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Molecules (Basel, Switzerland) Dec 2021(), which belongs to the Moringaceae family, is a common herb, rich in plant compounds. It has a variety of bioactive compounds that can act as antioxidants,... (Review)
Review
(), which belongs to the Moringaceae family, is a common herb, rich in plant compounds. It has a variety of bioactive compounds that can act as antioxidants, antibiotics, anti-inflammatory and anti-cancer agents, etc., which can be obtained in different body parts of . Isothiocyanates (ITCs) from are one class of these active substances that can inhibit cancer proliferation and promote cancer cell apoptosis through multiple signaling pathways, thus curbing cancer migration and metastasis, at the same time they have little adverse effect on normal cells. There are multiple variants of ITCs in , but the predominant phytochemical is 4-(α-L-rhamnosyloxy)benzyl isothiocyanate, also known as moringa isothiocyanate (MIC-1). Studies have shown that MIC-1 has the possibility to be used clinically for the treatment of diabetes, neurologic diseases, obesity, ulcerative colitis, and several cancer types. In this review, we focus on the molecular mechanisms underlying the anti-cancer and anti-chronic disease effects of MIC-1, current trends, and future direction of MIC-1 based treatment strategies. This review combines the relevant literature of the past 10 years, in order to provide more comprehensive information of MIC-1 and to fully exploit its potentiality in the clinical settings.
Topics: Anti-Inflammatory Agents; Anti-Obesity Agents; Anti-Ulcer Agents; Antineoplastic Agents, Phytogenic; Humans; Hypoglycemic Agents; Isothiocyanates; Moringa oleifera
PubMed: 34946594
DOI: 10.3390/molecules26247512 -
Journal of Ethnopharmacology Jan 2021The subtribe Hyptidinae contains approximately 400 accepted species distributed in 19 genera (Hyptis, Eriope, Condea, Cantinoa, Mesosphaerum, Cyanocephalus, Hypenia,... (Review)
Review
ETHNOPHARMACOLOGICAL RELEVANCE
The subtribe Hyptidinae contains approximately 400 accepted species distributed in 19 genera (Hyptis, Eriope, Condea, Cantinoa, Mesosphaerum, Cyanocephalus, Hypenia, Hyptidendron, Oocephalus, Medusantha, Gymneia, Marsypianthes, Leptohyptis, Martianthus, Asterohyptis, Eplingiella, Physominthe, Eriopidion and Rhaphiodon). This is the Lamiaceae clade with the largest number of species in Brazil and high rates of endemism. Some species have been used in different parts of the world mainly as insecticides/pest repellents, wound healing and pain-relief agents, as well as for the treatment of respiratory and gastrointestinal disorders.
AIM OF THE REVIEW
This review aims to discuss the current status concerning the taxonomy, ethnobotanical uses, phytochemistry and biological properties of species which compose the subtribe Hyptidinae.
MATERIALS AND METHODS
The available information was collected from scientific databases (ScienceDirect, Pubmed, Web of Science, Scopus, Google Scholar, ChemSpider, SciFinder ACS Publications, Wiley Online Library), as well as other literature sources (e.g. books, theses).
RESULTS
The phytochemical investigations of plants of this subtribe have led to the identification of almost 300 chemical constituents of different classes such as diterpenes, triterpenes, lignans, α-pyrones, flavonoids, phenolic acids and monoterpenes and sesquiterpenes, as components of essential oils. Extracts, essential oils and isolated compounds showed a series of biological activities such as insecticide/repellent, antimicrobial and antinociceptive, justifying some of the popular uses of the plants. In addition, a very relevant fact is that several species produce podophyllotoxin and related lignans.
CONCLUSION
Several species of Hyptidinae are used in folk medicine for treating many diseases but only a small fraction of the species has been explored and most of the traditional uses have not been validated by current investigations. In addition, the species of the subtribe appear to be very promising as alternative sources of podophyllotoxin-like lignans which are the lead compounds for the semi-synthesis of teniposide and etoposide, important antineoplastic agents. Thus, there is a wide-open door for future studies, both to support the popular uses of the plants and to find new biologically active compounds in this large number of species not yet explored.
Topics: Animals; Anti-Ulcer Agents; Ethnobotany; Ethnopharmacology; Humans; Hypoglycemic Agents; Lamiaceae; Medicine, Traditional; Phytochemicals; Plant Extracts
PubMed: 32763419
DOI: 10.1016/j.jep.2020.113225 -
Journal of Postgraduate Medicine 2002
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Anti-Ulcer Agents; Benzimidazoles; Clinical Trials as Topic; Humans; Omeprazole; Peptic Ulcer; Rabeprazole
PubMed: 12082341
DOI: No ID Found -
Molecules (Basel, Switzerland) Dec 2008Peptic ulcer disease is a deep gastrointestinal erosion disorder that involves the entire mucosal thickness and can even penetrate the muscular mucosa. Numerous natural... (Review)
Review
Peptic ulcer disease is a deep gastrointestinal erosion disorder that involves the entire mucosal thickness and can even penetrate the muscular mucosa. Numerous natural products have been evaluated as therapeutics for the treatment of a variety of diseases, including this one. These products usually derive from plant and animal sources that contain active constituents such as alkaloids, flavonoids, terpenoids, tannins and others. The alkaloids are natural nitrogen-containing secondary metabolites mostly derived from amino acids and found in about 20% of plants. There has been considerable pharmacological research into the antiulcer activity of these compounds. In this work we review the literature on alkaloids with antiulcer activity, which covers about sixty-one alkaloids, fifty-five of which have activity against this disease when induced in animals.
Topics: Alkaloids; Animals; Anti-Ulcer Agents; Duodenal Ulcer; Models, Animal; Stomach Ulcer
PubMed: 19104486
DOI: 10.3390/molecules13123198 -
International Journal of Nanomedicine 2018Naringin is one of the most interesting phytopharmaceuticals that has been widely investigated for various biological actions. Yet, its low water solubility, limited...
Naringin is one of the most interesting phytopharmaceuticals that has been widely investigated for various biological actions. Yet, its low water solubility, limited permeability, and suboptimal bioavailability limited its use. Therefore, in this study, polymeric micelles of naringin based on pluronic F68 (PF68) were developed, fully characterized, and optimized. The optimized formula was investigated regarding in vitro release, storage stability, and in vitro cytotoxicity vs different cell lines. Also, cytoprotection against ethanol-induced ulcer in rats and antitumor activity against Ehrlich ascites carcinoma in mice were investigated. Nanoscopic and nearly spherical 1:50 micelles with the mean diameter of 74.80±6.56 nm and narrow size distribution were obtained. These micelles showed the highest entrapment efficiency (EE%; 96.14±2.29). The micelles exhibited prolonged release up to 48 vs 10 h for free naringin. The stability of micelles was confirmed by insignificant changes in drug entrapment, particle size, and retention (%) (91.99±3.24). At lower dose than free naringin, effective cytoprotection of 1:50 micelles against ethanol-induced ulcer in rat model has been indicated by significant reduction in mucosal damage, gastric level of malondialdehyde, gastric expression of tumor necrosis factor-alpha, caspase-3, nuclear factor kappa-light-chain-enhancer of activated B cells, and interleukin-6 with the elevation of gastric reduced glutathione and superoxide dismutase when compared with the positive control group. As well, these micelles provoked pronounced antitumor activity assessed by potentiated in vitro cytotoxicity particularly against colorectal carcinoma cells and tumor growth inhibition when compared with free naringin. In conclusion, 1:50 naringin-PF68 micelles can be represented as a potential stable nanodrug delivery system with prolonged release and enhanced antiulcer as well as antitumor activities.
Topics: Animals; Anti-Ulcer Agents; Antineoplastic Agents; Biological Availability; Cell Line, Tumor; Drug Carriers; Drug Liberation; Female; Flavanones; Humans; Male; Mice; Micelles; Particle Size; Poloxamer; Rats, Sprague-Dawley; Solubility; Ulcer
PubMed: 29497294
DOI: 10.2147/IJN.S154325 -
Molecules (Basel, Switzerland) May 2014Essential oils have attracted considerable worldwide attention over the last few decades. These natural products have wide-ranging pharmacological activities and... (Review)
Review
Essential oils have attracted considerable worldwide attention over the last few decades. These natural products have wide-ranging pharmacological activities and biotechnological applications. Faced with the need to find new anti-ulcer agents and the great effort on the development of drugs for the treatment of ulcers, in this review, the anti-ulcer activities of 21 bioactive compounds found in essential oils are discussed.
Topics: Anti-Ulcer Agents; Humans; Oils, Volatile; Ulcer
PubMed: 24802985
DOI: 10.3390/molecules19055717 -
Pharmaceutical Biology Dec 2017Ostericum koreanum (Maxim.) Kitagawa (Apiaceae) roots are traditionally used as an analgesic and antiulcer agent. However, the antiulcer potential of isoimperatorin...
CONTEXT
Ostericum koreanum (Maxim.) Kitagawa (Apiaceae) roots are traditionally used as an analgesic and antiulcer agent. However, the antiulcer potential of isoimperatorin isolated from O. koreanum has not yet been explored.
AIM
To evaluate the antiulcer activity of isoimperatorin isolated from the roots of O. koreanum.
MATERIALS AND METHODS
Isoimperatorin was isolated as cubic crystals by repeated column chromatography of the ethyl acetate fraction and structure was verified with H NMR, C NMR and high-resolution mass spectrometry (HRMS-FAB). The crystals obtained were analyzed with the single crystal X-ray method. The MTT assay was used to determine its cytotoxicity against chondrocytes at different concentrations (0.0-737.74 μM, 24 h). The in vivo antiulcer activity of isoimperatorin (40 mg/kg) was determined against ethanol-, indomethacin- and pyloric ligation-induced ulcers in Sprague-Dawley rats. Furthermore, the effect of isoimperatorin (0.0-737.74 μM, 24 h) on the expression of type II collagen in chondrocytes was determined using western blot method. The in vitro urease inhibitory activity of isoimperatorin (0-80 μM) and molecular docking was also performed against urease.
RESULTS AND DISCUSSION
Isoimperatorin demonstrated significant inhibitory activity (IC 36.43 μM) against urease as compared to the standard drug thiourea (IC 33.57 μM) without cytotoxic effects. It provided 70.9%, 67.65% and 54.25% protection in ulcer models induced by ethanol, indomethacin and pyloric ligation, respectively. Isoimperatorin showed the highest expression level of type II collagen at 368.87 μM. The docking results confirmed strong binding affinity with the target protein.
CONCLUSION
Isoimperatorin may be used to develop antiulcer drugs with decreased side effects.
Topics: Animals; Anti-Ulcer Agents; Apiaceae; Binding Sites; Carbon-13 Magnetic Resonance Spectroscopy; Cells, Cultured; Chondrocytes; Collagen Type II; Crystallization; Crystallography, X-Ray; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ethanol; Furocoumarins; Indomethacin; Ligands; Ligation; Male; Mass Spectrometry; Molecular Docking Simulation; Phytotherapy; Plant Extracts; Plant Roots; Plants, Medicinal; Protein Binding; Proton Magnetic Resonance Spectroscopy; Pylorus; Rabbits; Rats, Sprague-Dawley; Stomach Ulcer; Urease
PubMed: 27927061
DOI: 10.1080/13880209.2016.1257641 -
Molecules (Basel, Switzerland) Jul 2022Forssk. Ex J.F.Gmel is traditionally used for inflammatory and digestive disorders, as a carminative, and for diarrhea. This plant is widely distributed in Asia,...
Forssk. Ex J.F.Gmel is traditionally used for inflammatory and digestive disorders, as a carminative, and for diarrhea. This plant is widely distributed in Asia, Africa, and the Mediterranean region. Aqueous methanolic extract of (Sf.Cr) was prepared and screened for phytoconstituents through qualitative and GC-MS analysis. Quantification of total phenolic and flavonoid contents was performed, while antioxidant capacity was determined by DPPH, CUPRAC, FRAP, and ABTS assays. The gastroprotective activity was assessed in an ethanol-induced ulcer model. Gastric secretory parameters and macroscopic ulcerated lesions were analyzed and scored for ulcer severity. After scoring, histopathology was performed, and gastric mucus contents were determined. Oral pre-treatment of Sf.Cr demonstrated significant gastroprotection. The gastric ulcer severity score and ulcer index were reduced while the %-inhibition of ulcer was increased dose-dependently. The Sf.Cr significantly elevated the pH of gastric juice, while a decrease in total acidity and gastric juice volume was observed. Histopathology demonstrated less oedema and neutrophil infiltration in gastric mucosa of rats pre-treated with the Sf.Cr in comparison to ethanol-intoxicated animals. Furthermore, the gastric mucus contents were increased as determined by alcian blue binding. Sf.Cr showed marked gastroprotective activity, which can be attributed to antioxidant, antisecretory, and cytoprotective effects.
Topics: Animals; Anti-Ulcer Agents; Antioxidants; Chenopodiaceae; Ethanol; Gastric Mucosa; Plant Extracts; Plant Leaves; Rats; Rats, Wistar; Stomach Ulcer; Ulcer
PubMed: 35889240
DOI: 10.3390/molecules27144368 -
Medicina 2018
Topics: Anti-Bacterial Agents; Anti-Ulcer Agents; Drug Therapy, Combination; Humans; Nobel Prize; Omeprazole; Peptic Ulcer
PubMed: 29360084
DOI: No ID Found -
Gut Aug 2001
Topics: Anti-Ulcer Agents; Drug Design; Esophagitis, Peptic; Humans; Proton Pumps; Treatment Outcome
PubMed: 11454811
DOI: 10.1136/gut.49.2.309