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Journal of Clinical Microbiology Oct 2004We present here the first case in the People's Republic of China of human disease caused by the fungus Arthrographis kalrae. The male patient had fungal panophthalmitis...
We present here the first case in the People's Republic of China of human disease caused by the fungus Arthrographis kalrae. The male patient had fungal panophthalmitis and invasive sinusitis involving the maxillary and ethmoid sinuses. He was an apparently healthy man before receiving trauma to his left eye. He complained of pain and loss of visual acuity in the injured eye, which displayed redness and edema and eventually discharged pus. His symptoms became more severe after he was treated with steroids and several antibacterial agents. A computed tomography scan of the left eye revealed that the maxillary and ethmoid sinuses were involved. A smear of purulent material from the left eye orbit revealed fungal elements, and cultures of the material grew a fungus. The isolate was identified as A. kalrae based on gross and microscopic morphologies, biochemical assays, and DNA sequence analysis. The patient received amphotericin B intravenously, itraconazole orally, and atomized allitridum by nebulizing allitridum therapy. The patient's wound healed following surgical intervention, but the patient lost the use of his left eye. This case should remind ophthalmologists and other clinicians to consider the possibility of infections being fungal when antibacterial agents have no effect and the patient's condition worsens.
Topics: Adult; Ascomycota; China; Ethmoid Sinusitis; Eye Infections, Fungal; Humans; Male; Maxillary Sinusitis; Molecular Sequence Data; Panophthalmitis; Sequence Analysis, DNA
PubMed: 15472353
DOI: 10.1128/JCM.42.10.4828-4831.2004 -
Arquivos Brasileiros de Oftalmologia 2020We describe a case of keratomycosis caused by Arthographis kalrae after excimer laser keratomileusis. A 38-year-old female developed stromal keratitis eight weeks after...
We describe a case of keratomycosis caused by Arthographis kalrae after excimer laser keratomileusis. A 38-year-old female developed stromal keratitis eight weeks after refractive surgery. She developed severe corneal stromal infiltration and mild anterior segment inflammation, which could not be treated with topical voriconazole 1%, but topical natamycin 5% ameliorated her condition. A reactivation of keratomycosis symptoms was observed; therefore, longer treatment was administered to the patient. It has been reported that A. kalrae keratomycosis is associated with exposure to soil and contact lens usage. However, the patient, who lived in a rural location, was neither involved in gardening activities nor had a history of wearing contact lenses. This is the first case of post-refractive A. kalrae keratomycosis.
Topics: Adult; Ascomycota; Eye Infections, Fungal; Female; Humans; Keratitis; Keratomileusis, Laser In Situ; Natamycin; Voriconazole
PubMed: 31531550
DOI: 10.5935/0004-2749.20200004 -
Journal of Clinical Microbiology Aug 2006The performance of repetitive-sequence-based PCR (rep-PCR) using the DiversiLab system for identification of Coccidioides species, Blastomyces dermatitidis, and... (Comparative Study)
Comparative Study
The performance of repetitive-sequence-based PCR (rep-PCR) using the DiversiLab system for identification of Coccidioides species, Blastomyces dermatitidis, and Histoplasma capsulatum was assessed by comparing data obtained to colony morphology and microscopic characteristics and to nucleic acid probe results. DNA from cultures of 23 Coccidioides, 24 B. dermatitidis, 24 H. capsulatum, 3 Arthrographis, and 2 Malbranchea isolates was extracted using a microbial DNA isolation kit as recommended by Bacterial Barcodes, Inc. Rep-PCR and probe results agreed for 97.2% of the dimorphic fungi when > or =85% similarity was used as the criterion for identification. Two H. capsulatum isolates were not identified, but no isolates were misidentified. From 43 of those cultures (15 Coccidioides, 14 B. dermatitidis, 14 H. capsulatum, 3 Arthrographis, and 2 Malbranchea), DNA also was extracted using an IDI lysis kit, a simpler method. Rep-PCR and probe results agreed for 97.7% of the dimorphic fungi when a criterion of > or =90% similarity was used for identification. One H. capsulatum isolate could not be identified; no isolates were misidentified. Using > or =85% similarity for identification resulted in one misidentification. These data suggest that the DiversiLab system can be used to identify Coccidioides and B. dermatitidis and, possibly, H. capsulatum isolates.
Topics: Blastomyces; Cluster Analysis; Coccidioides; DNA Fingerprinting; DNA, Fungal; Histoplasma; Humans; Microscopy; Nucleic Acid Hybridization; Polymerase Chain Reaction; Repetitive Sequences, Nucleic Acid; Sensitivity and Specificity
PubMed: 16891521
DOI: 10.1128/JCM.00687-06 -
Medical Mycology Case Reports 2012Rare reports of infection with Arthrographis kalrae have often demonstrated a protracted clinical course. We describe refractory infection of the native knee with...
Rare reports of infection with Arthrographis kalrae have often demonstrated a protracted clinical course. We describe refractory infection of the native knee with Arthrographis kalrae after a penetrating injury and Yttrium synovectomy, finally controlled with two stage joint revision and combination antifungal therapy. The paucity of worldwide data about such uncommon invasive fungal infections contributes to the diagnostic and therapeutic challenges of these cases.
PubMed: 24371754
DOI: 10.1016/j.mmcr.2012.10.005 -
Microorganisms Sep 2023Paracoccidioidomycosis ceti (PCM-C) is a chronic granulomatous keloidal dermatitis in cetaceans that has been reported worldwide and is caused by . Serological...
Paracoccidioidomycosis ceti (PCM-C) is a chronic granulomatous keloidal dermatitis in cetaceans that has been reported worldwide and is caused by . Serological cross-reactions among highly pathogenic fungal infections and related diseases have been reported. However, the true cross-reaction of antibodies against has remained unknown due to the use of positive control sera from infected dolphins. This study aimed to re-evaluate antibodies from mechanically dislodged fungal cells in the infected tissue of a PCM-C case and demonstrate the actual cross-reaction. The results revealed a limited cross-reaction between PCM-C and paracoccidioidomycosis, while the antibodies did not react with other pathogens such as , , and . Thus, the method for evaluation of the antibody against PCM-C is reliable, and there is potential for epidemiological study.
PubMed: 37894086
DOI: 10.3390/microorganisms11102428 -
Le Infezioni in Medicina Jun 2015To date, only 11 cases of infection by Arthrographis kalrae have been described. According to the literature, we report a second case of arthritis caused by this mycete...
To date, only 11 cases of infection by Arthrographis kalrae have been described. According to the literature, we report a second case of arthritis caused by this mycete after a penetrating wound successfully treated with voriconazole before arthroscopic knee washout for six weeks.
Topics: Aged; Antifungal Agents; Arthritis; Arthroscopy; Ascomycota; Humans; Knee; Male; Mycoses; Treatment Outcome; Voriconazole
PubMed: 26110303
DOI: No ID Found -
Journal of Cystic Fibrosis : Official... Nov 2019Respiratory infections are a major threat to cystic fibrosis patients. Besides bacteria, many fungi colonize the cystic fibrosis respiratory tract where an important...
Respiratory infections are a major threat to cystic fibrosis patients. Besides bacteria, many fungi colonize the cystic fibrosis respiratory tract where an important fungal biota has been described. We report here the case of a 7-year-old cystic fibrosis child with pulmonary exacerbation and Arthrographis kalrae isolated from bronchoalveolar lavage fluid. To the best of our knowledge, this is the first reported case of lung infection due to Arhtrographis kalrae in a cystic fibrosis pediatric patient.
Topics: Antifungal Agents; Ascomycota; Bronchoalveolar Lavage; Bronchoalveolar Lavage Fluid; Child; Cystic Fibrosis; Humans; Itraconazole; Lung; Lung Diseases, Fungal; Male; Respiratory Function Tests; Tomography, X-Ray Computed; Treatment Outcome
PubMed: 31300282
DOI: 10.1016/j.jcf.2019.06.015 -
Archivos Argentinos de Pediatria Dec 2017Arthrographis kalrae is a hyaline fungus that grows forming arthroconidia. It is an opportunistic pathogen that causes infections in immunocompromised as in...
BACKGROUND
Arthrographis kalrae is a hyaline fungus that grows forming arthroconidia. It is an opportunistic pathogen that causes infections in immunocompromised as in immunocompetent people and has been rarely isolated from human clinical samples.
CASE REPORT
We describe the case of a male child with primary immunodeficiency who initially presented unilateral pneumonia and progressed to bilateral involvement despite antibiotic, antifungal treatment. A. kalrae was diagnosed by pulmonary biopsy. He received posaconazole with resolution of disease.
CONCLUSIONS
This is the first case of A. kalrae pulmonary infection in a pediatric patient with chronic granulomatous disease in Argentina.
Topics: Ascomycota; Child, Preschool; Granulomatous Disease, Chronic; Humans; Lung Diseases, Fungal; Male; Mycoses
PubMed: 29087135
DOI: 10.5546/aap.2017.e458 -
Frontiers in Microbiology 2019Reductive soil disinfestation (RSD) has recently attracted much attention owing to its effectiveness for controlling pathogens. In this study, we aimed to evaluate the...
Reductive soil disinfestation (RSD) has recently attracted much attention owing to its effectiveness for controlling pathogens. In this study, we aimed to evaluate the effects of different C/N substrates on RSD and to explore the changes in microbial community structure during RSD treatment. The experimental set up included 10 groups, as follows: CK, without substrates; RSD treatments with alfalfa ()[AL], maize () straw [MS], and rice ( L.) straw [RS], with three levels of addition (0.5% [L], 2% [M], and 5% [H]), yielding ALL, ALM, ALH, MSL, MSM, MSH, RSL, RSM, and RSH groups. Compared with CK, RSD treatments significantly increased the content of -N, and effectively eliminated the accumulated -N in the soil. The relative abundances of organic acid producers, including , , and , in all RSD groups were significantly higher than those in the CK by day 21. Moreover, on day 21, and in all RSD groups were significantly lower than those in the CK. In summary, RSD treatments clearly increased the relative abundances of organic acid generators and effectively inhibited pathogens; however, when the C/N was too low and the amount of addition too high, ammonia poisoning and rapid growth of some microorganisms (e.g., and ) may occur.
PubMed: 31921033
DOI: 10.3389/fmicb.2019.02851 -
Journal of Clinical Microbiology Sep 2008We report an uncommon clinical presentation of a unique case of fatal invasive fungal cerebral vasculitis due to Arthrographis kalrae in a nonimmunocompromised host. The...
We report an uncommon clinical presentation of a unique case of fatal invasive fungal cerebral vasculitis due to Arthrographis kalrae in a nonimmunocompromised host. The identity of the fungus was determined by morphological characteristics and by analysis of internal transcribed spacer 1 sequences and was confirmed by postmortem examination of the brain tissues. Establishing rapidly the link between the clinical syndromes and the fungal infection of the central nervous system is essential to improve the outcome. As our case has shown, it is more challenging to make a diagnosis of fungal infection when there are no risk factors of immunodeficiency and when the clinical presentation seems uncommon.
Topics: Adult; Ascomycota; Central Nervous System Fungal Infections; Humans; Male; Stroke; Syndrome; Vasculitis, Central Nervous System
PubMed: 18650350
DOI: 10.1128/JCM.00800-08