Authors: Kenneth Timmis, Juan Luis Ramos, Willem de Vos...

Topics: Biotechnology; Industrial Microbiology

PubMed: 27509838
DOI: 10.1111/1751-7915.12403

Authors: Tara A Eastwood, Karen Baker, Bree R Streather...

We describe an innovative system that exports diverse recombinant proteins in membrane-bound vesicles from . These recombinant vesicles compartmentalize proteins within a micro-environment that enables production of otherwise challenging insoluble, toxic, or disulfide-bond containing proteins from bacteria. The release of vesicle-packaged proteins supports isolation from the culture and allows long-term storage of active protein. This technology results in high yields of vesicle-packaged, functional proteins for efficient downstream processing for a wide range of applications from discovery science to applied biotechnology and medicine.

Topics: Escherichia coli; Recombinant Proteins; Biotechnology; Escherichia coli Proteins

PubMed: 36936078
DOI: 10.1016/j.crmeth.2023.100396

Review

Authors: Lionel Clarke, Richard Kitney

Since the beginning of the 21st Century, synthetic biology has established itself as an effective technological approach to design and engineer biological systems. Whilst research and investment continues to develop the understanding, control and engineering infrastructural platforms necessary to tackle ever more challenging systems - and to increase the precision, robustness, speed and affordability of existing solutions - hundreds of start-up companies, predominantly in the US and UK, are already translating learnings and potential applications into commercially viable tools, services and products. Start-ups and SMEs have been the predominant channel for synthetic biology commercialisation to date, facilitating rapid response to changing societal interests and market pull arising from increasing awareness of health and global sustainability issues. Private investment in start-ups across the US and UK is increasing rapidly and now totals over $12bn. Health-related biotechnology applications have dominated the commercialisation of products to date, but significant opportunities for the production of bio-derived materials and chemicals, including consumer products, are now being developed. Synthetic biology start-ups developing tools and services account for between 10% (in the UK) and ∼25% (in the US) of private investment activity. Around 20% of synthetic biology start-ups address industrial biotechnology targets, but currently, only attract ∼11% private investment. Adopting a more networked approach - linking specialists, infrastructure and ongoing research to de-risk the economic challenges of scale-up and supported by an effective long-term funding strategy - is set to transform the impact of synthetic biology and industrial biotechnology in the bioeconomy.

Topics: Biomedical Technology; Biotechnology; Humans; Manufacturing Industry; Synthetic Biology

PubMed: 32077472
DOI: 10.1042/BST20190349

Review

Authors: Yu-Xuan Lyu, Qiang Fu, Dominika Wilczok...

The recent unprecedented progress in ageing research and drug discovery brings together fundamental research and clinical applications to advance the goal of promoting healthy longevity in the human population. We, from the gathering at the Aging Research and Drug Discovery Meeting in 2023, summarised the latest developments in healthspan biotechnology, with a particular emphasis on artificial intelligence (AI), biomarkers and clocks, geroscience, and clinical trials and interventions for healthy longevity. Moreover, we provide an overview of academic research and the biotech industry focused on targeting ageing as the root of age-related diseases to combat multimorbidity and extend healthspan. We propose that the integration of generative AI, cutting-edge biological technology, and longevity medicine is essential for extending the productive and healthy human lifespan.

Topics: Humans; Aging; Artificial Intelligence; Biomarkers; Biotechnology; Geroscience; Longevity

PubMed: 39418098
DOI: 10.18632/aging.206135

Review

Authors: Lee W Goldman

This article provides a review of the basic principles of CT within the context of the evolution of CT. Modern CT technology can be understood as a natural progression of improvements and innovations in response to both engineering problems and clinical requirements. Detailed discussions of multislice CT, CT image quality evaluation, and radiation doses in CT will be presented in upcoming articles in this series.

Topics: Biotechnology; Equipment Design; Radiographic Image Enhancement; Technology Assessment, Biomedical; Tomography, X-Ray Computed

PubMed: 17823453
DOI: 10.2967/jnmt.107.042978

Authors: Fernando de la Cruz, Geoffrey M Gadd

Topics: Animals; Biodegradation, Environmental; Bioengineering; Biosensing Techniques; Biotechnology; DNA; Humans; Nanotechnology; Proteins

PubMed: 22683114
DOI: 10.1016/j.copbio.2012.05.002

Authors: Jen-Tsung Chen

Ginsenosides are unique to plants that belong to the genus [...].

Topics: Biotechnology; Ginsenosides

PubMed: 32354079
DOI: 10.3390/biom10050681

Authors: Antoine, Auxi, Juan Luis...

Topics: Biotechnology; Editorial Policies; Microbiological Techniques; Periodicals as Topic; Synthetic Biology

PubMed: 28052580
DOI: 10.1111/1751-7915.12598

Review

Authors: M J Dutt, K H Lee

The field of proteomics is becoming increasingly important as genome sequences are being completed and annotated. Recent advances in proteomics include experimental and mathematical proofs of the need to complement microarray analysis with protein analysis, improved sensitivity for mass spectrometric analysis of separated proteins, better informatic tools for gel analysis and protein spot annotation, first steps towards automated experimental procedures, and new technology for quantitation of protein changes.

Topics: Animals; Biotechnology; Computational Biology; Humans; Proteome

PubMed: 10753759
DOI: 10.1016/s0958-1669(00)00078-1

Authors: Eldon R Rene, Prakash K Sarangi, Violeta Sànchez I Nogué...

This paper presents the scientific breakthroughs made in bioprocess engineering and microbial biotechnology for the conversion of wastes into products with added value and/or biofuels. The significant results obtained in the emerging fields of hybrid electrosynthesis, the role of enzymes in the degradation of plastics, polyhydroxyalkanoate and 5-aminolevulinic acid production, fermentation technology and the application of molecular engineering tools to bioprocess technology are highlighted.

Topics: Biotechnology; Fermentation; Polyhydroxyalkanoates; Biofuels

PubMed: 36542752
DOI: 10.1111/1751-7915.14198