-
Annals of Internal Medicine Jun 2020Systemic lupus erythematosus (lupus) is characterized by aberrant activity of the immune system, leading to variable clinical symptoms. Lupus is more prevalent in... (Review)
Review
Systemic lupus erythematosus (lupus) is characterized by aberrant activity of the immune system, leading to variable clinical symptoms. Lupus is more prevalent in African American women and women in other ethnic minority groups. Diagnosing, treating, and identifying novel therapies for lupus is challenging because of its genetic and phenotypic heterogeneity. Lupus nephritis is the most common target-organ manifestation and requires individualized care to minimize toxicity. A multidisciplinary approach to caring for pregnant patients with lupus is essential to optimize outcomes.
Topics: Diagnosis, Differential; Humans; Lupus Erythematosus, Systemic
PubMed: 32479157
DOI: 10.7326/AITC202006020 -
Biomolecules Jun 2021Systemic lupus erythematosus (SLE) is characterized by immune system dysfunction and is clinically heterogeneous, exhibiting renal, dermatological, neuropsychiatric, and... (Review)
Review
Systemic lupus erythematosus (SLE) is characterized by immune system dysfunction and is clinically heterogeneous, exhibiting renal, dermatological, neuropsychiatric, and cardiovascular symptoms. Clinical and physiological assessment is usually inadequate for diagnosing and assessing pathophysiological processes in SLE. Clinical and immunological biomarkers could play a critical role in improving diagnosis, assessment, and ultimately, control of SLE. This article reviews clinical and immunological biomarkers that could diagnose and monitor disease activity in SLE, with and without organ-specific injury. In addition, novel SLE biomarkers that have been discovered through "omics" research are also reviewed.
Topics: Biomarkers; Humans; Lupus Erythematosus, Systemic
PubMed: 34206696
DOI: 10.3390/biom11070928 -
Frontiers in Immunology 2019
Topics: Antiphospholipid Syndrome; Diagnosis, Differential; Disease Susceptibility; Humans; Lupus Erythematosus, Systemic
PubMed: 30858846
DOI: 10.3389/fimmu.2019.00199 -
Pediatric Clinics of North America Apr 2012Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a wide range of disease manifestations that can involve any organ system, and can lead to... (Review)
Review
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a wide range of disease manifestations that can involve any organ system, and can lead to significant morbidity and even mortality. This article reviews the epidemiology, common clinical features, and complications of the disease, and briefly discusses the available treatment options. In addition, important medical and psychosocial issues relevant to the pediatrician caring for children and adolescents with SLE are discussed.
Topics: Adolescent; Child; Humans; Immunosuppressive Agents; Lupus Erythematosus, Systemic; Treatment Outcome
PubMed: 22560574
DOI: 10.1016/j.pcl.2012.03.007 -
Frontiers in Immunology 2022
Topics: Humans; Antibodies, Antinuclear; Lupus Erythematosus, Systemic; Disease Susceptibility
PubMed: 36591294
DOI: 10.3389/fimmu.2022.1118180 -
Journal of the American Academy of... Dec 2022The word lupus (Latin term for the wolf) was used indistinctively since the Middle Ages for several types of diseases characterized by ulcerous lesions, mainly in the... (Review)
Review
The word lupus (Latin term for the wolf) was used indistinctively since the Middle Ages for several types of diseases characterized by ulcerous lesions, mainly in the lower limbs. In the middle of the 18th century, the French dermatologist Cazenave mentioned for the first time the term "lupus érythémateux," while Kaposi reported discoid lupus as a separate entity. The true turning point in the history of lupus occurred at the beginning of the 19th century, when the distinction between lupus vulgaris and cutaneous lupus in its modern sense emerged slowly. Major subsequent contributions from Kaposi, Sequiera and Balean, and Osler enabled the recognition of the systemic nature of the disease, with its modern history being marked by the recognition of DNA as the main target of antinuclear antibodies and the central role of interferons. Although many nonpharmacologic treatments have been used throughout the ages, glucocorticoids, hydroxychloroquine, and immunosuppressive agents mainly appeared in the second half of the 20th century. The beginning of the 21st century is now characterized by an in-depth understanding of the pathogenesis of the disease and the appearance of biologic and targeted treatments, paving the way for a better care of lupus patients.
Topics: Humans; Lupus Vulgaris; Antibodies, Antinuclear; Immunosuppressive Agents; Glucocorticoids; Hydroxychloroquine; Lupus Erythematosus, Systemic; Lupus Erythematosus, Discoid
PubMed: 32380218
DOI: 10.1016/j.jaad.2020.04.150 -
Modern Rheumatology Sep 2018Systemic lupus erythematosus (SLE) is a representative systemic autoimmune disease that has various types of manifestations in multiple organs. Additionally, SLE is one... (Review)
Review
Systemic lupus erythematosus (SLE) is a representative systemic autoimmune disease that has various types of manifestations in multiple organs. Additionally, SLE is one of the most variable diseases in its epidemiology and etiology with heterogenous types of immune dysfunction. Since the word 'lupus' has first appeared in the literature in the Middle Ages, clinical/pathological knowledges have massively accumulated that contributed to the establishments and improvements of classification criteria, therapeutic agents or assessments of disease activity. Along with them, the survival rate of patients with SLE has dramatically improved. However, the mortality rate is still higher compared with the healthy population and the progress in basic, translational and clinical research are expected to lead to new insights into pathogenesis and identifying novel targets for therapy.
Topics: Humans; Lupus Erythematosus, Systemic
PubMed: 29947275
DOI: 10.1080/14397595.2018.1494239 -
Rheumatic Diseases Clinics of North... Aug 1997This article discusses neonatal lupus erythematosus, which is a disease of the newborn defined by the presence of maternal autoantibodies and characteristic clinical... (Review)
Review
This article discusses neonatal lupus erythematosus, which is a disease of the newborn defined by the presence of maternal autoantibodies and characteristic clinical features in the neonatal period. Although the autoantibodies often are not associated with clinical disease in the mother, neonatal lupus erythematosus is likely the result of fetal or neonatal tissue damage caused by maternally transmitted IgG autoantibodies.
Topics: Animals; Female; Humans; Infant, Newborn; Lupus Erythematosus, Systemic; Male
PubMed: 9287379
DOI: 10.1016/s0889-857x(05)70349-5 -
The New England Journal of Medicine Jun 1994
Review
Topics: Female; Humans; Lupus Erythematosus, Systemic; Male; Sex Factors
PubMed: 8196732
DOI: 10.1056/NEJM199406303302608 -
Deutsche Medizinische Wochenschrift... Apr 2016The management of patients with SLE still brings significant challenges, also on intellectual grounds. However, for most of the standard situations, clear principles can... (Review)
Review
The management of patients with SLE still brings significant challenges, also on intellectual grounds. However, for most of the standard situations, clear principles can be delineated for diagnosis and therapy. New drugs and international definitions of strategies in SLE patient care constitute significant improvement and promise further progress for the coming years.
Topics: Glucocorticoids; Humans; Immunosuppressive Agents; Lupus Erythematosus, Systemic
PubMed: 27022764
DOI: 10.1055/s-0041-110604