Pharmacologic Substance
sulfasalazine Audio
sul·fa·sal·a·zine [ suhl-fuh-sal-uh-zeen ]
Brand Names:
Azulfidine; Sulfazine
Effect:
Decreased Platelet Aggregation; Decreased Prostaglandin Production; Decreased Thromboxane Production
May Treat:
Arthritis, Juvenile; Arthritis, Rheumatoid; Colitis, Ulcerative
More Information:
ChemID; DrugBank; DailyMed; DrugInfo; PDR
Definitions related to sulfasalazine:
  • A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907)
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
  • A synthetic salicylic acid derivative with affinity for connective tissues containing elastin and formulated as a prodrug, antiinflammatory Sulfasalazine acts locally in the intestine through its active metabolites, sulfamide 5-aminosalicylic acid and salicylic acid, by a mechanism that is not clear. It appears inhibit cyclooxygenase and prostaglandin production and is used in the management of inflammatory bowel diseases. (NCI04)
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.