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Acta Paediatrica (Oslo, Norway : 1992) Jul 2019This paper integrates clinical expertise to earlier research about the behaviours of the healthy, alert, full-term infant placed skin-to-skin with the mother during the... (Review)
Review
AIM
This paper integrates clinical expertise to earlier research about the behaviours of the healthy, alert, full-term infant placed skin-to-skin with the mother during the first hour after birth following a noninstrumental vaginal birth.
METHOD
This state-of-the-art article forms a link within the knowledge-to-action cycle, integrating clinical observations and practice with evidence-based findings to guide clinicians in their work to implement safe uninterrupted skin-to-skin contact the first hours after birth.
RESULTS
Strong scientific research exists about the importance of skin-to-skin in the first hour after birth. This unique time for both mother and infant, individually and in relation to each other, provides vital advantages to short- and long-term health, regulation and bonding. However, worldwide, clinical practice lags. A deeper understanding of the implications for clinical practice, through review of the scientific research, has been integrated with enhanced understanding of the infant's instinctive behaviour and maternal responses while in skin-to-skin contact.
CONCLUSION
The first hour after birth is a sensitive period for both the infant and the mother. Through an enhanced understanding of the newborn infant's instinctive behaviour, practical, evidence-informed suggestions strive to overcome barriers and facilitate enablers of knowledge translation. This time must be protected by evidence-based routines of staff.
Topics: Breast Feeding; Humans; Infant Behavior; Infant, Newborn; Kangaroo-Mother Care Method; Perinatal Care
PubMed: 30762247
DOI: 10.1111/apa.14754 -
Learning & Memory (Cold Spring Harbor,... Sep 2017Fear, which can be expressed innately or after conditioning, is triggered when a danger or a stimulus predicting immediate danger is perceived. Its role is to prepare... (Review)
Review
Fear, which can be expressed innately or after conditioning, is triggered when a danger or a stimulus predicting immediate danger is perceived. Its role is to prepare the body to face this danger. However, dysfunction in fear processing can lead to psychiatric disorders in which fear outweighs the danger or possibility of harm. Although recognized as highly debilitating, pathological fear remains insufficiently treated, indicating the importance of research on fear processing. The neurobiological basis of normal and pathological fear reactions is reviewed in this article. Innate and learned fear mechanisms, particularly those involving the amygdala, are considered. These fear mechanisms are also distinguished in specific phobias, which can indeed be nonexperiential (implicating innate, learning-independent mechanisms) or experiential (implicating learning-dependent mechanisms). Poor habituation and poor extinction are presented as dysfunctional mechanisms contributing to persistence of nonexperiential and experiential phobias, respectively.
Topics: Animals; Brain; Fear; Humans; Instinct; Neurobiology; Phobic Disorders
PubMed: 28814472
DOI: 10.1101/lm.044115.116 -
Frontiers in Neuroscience 2023Humans and animals are evolved to have instinctive physiological responses to threats. The perception of threat by the brain triggers a multitude of changes across the... (Review)
Review
Humans and animals are evolved to have instinctive physiological responses to threats. The perception of threat by the brain triggers a multitude of changes across the brain and body. A large body of research have demonstrated that our hardwired survival instinct, the stress response, can become maladaptive and promote major depressive disorders and other neuropsychiatric impairments. However, gaps in our understanding of how chronic stress contributes to depression and mental disorders suggest that we also need to consider factors beyond the biology of the host. The unravelling of the structure and function of microorganisms that humans and animals are host to have driven a paradigm shift in understanding the individual as a collective network composed of the host plus microbes. Well over 90% of bacteria in the body reside in the large intestines, and these microbes in the lower gut function almost like an organ in the body in the way it interacts with the host. Importantly, bidirectional interactions between the gut microbiota and the brain (i.e., the two-way microbiota-gut-brain axis) have been implicated in the pathophysiology of mental disorders including depression. Here, in summarizing the emerging literature, we envisage that further research particularly on the efferent brain-gut-microbiota axis will uncover transformative links in the biology of stress and depression.
PubMed: 37123352
DOI: 10.3389/fnins.2023.1151478 -
Nature Jun 2018Escaping from imminent danger is an instinctive behaviour that is fundamental for survival, and requires the classification of sensory stimuli as harmless or...
Escaping from imminent danger is an instinctive behaviour that is fundamental for survival, and requires the classification of sensory stimuli as harmless or threatening. The absence of threat enables animals to forage for essential resources, but as the level of threat and potential for harm increases, they have to decide whether or not to seek safety . Despite previous work on instinctive defensive behaviours in rodents, little is known about how the brain computes the threat level for initiating escape. Here we show that the probability and vigour of escape in mice scale with the saliency of innate threats, and are well described by a model that computes the distance between the threat level and an escape threshold. Calcium imaging and optogenetics in the midbrain of freely behaving mice show that the activity of excitatory neurons in the deep layers of the medial superior colliculus (mSC) represents the saliency of the threat stimulus and is predictive of escape, whereas glutamatergic neurons of the dorsal periaqueductal grey (dPAG) encode exclusively the choice to escape and control escape vigour. We demonstrate a feed-forward monosynaptic excitatory connection from mSC to dPAG neurons, which is weak and unreliable-yet required for escape behaviour-and provides a synaptic threshold for dPAG activation and the initiation of escape. This threshold can be overcome by high mSC network activity because of short-term synaptic facilitation and recurrent excitation within the mSC, which amplifies and sustains synaptic drive to the dPAG. Therefore, dPAG glutamatergic neurons compute escape decisions and escape vigour using a synaptic mechanism to threshold threat information received from the mSC, and provide a biophysical model of how the brain performs a critical behavioural computation.
Topics: Animals; Calcium; Decision Making; Escape Reaction; Female; Male; Mice; Mice, Inbred C57BL; Models, Neurological; Neural Pathways; Optogenetics; Periaqueductal Gray; Superior Colliculi; Synapses
PubMed: 29925954
DOI: 10.1038/s41586-018-0244-6 -
RSC Advances May 2022Ideal halogen-free instinct flame-retardant waterborne polyurethanes have high flame-retardant efficiency, environmental friendliness, fine compatibility, and good... (Review)
Review
Ideal halogen-free instinct flame-retardant waterborne polyurethanes have high flame-retardant efficiency, environmental friendliness, fine compatibility, and good thermostability. Phosphorus flame-retardants are currently widely used in halogen-free instinct flame-retardant waterborne polyurethanes (HIFWPU), especially those with phosphorous-nitrogen co-structures. Phosphorous-nitrogen HIFWPU have become a hotspot because their co-structures provide higher flame-retardance as compared to waterborne polyurethanes. This review introduces three main types of HIFWPU based on composition, performance and application. HIFWPU not only have improved flame-retardance but also satisfy the various requirements for functionality. HIFWPU have been widely developed in textile, furniture, automobile, and aerospace applications.
PubMed: 35702241
DOI: 10.1039/d2ra01822e -
Current Biology : CB Nov 2021Many animals shape and modify their physical environment, thereby creating a diversity of structures, from underground burrows to constructed nests to towering...
Many animals shape and modify their physical environment, thereby creating a diversity of structures, from underground burrows to constructed nests to towering above-ground edifices, all of which are referred to as 'animal architecture'. Examples of animal architecture are found everywhere on Earth: beneath the sea and on land, below and above ground, and hanging into the air off trees and precipices. Fossils suggest that animals have been acting as architects by constructing shelters and other built structures for hundreds of millions of years. Animal architects are widespread taxonomically, spanning invertebrates (Figure 1) and vertebrates (Figure 2). Their architectural creations are diverse, including: the fortress-like mounds of termites, the housing markets of architecturally remodeled shells of social hermit crabs, the subterranean tunnel systems of naked mole rats, the intricately decorated bowers of bowerbirds or the engineered dams of beavers. Even the tallest of human architecture is rivaled by animal architecture: termite mounds exceed skyscrapers in their size relative to that of the architects. Animal architecture raises many fascinating questions at the interface of behavior, ecology and evolution: How is this architecture built? What instinctive 'blueprints' or cognitive mechanisms underlie its creation? What functions does the architecture serve? And why did it evolve? Notably, because architecture changes the world, it may have far-reaching impacts on collective behavior and social life, interactions among communities of species and whole ecosystems. Architecture may even have altered the very course of evolution.
Topics: Animals; Anomura; Ecology; Ecosystem; Fossils; Isoptera
PubMed: 34813746
DOI: 10.1016/j.cub.2021.09.082 -
Frontiers in Psychology 2021Addictive drugs are responsible for mass killing. Neither persons with addiction nor the general populace seem conscious of the malevolence of governments and drug...
Addictive drugs are responsible for mass killing. Neither persons with addiction nor the general populace seem conscious of the malevolence of governments and drug dealers working together. How could this be? What is the place of psychoanalysis in thinking about deaths from addiction and in responding to patients with addiction? To answer these questions, we revise concepts of SEEKING, drive, instinct, pleasure, and unpleasure as separable. We review the neurobiological mechanism of cathexis. We discuss how addictive drugs take over the will by changing the SEEKING system. We review how opioid tone in the central nervous system regulates human relationships and how this endogenous hormonal system is modified by external opioid administration. We differentiate the pleasure of relatedness from the unpleasure of urgent need including the urgent need for drugs. We show how addictive drug-induced changes in the SEEKING system diminish dopaminergic tone, reducing the motivation to engage in the pursuit of food, water, sex, sleep, and relationships in favor of addictive drugs. With this neuropsychoanalytic understanding of how drugs work, we become more confidently conscious of our ability to respond individually and socially.
PubMed: 34177709
DOI: 10.3389/fpsyg.2021.657944 -
Trends in Cognitive Sciences Apr 2019When faced with potential predators, animals instinctively decide whether there is a threat they should escape from, and also when, how, and where to take evasive... (Review)
Review
When faced with potential predators, animals instinctively decide whether there is a threat they should escape from, and also when, how, and where to take evasive action. While escape is often viewed in classical ethology as an action that is released upon presentation of specific stimuli, successful and adaptive escape behaviour relies on integrating information from sensory systems, stored knowledge, and internal states. From a neuroscience perspective, escape is an incredibly rich model that provides opportunities for investigating processes such as perceptual and value-based decision-making, or action selection, in an ethological setting. We review recent research from laboratory and field studies that explore, at the behavioural and mechanistic levels, how elements from multiple information streams are integrated to generate flexible escape behaviour.
Topics: Animals; Behavior, Animal; Decision Making; Ethology; Executive Function; Neurosciences; Perception
PubMed: 30852123
DOI: 10.1016/j.tics.2019.01.012