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American Family Physician Nov 2020Central retinal artery occlusions, chemical injuries, mechanical globe injuries, and retinal detachments are eye emergencies that can result in permanent vision loss if...
Central retinal artery occlusions, chemical injuries, mechanical globe injuries, and retinal detachments are eye emergencies that can result in permanent vision loss if not treated urgently. Family physicians should be able to recognize the signs and symptoms of each condition and be able to perform a basic eye examination. Patients with a central retinal artery occlusion require urgent referral for stroke evaluation and should receive therapy to lower intraocular pressure and vasodilating agents to minimize retinal ischemia. Chemical injuries require immediate irrigation of the eye to neutralize the pH of the ocular surface. A globe laceration or rupture is common in patients with a recent history of trauma from a blunt or penetrating object. Physicians should administer prophylactic oral antibiotics after a globe injury to prevent endophthalmitis. The eye should be covered with a metal shield until evaluation by an ophthalmologist. Patients with symptomatic floaters and flashing lights should be referred to an ophthalmologist for a dilated funduscopic examination to evaluate for a retinal tear or detachment.
Topics: Adult; Aged; Consultants; Eye Injuries; Humans; Male; Retinal Artery Occlusion; Retinal Detachment
PubMed: 33118787
DOI: No ID Found -
International Journal of Ophthalmology 2017Paediatric retinal detachment (PRD) is an uncommon and challenging disease; it differs from adult detachments in etiology, anatomical characteristics, management and... (Review)
Review
Paediatric retinal detachment (PRD) is an uncommon and challenging disease; it differs from adult detachments in etiology, anatomical characteristics, management and prognosis. PRDs can be particularly challenging, even for the most expert paediatric surgeons due to the higher prevalence of total retinal detachments, late diagnosis and bilateral involvement with respect to those which occur in adulthood. Moreover, the anatomical success, when achieved, is frequently not related to a functional recover. Postsurgical adverse events, refractive errors and amblyopia may additionally undermine the final outcome. Up to date there are few reviews regarding the approach of retinal detachment in children, mainly dealing with rhegmatogenous retinal detachment. In this review, rhegmatogenous, retinopathy of prematurity-related and Coats'-related PRDs were considered. The available literature from the last decades were reviewed and summarized. Epidemiology, etiology and clinical presentation, together with therapeutic approaches and outcomes have been reviewed and discussed.
PubMed: 29062781
DOI: 10.18240/ijo.2017.10.18 -
Plant-environment Interactions... Aug 2021Leaf level gas-exchange measurements can be made on detached foliage to address the challenge of access to the crown of tall trees. However, detachment may impact leaf...
Leaf level gas-exchange measurements can be made on detached foliage to address the challenge of access to the crown of tall trees. However, detachment may impact leaf gas exchange. This necessitates the study of gas-exchange characteristics of foliage on detached branches to assess the feasibility of using detached branches for gas-exchange analysis. We compared photosynthetic parameters and stomatal conductance in foliage of attached and detached branches of balsam fir [ (L.) Mill.] during the growing season. Data were analyzed using a linear mixed-effect model, with fixed and random effects (branch status and measurement month, and tree number, respectively). Branch detachment had no significant effects on: (i) photosynthesis at the current ambient CO concentration (400 µmol mol, ); (ii) maximum rates of Ribulose-1,5-bisphosphate (RuBP) carboxylation ( ) and regeneration ( ); (iii) the ratio of to (i.e., : ), and (iv) stomatal conductance ( ) during the study period ( = 0.120-0.335). There was a strong seasonal effect on all gas-exchange variables ( ≤ 0.001-0.015). Gas-exchange measurements made on detached foliage during the warm summer months should be performed with care. Reliable gas-exchange measurements can be obtained using balsam fir foliage on detached branches 50-80 cm in length, in cooler growing-season months, up to 30 min after detachment.
PubMed: 37283699
DOI: 10.1002/pei3.10059 -
The Journal of Analytical Psychology Jun 2021This paper attempts to read the psychological and emotional impact of the COVID-19 pandemic through the archetypal images contained in patients' dreams. In these dreams,...
This paper attempts to read the psychological and emotional impact of the COVID-19 pandemic through the archetypal images contained in patients' dreams. In these dreams, symbols related to the power of nature and to extreme danger are paired with feelings of detachment that seem to point to a traumatic dissociation, due to the archetypal experience that erupts in familiar surroundings. Through the humanization of the ineffable experience, dissociation, which in the beginning of the pandemic showed in high levels of anxiety, panic attacks and depersonalization, can be transformed into the overview needed for the search for meaning. The container for this process of transformation is the analyst, the real, virtual or imagined one, and his or her ability to relate and feel.
Topics: Adult; COVID-19; Dreams; Humans; Professional-Patient Relations; Psychoanalytic Interpretation; Psychoanalytic Therapy; Psychotherapeutic Processes
PubMed: 34231897
DOI: 10.1111/1468-5922.12676 -
Cell May 2018The detachment of plant organs is highly choreographed, requiring the enzymatic dissolution of the middle lamella between cell layers at the base of the detaching organ....
The detachment of plant organs is highly choreographed, requiring the enzymatic dissolution of the middle lamella between cell layers at the base of the detaching organ. Now, Lee et al. demonstrate that abscission efficiency and plant health rely on the spatial confinement of enzymatic activity and mechanical features that ensure a smooth separation.
Topics: Arabidopsis; Arabidopsis Proteins; Cell Wall; Lignin
PubMed: 29856951
DOI: 10.1016/j.cell.2018.05.025 -
Proceedings. Biological Sciences Mar 2021Animals can be permanently attached to a substrate in terrestrial environments at certain stages of their development. Pupa adhesion has evolved multiple times in...
Animals can be permanently attached to a substrate in terrestrial environments at certain stages of their development. Pupa adhesion has evolved multiple times in insects and is thought to maintain the animal in a place where it is not detectable by predators. Here, we investigate whether pupa adhesion in can also protect the animal by preventing potential predators from detaching the pupa. We measured the adhesion of species sampled from the same area and found that pupa adhesion varies among species, which can be explained by different glue production strategies. Then, we compared attached and manually detached pupae in both field and laboratory assays to investigate the role of pupa adhesion to prevent predation. First, we found that attached pupae remain onsite 30% more than detached pupae in the field after 3 days, probably because they are less predated. Second, we observed that attached pupae are less efficiently predated by ants in the laboratory: they are not carried back to the ant nest and more ants are needed to consume them onsite. Our results show that pupa adhesion can prevent the animal from being taken away by predators and is crucial for fly survival.
Topics: Animals; Ants; Drosophila; Insecta; Predatory Behavior; Pupa
PubMed: 33726597
DOI: 10.1098/rspb.2021.0088 -
Indian Journal of Ophthalmology Dec 2018Rhegmatogenous retinal detachment (RRD) repair is one of the most common vitreoretinal surgeries a surgeon performs. In an ideal scenario, RRD can be repaired with a... (Review)
Review
Rhegmatogenous retinal detachment (RRD) repair is one of the most common vitreoretinal surgeries a surgeon performs. In an ideal scenario, RRD can be repaired with a single surgical intervention; however, despite excellent skill, flawless technique, and the introduction of high-end technology, up to 10% of cases require additional interventions to ultimately repair recurrent detachments. It is thus important to study the outcomes of multiple interventions to understand whether performing repeat vitrectomy on patients with a history of failed surgeries is worthwhile. Thus, recurrent retinal detachment (re-RD) remains a significant challenge for vitreoretinal surgeons as well as the patients considering the economic and the emotional burden of undergoing multiple interventions. The advent of microincision vitrectomy system, perfluorocarbon liquids, and effective intraocular tamponades has opened new doors for managing re-RDs. In this article, we have reviewed and summarized the various causes and approaches for management for optimal anatomical and functional outcomes.
Topics: Disease Management; Humans; Recurrence; Retinal Detachment; Scleral Buckling; Treatment Outcome; Visual Acuity; Vitrectomy
PubMed: 30451176
DOI: 10.4103/ijo.IJO_1212_18 -
Biophysical Journal Nov 2020Kinesin-1 is an ATP-driven molecular motor that transports cellular cargo along microtubules. At low loads, kinesin-1 almost always steps forward, toward microtubule...
Kinesin-1 is an ATP-driven molecular motor that transports cellular cargo along microtubules. At low loads, kinesin-1 almost always steps forward, toward microtubule plus ends, but at higher loads, it can also step backward. Backsteps are usually 8 nm but can be larger. These larger backward events of 16 nm, 24 nm, or more are thought to be slips rather than steps because they are too fast to consist of multiple, tightly coupled 8-nm steps. Here, we propose that not only these larger backsteps, but all kinesin-1 backsteps, are slips. We show first that kinesin waits before forward steps for less time than before backsteps and detachments; second, we show that kinesin waits for the same amount of time before backsteps and detachments; and third, we show that by varying the microtubule type, we can change the ratio of backsteps to detachments without affecting forward stepping. Our findings indicate that backsteps and detachments originate from the same state and that this state arises later in the mechanochemical cycle than the state that gives rise to forward steps. To explain our data, we propose that, in each cycle of ATP turnover, forward kinesin steps can only occur before Pi release, whereas backslips and detachments can only occur after Pi release. In the scheme we propose, Pi release gates access to a weak binding K⋅ADP-K⋅ADP state that can slip back along the microtubule, re-engage, release ADP, and try again to take an ATP-driven forward step. We predict that this rescued detachment pathway is key to maintaining kinesin processivity under load.
Topics: Adenosine Triphosphate; Hydrolysis; Kinesins; Kinetics; Microtubules
PubMed: 33091340
DOI: 10.1016/j.bpj.2020.09.034 -
Frontiers in Robotics and AI 2021Collaborative robots promise to add flexibility to production cells thanks to the fact that they can work not only humans but also humans. The possibility of a direct...
Collaborative robots promise to add flexibility to production cells thanks to the fact that they can work not only humans but also humans. The possibility of a direct physical interaction between humans and robots allows to perform operations that were inconceivable with industrial robots. Collaborative soft grippers have been recently introduced to extend this possibility beyond the robot end-effector, making humans able to directly act on robotic hands. In this work, we propose to exploit collaborative grippers in a novel paradigm in which these devices can be easily attached and detached from the robot arm and used also independently from it. This is possible only with self-powered hands, that are still quite uncommon in the market. In the presented paradigm not only hands can be attached/detached to/from the robot end-effector as if they were simple tools, but they can also remain active and fully functional after detachment. This ensures all the advantages brought in by tool changers, that allow for quick and possibly automatic tool exchange at the robot end-effector, but also gives the possibility of using the hand capabilities and degrees of freedom without the need of an arm or of external power supplies. In this paper, the concept of is introduced and demonstrated through two illustrative tasks conducted with a new tool changer designed for collaborative grippers. The novel tool changer embeds electromagnets that are used to add safety during attach/detach operations. The activation of the electromagnets is controlled through a wearable interface capable of providing tactile feedback. The usability of the system is confirmed by the evaluations of 12 users.
PubMed: 34222348
DOI: 10.3389/frobt.2021.644532