-
JACC. Case Reports Jul 2020Coronavirus disease-19 (COVID-19)-related severe acute respiratory distress syndrome can lead to acute cor pulmonale. We report a case of acute cor pulmonale secondary...
Coronavirus disease-19 (COVID-19)-related severe acute respiratory distress syndrome can lead to acute cor pulmonale. We report a case of acute cor pulmonale secondary to severe COVID-19 acute respiratory distress syndrome diagnosed with transesophageal echocardiography. Almitrine infusion allowed rapid enhancement of right ventricular function as well as improvement in oxygenation. ().
PubMed: 32835274
DOI: 10.1016/j.jaccas.2020.06.011 -
British Journal of Clinical Pharmacology Mar 1989Almitrine bismesylate can induce a stereotypical sensory peripheral neuropathy probably through a toxic mechanism. High plasma concentrations of almitrine have been...
Almitrine bismesylate can induce a stereotypical sensory peripheral neuropathy probably through a toxic mechanism. High plasma concentrations of almitrine have been reported in a patient with neuropathy. Since large inter-individual variations in plasma drug concentrations are found it is possible that the development of toxicity may be linked to genetically determined polymorphic oxidation of the drug. Oxidation phenotyping was performed in fifteen patients with almitrine neuropathy using dextromethorphan, a test compound subject to oxidative metabolism similar to that of debrisoquine. All patients were of the extensive metaboliser phenotype. This result shows that, in contrast to perhexiline neuropathy, almitrine neuropathy is not related to slow oxidation of the compound with regard to the particular P-450 iso-enzyme involved in dextromethorphan and debrisoquine metabolism.
Topics: Aged; Almitrine; Debrisoquin; Dextromethorphan; Female; Hereditary Sensory and Autonomic Neuropathies; Humans; Levorphanol; Male; Middle Aged; Piperazines
PubMed: 2719897
DOI: 10.1111/j.1365-2125.1989.tb05382.x -
European Neurology 1995
Cerebral ischemia: from pharmacology to modern techniques and clinical implications. Value of almitrine-raubasin (Duxil Duxaril). International symposium, Hangzhou, People's Republic of China, May 14, 1994.
Topics: Almitrine; Brain Ischemia; Drug Combinations; Humans; Neuroprotective Agents; Piperazines; Secologanin Tryptamine Alkaloids; Yohimbine
PubMed: 8529722
DOI: 10.1159/000119489 -
British Medical Journal (Clinical... Jan 1988
Review
Topics: Almitrine; Anti-Bacterial Agents; Antitubercular Agents; Central Nervous System Stimulants; Humans; Hypertension, Pulmonary; Lung Diseases, Obstructive; Piperazines; Respiratory Tract Infections; Vasodilator Agents
PubMed: 2892564
DOI: 10.1136/bmj.296.6615.111 -
Anesthesiology Feb 1984The changes in ventilation and breathing pattern induced by the substitution of pure oxygen for room air were tested in patients during stable halothane anesthesia...
The changes in ventilation and breathing pattern induced by the substitution of pure oxygen for room air were tested in patients during stable halothane anesthesia before and after the administration of almitrine bismesilate, a specific stimulant of the peripheral chemoreceptors. Ventilation was monitored in 25 patients for 15 min while breathing an air-halothane (1.5%) mixture and while breathing then for 10 min an O2-halothane (1.5%) mixture. The maneuver was repeated in 11 of these patients after the infusion of 0.5 mg/kg of almitrine bismesilate. Before almitrine administration, O2 inhalation caused a progressive decrease of minute-ventilation (VE) reaching 94.5 +/- 1.4% (mean +/- SEM) of the initial value at the tenth minute (P less than 0.01). This decrease was secondary to a progressive increase of inspiratory and expiratory times. Almitrine bismesilate caused a significant increase in VE (+11.6%), tidal volume (+14.0%), and mean inspiratory flow (+10.0%) when breathing the air-halothane mixture. Ten minutes after O2 administration, these variables were not different from those observed before almitrine infusion. This study shows that during halothane anesthesia, hypoxic ventilatory drive is not abolished but is depressed severely. Almitrine bismesilate can restore the hypoxic ventilatory drive.
Topics: Adult; Almitrine; Chemoreceptor Cells; Halothane; Humans; Male; Oxygen; Piperazines; Pulmonary Ventilation; Respiration; Tidal Volume
PubMed: 6696234
DOI: 10.1097/00000542-198402000-00008 -
British Medical Journal (Clinical... Mar 1985
Topics: Almitrine; Humans; Lung Diseases, Obstructive; Male; Middle Aged; Peripheral Nervous System Diseases; Piperazines
PubMed: 2983821
DOI: 10.1136/bmj.290.6472.896 -
Anesthesiology Nov 1984
Topics: Almitrine; Chemoreceptor Cells; Halothane; Humans; Oxygen; Piperazines; Respiration
PubMed: 6497013
DOI: 10.1097/00000542-198411000-00038