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Seminars in Diagnostic Pathology Aug 2009Keratoacanthomas are common self limited squamous proliferations. They have been considered a benign neoplasm with involution and complete resolution within few months.... (Review)
Review
Keratoacanthomas are common self limited squamous proliferations. They have been considered a benign neoplasm with involution and complete resolution within few months. Although considered the prototypical example of cutaneous pseudomalignancy, some believe that these tumors are squamous cell carcinomas and through the years there have been sporadic reports of "metastasizing keratoacanthomas". The question has been raised as to whether keratoacanthoma is an unreliable histological diagnosis or these tumors have a latent, albeit rare, malignant potential. To date, just a handful of "metastasizing keratoacanthomas" have been reported. Since a benign lesion is incapable of metastasis, some other explanation must be considered; the most likely one being a misdiagnosis. While it is clear that in some cases, the histological and cytological features of squamous cell carcinoma and keratoacanthoma are difficult to distinguish by current techniques, these occasional limitations in diagnosis do not make keratoacanthomas a carcinoma. We believe the evidence supports that keratoacanthomas are benign squamous proliferations. The diagnosis can be made with confidence in appropriate biopsies and using well established clinicopathological criteria.
Topics: Biomarkers; Carcinoma, Squamous Cell; Diagnosis, Differential; Diagnostic Errors; Humans; Hyperplasia; Keratoacanthoma; Neoplasm Metastasis; Skin Neoplasms
PubMed: 20043514
DOI: 10.1053/j.semdp.2009.09.003 -
JAAPA : Official Journal of the... May 2009
Review
Topics: Adrenal Cortex Hormones; Aminoquinolines; Antineoplastic Agents; Child, Preschool; Female; Hemangioma; Humans; Imiquimod; Infant; Infant, Newborn; Interferon-alpha; Laser Therapy; Male; Skin Neoplasms
PubMed: 19469391
DOI: 10.1097/01720610-200905000-00010 -
Advances in Oto-rhino-laryngology 2016Salivary neoplasms are relatively infrequent entities that account for only 4% of tumors of the head and neck. Although slow-growing lesions of the preauricular area and... (Review)
Review
Salivary neoplasms are relatively infrequent entities that account for only 4% of tumors of the head and neck. Although slow-growing lesions of the preauricular area and submandibular space are often confused with sebaceous cysts, lymph nodes, or lipomas by the non-otolaryngologist, otolaryngologists-head and neck surgeons recognize that all preauricular and submandibular masses should be considered a salivary neoplasm until proven otherwise. Surgery remains the treatment of choice for benign salivary gland neoplasms; however, techniques continue to evolve in order to preserve salivary function and reduce surgical morbidity. The goals of management of benign salivary neoplasms include accurate diagnosis of the lesion, complete surgical extirpation, and functional preservation of adjacent cranial nerves. Accurate diagnosis is aided by appropriate preoperative physical examination, imaging, and fine needle aspiration biopsy. Benign neoplasms typically present as slow-growing, painless, mobile masses without adverse features, such as tissue fixation, ulceration, a cranial nerve deficit, or regional lymphadenopathy. Preoperative imaging with ultrasonography, computed tomography, or magnetic resonance imaging reveals well-circumscribed lesions without an infiltrative growth pattern or associated adenopathy. Fine needle aspiration biopsy may favor a benign neoplasm, supporting the clinical presentation. Surgery for a benign or malignant salivary neoplasm is in essence a false dichotomy since the surgeon can never be completely confident of the diagnosis until the specimen is removed. The surgeon must recognize the significant overlap between benign and malignant salivary masses in terms of clinical presentation, imaging, and cytology, which requires the surgeon to remain vigilant and flexible at the time of surgery should tissue characteristics or frozen section analysis suggest a malignant process.
Topics: Biopsy; Diagnosis, Differential; Humans; Otorhinolaryngologic Surgical Procedures; Salivary Gland Neoplasms; Tomography, X-Ray Computed
PubMed: 27093461
DOI: 10.1159/000442125 -
Oral and Maxillofacial Surgery Clinics... Aug 2017The proper ablation of any neoplasm of the head and neck requires the inclusion of linear and anatomic barrier margins surrounding the neoplasm. Extirpative surgery of... (Review)
Review
The proper ablation of any neoplasm of the head and neck requires the inclusion of linear and anatomic barrier margins surrounding the neoplasm. Extirpative surgery of the major and minor salivary glands is certainly no exception to this surgical principle. To this end, the selection and execution of the most appropriate ablative surgical procedure for a major or minor benign salivary gland neoplasm is an essential exercise in oral and maxillofacial surgery. Of equal importance is the intraoperative identification and preservation of the pseudocapsule surrounding the benign neoplasm. This article reviews these important elements specifically related to ablative surgery of benign neoplasms of the parotid, submandibular and minor salivary glands with strict attention to observed nomenclature.
Topics: Humans; Margins of Excision; Parotid Neoplasms; Postoperative Complications; Salivary Gland Neoplasms; Sublingual Gland Neoplasms; Submandibular Gland Neoplasms
PubMed: 28709532
DOI: 10.1016/j.coms.2017.03.009 -
Radiologic Clinics of North America Mar 2022The overwhelming majority of soft tissue masses encountered on routine imaging are incidental and benign. When incidental, the radiologist is usually limited to routine... (Review)
Review
The overwhelming majority of soft tissue masses encountered on routine imaging are incidental and benign. When incidental, the radiologist is usually limited to routine MR imaging sequences, often without contrast. In these situations, there are typical imaging features pointing to a single diagnosis or limited differential diagnosis. Although these imaging features can be helpful, many lesions are nonspecific and may require contrast administration, evaluation with other imaging modalities, follow-up imaging, or biopsy for diagnosis. This article will provide an overview of the most commonly encountered benign soft tissue masses along with some of their characteristic MR imaging features.
Topics: Diagnosis, Differential; Humans; Magnetic Resonance Imaging; Radiologists; Soft Tissue Neoplasms
PubMed: 35236593
DOI: 10.1016/j.rcl.2021.11.006 -
Journal of Pediatric Surgery Jun 2001Lipoblastoma is a rare benign mesenchymal tumor of embryonal fat that occurs almost exclusively in infants and children. This study was done to determine the clinical...
BACKGROUND/PURPOSE
Lipoblastoma is a rare benign mesenchymal tumor of embryonal fat that occurs almost exclusively in infants and children. This study was done to determine the clinical and pathologic characteristics of lipoblastoma.
METHODS
Nine cases of pathologically proven lipoblastoma from 1979 to 1997 were reviewed. There were 6 boys and 3 girls ranging in age from 3 months to 29 months.
RESULTS
A soft tissue mass was the chief complaint in 7 patients, abdominal distension in 1 patient with a retroperitoneal mass, and defecation difficulty in 1 patient with a perirectal mass. In 4 patients, tumors occurred on the back. Other tumor location includes the neck, scrotum, retroperitoneum, perirectal area, and buttock in 1 patient each. Lesions measured 2.3 to 19.5 cm. Complete excision was done in 8 patients. One perirectal tumor was removed by both the posterior sagittal approach and the intraabdominal approach but incompletely resected. Two tumors located on the back recurred with intraspinal extension 12 months and 18 months after resection. Second resection and second resection with laminectomy were done. Leg pain and urinary incontinence developed in 1 patient but improved on conservative treatment.
CONCLUSIONS
Lipoblastoma is a benign neoplasm but can frequently recur (25%) in spite of complete excision. Lipoblastomas occurring on the back had a high recurrence rate (50%) and associated with intraspinal extension. J Pediatr Surg 36:905-907.
Topics: Child, Preschool; Female; Humans; Infant; Lipoma; Male; Rectal Neoplasms; Retroperitoneal Neoplasms; Retrospective Studies; Soft Tissue Neoplasms; Treatment Outcome
PubMed: 11381423
DOI: 10.1053/jpsu.2001.23969 -
Emerging Infectious Diseases Aug 2020Cryptosporidium baileyi, a bird-specific parasite, infects gastrointestinal, pulmonary, and urinary tracts of its host. We report on a C. baileyi infection associated...
Cryptosporidium baileyi, a bird-specific parasite, infects gastrointestinal, pulmonary, and urinary tracts of its host. We report on a C. baileyi infection associated with pulmonary hamartoma in an immunocompetent patient in Poland. Further work is needed to investigate the association between Cryptosporidium infections and tumors.
Topics: Animals; Chickens; Cryptosporidiosis; Cryptosporidium; Female; Humans; Neoplasms; Poland; Poultry Diseases
PubMed: 32687044
DOI: 10.3201/eid2608.201117 -
Journal of the American Academy of... Aug 1995We describe a cutaneous angiomyxoma on the head of a 38-year-old man without evidence of Carney's complex. Complete excision of the tumor appeared to be curative.... (Review)
Review
We describe a cutaneous angiomyxoma on the head of a 38-year-old man without evidence of Carney's complex. Complete excision of the tumor appeared to be curative. Histologic examination revealed fibroblast-like cells embedded in a well-demarcated, lobulate, mucinous, and vascularized stroma with a delicate reticulin network. Immunohistologically, the stromal cells were consistently positive for vimentin and focally positive for smooth muscle A-actin but were negative for desmin, KP1, MAC387, factor XIIIa, CD34, Leu-7, and S-100. Cutaneous angiomyxoma appears to represent a myofibroblastic neoplasm that should be distinguished from cutaneous focal mucinosis.
Topics: Adult; Diagnosis, Differential; Humans; Male; Mucinoses; Myxoma; Scalp; Skin Neoplasms
PubMed: 7615884
DOI: 10.1016/0190-9622(95)91432-3 -
Seminars in Nuclear Medicine Jan 1976There is little information in the literature concerning the role of bone scanning in benign bone neoplasms except for sporadic reports. Since the advent of...
There is little information in the literature concerning the role of bone scanning in benign bone neoplasms except for sporadic reports. Since the advent of 99mTc-polyphosphate, bone imaging has proven feasible and useful in locating the cause of bone pain, such as in osteoid osteomas, which are not always radiologically apparent, and in evaluating whether or not a radiologic lesion is indeed benign and solitary. Blood-pool images are particularly important in neoplastic disease, since the absence of hyperemia in the immediate postinjection period favors the diagnosis of a benign neoplasm, as does low-grade uptake on the delayed study. The scan, including pinhole magnification images, is especially valuable in diagnosing lesions in the spine and pelvis, which are poorly seen radiologically. We have studied various types of benign bone tumors, including simple and aneurysmal bone cysts, fibrous cortical defects, and nonossifying fibromas, all of which had minimal or no increased uptake of the radiopharmaceutical, unless traumatized. Although osteochondromas and enchondromas showed varied accumulation of activity, the scan was useful in differentiating these from sarcomatous lesions. All osteoid osteomas demonstrated marked activity, and could be accurately located preoperatively, as could the extent of fibrous dysplasia. The bone scan in the reticuloses also showed abnormal accumulation of activity, and aided in arriving at the prognosis and treatment of histiocytic bone lesions.
Topics: Bone Cysts; Bone Neoplasms; Child; Chondroma; Eosinophilic Granuloma; Femoral Neoplasms; Femur Neck; Fibroma; Fibrous Dysplasia of Bone; Gaucher Disease; Histiocytosis, Langerhans-Cell; Humans; Osteoma; Osteoma, Osteoid; Phosphates; Radionuclide Imaging; Spinal Neoplasms; Technetium
PubMed: 1082170
DOI: 10.1016/s0001-2998(76)80034-7 -
BMC Cancer Jan 2024The increasing cancer burden calls for reliably assessed changes in the hospitalizations for tumors over time and space in China. This study evaluated trends in...
The increasing cancer burden calls for reliably assessed changes in the hospitalizations for tumors over time and space in China. This study evaluated trends in hospitalization rate, in-hospital mortality, length of stay (LOS), and medical costs for malignant and benign neoplasms. Data were derived from China Health Statistical Yearbooks from 2004 to 2020. Temporal trends in hospitalization rates and in-hospital mortality rates were assessed through the Cochran-Armitage Test. We used the linear model with continuous variables to test for the trend. The malignant neoplasm hospitalization rate increased from 1.1‰ to 5.8‰ and the benign neoplasm increased from 1.0‰ to 2.0‰. The in-hospital mortality rate due to malignant neoplasm and benign neoplasm decreased from 5.11 to 2.87% (P for trend < 0.001) and 0.14-0.01% (P for trend < 0.001), respectively. Among all patients hospitalized with malignant neoplasm, the average cost per hospitalization significantly increased during the study period (P for trend < 0.001), adjusted for the Consumer Price Index. However, the average LOS gradually decreased (P for trend < 0.001). In line with the trend of malignant neoplasm, the average cost per hospitalization increased significantly among all patients hospitalized for benign neoplasm (P for trend < 0.001), and the average LOS showed a steady downward trend (P for trend < 0.001). We found upward trends in hospitalization rates, and medical costs in neoplasms. By contrast, substantial decreases in in-hospital mortality and LOS. The hospitalization rate gap between urban and rural areas is narrowed.
Topics: Humans; Hospitalization; Length of Stay; Brain Neoplasms; China; Hospital Mortality
PubMed: 38291411
DOI: 10.1186/s12885-024-11866-x