Authors: Enming Yong, Enhui Yong, Junice Shi Hui Wong...

Topics: Aged; Biopsy; Duodenal Diseases; Duodenum; Endoscopy; Gastric Fistula; Humans; Male; Pylorus

PubMed: 29974123
DOI: 10.11622/smedj.2018073

Review

Authors: Chang Moo Kang, Jin Ho Lee

Pancreaticoduodenectomy (PD) will result in removal of important multiorgans in upper intestinal tract and subsequently secondary physiologic change. In the past, surgeons just focused on the safety of surgical procedure; however, PD is regarded as safe and widely applied to treatment of periampullary lesions. Practical issues after PD, such as, effect of duodenectomy, metabolic surgery-like effect, alignment effect of gastrointestinal continuity, and non-alcoholic fatty liver disease were summarized and discussed.

Topics: Duodenum; Energy Metabolism; Gastrointestinal Diseases; Gastrointestinal Motility; Humans; Non-alcoholic Fatty Liver Disease; Pancreas; Pancreaticoduodenectomy; Risk Factors; Time Factors; Treatment Outcome

PubMed: 26019443
DOI: 10.3748/wjg.v21.i19.5794

Review

Authors: Guo-qing Chen, Hua Yang

Duodenal trauma is uncommon but nowadays seen more and more frequently due to the increased automobile accidents and violent events. The management of duodenal trauma can be complicated, especially when massive injury to the pancreatic-duodenal-biliary complex occurs simultaneously. Even the patients receive surgeries in time, multiple postoperative complications and high mortality are common. To know and manage duodenal trauma better, we searched the recent related literature in PubMed by the keywords of duodenal trauma, therapy, diagnosis and abdomen. It shows that because the diagnosis and management are complicated and the mortality is high, duodenal trauma should be treated in time and tactfully. And application of new technology can help improve the management. In this review, we discussed the incidence, diagnosis, management, and complications as well as mortality of duodenal trauma.

Topics: Duodenum; Humans; Incidence; Postoperative Complications

PubMed: 21276371
DOI: No ID Found

Authors: Elizabeth Ebert-Zavos, Maria Horvat-Gordon, Alexander Taylor...

Serotonin in blood plasma is primarily synthesized in the duodenum, as brain derived serotonin does not cross the blood-brain barrier. Because serotonin in the brain and retina is synthesized under the control of a circadian clock, we sought to determine if a circadian clock in the duodenum regulates serotonin synthesis and release in blood. We examined gene expression in the duodenum of chickens at different times of the day and found that the duodenum rhythmically expresses molecular circadian clock genes and genes controlling serotonin biosynthesis, specifically tryptophan hydroxylase, in a light dark cycle (LD). Analysis of the duodenum and blood plasma showed that the amount of serotonin in the duodenum varies across the day and that serotonin profiles in blood plasma are also rhythmic in LD, but were not rhythmic in constant darkness. Because serotonin in the gut affects duodenal nutrient absorption and gut motility, the control of serotonin production in the duodenum by LD cycles could provide an additional mechanism by which the external environment controls nutrient uptake and digestive function. The diurnal regulation of plasma serotonin may also serve as an additional biochemical signal in the blood encoding time and could be used by target tissues to indicate the status of nutrient absorption.

Topics: Animals; Biological Clocks; Chickens; Circadian Rhythm; Duodenum; Female; Oviposition; Serotonin

PubMed: 23737937
DOI: 10.1371/journal.pone.0058477

Review

Authors: Sam Simmonds, Jan D Huizinga, Andrew J Taberner...

The gastroduodenal junction is uniquely capable of regulating digestive functions in the gastrointestinal system. The pyloric sphincter, which demarcates the stomach from the small intestine, acts as a mechanical and electrical barrier, isolating each organ, thus enabling independent behaviors that are critical for proper digestion. Unique electrical patterns in the stomach, pylorus, and duodenum underpin the distinct contractile patterns of these regions, and improper organization of these mechanical behaviors leads to clinical conditions such as gastroparesis and dumping syndrome. For this reason, the gastroduodenal junction should be a focal point in investigations of novel biomarkers of gastrointestinal dysfunction. This review summarizes the current knowledge of bioelectrical and mechanical characteristics of the gastroduodenal junction, as well as the relevant underlying anatomy. As there is limited documentation of physiological recordings from the gastroduodenal junction of humans, inferences are made from animal studies and from measurements taken from other regions of the gastrointestinal tract, where appropriate. We suggest hypotheses on gastroduodenal electromechanical coupling and propose further studies to support or reject these ideas. Improved physiological understanding of this region, and the advent of novel diagnostic and therapeutic tools are crucial aspects for the future of clinical gastrointestinal medicine.

Topics: Humans; Animals; Duodenum; Stomach; Gastrointestinal Motility; Pylorus

PubMed: 39976325
DOI: 10.1111/apha.70008

Authors: Haggai Bar-Yoseph, Yaniv Zohar, Margalit Lorber...

Helminthic infection and HIV have been reported to coexist, particularly in sub-Saharan African patients living with HIV. Strongyloidiasis is one of the most common helminths, usually leading to cutaneous and gastrointestinal (GI) symptoms. In the immunocompromised host, this infection can lead to strongyloidiasis hyperinfection syndrome (SHS), not common in HIV-infected patients. Immune reconstitution inflammatory syndrome (IRIS) can follow the initiation of antiretroviral therapy (ART), with a variety of presentations. The authors present here a 32-year-old HIV-infected female who was recently diagnosed with AIDS, started ART, and recovered from SHS. Her upper endoscopy revealed severe duodenitis but no causal agent per biopsy or stool examination. After receiving symptomatic therapy, she showed improvement, a course of events that fit the diagnosis of GI-related IRIS.

Topics: AIDS-Related Opportunistic Infections; Adult; Anti-Retroviral Agents; Duodenum; Female; HIV Infections; Humans; Immune Reconstitution Inflammatory Syndrome; Strongyloidiasis

PubMed: 27733639
DOI: 10.1177/2325957416673149

Authors: M H Childress

Duodenum inversum is usually associated with chronic abdominal pain which is of unknown etiology. Incomplete rotation of the bowel may be associated with this anomaly. An unusually high incidence of pancreatitis, elevated bilirubin, and hypoalbuminemia was noted in this series of nine patients.

Topics: Abdomen; Adult; Duodenum; Female; Humans; Laparotomy; Pain; Radiography

PubMed: 448763
DOI: No ID Found

Authors: W M CAPPER

Topics: Bile Ducts; Choledochostomy; Common Bile Duct; Duodenum; Humans; Intestines

PubMed: 13436811
DOI: 10.1136/bmj.1.5032.1417-a

Review

Authors: Ebru Dusunceli Atman, Ayse Erden, Evren Ustuner...

This pictorial review aims to illustrate the magnetic resonance imaging (MRI) findings and presentation patterns of anatomical variations and various benign and malignant pathologies of the duodenum, including sphincter contraction, major papilla variation, prominent papilla, diverticulum, annular pancreas, duplication cysts, choledochocele, duodenal wall thickening secondary to acute pancreatitis, postbulbar stenosis, celiac disease, fistula, choledochoduodenostomy, external compression, polyps, Peutz-Jeghers syndrome, ampullary carcinoma and adenocarcinoma. MRI is a useful imaging tool for demonstrating duodenal pathology and its anatomic relationships with adjacent organs, which is critical for establishing correct diagnosis and planning appropriate treatment, especially for surgery.

Topics: Ampulla of Vater; Choledochal Cyst; Diverticulum; Duodenal Diseases; Duodenum; Humans; Magnetic Resonance Imaging; Pancreas; Pancreatic Diseases; Radiography

PubMed: 26576112
DOI: 10.3348/kjr.2015.16.6.1240

Authors: I Jit, S S Grewal

The gross anatomy, microscopic structure and nerve supply of the suspensory muscle of the duodenum and Hilfsmuskel have been studied in cadavers of 88 adults, 5 children, 1 infant and 6 neonates. The suspensory muscle of the duodenum, consisting of plain muscle fibres, arose from the connective tissue around the stems of the coeliac and superior mementeric arteries. It was inserted into the third and fourth parts of the duodenum in 53%, and into the duodeno-jejunal flexure in addition in 40%. It was innervated by non-myelinated fibres arising from the coeliac and superior mesenteric plexuses. Although both the longitudinal and circular muscle coats of the duodenum extended into the suspensory muscle, it was not supplied by Auerbach's plexus. The Halfsmuskel, which is a slip of the diaphragm is attached above to the margin of the oesophageal hiatus and below to the connective tissue in the region of the stem of the coeliac artery, sometimes extending to the stem of the superior mesenteric artery. The Hilfmuskel and the suspensory muscle of the duodenum are separate entities.

Topics: Adult; Aged; Celiac Artery; Child; Connective Tissue; Duodenum; Humans; Infant; Infant, Newborn; Mesenteric Arteries; Middle Aged; Muscle, Smooth; Muscles

PubMed: 870476
DOI: No ID Found