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Clinical Infectious Diseases : An... Oct 1995The old therapies for sporotrichosis--saturated solution of potassium iodide (SSKI) and amphotericin B--have largely been supplanted by itraconazole treatment. Although... (Comparative Study)
Comparative Study Review
The old therapies for sporotrichosis--saturated solution of potassium iodide (SSKI) and amphotericin B--have largely been supplanted by itraconazole treatment. Although SSKI is effective for the treatment of lymphocutaneous sporotrichosis, it is difficult to administer and is frequently associated with side effects; response rates of >90% are associated with itraconazole therapy for lymphocutaneous sporotrichosis. Patients with osteoarticular sporotrichosis rarely have systemic symptoms and can be effectively treated with a prolonged course of itraconazole, thus obviating the need for intravenous amphotericin B therapy with its associated toxic effects. Pulmonary sporotrichosis in patients infected with human immunodeficiency virus continue to be difficult therapeutic problems, but itraconazole appears to be at least as effective as amphotericin B as treatment for these forms of sporotrichosis.
Topics: Amphotericin B; Animals; Antifungal Agents; Azoles; Humans; Itraconazole; Potassium Iodide; Sporotrichosis
PubMed: 8645851
DOI: 10.1093/clinids/21.4.981 -
Internal Medicine (Tokyo, Japan) Feb 2020A patient with underlying Hashimoto's thyroiditis developed amiodarone-induced thyrotoxicosis type 1 that was successfully treated using methimazole in combination with...
A patient with underlying Hashimoto's thyroiditis developed amiodarone-induced thyrotoxicosis type 1 that was successfully treated using methimazole in combination with potassium iodide. A 35-year-old woman admitted for perinatal care of twin-to-twin transfusion syndrome was given amiodarone for 7 days for paroxysmal ventricular contraction following pulseless ventricular tachycardia 1 day after delivery. She developed thyrotoxicosis one month after the discontinuation of amiodarone therapy and was negative for thyroid-stimulating hormone receptor antibody. An increased peak velocity of the superior thyroid artery suggested amiodarone-induced thyrotoxicosis type 1. Her thyroid function recovered after combination therapy with methimazole and potassium iodide.
Topics: Adult; Amiodarone; Anti-Arrhythmia Agents; Antithyroid Agents; Female; Hashimoto Disease; Humans; Methimazole; Potassium Iodide; Thyrotoxicosis; Treatment Outcome
PubMed: 31554750
DOI: 10.2169/internalmedicine.2179-18 -
Lancet (London, England) Jul 1971
Topics: Antithyroid Agents; Follow-Up Studies; Humans; Hyperthyroidism; Potassium Iodide; Recurrence; Remission, Spontaneous; Thyroxine; Time Factors
PubMed: 4104847
DOI: 10.1016/s0140-6736(71)90895-6 -
Canadian Medical Association Journal May 1972
Topics: Adult; Aged; Female; Humans; Middle Aged; Potassium Iodide; Sporotrichosis
PubMed: 5032143
DOI: No ID Found -
Radiation Protection Dosimetry 2008In a breach-of-containment nuclear reactor accident, the near-field exposure is primarily through inhalation of radioiodine. Thyroid blockade by oral potassium iodide...
In a breach-of-containment nuclear reactor accident, the near-field exposure is primarily through inhalation of radioiodine. Thyroid blockade by oral potassium iodide (KI) is a practical and effective protective measure for the general public in such an emergency. The retention functions incorporating the thyroid blocking effects by KI have been derived using a standard three-compartment model of iodine metabolism. This allows more accurate estimation of the thyroid dose by calculating the blocking factor.
Topics: Adolescent; Adult; Child; Child, Preschool; Humans; Infant; Iodine Radioisotopes; Potassium Iodide; Radiation Injuries; Radioactive Hazard Release; Thyroid Gland; Tissue Distribution
PubMed: 19054795
DOI: 10.1093/rpd/ncn299 -
Public Health Reports (Washington, D.C.... 1983Tennessee public health officials made a decision to predistribute potassium iodide tablets (KI) to householders in the vicinity of a nuclear powerplant. The tablets...
Tennessee public health officials made a decision to predistribute potassium iodide tablets (KI) to householders in the vicinity of a nuclear powerplant. The tablets would be stored until needed in the event of a radiation emergency. The officials believed that it was important to have the option available as a means of protecting nearby residents. KI, ingested before or soon after exposure to radioactive iodine, can act as a thyroid blocker to protect the gland from accepting further iodine and, therefore, the radiation. A pilot project was undertaken to deliver, door to door, a package that contained KI tablets in sufficient quantity to supply a starter dose to each member of households within a 5-mile radius of the Sequoyah nuclear powerplant near Chattanooga. The package consisted of a vial of 14 130-mg tablets and a package insert from the manufacturer enclosed in a larger vial with a childproof cap. Home visitors who delivered the vials were professionals from the local public health departments, especially trained to answer questions about the project. About 66 percent of 5,591 homes accepted the medication. Extensive coverage of the project by information media was helpful in explaining local emergency plans as well as the KI distribution to the public.
Topics: Disaster Planning; Humans; Nuclear Reactors; Potassium Iodide; Public Health Administration; Radiation Injuries; Radiation-Protective Agents; Tennessee
PubMed: 6856735
DOI: No ID Found -
Dermatologia Internationalis 1969
Topics: Humans; Iodine; Potassium Iodide; Sporothrix; Sporotrichosis
PubMed: 5343406
DOI: 10.1111/j.1365-4362.1969.tb05327.x -
Annales D'endocrinologie Feb 2016The better knowledge of the mechanisms of nuclear incidents and lessons learned from accidents in the recent past to improve the effectiveness of measures taken... (Review)
Review
The better knowledge of the mechanisms of nuclear incidents and lessons learned from accidents in the recent past to improve the effectiveness of measures taken following a nuclear accident exposure to fallout of radioactive iodine isotopes. Thus, immediate, passive measures, such as containment, and stopping consumption of contaminated products are paramount. The earliest possible administration of stable iodine as potassium iodide (KI) reduces significantly (up to 90% if taken at the same time of the accident) thyroid radioactive contamination. These tablets should be given in priority to children and pregnant women. The side effects are minor. KI is not recommended for persons aged over 60 years, or for adults suffering from cardiovascular disorders.
Topics: Chernobyl Nuclear Accident; Child; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Iodine Radioisotopes; Nuclear Power Plants; Potassium Iodide; Pregnancy; Radioactive Fallout; Radioactive Hazard Release; Thyroid Diseases; Thyroid Neoplasms
PubMed: 26830953
DOI: 10.1016/j.ando.2015.12.003 -
Biosecurity and Bioterrorism :... Dec 2011
Topics: Disaster Planning; Drug Storage; Health Policy; Humans; Potassium Iodide; Radiation Injuries; Radiation-Protective Agents; Radioactive Hazard Release; Thyroid Neoplasms; United States
PubMed: 22077703
DOI: 10.1089/bsp.2011.1026 -
Mycopathologia Feb 1987The ultrastructural changes produced by iodine-potassium iodide solution on yeast cells of Sporothrix schenckii were investigated by transmission electron microscopy in...
The ultrastructural changes produced by iodine-potassium iodide solution on yeast cells of Sporothrix schenckii were investigated by transmission electron microscopy in order to clarify the mechanism of oral potassium iodide therapy for sporotrichosis. Yeast cells were dipped with solutions containing various concentrations of iodine. The rate of germination decreased markedly between the range of iodine concentrations from 0.63 microgram/ml to 5.0 micrograms/ml. No significant ultrastructural changes were seen at the concentration of the iodine of 1.25 microgram/ml (80% germination) or less. In the concentration of 2.5 micrograms/ml (50% germination), normal cells and degenerated cells coexisted. When the cells were treated with 5.0 micrograms of iodine per ml (0% germination) or more, their interior structures were completely destroyed. It is assumed that iodine treatment of the organism causes rapid destruction in the whole cell.
Topics: Iodine; Microscopy, Electron; Potassium Iodide; Sporothrix
PubMed: 3574432
DOI: 10.1007/BF00436850