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Microbial Biotechnology Sep 2016
Topics: Biotechnology; Industrial Microbiology
PubMed: 27509838
DOI: 10.1111/1751-7915.12403 -
Biochemical Society Transactions Feb 2020Since the beginning of the 21st Century, synthetic biology has established itself as an effective technological approach to design and engineer biological systems.... (Review)
Review
Since the beginning of the 21st Century, synthetic biology has established itself as an effective technological approach to design and engineer biological systems. Whilst research and investment continues to develop the understanding, control and engineering infrastructural platforms necessary to tackle ever more challenging systems - and to increase the precision, robustness, speed and affordability of existing solutions - hundreds of start-up companies, predominantly in the US and UK, are already translating learnings and potential applications into commercially viable tools, services and products. Start-ups and SMEs have been the predominant channel for synthetic biology commercialisation to date, facilitating rapid response to changing societal interests and market pull arising from increasing awareness of health and global sustainability issues. Private investment in start-ups across the US and UK is increasing rapidly and now totals over $12bn. Health-related biotechnology applications have dominated the commercialisation of products to date, but significant opportunities for the production of bio-derived materials and chemicals, including consumer products, are now being developed. Synthetic biology start-ups developing tools and services account for between 10% (in the UK) and ∼25% (in the US) of private investment activity. Around 20% of synthetic biology start-ups address industrial biotechnology targets, but currently, only attract ∼11% private investment. Adopting a more networked approach - linking specialists, infrastructure and ongoing research to de-risk the economic challenges of scale-up and supported by an effective long-term funding strategy - is set to transform the impact of synthetic biology and industrial biotechnology in the bioeconomy.
Topics: Biomedical Technology; Biotechnology; Humans; Manufacturing Industry; Synthetic Biology
PubMed: 32077472
DOI: 10.1042/BST20190349 -
Cell Reports Methods Feb 2023We describe an innovative system that exports diverse recombinant proteins in membrane-bound vesicles from . These recombinant vesicles compartmentalize proteins within...
We describe an innovative system that exports diverse recombinant proteins in membrane-bound vesicles from . These recombinant vesicles compartmentalize proteins within a micro-environment that enables production of otherwise challenging insoluble, toxic, or disulfide-bond containing proteins from bacteria. The release of vesicle-packaged proteins supports isolation from the culture and allows long-term storage of active protein. This technology results in high yields of vesicle-packaged, functional proteins for efficient downstream processing for a wide range of applications from discovery science to applied biotechnology and medicine.
Topics: Escherichia coli; Recombinant Proteins; Biotechnology; Escherichia coli Proteins
PubMed: 36936078
DOI: 10.1016/j.crmeth.2023.100396 -
Angewandte Chemie (International Ed. in... Jan 2021Biocatalysis has found numerous applications in various fields as an alternative to chemical catalysis. The use of enzymes in organic synthesis, especially to make... (Review)
Review
Biocatalysis has found numerous applications in various fields as an alternative to chemical catalysis. The use of enzymes in organic synthesis, especially to make chiral compounds for pharmaceuticals as well for the flavors and fragrance industry, are the most prominent examples. In addition, biocatalysts are used on a large scale to make specialty and even bulk chemicals. This review intends to give illustrative examples in this field with a special focus on scalable chemical production using enzymes. It also discusses the opportunities and limitations of enzymatic syntheses using distinct examples and provides an outlook on emerging enzyme classes.
Topics: Biocatalysis; Biotechnology; Enzymes
PubMed: 32558088
DOI: 10.1002/anie.202006648 -
Journal of Nuclear Medicine Technology Sep 2007This article provides a review of the basic principles of CT within the context of the evolution of CT. Modern CT technology can be understood as a natural progression... (Review)
Review
This article provides a review of the basic principles of CT within the context of the evolution of CT. Modern CT technology can be understood as a natural progression of improvements and innovations in response to both engineering problems and clinical requirements. Detailed discussions of multislice CT, CT image quality evaluation, and radiation doses in CT will be presented in upcoming articles in this series.
Topics: Biotechnology; Equipment Design; Radiographic Image Enhancement; Technology Assessment, Biomedical; Tomography, X-Ray Computed
PubMed: 17823453
DOI: 10.2967/jnmt.107.042978 -
Journal of Microbiology and... Mar 2021Monoclonal antibodies are widely used as diagnostic reagents and for therapeutic purposes, and their demand is increasing extensively. To produce these proteins in... (Review)
Review
Monoclonal antibodies are widely used as diagnostic reagents and for therapeutic purposes, and their demand is increasing extensively. To produce these proteins in sufficient quantities for commercial use, it is necessary to raise the output by scaling up the production processes. This review describes recent trends in high-density cell culture systems established for monoclonal antibody production that are excellent methods to scale up from the lab-scale cell culture. Among the reactors, hollow fiber bioreactors contribute to a major part of high-density cell culture as they can provide a tremendous amount of surface area in a small volume for cell growth. As an alternative to hollow fiber reactors, a novel disposable bioreactor has been developed, which consists of a polymer-based supermacroporous material, cryogel, as a matrix for cell growth. Packed bed systems and disposable wave bioreactors have also been introduced for high cell density culture. These developments in high-density cell culture systems have led to the monoclonal antibody production in an economically favourable manner and made monoclonal antibodies one of the dominant therapeutic and diagnostic proteins in biopharmaceutical industry.
Topics: Animals; Antibodies, Monoclonal; Antibody Formation; Bioreactors; Biotechnology; Cell Culture Techniques; Humans
PubMed: 32238761
DOI: 10.4014/jmb.1911.11066 -
Biomolecules Apr 2020Ginsenosides are unique to plants that belong to the genus [...].
Ginsenosides are unique to plants that belong to the genus [...].
Topics: Biotechnology; Ginsenosides
PubMed: 32354079
DOI: 10.3390/biom10050681 -
Microbial Biotechnology Jan 2017
Topics: Biotechnology; Editorial Policies; Microbiological Techniques; Periodicals as Topic; Synthetic Biology
PubMed: 28052580
DOI: 10.1111/1751-7915.12598 -
Microbial Biotechnology Mar 2021
Topics: Biotechnology; China; Industrial Microbiology; Microbiology
PubMed: 33609328
DOI: 10.1111/1751-7915.13777 -
Microbial Biotechnology Feb 2023This paper presents the scientific breakthroughs made in bioprocess engineering and microbial biotechnology for the conversion of wastes into products with added value...
This paper presents the scientific breakthroughs made in bioprocess engineering and microbial biotechnology for the conversion of wastes into products with added value and/or biofuels. The significant results obtained in the emerging fields of hybrid electrosynthesis, the role of enzymes in the degradation of plastics, polyhydroxyalkanoate and 5-aminolevulinic acid production, fermentation technology and the application of molecular engineering tools to bioprocess technology are highlighted.
Topics: Biotechnology; Fermentation; Polyhydroxyalkanoates; Biofuels
PubMed: 36542752
DOI: 10.1111/1751-7915.14198