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Cell Aug 2022Aedes aegypti mosquitoes are a persistent human foe, transmitting arboviruses including dengue when they feed on human blood. Mosquitoes are intensely attracted to body...
Aedes aegypti mosquitoes are a persistent human foe, transmitting arboviruses including dengue when they feed on human blood. Mosquitoes are intensely attracted to body odor and carbon dioxide, which they detect using ionotropic chemosensory receptors encoded by three large multi-gene families. Genetic mutations that disrupt the olfactory system have modest effects on human attraction, suggesting redundancy in odor coding. The canonical view is that olfactory sensory neurons each express a single chemosensory receptor that defines its ligand selectivity. We discovered that Ae. aegypti uses a different organizational principle, with many neurons co-expressing multiple chemosensory receptor genes. In vivo electrophysiology demonstrates that the broad ligand-sensitivity of mosquito olfactory neurons depends on this non-canonical co-expression. The redundancy afforded by an olfactory system in which neurons co-express multiple chemosensory receptors may increase the robustness of the mosquito olfactory system and explain our long-standing inability to disrupt the detection of humans by mosquitoes.
Topics: Aedes; Animals; Humans; Ligands; Odorants; Olfactory Receptor Neurons
PubMed: 35985288
DOI: 10.1016/j.cell.2022.07.024 -
Science Advances Jun 2022Nonhuman terrestrial mammals sniff themselves and each other to decide who is friend or foe. Humans also sniff themselves and each other, but the function of this is...
Nonhuman terrestrial mammals sniff themselves and each other to decide who is friend or foe. Humans also sniff themselves and each other, but the function of this is unknown. Because humans seek friends who are similar to themselves, we hypothesized that humans may smell themselves and others to subconsciously estimate body odor similarity, which, in turn, may promote friendship. To test this, we recruited nonromantic same-sex friend dyads and harvested their body odor. We found that objective ratings obtained with an electronic nose, and subjective ratings obtained from independent human smellers converged to suggest that friends smell more similar to each other than random dyads. Last, we recruited complete strangers, smelled them with an electronic nose, and engaged them in nonverbal same-sex dyadic interactions. We observed that dyads who smelled more similar had more positive dyadic interactions. In other words, we could predict social bonding with an electronic nose. We conclude that there is indeed chemistry in social chemistry.
PubMed: 35749498
DOI: 10.1126/sciadv.abn0154 -
Evolutionary Human Sciences 2022Recent work has demonstrated that human body odour alters with changing emotional state and that emotionally laden odours can affect the physiology and behaviour of... (Review)
Review
Recent work has demonstrated that human body odour alters with changing emotional state and that emotionally laden odours can affect the physiology and behaviour of people exposed to them. Here we review these discoveries, which we believe add to a growing recognition that the human sense of smell and its potential role in social interactions have been underappreciated. However, we also critically evaluate the current evidence, with a particular focus on methodology and the interpretation of emotional odour studies. We argue that while the evidence convincingly indicates that humans retain a capacity for olfactory communication of emotion, the extent to which this occurs in ordinary social interaction remains an open question. Future studies should place fewer restrictions on participant selection and lifestyle and adopt more realistic experimental designs. We also need to devote more consideration to underlying mechanisms and to recognise the constraints that these may place on effective communication. Finally, we outline some promising approaches to address these issues, and raise some broader theoretical questions that such approaches may help us to answer.
PubMed: 37588919
DOI: 10.1017/ehs.2022.44 -
IScience Jul 2023Sportswear worn next to the skin is easily soaked by sweat and may become a breeding ground for the microbiome, thus a source of malodor. Malodor can cause social... (Review)
Review
Sportswear worn next to the skin is easily soaked by sweat and may become a breeding ground for the microbiome, thus a source of malodor. Malodor can cause social embarrassment and discomfort to both wearer and others. Given the risks current deodorant products pose to nature and human life, the development of sustainable textiles for odor control comes to the forefront. This review introduces the odor-generating mechanism in clothing from the perspectives of perspiration composition and cutaneous microbiome. With the knowledge of the significant role of sweat in odor formation, the sweat distribution of the human body, measurement techniques, and advanced technologies developed for quick-dry function are presented in the second part. Lastly, odor management in sportswear is evaluated, covering the odor-assessing techniques, the effects of various textile materials, and emerging solutions in terms of antibacterial treatment, adsorbent materials, and photocatalytic degradations of odorous compounds. Overall, it is of both personal and social value to develop novel textile materials with odor-control functions by making use of natural materials and fabric designs.
PubMed: 37534139
DOI: 10.1016/j.isci.2023.107067