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Infectious Disease Clinics of North... Jun 2015Babesiosis is caused by intraerythrocytic protozoan parasites that are transmitted by ticks, or less commonly through blood transfusion or transplacentally. Human... (Review)
Review
Babesiosis is caused by intraerythrocytic protozoan parasites that are transmitted by ticks, or less commonly through blood transfusion or transplacentally. Human babesiosis was first recognized in a splenectomized patient in Europe but most cases have been reported from the northeastern and upper midwestern United States in people with an intact spleen and no history of immune impairment. Cases are reported in Asia, Africa, Australia, Europe, and South America. Babesiosis shares many clinical features with malaria and can be fatal, particularly in the elderly and the immunocompromised.
Topics: Anti-Bacterial Agents; Babesia; Babesiosis; DNA, Protozoan; Enzyme Inhibitors; Erythrocytes; Humans; Polymerase Chain Reaction
PubMed: 25999229
DOI: 10.1016/j.idc.2015.02.008 -
Parasites & Vectors Jun 2016Canine babesiosis is a significant tick-borne disease caused by various species of the protozoan genus Babesia. Although it occurs worldwide, data relating to European... (Review)
Review
Canine babesiosis is a significant tick-borne disease caused by various species of the protozoan genus Babesia. Although it occurs worldwide, data relating to European infections have now been collected for many years. These data have boosted the publication record and increased our working knowledge of these protozoan parasites. Both the large and small forms of Babesia species (B. canis, B. vogeli, B. gibsoni, and B. microti-like isolates also referred to as "B. vulpes" and "Theileria annae") infect dogs in Europe, and their geographical distribution, transmission, clinical signs, treatment, and prognosis vary widely for each species. The goal of this review is to provide veterinary practitioners with practical guidelines for the diagnosis, treatment and prevention of babesiosis in European dogs. Our hope is that these guidelines will answer the most frequently asked questions posed by veterinary practitioners.
Topics: Animals; Babesia; Babesiosis; Dog Diseases; Dogs; Europe
PubMed: 27289223
DOI: 10.1186/s13071-016-1596-0 -
Veterinary Parasitology Apr 2018Canine babesiosis is a tick-borne disease caused by several Babesia spp. which have different susceptebility to anti-protozoal drugs. A few drugs and drug combinations... (Review)
Review
Canine babesiosis is a tick-borne disease caused by several Babesia spp. which have different susceptebility to anti-protozoal drugs. A few drugs and drug combinations are used in the treatment of canine babesiosis often without complete parasite elimination leaving treated dogs as carriers which could relapse with clinical disease and also transmit infection further. Although the large form canine babesial species Babesia canis, Babesia vogeli and Babesia rossi are sensitive to the aromatic diamidines imidocarb dipropionate and diminazene aceturate, small form species such as Babesia gibsoni, Babesia conradae and Babesia vulpes (Theileria annae) are relatively resistant to these drugs and are treated with the combination of the hydroxynaphthoquinone atovaquone and the antibiotic azithromycin. Azithromycin and other antibiotics that have anti-protozoal properties target the apicoplast, a relict plastid found in protozoa, and exert a delayed death effect. The triple combination of clindamycin, diminazene aceturate and imidocarb dipropionate is also effective against B. gibsoni and used to treat atovaquone-resistant strains of this species. Novel drugs and the synergistic effects of drug combinations against Babesia infection should be explored further to find new treatments for canine babesiosis.
Topics: Animals; Antiprotozoal Agents; Babesia; Babesiosis; Dog Diseases; Dogs
PubMed: 29657012
DOI: 10.1016/j.vetpar.2018.03.001 -
Revue Scientifique Et Technique... Aug 2015Babesiosis is the disease caused by infection of the erythrocytes of mammals by Babesia species, which are Apicomplexa protozoa belonging to the suborder Piroplasmidea... (Review)
Review
Babesiosis is the disease caused by infection of the erythrocytes of mammals by Babesia species, which are Apicomplexa protozoa belonging to the suborder Piroplasmidea and the family Babesiidae. They are different from the Theileriidae, which can also infect white blood cells and endothelial cells. Babesiosis is one of the most important tick-borne infectious diseases of domestic and wild mammals and still poses significant diagnostic and therapeutic challenges for veterinary practitioners around the world. It is an increasing problem worldwide because of the expansion of tick habitats and the increased mobility of animals, which promote the spread of parasites into new geographical areas. Babesia species can, exceptionally, infect humans, especially splenectomised or immunocompromised individuals. The majority of human cases involve B. microti, a parasite of rodents, but human infections may also be caused by B. divergens, which infects cattle, or by Babesia related to B. odocoilei, which infect cervids. The majority of new developments, in regard to taxonomy, epidemiology, pathogenesis and control, concern canine babesiosis, whereas piroplasmosis in horses or cattle retains the classical description, therefore the focus of this article will be on infection in dogs.
Topics: Animals; Babesia; Babesiosis; Europe; Humans
PubMed: 26601462
DOI: 10.20506/rst.34.2.2385 -
Archives of Pathology & Laboratory... Jan 2019Babesiosis is most commonly caused by Babesia microti and is transmitted via the bite of an infected Ixodes spp tick. However, Babesia is also transmitted via blood...
Babesiosis is most commonly caused by Babesia microti and is transmitted via the bite of an infected Ixodes spp tick. However, Babesia is also transmitted via blood transfusion. In the United States, the first case of transfusion-transmitted babesiosis was recognized in 1979, and in recent years, the incidence has rapidly increased. Because most of the infected blood donors do not experience any symptoms, they pose a significant risk to the blood supply. Donor deferral for a history of babesiosis is currently performed but is ineffective. In March 2018, the FDA licensed a DNA PCR and antibody assay that were used in tandem in pivotal trials for screening blood donors for B microti; with other assays still being evaluated under investigational new drug protocols. Blood donation screening is essential to reducing the risk of transfusion-transmitted babesiosis, which is why blood centers collecting in geographic regions of highest risk have been testing since approximately 2010. Investigational NAT assays of higher sensitivity are pending FDA review. Further, in July 2018, the FDA issued a draft guidance for reducing the risk of transfusion-transmitted babesiosis. Release of the final guidance may be postponed until sensitivities and specificities of all current and potential strategies have been properly evaluated.
Topics: Babesiosis; Blood Donors; Cost-Benefit Analysis; Donor Selection; Erythrocytes; Humans; Transfusion Reaction
PubMed: 30376376
DOI: 10.5858/arpa.2017-0250-RS -
Przeglad Epidemiologiczny 2015Babesiosis is an emerging parasitic, anthropo-zoonotic tick-borne disease, seldom diagnosed in humans. Caused by Protozoa, Babesia (also called Piroplasma)... (Review)
Review
Babesiosis is an emerging parasitic, anthropo-zoonotic tick-borne disease, seldom diagnosed in humans. Caused by Protozoa, Babesia (also called Piroplasma) intraerytrocytic piriform microorganism. Infection of vertebrates is transmitted by ticks. Out of more than 100 Babesia species/genotypes described so far, only some were diagnosed in infected humans, mostly B. microti, B. divergens and B. venatorum (Babesia sp. EU1). Infection in humans is often asymptomatic or mild but is of a particular risk for asplenic individuals, those with congenital or acquired immunodeficiencies, and elderly. Infections transmitted with blood and blood products raise concerns in hemotherapy. Epidemiological situation of babesiosis varies around the world. In Europe, no increase in the number of cases was reported, but in the USA its prevalence is increasing and extension of endemic areas is observed. The aim of this publication is to describe the problems connected with the current epidemiological situation, diagnosis and treatment of human babesiosis with regard to clinical status of patients.
Topics: Animals; Babesia; Babesiosis; Communicable Diseases, Emerging; Europe; Humans; Poland; Zoonoses
PubMed: 26519845
DOI: No ID Found -
Infectious Disease Clinics of North... Sep 2008Human babesiosis is an emerging intraerythrocytic infection caused by protozoal parasites transmitted by ixodid ticks. Babesiosis is endemic in the northeastern and... (Review)
Review
Human babesiosis is an emerging intraerythrocytic infection caused by protozoal parasites transmitted by ixodid ticks. Babesiosis is endemic in the northeastern and upper midwestern regions of the United States and is found sporadically in other parts of the United States, Europe, Asia, Africa, and South America. Babesial infections range from asymptomatic to severe and occasionally are fatal. Specific laboratory diagnosis of babesial infection is made by morphologic examination of Giemsa-stained blood smears, serology, and amplification of babesial DNA using polymerase chain reaction. The combination of atovaquone and azithromycin is the treatment of choice for mild-to-moderate illness, whereas clindamycin and quinine and exchange transfusion are indicated for severe disease.
Topics: Animals; Antiprotozoal Agents; Arachnid Vectors; Babesia; Babesiosis; DNA, Protozoan; Diagnosis, Differential; Humans; Ixodidae; Polymerase Chain Reaction; Severity of Illness Index; United States; Zoonoses
PubMed: 18755385
DOI: 10.1016/j.idc.2008.03.010 -
Clinical Microbiology Reviews Jul 2000Babesiosis is an emerging, tick-transmitted, zoonotic disease caused by hematotropic parasites of the genus Babesia. Babesial parasites (and those of the closely related... (Review)
Review
Babesiosis is an emerging, tick-transmitted, zoonotic disease caused by hematotropic parasites of the genus Babesia. Babesial parasites (and those of the closely related genus Theileria) are some of the most ubiquitous and widespread blood parasites in the world, second only to the trypanosomes, and consequently have considerable worldwide economic, medical, and veterinary impact. The parasites are intraerythrocytic and are commonly called piroplasms due to the pear-shaped forms found within infected red blood cells. The piroplasms are transmitted by ixodid ticks and are capable of infecting a wide variety of vertebrate hosts which are competent in maintaining the transmission cycle. Studies involving animal hosts other than humans have contributed significantly to our understanding of the disease process, including possible pathogenic mechanisms of the parasite and immunological responses of the host. To date, there are several species of Babesia that can infect humans, Babesia microti being the most prevalent. Infections with Babesia species generally follow regional distributions; cases in the United States are caused primarily by B. microti, whereas cases in Europe are usually caused by Babesia divergens. The spectrum of disease manifestation is broad, ranging from a silent infection to a fulminant, malaria-like disease, resulting in severe hemolysis and occasionally in death. Recent advances have resulted in the development of several diagnostic tests which have increased the level of sensitivity in detection, thereby facilitating diagnosis, expediting appropriate patient management, and resulting in a more accurate epidemiological description.
Topics: Animals; Babesia; Babesiosis; Disease Susceptibility; Humans; Phylogeny; Protozoan Vaccines; Vaccines, Synthetic
PubMed: 10885987
DOI: 10.1128/CMR.13.3.451 -
Scientific Reports Apr 2022Babesiosis, caused by protozoan parasites of the genus Babesia, and ixodid ticks are considered to be one of the most important causes that result in significant...
Babesiosis, caused by protozoan parasites of the genus Babesia, and ixodid ticks are considered to be one of the most important causes that result in significant economic losses in cattle production worldwide, including in Ethiopia. A cross-sectional study was undertaken in the Dasenech and Salamago Districts of South Omo zone Ethiopia to determine the prevalence and associated risk factors of babesia infection and ixodid ticks of cattle using Giemsa-stained thin and thick film techniques and morphological identification keys for babesia species and tick identification, respectively. Out of 470 examined cattle, 102 (21.7%) were infected by Babesiosis (15.53% Babesia bigemina and 6.17% Babesia bovis). A statistically significant association (p < 0.05) was observed between babesia infection and season and tick infestation. However, cattle that were infected with the Babesia parasite revealed a lower mean PCV value (21.49%) than noninfected cattle (28.29%) and showed a statistically significant (p < 0.05) difference with the occurrence of Babesia infection. The overall prevalence of ixodid ticks was 53.8% (253/470) and revealed a statistically significant association (p < 0.05) between the season and origin of the animal. However, no statistically significant association (p > 0.05) was observed between sex, age, and body condition score of the animal with the occurrence of ixodid tick. A total of 8040 adult ticks belonging to four tick genera, Amblyomma, Rhipicephalus (Boophilus), Hyalomma, and Rhipicephalus, were collected from various body parts and identified. The high prevalence of Babesia infection and ixodid ticks in cattle at the study sites requires seroprevalence and molecular studies to identify the predominant Babesia species and to detect Babesia in tick hemolymph for the identification of tick genera responsible for the occurrence of Babesia infection. Additionally, tailoring suitable and coordinated tick management methods using chemotherapy as well as strategic treatment to overt clinical cases of bovine babesiosis is critical.
Topics: Animals; Babesia; Babesiosis; Cattle; Cattle Diseases; Cross-Sectional Studies; Ethiopia; Ixodidae; Rhipicephalus; Seroepidemiologic Studies
PubMed: 35430623
DOI: 10.1038/s41598-022-10416-4 -
CMAJ : Canadian Medical Association... Oct 2021
Topics: Aged; Animals; Anti-Bacterial Agents; Babesia microti; Babesiosis; Host-Parasite Interactions; Humans; Lyme Disease; Male
PubMed: 34663609
DOI: 10.1503/cmaj.201983-f