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CMAJ : Canadian Medical Association... Jul 1997
Topics: Antiemetics; Calcium Channel Blockers; Canada; Dicyclomine; Doxylamine; Drug Combinations; Humans; Medication Errors; Morpholines; Pyridoxine; Terminology as Topic
PubMed: 9220936
DOI: No ID Found -
Canadian Family Physician Medecin de... Feb 2002One of my patients suffers from a moderate-to-severe form of morning sickness. She responded only partially to doxylamine and pyridoxine (Dicletin), and I wish to try...
QUESTION
One of my patients suffers from a moderate-to-severe form of morning sickness. She responded only partially to doxylamine and pyridoxine (Dicletin), and I wish to try adding another medication. What should my priority be?
ANSWER
An algorithm used by Motherisk to manage thousands of patients takes a hierarchical approach to this condition. This approach is evidence based with regard to fetal safety as well as efficacy.
Topics: Adult; Algorithms; Antiemetics; Evidence-Based Medicine; Female; Humans; Nausea; Pregnancy; Pregnancy Complications; Vomiting
PubMed: 11889884
DOI: No ID Found -
Case Reports in Neurological Medicine 2012Paroxysmal hypnogenic dyskinesia is a rare clinical entity characterized by intermittent dystonia and choreoathetoid movements that begin exclusively during sleep, often...
Paroxysmal hypnogenic dyskinesia is a rare clinical entity characterized by intermittent dystonia and choreoathetoid movements that begin exclusively during sleep, often with consciousness preserved once the patient is awakened during the episodes. They occur almost every night and are often misdiagnosed as sleeping disorders. Paroxysmal hypnogenic dyskinesia is currently known to be a form of frontal lobe epilepsy, but not in all cases. We present a 19-year-old male patient with paroxysmal hypnogenic dyskinesia who responded to antihistamines. This supports an alternative theory from 1977 (before the cases had been adequately described) that the disorder lies in dysregulation in the basal ganglia. This description now appears similar to acute dystonic reactions such as extrapyramidal symptoms from antipsychotic medications, which also respond to antihistamines.
PubMed: 22937351
DOI: 10.1155/2012/484689 -
British Medical Journal Nov 1980An investigation was carried out in Northern Ireland into the alleged association between fetal abnormalities and Debendox, an antiemetic drug used in pregnancy. During...
An investigation was carried out in Northern Ireland into the alleged association between fetal abnormalities and Debendox, an antiemetic drug used in pregnancy. During the period 1966-78 the total number of births each year and the overall incidence of congenital malformations per 10 000 births fell. The incidences of cleft lip, cleft palate, reduction deformities, and defects of the heart and great vessels fell from 1966 to 1976 but increased in 1977 and 1978. During the same period (1966-78) the number of prescriptions for Debendox issued by general practitioners increased more than fourfold. These observations suggest that there is no relation between congenital malformations and the use of Debendox. This conclusion, however, does not take into account other drug- or environmental-related factors that may have resulted in a reduction in the number of congenital malformations and would hence have masked an increase associated with greater usage of Debendox. In particular, the amount of Debendox sold direct to the public without a prescription and the use of the drug by patients who were not pregnant could not be established. The amount of drug used in these ways is probably small, and it is difficult to see how it might influence the conclusions reached.
Topics: Abnormalities, Drug-Induced; Antiemetics; Cyclohexanecarboxylic Acids; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Northern Ireland; Pregnancy; Pregnancy Complications; Pyridines; Pyridoxine; Vomiting
PubMed: 7437804
DOI: 10.1136/bmj.281.6252.1379 -
Canadian Family Physician Medecin de... Sep 1997
Topics: Administration, Oral; Antiemetics; Doxylamine; Female; Humans; Hyperemesis Gravidarum; Infusions, Intravenous; Pregnancy; Pyridoxine
PubMed: 9303223
DOI: No ID Found -
Canadian Medical Association Journal Oct 1977
Topics: Abnormalities, Drug-Induced; Adult; Cleft Lip; Cleft Palate; Cyclohexanecarboxylic Acids; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Infant, Newborn; Nausea; Pregnancy; Pregnancy Complications; Pyridines; Pyridoxine
PubMed: 907941
DOI: No ID Found -
British Journal of Cancer Dec 1985Attention has recently focused on the possible teratogenic effects of the combination antiemetic doxylamine succinate, dicyclomine hydrochloride and pyridoxine...
Attention has recently focused on the possible teratogenic effects of the combination antiemetic doxylamine succinate, dicyclomine hydrochloride and pyridoxine hydrochloride (Debendox/Bendectin) prescribed to pregnant women. The Inter-Regional Epidemiological Study of Childhood Cancer (IRESCC), a case-control investigation has analysed data derived from interview reports and medical records of 555 mothers of children (under 15 years) with cancer and 1110 mothers of matched control children. Separate analyses of interview reports and medical records both suggested that antiemetic ingestion during the index pregnancy does not increase the risk of developing childhood malignant disease in the exposed foetus. No dose-response relationship was evident. The lack of any significant relative risks held good for diagnostic sub-groups and when the trimester of ingestion was considered. Our results suggest that antimetics of this type are unlikely to be transplacental carcinogens.
Topics: Adolescent; Antiemetics; Child; Cyclohexanecarboxylic Acids; Dicyclomine; Dose-Response Relationship, Drug; Doxylamine; Drug Combinations; Female; Humans; Neoplasms; Pregnancy; Pregnancy Complications; Prenatal Exposure Delayed Effects; Pyridines; Pyridoxine; Risk
PubMed: 4074645
DOI: 10.1038/bjc.1985.278 -
British Medical Journal (Clinical... May 1981
Topics: Antiemetics; Dicyclomine; Diethylstilbestrol; Doxylamine; Drug Combinations; Drug Industry; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Informed Consent; Legislation, Drug; Male; Pregnancy; Pyridoxine; United States
PubMed: 6786550
DOI: 10.1136/bmj.282.6275.1535 -
British Medical Journal Apr 1978
Topics: Abnormalities, Drug-Induced; Antiemetics; Cyclohexanecarboxylic Acids; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Limb Deformities, Congenital; Pregnancy; Pyridines; Pyridoxine; Time Factors
PubMed: 638604
DOI: 10.1136/bmj.1.6119.1055-a -
Journal of Medical Toxicology :... Dec 2008
Topics: Acetaminophen; Analgesics, Non-Narcotic; Antitussive Agents; Citrus; Crystallization; Dextromethorphan; Doxylamine; Drug Combinations; Gas Chromatography-Mass Spectrometry; Histamine H2 Antagonists; Illicit Drugs; Nasal Decongestants; Nonprescription Drugs; Pseudoephedrine; Solutions; Substance-Related Disorders
PubMed: 19031385
DOI: 10.1007/BF03161217