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The Western Journal of Medicine Jan 1984Sulfisoxazole, 75 mg per kg per day, was administered for 13 weeks to all children with otitis media recurring at a rate of at least once every other month. The first 26...
Sulfisoxazole, 75 mg per kg per day, was administered for 13 weeks to all children with otitis media recurring at a rate of at least once every other month. The first 26 patients began prophylaxis during the months of January and February of 1979. To compare rates of otitis media with those in children not receiving concurrent prophylaxis during the same season, a matched control was randomly chosen as a child who began prophylaxis on the day nearest that when a study patient completed prophylaxis. The rates of otitis media during this same period were determined as the number of episodes per patient-month. Of the 26 treated patients, 11 had 16 episodes of otitis media in 72 patient-months (0.22 episodes per patient-month), in contrast to the 26 untreated patients who had 63 episodes in the same period (0.88 episodes per patient-month). This 75% reduction in incidence was statistically significant by X(2) analysis (P<.005). The two groups of children were comparable in age, sex, nursery school attendance, family history of allergy and number of episodes in the three months preceding chemoprophylaxis. These findings support the short-term chemoprophylactic use of sulfisoxazole for recurrent otitis media.
Topics: Child, Preschool; Drug Evaluation; Female; Humans; Infant; Infant, Newborn; Male; Otitis Media; Recurrence; Sulfisoxazole
PubMed: 6702192
DOI: No ID Found -
The New England Journal of Medicine Sep 1974
Clinical Trial Randomized Controlled Trial
Topics: Acute Disease; Administration, Oral; Child; Child, Preschool; Clinical Trials as Topic; Cooperative Behavior; Female; Follow-Up Studies; Haemophilus influenzae; Humans; Infant; Male; Nasopharynx; Otitis Media; Placebos; Recurrence; Streptococcus; Streptococcus pneumoniae; Sulfisoxazole
PubMed: 4153093
DOI: 10.1056/NEJM197409262911307 -
The American Journal of Psychiatry Feb 1983
Topics: Adult; Ataxia; Drug Interactions; Drug Therapy, Combination; Female; Humans; Phenelzine; Sulfisoxazole; Vertigo
PubMed: 6849452
DOI: 10.1176/ajp.140.2.264 -
Environmental Research Aug 2020CoO-SnO/rice straw biochar (RSBC) was prepared for the first time via calcining oxalate precipitation precursor dispersed on the surface of RSBC and used as a catalyst...
CoO-SnO/rice straw biochar (RSBC) was prepared for the first time via calcining oxalate precipitation precursor dispersed on the surface of RSBC and used as a catalyst for activating PMS to degrade sulfisoxazole (SIZ). The results demonstrated that CoO-SnO/RSBC possessed much better catalytic performance than CoO, CoO-SnO, CoO/RSBC, and SnO/RSBC, which is ascribed to the synergy of CoO, SnO and RSBC. Approximately 98% of SIZ (50 mg/L) was decomposed by PMS (1 mmol/L) activated with CoO-SnO/RSBC (0.1 g/L) within 5 min. The optimal degradation efficiency of SIZ was realized at the initial pH 9. CoO-SnO/RSBC also displayed remarkable stability and reusability, and the degradation rate of SIZ maintained over 90% even after the fifth recycle run. The electron paramagnetic resonance (EPR) technique and quenching experiments proved singlet oxygen (O) to be the main reactive oxygen species (ROS) responsible for the SIZ decomposition in the CoO-SnO/RSBC/PMS system. On the basis of the characterization analysis, the identification of the ROS and the SIZ degradation products, the possible mechanism and pathways of the SIZ degradation by a combination of PMS and CoO-SnO/RSBC were further proposed. This study provides not only a new insight into non-radical mechanism for the heterogeneous activating PMS over CoO-SnO/RSBC to degrade organic pollutants but also an eco-friendly synthetic route for exploring novel and efficient catalysts.
Topics: Charcoal; Oryza; Peroxides; Singlet Oxygen; Sulfisoxazole
PubMed: 32464448
DOI: 10.1016/j.envres.2020.109665 -
Antimicrobial Agents and Chemotherapy Oct 1985We studied the elimination of sulfisoxazole in eight renal transplant patients. The patients received sulfisoxazole prophylactically for urinary tract infection...
We studied the elimination of sulfisoxazole in eight renal transplant patients. The patients received sulfisoxazole prophylactically for urinary tract infection commencing 7 days postoperatively. The renal elimination of sulfisoxazole (unbound renal clearance) was decreased in this patient population and was highly correlated with creatinine clearance. The unbound metabolic clearance and apparent unbound formation clearance of N4-acetyl sulfisoxazole did not differ from values found in healthy volunteers. The protein binding was marginally lower in this patient population than in healthy subjects after a single dose. The reduced binding was compatible with a reduced albumin concentration. In contrast to the situation for healthy subjects, the binding of sulfisoxazole decreased upon multiple dosing. This is probably due to a relatively higher sulfisoxazole and N4-acetyl sulfisoxazole-to-albumin ratio in this patient population than in healthy subjects. No complications of sulfisoxazole therapy were seen, although in three subjects concentration of the N4-acetyl sulfisoxazole in urine exceeded its theoretical solubility on a few occasions.
Topics: Acetylation; Adult; Creatinine; Female; Humans; Hydrogen-Ion Concentration; Kidney Transplantation; Kinetics; Male; Protein Binding; Sulfisoxazole
PubMed: 3907496
DOI: 10.1128/AAC.28.4.535 -
Journal of Environmental Sciences... May 2016Graphite and graphene electrodes were prepared by using pure graphite as precursor. The electrode materials were characterized by a scanning electron microscope (SEM),...
Graphite and graphene electrodes were prepared by using pure graphite as precursor. The electrode materials were characterized by a scanning electron microscope (SEM), X-ray diffraction (XRD) and cyclic voltammetry (CV) measurements. The electro-catalytic activity for degradation of sulfisoxazole (SIZ) was investigated by using prepared graphene or graphite anode. The results showed that the degradation of SIZ was much more rapid on the graphene than that on the graphite electrode. Moreover, the graphene electrode exhibited good stability and recyclability. The analysis on the intermediate products and the measurement of active species during the SIZ degradation demonstrated that indirect oxidation is the dominant mechanism, involving the electro-catalytic generation of OH and O2(-) as the main active oxygen species. This study implies that graphene is a promising potential electrode material for long-term application to electro-catalytic degradation of organic pollutants.
Topics: Electrochemical Techniques; Electrodes; Environmental Pollutants; Graphite; Sulfisoxazole
PubMed: 27155409
DOI: 10.1016/j.jes.2015.08.014 -
International Journal of Pharmaceutics Oct 2017In this study, our aim was to develop solid drug-cyclodextrin inclusion complex system having nanofibrous morphology in order to have fast-dissolving property and...
Polymer-free electrospun nanofibers from sulfobutyl ether-beta-cyclodextrin (SBE-β-CD) inclusion complex with sulfisoxazole: Fast-dissolving and enhanced water-solubility of sulfisoxazole.
In this study, our aim was to develop solid drug-cyclodextrin inclusion complex system having nanofibrous morphology in order to have fast-dissolving property and enhanced water-solubility of poorly water-soluble drug. Here, we prepared a highly concentrated aqueous solution of inclusion complex between sulfisoxazole and sulfobutyl ether-beta-cyclodextrin (SBE-β-CD, Captisol), and then, without using any polymeric matrix, the electrospinning of sulfisoxazole/SBE-β-CD-IC nanofibers was performed in order to obtain free-standing and handy nanofibrous web. As a control sample, nanofibers from pure SBE-β-CD was also electrospun and free-standing nanofibrous web was obtained. The SEM imaging revealed that the bead-free and uniform nanofiber morphology with the average fiber diameter (AFD) of 650±290nm for sulfisoxazole/SBE-β-CD-IC NF and 890±415nm for pure SBE-β-CD NF was obtained. The inclusion complex formation between sulfisoxazole and SBE-β-CD in sulfisoxazole/SBE-β-CD-IC NF sample was confirmed by H NMR, TGA, DSC, XRD and FTIR analyses. Due to the combined advantage of cyclodextrin inclusion complexation and high surface area of electrospun nanofibers, fast-dissolving property with enhanced water-solubility was successfully achieved for sulfisoxazole/SBE-β-CD-IC NF. Our findings suggest that electrospun nanofibers/nanowebs from CD-IC of poorly water-soluble drugs may offer applicable approaches for high water-solubility and fast-dissolving tablet formulations for drug delivery systems.
Topics: Drug Carriers; Nanofibers; Polymers; Solubility; Sulfisoxazole; beta-Cyclodextrins
PubMed: 28445768
DOI: 10.1016/j.ijpharm.2017.04.047 -
Marine Pollution Bulletin Jan 2022It's a new perspective to explore the influences of chromophoric dissolved organic matter (CDOM) components and environmental factors on the removal of sulfisoxazole...
It's a new perspective to explore the influences of chromophoric dissolved organic matter (CDOM) components and environmental factors on the removal of sulfisoxazole (SIX) from the water matrix. Reactive intermediates (RIs) trapping experiments demonstrated that excited triplet-state CDOM (CDOM) played a dominant promoting role (54.11%) in the CDOM-mediated SIX indirect photodegradation. Additionally, terrestrial humic-like (C1, C3 and C4) and marine humic-like (C2) fluorescent components were identified by parallel factor (PARAFAC) analysis of CDOM excitation-emission matrix spectroscopy (EEMs). C1 and C4 were significantly correlated (R > 0.91) with the SIX degradation rate owing to their higher productivity of RIs and a greater contribution to the production of CDOM compared to others. Salinity, pH and HCO were conducive to the SIX indirect photodegradation, while metal ions (Fe and Cu), halogen ions (Cl and Br) and NO were opposite. These findings are essential for understanding the environmental fate of SIX in coastal waters.
Topics: Dissolved Organic Matter; Halogens; Hydrogen-Ion Concentration; Organic Chemicals; Photolysis; Salinity; Spectrometry, Fluorescence; Sulfisoxazole; Water
PubMed: 35090301
DOI: 10.1016/j.marpolbul.2022.113320 -
Environmental Science and Pollution... Aug 2015Although sulfonamides (SAs) are among the most commonly used veterinary drugs and their presence in the environment is well documented, knowledge of their fate and...
Although sulfonamides (SAs) are among the most commonly used veterinary drugs and their presence in the environment is well documented, knowledge of their fate and behavior in the soil environment is still limited, especially for sulfisoxazole (SSX) which is characterized by the lowest (among other SAs) pK a value associated with acid-base equilibrium of sulfonamide group. Thus, this work was focused on determining the sorption potential of SSX onto natural soils differing in physicochemical properties. All the results were modeled using linear, Freundlich, Langmuir, Dubinin-Radushkevich, and Temkin sorption isotherms. The established sorption coefficients (K(d)) for SSX were quite low (from 0.27 to 0.95 L kg(-1)), which indicated that this substance is highly mobile and has the potential to run off into surface waters and/or infiltrate ground water. The sorption data of SSX is well fitted to the Freundlich isotherm model (R(2) > 0.968). Moreover, we assessed the sorption mechanism of these compounds in the edaphic environment with respect to organic matter (OM) content, pH, and ionic strength. To clarify the current state of knowledge, these factors were examined much more thoroughly than in previous investigations concerning other SAs. The wide range of ionic strength examined showed positive correlation of this factor and sorption of SAs. The results also yielded new insight into dependency of sorption of SAs on organic matter content in soil.
Topics: Acid-Base Equilibrium; Adsorption; Models, Chemical; Soil; Soil Pollutants; Sulfisoxazole; Veterinary Drugs
PubMed: 25893618
DOI: 10.1007/s11356-015-4445-3 -
Archives of Internal Medicine Apr 1980The prothrombin time (PT) of a patient undergoing warfarin sodium anticoagulation became elevated when sulfisoxazole was given concurrently. The warfarin dose index is...
The prothrombin time (PT) of a patient undergoing warfarin sodium anticoagulation became elevated when sulfisoxazole was given concurrently. The warfarin dose index is used to demonstrate that this PT prolongation was the result of a warfarin-sulfisoxazole interaction. The mechanism of this interaction may involve displacement of warfarin from serum albumin. Sulfisoxazole should be used cautiously, if at all, in patients taking warfarin.
Topics: Aged; Blood Coagulation; Drug Synergism; Female; Humans; Pulmonary Embolism; Sulfisoxazole; Urinary Tract Infections; Warfarin
PubMed: 7362390
DOI: No ID Found