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Ugeskrift For Laeger Jul 2014The literature reports a large variety of adverse reactions to potassium iodide. A severe hypersensitivity reaction to potassium iodide in a 51-year-old woman with...
The literature reports a large variety of adverse reactions to potassium iodide. A severe hypersensitivity reaction to potassium iodide in a 51-year-old woman with Graves' thyrotoxicosis is described. Following administration the patient developed sialadenitis, conjunctivitis, stomatitis and acneiform iododerma that responded dramatically to withdrawal of the potassium iodide and administration with corticosteroids. Awareness of these adverse reactions may prevent prolonged hospitalization and unnecessary tests and treatments.
Topics: Drug Eruptions; Female; Graves Disease; Humans; Middle Aged; Potassium Iodide; Thyrotoxicosis
PubMed: 25292005
DOI: No ID Found -
The British Journal of Dermatology Jan 1976Twenty-four of twenty-eight patients with erythema nodosum and sixteen of seventeen patients with nodular vasculitis responded to treatment with potassium iodide. Relief...
Twenty-four of twenty-eight patients with erythema nodosum and sixteen of seventeen patients with nodular vasculitis responded to treatment with potassium iodide. Relief of symptoms occurred within 2 days. The average duration of treatment was 3 weeks and the lesions took an average of 2 weeks to resolve. The possible mode of action of potassium iodide is discussed and an immunosuppressive effect mediated by heparin is suggested.
Topics: Adolescent; Adult; Erythema Nodosum; Female; Humans; Hypersensitivity; Male; Middle Aged; Potassium Iodide; Vascular Diseases
PubMed: 943168
DOI: 10.1111/j.1365-2133.1976.tb04345.x -
Journal of Photochemistry and... Sep 2018A new fullerene (BB4-PPBA) functionalized with a tertiary amine and carboxylic acid was prepared and compared with BB4 (cationic quaternary group) for antimicrobial... (Comparative Study)
Comparative Study
A new fullerene (BB4-PPBA) functionalized with a tertiary amine and carboxylic acid was prepared and compared with BB4 (cationic quaternary group) for antimicrobial photodynamic inactivation (aPDI). BB4 was highly active against Gram-positive methicillin resistant Staphylococcus aureus (MRSA) and BB4-PPBA was moderately active when activated by blue light. Neither compound showed much activity against Gram-negative Escherichia coli or fungus Candida albicans. Therefore, we examined potentiation by addition of potassium iodide. Both compounds were highly potentiated by KI (1-6 extra logs of killing). BB4-PPBA was potentiated more than BB4 against MRSA and E. coli, while for C. albicans the reverse was the case. Addition of azide potentiated aPDI mediated by BB4 against MRSA, but abolished the potentiation caused by KI with both compounds. The killing ability after light decayed after 24 h in the case of BB4, implying a contribution from hypoiodite as well as free iodine. Tyrosine was readily iodinated with BB4-PPBA plus KI, but less so with BB4. We conclude that the photochemical mechanisms of these two fullerenes are different. BB4-PPBA is more Type 2 (singlet oxygen) while BB4 is more Type 1 (electron transfer). There is also a possibility of direct bacterial killing by electron transfer, but this will require more study to prove.
Topics: Amines; Anti-Infective Agents; Candida albicans; Carboxylic Acids; Electron Transport; Escherichia coli; Fullerenes; Light; Methicillin-Resistant Staphylococcus aureus; Potassium Iodide; Singlet Oxygen
PubMed: 30075425
DOI: 10.1016/j.jphotobiol.2018.07.027 -
Biomolecules Dec 2019Follow-up studies after the Chernobyl and Fukushima accidents have shown that Cs and I made up the major amount of harmful contaminants in the atmospheric dispersion and... (Review)
Review
Follow-up studies after the Chernobyl and Fukushima accidents have shown that Cs and I made up the major amount of harmful contaminants in the atmospheric dispersion and fallout. Other potential sources for such radionuclide exposure may be terrorist attacks, e.g., via contamination of drinking water reservoirs. A primary purpose of radionuclide mobilization is to minimize the radiation dose. Rapid initiation of treatment of poisoned patients is imperative after a contaminating event. Internal contamination with radioactive material can expose patients to prolonged radiation, thus leading to short- and long-term clinical consequences. After the patient's emergency conditions are addressed, the treating physicians and assisting experts should assess the amount of radioactive material that has been internalized. This evaluation should include estimation of the radiation dose that is delivered and the specific radionuclides inside the body. These complex assessments warrant the reliance on a multidisciplinary approach that incorporates regional experts in radiation medicine and emergencies. Regional hospitals should have elaborated strategies for the handling of radiation emergencies. If radioactive cesium is a significant pollutant, Prussian blue is the approved antidote for internal detoxification. Upon risks of radioiodine exposure, prophylactic or immediate treatment with potassium iodide tablets is recommended. Chelators developed from calcium salts have been studied for gastrointestinal trapping and enhanced mobilization after strontium exposure.
Topics: Cesium Radioisotopes; Ferrocyanides; Humans; Iodine Radioisotopes; Post-Exposure Prophylaxis; Potassium Iodide; Pre-Exposure Prophylaxis; Radiation Exposure; Radioactive Hazard Release
PubMed: 31835766
DOI: 10.3390/biom9120856 -
Presse Medicale (Paris, France : 1983) Nov 1983
Topics: Adolescent; Adult; Aged; Child; Erythema Nodosum; Female; Humans; Middle Aged; Potassium Iodide
PubMed: 6227893
DOI: No ID Found -
Science (New York, N.Y.) Jul 1983
Topics: Accidents; Humans; Iodine Radioisotopes; New York City; Nuclear Reactors; Potassium Iodide
PubMed: 6867710
DOI: 10.1126/science.6867710 -
JAMA
Topics: Accidents; Nuclear Reactors; Potassium Iodide
PubMed: 2308195
DOI: No ID Found -
JAMA Jun 1967
Clinical Trial
Topics: Adult; Aged; Clinical Trials as Topic; Female; Humans; Iodine Isotopes; Male; Middle Aged; Potassium Iodide; Pregnancy; Radiation-Protective Agents; Radioactive Fallout; Thyroid Gland
PubMed: 5337789
DOI: No ID Found -
The Journal of Clinical Endocrinology... Jul 1966
Topics: Antithyroid Agents; Graves Disease; Humans; Hyperthyroidism; Iodine Isotopes; Potassium Iodide; Thyroxine
PubMed: 4161989
DOI: 10.1210/jcem-26-7-778 -
New York State Journal of Medicine Sep 1965
Topics: Drug Hypersensitivity; Fever; Humans; Potassium Iodide; Toxicology
PubMed: 14336311
DOI: No ID Found