-
Microbial Biotechnology Sep 2016
Topics: Biotechnology; Industrial Microbiology
PubMed: 27509838
DOI: 10.1111/1751-7915.12403 -
IEEE Pulse 2019Could biotechnology stop aging? The answer may be yes, no, or something in between, depending on who is being asked and what it means to "stop" aging. For those at one... (Review)
Review
Could biotechnology stop aging? The answer may be yes, no, or something in between, depending on who is being asked and what it means to "stop" aging. For those at one end of the spectrum- life extension seekers (including some deep-pocketed Silicon Valley investors)-the answer is "yes." They believe biotechnology will lengthen human life spans to range anywhere from 1,000 years to forever. But for most, the answer is more nuanced and in- volves a dream of extended healthspan, rather than immortality. They imagine a future in which people over the age of 65 years are healthy, active, independent, and not burdened by disease, and that this is the norm rather than the exception. "Healthspanners" believe that one day, science will delay the onset of aging-related conditions and, as a side-effect, modestly extend life. Aging as we know it-and dread it-could become ancient history.
Topics: Biotechnology; Humans; Longevity
PubMed: 31021750
DOI: 10.1109/MPULS.2019.2899701 -
Biotechnology Advances Nov 2022Industrial biotechnology encompasses a large area of multi-scale and multi-disciplinary research activities. With the recent megatrend of digitalization sweeping across... (Review)
Review
Industrial biotechnology encompasses a large area of multi-scale and multi-disciplinary research activities. With the recent megatrend of digitalization sweeping across all industries, there is an increased focus in the biotechnology industry on developing, integrating and applying digital models to improve all aspects of industrial biotechnology. Given the rapid development of this field, we systematically classify the state-of-art modelling concepts applied at different scales in industrial biotechnology and critically discuss their current usage, advantages and limitations. Further, we critically analyzed current strategies to couple cell models with computational fluid dynamics to study the performance of industrial microorganisms in large-scale bioprocesses, which is of crucial importance for the bio-based production industries. One of the most challenging aspects in this context is gathering intracellular data under industrially relevant conditions. Towards comprehensive models, we discuss how different scale-down concepts combined with appropriate analytical tools can capture intracellular states of single cells. We finally illustrated how the efforts could be used to develop digitals models suitable for both cell factory design and process optimization at industrial scales in the future.
Topics: Biotechnology; Industrial Microbiology
PubMed: 35781047
DOI: 10.1016/j.biotechadv.2022.108015 -
Trends in Biotechnology Feb 2021Biotechnology has a Valley of Death challenge. Arrhenius's model is used to consider this journey by visualizing the factors critical to identifying appropriate business... (Review)
Review
Biotechnology has a Valley of Death challenge. Arrhenius's model is used to consider this journey by visualizing the factors critical to identifying appropriate business models. Examples illustrate this interplay and the routes to industrial readiness. The insights provided are useful to research and development managers, policy makers, entrepreneurs, and biotechnologists.
Topics: Biotechnology; Commerce; Industry; Models, Theoretical
PubMed: 32718779
DOI: 10.1016/j.tibtech.2020.06.013 -
New Biotechnology Jan 2018This paper addresses recent government initiatives in biotechnology and various federal and regional initiatives. It presents an overview of the most visible industrial... (Review)
Review
This paper addresses recent government initiatives in biotechnology and various federal and regional initiatives. It presents an overview of the most visible industrial biotechnology projects under implementation and highlights changes in legislation affecting development of the bioeconomy in the Russian Federation.
Topics: Agriculture; Biotechnology; Industrial Development; Russia
PubMed: 28634066
DOI: 10.1016/j.nbt.2017.06.001 -
JAMA Mar 1988The practice of biology and medicine has been revolutionized during the past ten years by the advent of three biotechnologies--recombinant DNA techniques, the monoclonal... (Review)
Review
The practice of biology and medicine has been revolutionized during the past ten years by the advent of three biotechnologies--recombinant DNA techniques, the monoclonal antibody technology, and the development of microchemical instrumentation, machines that permit the rapid and effective synthesis and sequence analysis of proteins and genes. In this article, these powerful biotechnologies will be discussed, with particular emphasis on microchemical instrumentation, a major focus of my efforts for the past 15 years. I will also discuss two fundamental problems in modern medicine that are being explored in my laboratory using these techniques--genetic engineering of the nervous system and the mapping and sequencing of the human genome.
Topics: Animals; Antibodies, Monoclonal; Biotechnology; Chromosome Mapping; DNA, Recombinant; Genetic Engineering; Humans; Microchemistry; Myelin Proteins
PubMed: 3278155
DOI: No ID Found -
Biotechnology Journal Nov 2006From the review of the achievements and advantages in the development of biotechnology (BT) and bioindustry in China, it is clear that the bioeconomy would provide a... (Review)
Review
From the review of the achievements and advantages in the development of biotechnology (BT) and bioindustry in China, it is clear that the bioeconomy would provide a tremendous opportunity for China to develop sustainably or even surpass a few developed countries. A long-term vision has been made to guide the research and development and industrialization of BT in China. This review detailed the strategies, targets, priorities, and key technologies in each stage. Furthermore, the reviewers expatiated on the establishment of the favorable policies, the foundation of the professional groups, the establishment of the advanced laboratories or centers, the investment mechanisms, the development and evaluation of biosafety, the encouragement and support for the international collaborations and exchanges, and the establishment of the general organizational structure.
Topics: Biotechnology; China; Developing Countries; Genetic Engineering; Industry; Research; Research Support as Topic; Technology Transfer
PubMed: 17109491
DOI: 10.1002/biot.200600133 -
Microbial Biotechnology Nov 2017
Topics: Anniversaries and Special Events; Biotechnology; Editorial Policies; Periodicals as Topic
PubMed: 29063739
DOI: 10.1111/1751-7915.12876 -
Cellular and Molecular Biology... Dec 2001Biotechnology permits our world to progress. It's a tool to better apprehend the human being, but as well to let him go ahead. Applied to the living, biotechnologies... (Review)
Review
Biotechnology permits our world to progress. It's a tool to better apprehend the human being, but as well to let him go ahead. Applied to the living, biotechnologies present the same finality. But since their matter concerns effectively the living, they are the sources of specific dangers and particularly of that one to use the improvements obtained on the human to modify the human species. The right of the persons has to find its place to avoid that the fundamental rights of the human personality shall undergo harm. This mission assigned to the right of the persons is as so much invaluable that the economical stakes are particularly important in the domain of the biotechnologies.
Topics: Biotechnology; Genetic Engineering; Genome, Human; Human Rights; Humans
PubMed: 11838956
DOI: No ID Found -
World Journal of Microbiology &... Sep 2015A new scientific and engineering discipline, Construction Biotechnology, is developing exponentially during the last decade. The major directions of this discipline are... (Review)
Review
A new scientific and engineering discipline, Construction Biotechnology, is developing exponentially during the last decade. The major directions of this discipline are selection of microorganisms and development of the microbially-mediated construction processes and biotechnologies for the production of construction biomaterials. The products of construction biotechnologies are low cost, sustainable, and environmentally friendly microbial biocements and biogrouts for the construction ground improvement. The microbial polysaccharides are used as admixtures for cement. Microbially produced biodegradable bioplastics can be used for the temporarily constructions. The bioagents that are used in construction biotechnologies are either pure or enrichment cultures of microorganisms or activated indigenous microorganisms of soil. The applications of microorganisms in the construction processes are bioaggregation, biocementation, bioclogging, and biodesaturation of soil. The biotechnologically produced construction materials and the microbially-mediated construction technologies have a lot of advantages in comparison with the conventional construction materials and processes. Proper practical implementations of construction biotechnologies could give significant economic and environmental benefits.
Topics: Bacteria; Biotechnology; Construction Industry; Construction Materials; Fungi
PubMed: 26070432
DOI: 10.1007/s11274-015-1881-7