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Nature Communications Feb 2021
Topics: Bodily Secretions; Extracellular Vesicles; Receptors, Endothelin; Sulfisoxazole
PubMed: 33579909
DOI: 10.1038/s41467-021-21074-x -
Bioorganic & Medicinal Chemistry May 2020New functionalized acrylamide derivatives bearing sulfisoxazole moiety were designed to target bacterial dihydropteroate synthase (DHPS). The in vitro antimicrobial...
New functionalized acrylamide derivatives bearing sulfisoxazole moiety were designed to target bacterial dihydropteroate synthase (DHPS). The in vitro antimicrobial activities of these compounds were assessed. The E-configuration of compound 5b was proved by single crystal X-ray analysis. Compounds 5g and 5h displayed double the activity of ampicillin against B. subtilis. Also, 5h was two times more active than gentamycin against E. coli. Interestingly, compounds 5f-g, 7c, 8a, 8c exhibited two folds the potency of amphotericin B against S. racemosum while 5h displayed three folds the activity of amphotericin B against S. racemosum. Most of the synthesized compounds showed superior activities to the parent sulfisoxazole and were non-toxic to normal cells. DHPS is confirmed to be a putative target for our compounds via antagonizing their antibacterial activity by the folate precursor (p-aminobenzoic acid) and product (methionine) on E. coli ATCC 25922. Docking experiments against DHPS rationalized the observed antibacterial activity. Additionally, compound 5g was evaluated as a selective targeting vector for Tc that showed a remarkable uptake and targeting ability towards the infection site that was induced in mice.
Topics: Acrylamide; Anti-Bacterial Agents; Cells, Cultured; Dihydropteroate Synthase; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gram-Negative Bacteria; Gram-Positive Bacteria; Humans; Microbial Sensitivity Tests; Molecular Docking Simulation; Molecular Structure; Structure-Activity Relationship; Sulfisoxazole
PubMed: 32220521
DOI: 10.1016/j.bmc.2020.115444 -
Advanced Science (Weinheim,... Feb 2022Despite their potent antitumor activity, clinical application of immune checkpoint inhibitors has been significantly limited by their poor response rates (<30%) in...
Despite their potent antitumor activity, clinical application of immune checkpoint inhibitors has been significantly limited by their poor response rates (<30%) in cancer patients, primarily due to immunosuppressive tumor microenvironments. As a representative immune escape mechanism, cancer-derived exosomes have recently been demonstrated to exhaust CD8 cytotoxic T cells. Here, it is reported that sulfisoxazole, a sulfonamide antibacterial, significantly decreases the exosomal PD-L1 level in blood when orally administered to the tumor-bearing mice. Consequently, sulfisoxazole effectively reinvigorates exhausted T cells, thereby eliciting robust antitumor effects in combination with anti-PD-1 antibody. Overall, sulfisoxazole regulates immunosuppression through the inhibition of exosomal PD-L1, implying its potential to improve the response rate of anti-PD-1 antibodies.
Topics: Animals; B7-H1 Antigen; Exosomes; Humans; Immune Checkpoint Inhibitors; Immunity; Mice; Neoplasms; Sulfisoxazole; Tumor Microenvironment
PubMed: 34927389
DOI: 10.1002/advs.202103245 -
Environmental Science & Technology Nov 2023Permanganate (Mn(VII)) is extensively applied in water purification due to its stability and ease of handling, but it is a mild oxidant for trace organic contaminants...
Permanganate (Mn(VII)) is extensively applied in water purification due to its stability and ease of handling, but it is a mild oxidant for trace organic contaminants (TrOCs). Hence, there is significant interest in strategies for enhancing reaction kinetics, especially in combination with efficient and economical carbocatalysts. This study compared the performance of four carbocatalysts (graphite, graphene oxide (GO), reduced-GO (rGO), and nitrogen-doped rGO (N-rGO)) in accelerating sulfisoxazole (SSX) oxidation by Mn(VII) and found that GO exhibited the greatest catalytic performance. Besides, the Mn(VII)/GO system shows desirable capacities to remove a broad spectrum of TrOCs. We proposed that the degradation of SSX in Mn(VII)-GO suspensions follows two routes: (i) direct oxidation of SSX by Mn species [both Mn(VII) and formed MnO] and (ii) a carbocatalyst route, where GO acts as an electron mediator, accepting electrons from SSX and transferring them to Mn(VII). We developed a mathematical model to show the contribution of each parallel pathway and found one-electron transfer is primarily responsible for accelerating SSX removal in the Mn(VII)/GO system. Findings in this study showed that GO provides a simple and effective strategy for enhancing the reactivity of Mn(VII) and provided mechanistic insights into the GO-catalyzed redox reaction between SSX and Mn(VII).
Topics: Sulfisoxazole; Oxides; Oxidation-Reduction; Manganese Compounds
PubMed: 36727553
DOI: 10.1021/acs.est.2c08141 -
Nature Communications Feb 2021
Topics: Bodily Secretions; Extracellular Vesicles; Receptors, Endothelin; Sulfisoxazole
PubMed: 33579906
DOI: 10.1038/s41467-021-21075-w -
Journal of the American Pharmaceutical... Nov 1976
Topics: Adult; Biological Availability; Humans; Middle Aged; Sulfisoxazole
PubMed: 977890
DOI: No ID Found -
The Journal of Pediatrics Jul 1981
Topics: Adult; Bilirubin; Breast Feeding; Female; Humans; Infant, Newborn; Milk, Human; Sulfisoxazole
PubMed: 7252664
DOI: 10.1016/s0022-3476(81)81002-5 -
Journal of the American Medical... Dec 1951
Topics: Agranulocytosis; Sulfanilamide; Sulfanilamides; Sulfisoxazole; Sulfonamides
PubMed: 14880425
DOI: 10.1001/jama.1951.73670340006010e -
The Journal of Pediatrics Nov 1980
Topics: Adult; Female; Humans; Infant; Male; Milk, Human; Sulfisoxazole
PubMed: 7431180
DOI: 10.1016/s0022-3476(80)80284-8 -
Environmental Science and Pollution... Jun 2022A novel Ag/BiOBr/CeO composite was successfully prepared for the first time, which had excellent performance in degrading sulfisoxazole (SSX) under visible light...
A novel Ag/BiOBr/CeO composite was successfully prepared for the first time, which had excellent performance in degrading sulfisoxazole (SSX) under visible light irradiation. The as-prepared samples were characterized by SEM, XRD, UV-vis DRS and BET et al. The composite of 10% Ag/BiOBr/CeO showed the best photocatalytic activity and more than 99.5% SSX can be removed within 20 min. It exhibited the highest k value of 0.2428 min, which was about 39.7 times higher than pure BiOBr (6.11 × 10 min) and 22.1 times higher than BiOBr/CeO (1.09 × 10 min), respectively. The addition of Ag significantly improved the absorption rate of visible light and the separation rate of photogenerated electron-hole pairs. The initial pH and dosage of samples could have an influence on the photocatalytic activity. The radical trapping experiments proved that ·O and h were the main active species involved in photocatalytic degradation. Finally, the synthesized catalyst maintained excellent photocatalytic activity after 5 repeated cycles, which indicated the extraordinary stability and recyclability of Ag/BiOBr/CeO.
Topics: Bismuth; Catalysis; Light; Sulfisoxazole
PubMed: 35167019
DOI: 10.1007/s11356-021-17669-y