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Periodontology 2000 Feb 2024Platelet-rich fibrin (PRF) has been characterized as a regenerative biomaterial that is fully resorbed within a typical 2-3 week period. Very recently, however, a... (Review)
Review
Platelet-rich fibrin (PRF) has been characterized as a regenerative biomaterial that is fully resorbed within a typical 2-3 week period. Very recently, however, a novel heating process was shown to extend the working properties of PRP/PRF from a standard 2-3 week period toward a duration of 4-6 months. Numerous clinicians have now utilized this extended-PRF (e-PRF) membrane as a substitute for collagen barrier membranes in various clinical applications, such as guided tissue/bone regeneration. This review article summarizes the scientific work to date on this novel technology, including its current and future applications in periodontology, implant dentistry, orthopedics and facial aesthetics. A systematic review was conducted investigating key terms including "Bio-Heat," "albumin gel," "albumin-PRF," "Alb-PRF," "extended-PRF," "e-PRF," "activated plasma albumin gel," and "APAG" by searching databases such as MEDLINE, EMBASE and PubMed. Findings from preclinical studies demonstrate that following a simple 10-min heating process, the transformation of the liquid plasma albumin layer into a gel-like injectable albumin gel extends the resorption properties to at least 4 months according to ISO standard 10 993 (subcutaneous animal model). Several clinical studies have now demonstrated the use of e-PRF membranes as a replacement for collagen membranes in GTR/GBR procedures, closing lateral windows in sinus grafting procedures, for extraction site management, and as a stable biological membrane during recession coverage procedures. Furthermore, Alb-PRF may also be injected as a regenerative biological filler that lasts extended periods with advantages in joint injections, osteoarthritis and in the field of facial aesthetics. This article highlights the marked improvement in the stability and degradation properties of the novel Alb-PRF/e-PRF technology with its widespread future potential use as a potential replacement for collagen membranes with indications including extraction site management, GBR procedures, lateral sinus window closure, recession coverage among others, and further highlights its use as a biological regenerative filler for joint injections and facial aesthetics. It is hoped that this review will pioneer future opportunities and research development in the field, leading to further progression toward more natural and less costly biomaterials for use in medicine and dentistry.
Topics: Platelet-Rich Fibrin; Humans; Animals; Biocompatible Materials; Bone Regeneration; Guided Tissue Regeneration, Periodontal; Membranes, Artificial
PubMed: 37986559
DOI: 10.1111/prd.12537 -
PeerJ 2023Zirconia, a crystalline oxide of zirconium, holds good mechanical, optical, and biological properties. The metal-free restorations, mostly consisting of... (Review)
Review
Zirconia, a crystalline oxide of zirconium, holds good mechanical, optical, and biological properties. The metal-free restorations, mostly consisting of all-ceramic/zirconia restorations, are becoming popular restorative materials in restorative and prosthetic dentistry choices for aesthetic and biological reasons. Dental zirconia has increased over the past years producing wide varieties of zirconia for prosthetic restorations in dentistry. At present, literature is lacking on the recent zirconia biomaterials in dentistry. Currently, no article has the latest information on the various zirconia biomaterials in dentistry. Hence, the aim of this article is to present an overview of recent dental zirconia biomaterials and tends to classify the recent zirconia biomaterials in dentistry. This article is useful for dentists, dental technicians, prosthodontists, academicians, and researchers in the field of dental zirconia.
Topics: Zirconium; Biocompatible Materials; Ceramics; Dentistry
PubMed: 37465158
DOI: 10.7717/peerj.15669 -
Aesthetic Surgery Journal Sep 2023For decades, a wide variety of natural and synthetic materials have been used to augment human tissue to improve aesthetic outcomes. Dermal fillers are some of the most... (Review)
Review
For decades, a wide variety of natural and synthetic materials have been used to augment human tissue to improve aesthetic outcomes. Dermal fillers are some of the most widely used aesthetic treatments throughout the body. Initially, the primary function of dermal fillers was to restore depleted volume. As biomaterial research has advanced, however, a variety of biostimulatory fillers have become staples in aesthetic medicine. Such fillers often contain a carrying vehicle and a biostimulatory material that induces de novo synthesis of major structural components of the extracellular matrix. One such filler, Radiesse (Merz Aesthetics, Raleigh, NC), is composed of calcium hydroxylapatite microspheres suspended in a carboxymethylcellulose gel. In addition to immediate volumization, Radiesse treatment results in increases of collagen, elastin, vasculature, proteoglycans, and fibroblast populations via a cell-biomaterial-mediated interaction. When injected, Radiesse acts as a cell scaffold and clinically manifests as immediate restoration of depleted volume, improvements in skin quality and appearance, and regeneration of endogenous extracellular matrices. This narrative review contextualizes Radiesse as a regenerative aesthetic treatment, summarizes its unique use cases, reviews its rheological, material, and regenerative properties, and hypothesizes future combination treatments in the age of regenerative aesthetics.
Topics: Humans; Calcium; Durapatite; Dermal Fillers; Biocompatible Materials; Esthetics
PubMed: 37635437
DOI: 10.1093/asj/sjad173 -
Advanced Science (Weinheim,... Aug 2023Treatment of infected wounds remains a challenge owing to antibiotic resistance; thus, developing smart biomaterials for the healing of infected wounds is urgently...
Treatment of infected wounds remains a challenge owing to antibiotic resistance; thus, developing smart biomaterials for the healing of infected wounds is urgently needed. In this study, a microneedle (MN) patch system with antimicrobial and immunomodulatory properties is developed to promote and accelerate infected wound healing. In the MN patch (termed PFG/M MNs), a nanoparticle with polydopamine (PDA)-loaded iron oxide is grafted with glucose oxidase (GOx) and hyaluronic acid (HA) and then integrated into the tips, and amine-modified mesoporous silica nanoparticles (AP-MSNs) are incorporated into the bases. Results show that PFG/M MNs eradicate bacterial infections and modulate the immune microenvironment, combining the advantages of chemodynamic therapy, photothermal therapy, and M2 macrophage polarization from Fe/PDA@GOx@HA in the tips as well as anti-inflammatory effect of AP-MSNs from the MN bases. Thus, the PFG/M MN system is a promising clinical candidate for promoting infected wound healing.
Topics: Anti-Infective Agents; Amines; Biocompatible Materials; Drug Delivery Systems; Glucose Oxidase; Hyaluronic Acid
PubMed: 37202594
DOI: 10.1002/advs.202300576 -
Marine Drugs Jul 2023The marine-derived hyaluronic acid and other natural biopolymers offer exciting possibilities in the field of biomaterials, providing sustainable and biocompatible... (Review)
Review
The marine-derived hyaluronic acid and other natural biopolymers offer exciting possibilities in the field of biomaterials, providing sustainable and biocompatible alternatives to synthetic materials. Their unique properties and abundance in marine sources make them valuable resources for various biomedical and industrial applications. Due to high biocompatible features and participation in biological processes related to tissue healing, hyaluronic acid has become widely used in tissue engineering applications, especially in the wound healing process. The present review enlightens marine hyaluronan biomaterial providing its sources, extraction process, structures, chemical modifications, biological properties, and biocidal applications, especially for wound healing/dressing purposes. Meanwhile, we point out the future development of wound healing/dressing based on hyaluronan and its composites and potential challenges.
Topics: Hyaluronic Acid; Bandages; Biocompatible Materials; Tissue Engineering; Wound Healing
PubMed: 37623707
DOI: 10.3390/md21080426 -
SLAS Technology Jun 2023
Topics: Bioprinting; Biocompatible Materials; Tissue Engineering
PubMed: 37257562
DOI: 10.1016/j.slast.2023.05.003 -
Tracing immune cells around biomaterials with spatial anchors during large-scale wound regeneration.Nature Communications Sep 2023Skin scarring devoid of dermal appendages after severe trauma has unfavorable effects on aesthetic and physiological functions. Here we present a method for large-area...
Skin scarring devoid of dermal appendages after severe trauma has unfavorable effects on aesthetic and physiological functions. Here we present a method for large-area wound regeneration using biodegradable aligned extracellular matrix scaffolds. We show that the implantation of these scaffolds accelerates wound coverage and enhances hair follicle neogenesis. We perform multimodal analysis, in combination with single-cell RNA sequencing and spatial transcriptomics, to explore the immune responses around biomaterials, highlighting the potential role of regulatory T cells in mitigating tissue fibrous by suppressing excessive type 2 inflammation. We find that immunodeficient mice lacking mature T lymphocytes show the typical characteristic of tissue fibrous driven by type 2 macrophage inflammation, validating the potential therapeutic effect of the adaptive immune system activated by biomaterials. These findings contribute to our understanding of the coordination of immune systems in wound regeneration and facilitate the design of immunoregulatory biomaterials in the future.
Topics: Mice; Animals; Biocompatible Materials; Wound Healing; Cicatrix; Hair Follicle; Inflammation; Skin
PubMed: 37752124
DOI: 10.1038/s41467-023-41608-9 -
International Journal of Molecular... Nov 2023The purpose of this Special Issue was to review research focusing on the development of formulations based on chitosan or its derivatives together with other molecules,...
The purpose of this Special Issue was to review research focusing on the development of formulations based on chitosan or its derivatives together with other molecules, producing biomaterials with improved physicochemical properties and effects [...].
Topics: Biocompatible Materials; Chitosan
PubMed: 38003340
DOI: 10.3390/ijms242216150 -
Tissue Engineering and Regenerative... Jun 2023Various immune cells participate in repair and regeneration following tissue injury or damage, orchestrating tissue inflammation and regeneration processes. A deeper... (Review)
Review
Various immune cells participate in repair and regeneration following tissue injury or damage, orchestrating tissue inflammation and regeneration processes. A deeper understanding of the immune system's involvement in tissue repair and regeneration is critical for the development of successful reparatory and regenerative strategies. Here we review recent technologies that facilitate cell-based and biomaterial-based modulation of the immune systems for tissue repair and regeneration. First, we summarize the roles of various types of immune cells in tissue repair. Second, we review the principle, examples, and limitations of regulatory T (Treg) cell-based therapy, a representative cell-based immunotherapy. Finally, we discuss biomaterial-based immunotherapy strategies that aim to modulate immune cells using various biomaterials for tissue repair and regeneration.
Topics: Regeneration; Immunity; Biocompatible Materials; Immunomodulation
PubMed: 36920675
DOI: 10.1007/s13770-023-00525-0 -
Molecular Biomedicine Jan 2024In the world of biomedical breakthroughs, Rice University bioengineer Omid Veiseh and his team are making waves with their recent publication in Nature Biomedical...
In the world of biomedical breakthroughs, Rice University bioengineer Omid Veiseh and his team are making waves with their recent publication in Nature Biomedical Engineering (2023) (Mukherjeeet al., Nat Biomed Eng. 7:867–886, 2023). This study is a pivotal step in our fight against fibrosis, an issue that has long hindered medical progress. Their pioneering research isn’t just a scientific milestone; it’s a game-changer in how we tackle tissue scarring. Veiseh and his team have introduced an innovative method that allows for rapid testing of various materials within living organisms. By employing cellular barcoding and cutting-edge sequencing techniques, they’ve accelerated the assessment of multiple hydrogels. As we delve deeper into the specifics of this groundbreaking study, we uncover not just scientific insights, but the potential to revolutionize how we conceptualize and utilize biomaterials. This discussion isn’t merely about research methods; it’s about the ray of hope and boundless opportunities this study illuminates across the spectrum of biomaterials science.
Topics: Humans; Biocompatible Materials; High-Throughput Screening Assays
PubMed: 38165582
DOI: 10.1186/s43556-023-00163-x