use of a nontoxic dye or photosensitizer excited with visible light to produce reactive oxygen species that can kill all classes of microorganisms. Antimicrobial photodynamic therapy (aPDT) can be used in vivo as an alternative therapeutic strategy to treat localized infections due to its ability to selectively kill microbes while preserving host mammalian cells. aPDI can be potentiated by the addition of the nontoxic inorganic salt potassium iodide (KI). KI is an approved drug for antifungal therapy. The mechanism of potentiation with iodide is likely to be singlet oxygen addition to iodide to form iodine radicals, hydrogen peroxide, and molecular iodine. A previous chapter in this volume described potentiation of aPDI in vitro by addition of KI, while in this chapter we address the ability of KI to potentiate aPDT in vivo using an animal model of localized fungal infection. We employed oral candidiasis in immunosuppressed mice caused by a bioluminescent strain of Candida albicans and monitored by bioluminescence imaging.
Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents; Disease Models, Animal; Iodides; Iodine; Mammals; Mice; Mycoses; Photochemotherapy; Potassium Iodide
PubMed: 35505038
DOI: 10.1007/978-1-0716-2099-1_33