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Annals of the Rheumatic Diseases Mar 1990
Clinical Trial Randomized Controlled Trial
Topics: Adult; Aged; Arthritis, Rheumatoid; Female; Humans; Male; Middle Aged; Randomized Controlled Trials as Topic; Sulfasalazine
PubMed: 1969729
DOI: 10.1136/ard.49.3.202-a -
Postgraduate Medical Journal Sep 1973A case report of a patient with agranulocytosis associated with sulphasalazine therapy is described. Recovery followed supportive therapy and withdrawal of the drug....
A case report of a patient with agranulocytosis associated with sulphasalazine therapy is described. Recovery followed supportive therapy and withdrawal of the drug. Investigations including tests for leucocyte antibodies, the presence of which might have suggested an immunological cause for the drug reaction, were negative; an acetylation study, however, characterized the patient as a ‘slow’ acetylator phenotype, suggesting that the drug reaction was more likely to have been toxic in nature. It is suggested that acetylation studies be performed in patients who have previously shown serious side effects to sulphasalazine to assess the incidence of ‘slow’ acetylators.
Topics: Acetylation; Aged; Agranulocytosis; Antibodies; Female; Humans; Leukocytes; Sulfasalazine; Time Factors
PubMed: 4151092
DOI: 10.1136/pgmj.49.575.669 -
Pharmacology & Therapeutics 1989
Review
Topics: Arthritis, Rheumatoid; Humans; Sulfasalazine
PubMed: 2570427
DOI: 10.1016/0163-7258(89)90035-1 -
Klinicheskaia Meditsina 1997
Review
Topics: Antirheumatic Agents; Humans; Rheumatic Diseases; Sulfasalazine
PubMed: 9273399
DOI: No ID Found -
British Journal of Rheumatology Nov 1995Sulphasalazine was initially used more than 50 yr ago to treat inflammatory arthritis but fell into disuse, only to be revived 25 yr ago for rheumatoid arthritis. Since... (Review)
Review
Sulphasalazine was initially used more than 50 yr ago to treat inflammatory arthritis but fell into disuse, only to be revived 25 yr ago for rheumatoid arthritis. Since then its place as a second-line agent has been established and its toxicity profile has been outlined. Subsequently, its use has been widened to include other inflammatory rheumatic diseases, with strong suggestions that it may be useful for several indications. The history of its initial use, its reintroduction and the establishment of its place in modern rheumatology are reviewed.
Topics: Antirheumatic Agents; Clinical Trials as Topic; Humans; Rheumatic Diseases; Sulfasalazine
PubMed: 8535643
DOI: No ID Found -
Indian Journal of Gastroenterology :... Jul 1989
Topics: Adult; Colitis, Ulcerative; Drug Hypersensitivity; Humans; Male; Sulfasalazine
PubMed: 2568340
DOI: No ID Found -
The Medical Journal of Australia Apr 1976A patient developed the rare complication of pulmonary eosinophilia whilst receiving sulphasalazine. A review of the world literature on sulphasalazine-induced lung...
A patient developed the rare complication of pulmonary eosinophilia whilst receiving sulphasalazine. A review of the world literature on sulphasalazine-induced lung disease is presented.
Topics: Humans; Male; Middle Aged; Pulmonary Eosinophilia; Sulfasalazine
PubMed: 6865
DOI: No ID Found -
Gut Mar 1974A woman with ulcerative colitis was treated with sulphasalazine and prednisolone. After four months' treatment she began to get short of breath and she died a month...
A woman with ulcerative colitis was treated with sulphasalazine and prednisolone. After four months' treatment she began to get short of breath and she died a month later with severe subacute fibrosing alveolitis. It is believed that the lung disease was caused by sulphasalazine and that prednisolone was not able to prevent its development. A reversible form of lung disease has previously been attributed to this drug.
Topics: Autopsy; Colitis, Ulcerative; Female; Humans; Lung; Middle Aged; Prednisolone; Pulmonary Fibrosis; Radiography; Sulfasalazine
PubMed: 4152289
DOI: 10.1136/gut.15.3.185 -
British Medical Journal (Clinical... Sep 1983
Topics: Chemical and Drug Induced Liver Injury; Colitis, Ulcerative; Humans; Liver Function Tests; Sulfasalazine; Time Factors
PubMed: 6137258
DOI: 10.1136/bmj.287.6394.759-a -
British Medical Journal Dec 1979
Topics: Colitis, Ulcerative; Female; Humans; Maternal-Fetal Exchange; Milk, Human; Pregnancy; Pregnancy Complications; Sulfapyridine; Sulfasalazine
PubMed: 43760
DOI: 10.1136/bmj.2.6204.1553