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Cutis May 2022
Topics: Hemorrhage; Humans; Lip; Lip Diseases; Lip Neoplasms
PubMed: 35856754
DOI: 10.12788/cutis.0520 -
Oral Surgery, Oral Medicine, Oral... May 2008
Topics: Antiporters; Carcinoma, Merkel Cell; Chromogranin A; Diagnosis, Differential; Fatal Outcome; Humans; Immunohistochemistry; Lip Neoplasms; Male; Middle Aged; Neoplasm Recurrence, Local; Synaptophysin
PubMed: 18329908
DOI: 10.1016/j.tripleo.2007.10.015 -
Journal of Cancer Research and... 2017This paper comes with a purpose to help the clinician as how to arrive at a logical differential diagnosis when an upper lip mass is encountered in day-to-day practice.... (Review)
Review
This paper comes with a purpose to help the clinician as how to arrive at a logical differential diagnosis when an upper lip mass is encountered in day-to-day practice. The labial mucosa is commonly traumatized. One must be aware of the type of structures contained in the mucosa of the area of a lesion as well as the patients habits since they may relate to a lesion presented for diagnosis. It also helps them to procure a sound knowledge of the lesions by describing the lesions according to their clinical appearance and to aid the clinician in arriving at a differential diagnosis by considering that certain lesions have a predilection for the upper lip. All clinically similar appearing lesions are discussed according to their relative frequency of occurrence. This paper covers only a minority of plethora of elevated lesions that may appear on the upper lip since almost any soft tissue lesion or neoplasm (benign and malignant) may occur here.
Topics: Diagnosis, Differential; Humans; Lip Neoplasms; Salivary Calculi; Salivary Gland Neoplasms
PubMed: 28643729
DOI: 10.4103/0973-1482.204890 -
Dermatologic Surgery : Official... Apr 2017The lip is an anatomic junction for 2 disparate groups of cancer. Cutaneous squamous cell carcinoma (cSCC) is a common malignancy with a favorable prognosis, whereas... (Review)
Review
BACKGROUND
The lip is an anatomic junction for 2 disparate groups of cancer. Cutaneous squamous cell carcinoma (cSCC) is a common malignancy with a favorable prognosis, whereas oral-mucosal squamous cell carcinoma (omSCC) is associated with significantly higher rates of nodal disease and worse outcomes. The squamous cell carcinoma of the lip (lip SCC) is more aggressive than cSCC but less aggressive than omSCC. However, work-up and treatment vary between specialties.
OBJECTIVES
The authors sought to review and compare the risk factors and clinical behavior of cSCC, omSCC, and lip SCC, review tumor biology of squamous cell carcinoma, and compare work-up and treatment algorithms for lip SCC.
METHODS
A comprehensive PubMed and MEDLINE database search was performed with comparison of primary literature on cSCC, omSCC, and lip SCC.
RESULTS
Lip SCC exhibits rates of nodal metastasis and death that are intermediate between cSCC and omSCC, and shares many similar biologic mechanisms. There are variations in the treatment guidelines between dermatology and otolaryngology for lip SCC.
CONCLUSION
Lip SCC is an overlapping entity that poses many challenges to clinicians. Specialists should be aware of current staging modalities as well as imaging and treatment recommendations to optimize patient outcomes.
Topics: Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Humans; Lip Neoplasms; Lymphatic Metastasis; Mouth Mucosa; Mouth Neoplasms; Neoplasm Staging; Risk Factors; Skin Neoplasms
PubMed: 28157733
DOI: 10.1097/DSS.0000000000001020 -
American Journal of Surgery Oct 1975A retrospective analysis of 206 patients with lip cancer is presented. Poorly differentiated primary lesions have a high rate of metastases. The metastatic potential of... (Review)
Review
A retrospective analysis of 206 patients with lip cancer is presented. Poorly differentiated primary lesions have a high rate of metastases. The metastatic potential of well differentiated lesions, when classified by size in the TNM staging system, is the same as that of intraoral carcinoma. A therapeutic approach is proposed.
Topics: Adult; Animals; Carcinoma, Squamous Cell; Female; Humans; Leukoplakia, Oral; Lip Neoplasms; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Recurrence, Local; Retrospective Studies; Smoking; Ultraviolet Rays
PubMed: 1101725
DOI: 10.1016/0002-9610(75)90486-9 -
Head & Neck Sep 2015Management of clinically negative lymph nodes (cN0) in primary lip squamous cell carcinoma (SCC) has always been a controversial topic. (Meta-Analysis)
Meta-Analysis Review
BACKGROUND
Management of clinically negative lymph nodes (cN0) in primary lip squamous cell carcinoma (SCC) has always been a controversial topic.
METHODS
A systematic review of English-language electronic databases using Medline, Embase, Cochrane library, Google Scholar, SCI, and specific journals on the subject matter was done. Only the studies mentioning primary nonmetastatic lip SCC with cN0 neck treated by surgery only and having at least 2 years of follow-up data were selected. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement for reporting systematic reviews and meta-analysis was followed.
RESULTS
The pooled estimate of occult metastasis in neck dissected specimen was 0.17 (95% confidence interval [CI], 0.10-0.28) and that of delayed nodal metastasis in patients without neck dissection was 0.08 (95% CI, 0.01-0.18).
CONCLUSION
The results do not prove sufficient to justify elective treatment of the neck in primary cN0 lip SCC and close observation would be a viable option in such cases. © 2014 Wiley Periodicals, Inc. Head Neck 37: 1392-1400, 2015.
Topics: Carcinoma, Squamous Cell; Disease-Free Survival; Elective Surgical Procedures; Female; Humans; Lip Neoplasms; Male; Neck Dissection; Neoplasm Invasiveness; Neoplasm Staging; Prognosis; Risk Assessment; Survival Analysis; Treatment Outcome
PubMed: 24839013
DOI: 10.1002/hed.23772 -
Acta Otorhinolaryngologica Italica :... Feb 2011Lip cancer is the most frequent malignant neoplasm of the oral cavity. The study reported herewith refers to the clinico-pathological features and surgical treatment of...
Lip cancer is the most frequent malignant neoplasm of the oral cavity. The study reported herewith refers to the clinico-pathological features and surgical treatment of lip cancer. The most frequent tumour related to the lips is squamous cell carcinoma, with the lower lip more commonly involved than the upper lip. Typically, squamous cell carcinoma originates in the red lip, whereas basal cell carcinoma involves the white lip. The management of lip cancer involves the control not only of the primary tumours with oncologically appropriate margins and subsequent reconstruction to allow oral competence during the oral phase of swallowing, but also the possible metastatic spread to the neck. Reconstruction is a surgical challenge especially for advanced and extended lesions. A successful reconstruction depends on careful pre-operative planning, knowledge of the anatomy and use of the various surgical techniques. Lymph node neck metastases significantly reduce long-term survival. Although the management of the neck is controversial in lip cancer, particularly with respect to the neck, elective or curative supra-omohyoid neck dissection is the best choice for occult or evident loco-regional metastases. Early stage tumours have good prognostic, aesthetic and functional results after surgery compared to the treatment of advanced lesions, which alter the appearance and functionality of the lip. The Authors report their experience in the treatment of lip tumours at the primary site, considering reconstructive problems, together with management of neck metastases.
Topics: Aged; Aged, 80 and over; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Female; Humans; Lip Neoplasms; Male; Middle Aged
PubMed: 21808457
DOI: No ID Found -
Journal of Oral and Maxillofacial... Aug 1998
Review
Topics: Carcinoma; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Humans; Lip; Lip Neoplasms; Mohs Surgery; Neoplasm Recurrence, Local; Plastic Surgery Procedures; Surgical Flaps
PubMed: 9710190
DOI: 10.1016/s0278-2391(98)90658-9 -
Acta Medica Portuguesa Apr 1994Hemangioendothelioma is a relatively uncommon tumor of the oral cavity. This article reviews the literature on hemangioendothelioma and presents one additional case of... (Review)
Review
Hemangioendothelioma is a relatively uncommon tumor of the oral cavity. This article reviews the literature on hemangioendothelioma and presents one additional case of this neoplasm found on the lip.
Topics: Adult; Hemangioendothelioma; Humans; Lip Neoplasms; Male
PubMed: 8048359
DOI: No ID Found -
Oral Surgery, Oral Medicine, Oral... Feb 2018
Topics: Aged; Diagnosis, Differential; Female; Glomus Tumor; Humans; Lip Neoplasms
PubMed: 29248422
DOI: 10.1016/j.oooo.2017.10.012