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World Journal of Gastroenterology Jul 2016The incidence of inflammatory bowel diseases (IBD) - Crohn's disease (CD) and ulcerative colitis (UC) - has been increasing on a global scale, and progressively, more... (Review)
Review
The incidence of inflammatory bowel diseases (IBD) - Crohn's disease (CD) and ulcerative colitis (UC) - has been increasing on a global scale, and progressively, more gastroenterologists will be included in the diagnosis and treatment of IBD. Although IBD primarily affects the intestinal tract, extraintestinal manifestations of the disease are often apparent, including in the oral cavity, especially in CD. Specific oral manifestations in patients with CD are as follows: indurate mucosal tags, cobblestoning and mucogingivitis, deep linear ulcerations and lip swelling with vertical fissures. The most common non-specific manifestations, such as aphthous stomatitis and angular cheilitis, occur in both diseases, while pyostomatitis vegetans is more pronounced in patients with UC. Non-specific lesions in the oral cavity can also be the result of malnutrition and drugs. Malnutrition, followed by anemia and mineral and vitamin deficiency, affects the oral cavity and teeth. Furthermore, all of the drug classes that are applied to the treatment of inflammatory bowel diseases can lead to alterations in the oral cavity due to the direct toxic effects of the drugs on oral tissues, as well as indirect immunosuppressive effects with a risk of developing opportunistic infections or bone marrow suppression. There is a higher occurrence of malignant diseases in patients with IBD, which is related to the disease itself and to the IBD-related therapy with a possible oral pathology. Treatment of oral lesions includes treatment of the alterations in the oral cavity according to the etiology together with treatment of the primary intestinal disease, which requires adequate knowledge and a strong cooperation between gastroenterologists and specialists in oral medicine.
Topics: Cheilitis; Colitis, Ulcerative; Crohn Disease; Drug-Related Side Effects and Adverse Reactions; Gingivitis; Humans; Immunosuppressive Agents; Lip Diseases; Malnutrition; Mouth Diseases; Oral Ulcer; Stomatitis; Stomatitis, Aphthous
PubMed: 27433081
DOI: 10.3748/wjg.v22.i25.5655 -
Journal of the American Academy of... Sep 2007
Topics: Anti-Bacterial Agents; Cheilitis; Chronic Disease; Drug Therapy, Combination; Edema; Female; Humans; Lip Diseases; Middle Aged
PubMed: 17707158
DOI: 10.1016/j.jaad.2006.02.006 -
JAMA Otolaryngology-- Head & Neck... Feb 2014
Review
Topics: Black or African American; Angiolymphoid Hyperplasia with Eosinophilia; Biopsy, Needle; Diagnosis, Differential; Hemangioendothelioma, Epithelioid; Humans; Immunohistochemistry; Lip Diseases; Lymphatic Diseases; Male; Middle Aged; Neck; Watchful Waiting
PubMed: 24309590
DOI: 10.1001/jamaoto.2013.5879 -
The Practitioner Jan 1991
Review
Topics: Adolescent; Adult; Cheilitis; Child; Female; Humans; Infections; Lip Diseases; Lip Neoplasms; Male
PubMed: 2031041
DOI: No ID Found -
Journal of the American Academy of... Apr 1993
Topics: Adolescent; Adult; Child; Child, Preschool; Humans; Leishmaniasis, Cutaneous; Lip Diseases
PubMed: 8463476
DOI: 10.1016/s0190-9622(08)81793-8 -
Swiss Dental Journal 2017Crohns disease (CD) is a chronic inflammatory bowel disease whose oral features remain underrated at clinical examination. The aim of the study was to report...
Crohns disease (CD) is a chronic inflammatory bowel disease whose oral features remain underrated at clinical examination. The aim of the study was to report forerunner orofacial presentations leading to diagnosis of CD among nine patients of mean age 23 between 2008 and 2015. Linear ulcerative buccal lesions, cobblestoning, mucosal tags and perioral erythema are highly evocative and might precede intestinal signs for several years. Oral biopsies revealed highly suggestive lesions of CD for 45% of patients before any intestinal symptom or digestive investigation. Mean time to diagnosis was 14 months. Immunomodulatory therapy (azathioprine, infliximab, adalimumab) was introduced alone or in association for 89% of patients. Early diagnosis could lead to specific therapy, often necessary to reduce severity of lesions and improve quality of life.
Topics: Adolescent; Adult; Crohn Disease; Diagnosis, Differential; Female; Gingiva; Gingival Diseases; Humans; Lip Diseases; Male; Mouth Diseases; Mouth Mucosa; Prodromal Symptoms; Skin; Young Adult
PubMed: 28752504
DOI: No ID Found -
Cutis May 2022
Topics: Hemorrhage; Humans; Lip; Lip Diseases; Lip Neoplasms
PubMed: 35856754
DOI: 10.12788/cutis.0520 -
Clinics in Dermatology 2017Heath care providers should be comfortable with normal as well as pathologic findings in the lips, because the lips are highly visible and may display clinical... (Review)
Review
Heath care providers should be comfortable with normal as well as pathologic findings in the lips, because the lips are highly visible and may display clinical manifestations of local, as well as systemic inflammatory, allergic, irritant, and neoplastic alterations. Fortunately, the lips are easily accessible. The evaluation should include a careful history and physical examination, including visual inspection, as well as palpation of the lips and an examination of associated cervical, submandibular, and submental nodes. Pathologic and microscopic studies, as well as a review of medications, allergies, and habits, may further highlight possible etiologies. Many lip conditions, including premalignant changes, are relatively easy to treat, when the abnormalities are detected early; however, advanced disease and malignancies are challenging for both the patient and clinician. Treatment should be focused on eliminating potential irritants or allergens and treatment of the primary dermatosis. In this paper we review physiologic variants as well as pathologic conditions of the lips.
Topics: Carcinoma, Squamous Cell; Cheilitis; Herpes Labialis; Humans; Lip Diseases; Lupus Erythematosus, Discoid; Physical Examination; Pigmentation Disorders; Psoriasis; Sjogren's Syndrome
PubMed: 29289276
DOI: 10.1016/j.clindermatol.2017.11.003 -
The Medical Journal of Australia Feb 2013
Topics: Adult; Biopsy; Female; Humans; Lip; Lip Diseases; Lupus Erythematosus, Systemic
PubMed: 23418698
DOI: 10.5694/mja12.11518 -
Singapore Medical Journal Jun 2015A congenital lip sinus is a rare condition that has been reported to occur in both the upper and lower lips, either in isolation or in association with congenital... (Review)
Review
A congenital lip sinus is a rare condition that has been reported to occur in both the upper and lower lips, either in isolation or in association with congenital deformities such as a cleft lip and palate in Van der Woude syndrome. The prevalence of lower lip sinuses has been estimated to be about 0.00001% of the white population. Upper lip sinuses are even more uncommon. To date, there have been several case reports of upper lip sinuses and fistulas, but no similar cases have been described in Singapore. We herein report a case of congenital upper lip sinus presenting as a recurring upper lip abscess and review the current literature on this condition.
Topics: Child; Female; Fistula; Humans; Inflammation; Lip; Lip Diseases; Singapore; Surgical Procedures, Operative; Treatment Outcome
PubMed: 26106248
DOI: 10.11622/smedj.2015096