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International Journal of Molecular... Apr 2024, a Gram-negative bacillus commonly associated with respiratory infections in animals, has garnered attention for its sporadic cases in humans, particularly in...
, a Gram-negative bacillus commonly associated with respiratory infections in animals, has garnered attention for its sporadic cases in humans, particularly in immunocompromised individuals. Despite its opportunistic nature, there remains limited understanding regarding its pathogenicity, diagnostic challenges, and optimal treatment strategies, especially in the context of immunosuppression. Herein, we present the first documented case of acute bronchitis caused by in an immunocompromised patient following double-lung transplantation. The patient, a former smoker with sarcoidosis stage IV, underwent transplant surgery and subsequently developed a febrile episode, leading to the identification of in broncho-alveolar lavage samples. Antimicrobial susceptibility testing revealed resistance to multiple antibiotics, necessitating tailored treatment adjustments. Our case underscores the importance of heightened awareness among clinicians regarding infections and the imperative for further research to elucidate its epidemiology and optimal management strategies, particularly in immunocompromised populations.
Topics: Lung Transplantation; Humans; Bordetella; Bordetella Infections; Immunocompromised Host; Male; Middle Aged; Anti-Bacterial Agents; Transplant Recipients
PubMed: 38731927
DOI: 10.3390/ijms25094708 -
The Journal of International Medical... Jan 2024An increasing number of reports have described the pathogenic nature of several non-classical spp. Among them, and have been implicated in a myriad of...
An increasing number of reports have described the pathogenic nature of several non-classical spp. Among them, and have been implicated in a myriad of respiratory-associated infections in humans and animals. We report the isolation of a genetically close relative of and from the sputum of a woman in her early 60s with extensive bronchiectasis who presented with fever and brown colored sputum. The isolate had initially been identified as by API 20NE, the identification system for non-enteric Gram-negative rod bacteria. Sequencing of the 16S rDNA, , , and genes used in the multilocus sequence typing scheme could not resolve the identity of this isolate. Whole-genome single nucleotide polymorphism analysis positioned the isolate between and in the phylogenetic tree, forming a distinct cluster. Whole-genome sequencing enabled the further identification of this rare organism, and should be considered for wider applications, especially the confirmation of organism identity in the clinical diagnostic microbiology laboratory.
Topics: Humans; Animals; Female; Bordetella Infections; Phylogeny; Bordetella; Bronchiectasis; Respiratory Tract Infections
PubMed: 38216150
DOI: 10.1177/03000605231214464 -
Microorganisms Sep 2023Urban rats serve as reservoirs for several zoonotic pathogens that seriously endanger public health, destroy stored food, and damage infrastructure due to their close...
Urban rats serve as reservoirs for several zoonotic pathogens that seriously endanger public health, destroy stored food, and damage infrastructure due to their close interaction with humans and domestic animals. Here, we characterize the core microbiomes of stomach, gut, and lung using 16S rRNA next-generation Illumina HiSeq sequencing. The USEARCH software (v11) assigned the dataset to operational taxonomic units (OTUs). The alpha diversity index was calculated using QIIME1, while the beta diversity index was determined using the Bray-Curtis and Euclidean distances between groups. Principal component analyses visualized variation across samples based on the OTU information using the R package. Linear discriminant analysis, effect sizes (LEfSe), and phylogenetic investigation were used to identify differentially abundant taxa among groups. We reported an abundance of microbiota in the stomach, and they shared some of them with the gut and lung microbiota. A close look at the microbial family level reveals abundant Lactobacillaceae and Bifidobacteriaceae in the stomach, whereas Lactobacillaceae and Erysipelotrichaceae were more abundant in the gut; in contrast, Alcaligenaceae were abundant in the lungs. At the species level, some beneficial bacteria, particularly and , and some potential pathogens, such as , , , , etc., were identified in stomach, gut, and lung samples. Moreover, the alpha and beta diversity indexes revealed significant differences between the groups. Further analysis revealed abundant differential taxonomic biomarkers, i.e., increased Prevotellaceae and Clostridia in the lungs, whereas Campylobacteria and Lachnospirales were richest in the stomachs. In conclusion, we identified many beneficial, opportunistic, and highly pathogenic bacteria, confirming the importance of urban rats for public health. This study recommends a routine survey program to monitor rodent distribution and the pathogens they carry and transmit to humans and other domestic mammals.
PubMed: 37764203
DOI: 10.3390/microorganisms11092359 -
Emerging Microbes & Infections Dec 2023
Topics: Humans; COVID-19; SARS-CoV-2; Bordetella; Bacteremia
PubMed: 36367206
DOI: 10.1080/22221751.2022.2147276 -
Emerging Infectious Diseases Apr 2022Patients infected with severe acute respiratory syndrome coronavirus 2 might have bacterial and fungal superinfections develop. We describe a clinical case of...
Patients infected with severe acute respiratory syndrome coronavirus 2 might have bacterial and fungal superinfections develop. We describe a clinical case of coronavirus disease with pulmonary aspergillosis associated with Bordetella hinzii pneumonia in an immunocompetent patient in France. B. hinzii infections are rare in humans and develop secondary to immunosuppression or debilitating diseases.
Topics: Bordetella; COVID-19; Humans; Pneumonia; SARS-CoV-2
PubMed: 35318919
DOI: 10.3201/eid2804.212564 -
Revista Espanola de Quimioterapia :... Jun 2022
Topics: Bordetella; Bordetella Infections; COVID-19; Humans; Pneumonia; SARS-CoV-2
PubMed: 35247945
DOI: 10.37201/req/160.2021 -
Neurology. Clinical Practice Oct 2021
PubMed: 34840911
DOI: 10.1212/CPJ.0000000000001122 -
Emerging Infectious Diseases Nov 2021Although Bordetella hinzii coccobacilli is most commonly identified in respiratory tracts of birds and rodents, this organism has occasionally been isolated in human...
Although Bordetella hinzii coccobacilli is most commonly identified in respiratory tracts of birds and rodents, this organism has occasionally been isolated in human infections. We describe a case of B. hinzii spontaneous bacterial peritonitis in Missouri, USA. Whole-genome sequencing of blood and peritoneal fluid isolates confirmed B. hinzii infection.
Topics: Bordetella; Bordetella Infections; Humans; Missouri; Peritonitis
PubMed: 34463239
DOI: 10.3201/eid2711.211428 -
Emerging Infectious Diseases Sep 2021A patient in Virginia, USA, who had previously undergone multiple kidney transplantations showed signs of Bordetella hinzii bacteremia and meningitis. This emerging...
A patient in Virginia, USA, who had previously undergone multiple kidney transplantations showed signs of Bordetella hinzii bacteremia and meningitis. This emerging pathogen has been increasingly identified as a clinically significant pathogen in immunosuppressed and, less frequently, immunocompetent patients. This patient was treated and recovered without further issue.
Topics: Bordetella; Humans; Kidney Transplantation; Meningitis; Virginia
PubMed: 34424178
DOI: 10.3201/eid2709.210350 -
Emerging Infectious Diseases Nov 2021Patients with severe acute respiratory syndrome coronavirus 2 infection may have bacterial co-infections, including pneumonia and bacteremia. Bordetella hinzii...
Patients with severe acute respiratory syndrome coronavirus 2 infection may have bacterial co-infections, including pneumonia and bacteremia. Bordetella hinzii infections are rare, may be associated with exposure to poultry, and have been reported mostly among immunocompromised patients. We describe B. hinzii pneumonia and bacteremia in a severe acute respiratory syndrome coronavirus 2 patient.
Topics: Bacteremia; Bordetella; Bordetella Infections; COVID-19; Humans
PubMed: 34388087
DOI: 10.3201/eid2711.211468