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Oncology and Therapy Jun 2021Maintenance therapy post autologous stem cell transplant (ASCT) is commonly employed in myeloma patients to prolong remission, as relapse invariably occurs after ASCT.... (Review)
Review
Maintenance therapy post autologous stem cell transplant (ASCT) is commonly employed in myeloma patients to prolong remission, as relapse invariably occurs after ASCT. After initial diagnosis and risk stratification, patients receive initial therapy with a combination of drugs, typically a proteasome inhibitor and an immunomodulatory imide drug (IMiD), and in those considered eligible, high-dose chemotherapy followed by autologous stem cell transplant. The aim of our study was to review the literature and consolidate evidence regarding different maintenance therapies post stem cell transplant in myeloma patients. We reviewed major databases including PubMed, Cochrane Library and Evidence-Based Medicine Reviews (EBMR), along with American Society of Hematology/American Society of Clinical Oncology (ASH/ASCO) conference abstracts to include relevant literature. Ongoing clinical trials were also reviewed. Consolidation therapy is often employed to enhance the response to induction therapy and SCT and also to delay progression. Melphalan and thalidomide with or without steroids were initially used as maintenance therapy. More recently, lenalidomide-, bortezomib-, ixazomib-, or carfilzomib-based regimens have been employed as maintenance. Lenalidomide and bortezomib are the most commonly used drugs, with the latter being preferred in high-risk populations. Newer trials are utilizing tumor-specific antigen based vaccines along with adoptive T-cell therapies, and monoclonal antibodies as maintenance therapy. We conclude that maintenance therapy post SCT, with lenalidomide or bortezomib is the standard of care in myeloma patients. Patient tolerability, disease risk stratification and prior therapy received are major determinants of the choice of maintenance. Significant toxicity associated with maintenance therapies is a hindrance to long-term maintenance post stem cell transplant.
PubMed: 33615426
DOI: 10.1007/s40487-021-00143-7 -
Heliyon Apr 2023The upgrade and development of manufacturing industry makes predictive maintenance more and more important, but the traditional predictive maintenance can not meet the... (Review)
Review
The upgrade and development of manufacturing industry makes predictive maintenance more and more important, but the traditional predictive maintenance can not meet the development needs in many cases. In recent years, predictive maintenance based on digital twin has become a research hotspot in the manufacturing industry field. Firstly, this paper introduces the general methods of digital twin technology and predictive maintenance technology, analyzes the gap between them, and points out the importance of using digital twin technology to realize predictive maintenance. Secondly, this paper introduces the predictive maintenance method based on digital twin (PdMDT), introduces its characteristics, and gives its differences from traditional predictive maintenance. Thirdly, this paper introduces the application of this method in intelligent manufacturing, power industry, construction industry, aerospace industry, shipbuilding industry, and summarizes the latest development in these fields. Finally, the PdMDT puts forwards a reference framework in manufacturing industry, the framework describes the specific implementation process of equipment maintenance, and gives an example of industrial robot using the framework, and discusses the limitations, challenges and opportunities of the PdMDT.
PubMed: 37025897
DOI: 10.1016/j.heliyon.2023.e14534 -
Applied Microbiology Jul 1964Germ-free swine were routinely procured by both hysterectomy and hysterotomy (Caesarian section). By means of light-weight portable equipment, piglets could be obtained...
Germ-free swine were routinely procured by both hysterectomy and hysterotomy (Caesarian section). By means of light-weight portable equipment, piglets could be obtained and transported to the laboratory (without contamination) over distances in excess of 100 miles. The isolators employed in rearing were constructed of stainless steel and flexible plastic film. At weekly intervals, fecal swabs and waste from the floor of the isolator were cultured on blood-agar and in thioglycolate broth, as well as being examined microscopically for the presence of bacteria, yeast, and fungi. The presence of pleuropneumonia-like organisms (PPLO) and viruses in such material was not demonstrable, either by the use of enriched PPLO media or primary porcine-kidney cell cultures. Tissues, body fluids, and cecal contents of piglets sacrificed specifically for microbiological examination were also negative for PPLO, viruses, bacteria, yeast, and fungi. Prenatal infestations by ascarids were not observed. Nutritional problems related to rearing of germ-free piglets, such as hypoglycemia, were not encountered, and the use of an autoclaved commercial sow's milk replacer proved quite satisfactory. The temperature to which piglets were subjected during the first few days of life, however, was very important. The isolator design and application of gnotobiotic techniques to the procurement and rearing of a large germ-free animal such as the pig proved feasible and less difficult than anticipated.
Topics: Animals; Animals, Laboratory; Animals, Newborn; Bacteria; Bacteriological Techniques; Cesarean Section; Female; Germ-Free Life; Humans; Hysterectomy; Infant, Newborn; Laboratories; Maintenance; Microbiology; Milk; Mycoplasma; Pregnancy; Research; Sterilization; Swine
PubMed: 14199016
DOI: 10.1128/am.12.4.295-300.1964 -
PloS One 2019In this work, we establish that maintenance and inspection are a risk factor in helicopter accidents. Between 2005 and 2015, flawed maintenance and inspection were...
In this work, we establish that maintenance and inspection are a risk factor in helicopter accidents. Between 2005 and 2015, flawed maintenance and inspection were causal factors in 14% to 21% of helicopter accidents in the U.S. civil fleet. For these maintenance-related accidents, we examined the incubation time from when the maintenance error was committed to the time when it resulted in an accident. We found a significant clustering of maintenance accidents within a short number of flight-hours after maintenance was performed. Of these accidents, 31% of these accidents occurred within the first 10 flight-hours. This is reminiscent of infant mortality in reliability engineering, and we characterized it as maintenance error infant mortality. The last quartile of maintenance-related accidents occurred after 60 flight-hours following maintenance and inspection. We then examined the "physics of failures" underlying maintenance-related accidents and analyzed the prevalence of different types of maintenance errors in helicopter accidents. We found, for instance, that the improper or incomplete (re)assembly or installation of a part category accounted for the majority of maintenance errors with 57% of such cases, and within this category, the incorrect torquing of the B-nut and incomplete assembly of critical linkages were the most prevalent maintenance errors. We also found that within the failure to perform a required preventive maintenance and inspection task category, the majority of the maintenance programs were not executed in compliance with federal regulations, nor with the manufacturer maintenance plan. Maintenance-related accidents are particularly hurtful for the rotorcraft community, and they can be eliminated. This is a reachable objective when technical competence meets organizational proficiency and the collective will of all the stakeholders in this community. We conclude with a set of recommendations based on our findings, which borrow from the ideas underlying the defense-in-depth safety principle to address this disquieting problem.
Topics: Accidents, Aviation; Aircraft; Maintenance; Risk Factors
PubMed: 30707734
DOI: 10.1371/journal.pone.0211424 -
Frontiers in Cellular and Infection... 2020, the causative agent of cholera, could proliferate in aquatic environment and infect humans through contaminated food and water. Enormous microorganisms residing in... (Review)
Review
, the causative agent of cholera, could proliferate in aquatic environment and infect humans through contaminated food and water. Enormous microorganisms residing in human gastrointestinal tract establish a special microecological system, which immediately responds to the invasion of , through "colonization resistance" mechanisms, such as antimicrobial peptide production, nutrients competition, and intestinal barrier maintenances. Meanwhile, could quickly sense those signals and modulate the expression of relevant genes to circumvent those stresses during infection, leading to successful colonization on the surface of small intestinal epithelial cells. In this review, we summarized the crosstalks profiles between gut microbiota and in the terms of Type VI Secretion System (T6SS), Quorum Sensing (QS), Reactive Oxygen Species (ROS)/pH stress, and Bioactive metabolites. These mechanisms can also be applied to molecular bacterial pathogenesis of other pathogens in host.
Topics: Bacterial Proteins; Cholera; Gastrointestinal Microbiome; Gene Expression Regulation, Bacterial; Humans; Intestines; Type VI Secretion Systems; Vibrio cholerae
PubMed: 33194819
DOI: 10.3389/fcimb.2020.582554 -
Computational Intelligence and... 2022In the medical field, to ensure the use of large medical equipment, it is necessary to carry out regular maintenance on large medical equipment. In the process of...
In the medical field, to ensure the use of large medical equipment, it is necessary to carry out regular maintenance on large medical equipment. In the process of maintenance and maintenance of large-scale medical equipment, most medical personnel have not established a corresponding quality management system, neglecting daily maintenance and maintenance, resulting in many hidden dangers of medical accidents. To this end, the quality control of large medical devices should be strengthened, the control before, during, and after the event should be done well, and a comprehensive analysis of the operation methods of the equipment should be carried out to achieve reasonable maintenance of the equipment. Therefore, this paper discusses the maintenance, management, maintenance, and quality management of large medical equipment under the function of information fusion technology. This paper summarizes the problems encountered in the maintenance of medical equipment in the past and creates a medical quality control system to manage the maintenance and quality control of medical equipment. In the maintenance system of medical equipment, scientific management theories and methods are used to predict, adjust, inspect, and account for the quality of the entire production process of the equipment, and establish a complete quality monitoring and management system. To achieve optimal maintenance and economic benefits, the overall quality of medical equipment can be comprehensively improved. The data shows that the actual number of monitors for quality control testing in 2020 is 502 units, 496 units have passed the initial inspection, and 502 units have passed the maintenance, which shows that the maintenance and quality control of medical equipment based on information fusion technology is effective.
Topics: Quality Control; Information Technology
PubMed: 36275952
DOI: 10.1155/2022/9333328 -
Monaldi Archives For Chest Disease =... Mar 2011
Topics: Bronchoscopes; Disinfection; Equipment and Supplies; Humans; Maintenance; Sterilization
PubMed: 21626988
DOI: 10.4081/monaldi.2011.235 -
Uirusu 2018Arenavirus is a genetic term for viruses belonging to the family Arenaviridae and is presented from lymphocytic choriomeningitis virus (LCMV), which shows almost no... (Review)
Review
Arenavirus is a genetic term for viruses belonging to the family Arenaviridae and is presented from lymphocytic choriomeningitis virus (LCMV), which shows almost no pathogenicity to humans, to Lassa virus, Junin virus, Machupo virus, Chapare virus, Lujo virus, Sabia virus, and Guanarito virus, which shows high pathogenicity to humans. These viruses except for LCMV are risk group 4 pathogens specified by World Health Organization. Based on this designation, it is designated as Class I pathogens in Japan. Although there have been no reports excluding one imported case of the Lassa fever patient, it is not surprising whenever imported cases occur in our country. Considering the disease severity and mortality rate, it is an urgent matter to develop vaccines and therapeutic drugs in endemic areas, and maintenances of these are also important in countries other than endemic areas. However, basic research on highly pathogenic arenavirus infections and development of therapeutic drugs are not easily progressed, because handling in highly safe research facilities is indispensable. In this article, we will outline the current knowledge from the recent basic research on arenavirus to the development situation of antivirals against arenaviruses.
Topics: Africa, Western; Antiviral Agents; Arenaviridae Infections; Arenavirus; Disease Outbreaks; Drug Discovery; Genome, Viral; Humans; Research; Transcription, Genetic; Viral Vaccines; Virion
PubMed: 31105135
DOI: 10.2222/jsv.68.51 -
Frontiers in Psychology 2021A clear rationale can be made for promoting long-term regular physical activity (PA), yet despite some attempts to operationalize "maintenance," no robust definition has... (Review)
Review
A clear rationale can be made for promoting long-term regular physical activity (PA), yet despite some attempts to operationalize "maintenance," no robust definition has been agreed upon, beyond arbitrary time frames of regular PA. This has likely impaired the advancement of theory and practice. The purpose of this critical narrative review was to first overview the conception of maintenance and co-requisite theoretical constructs in theories used in PA research. Our subsequent aims were to engage in a critical analysis of this literature to propose a working definition of PA maintenance followed by recommendations for future research. Relevant behavioral theories were parsed for references to maintenance or maintenance-specific constructs and constructs most likely associated with maintenance were overviewed from a recent systematic review. Based on this information, we suggest PA maintenance be operationalized as a process marked by a shift in the mechanisms of action determining behavioral performance, that engender greater perceived behavioral enactment efficiency. We suggest that maintenance should not be considered an absolute state of behavioral performance (e.g., a stage), as some constructs that were critical to behavioral performance during initiation will still be critical during PA continuation. Based on this definition, we propose a method of falsifiability hypothesis testing of theoretical constructs that may determine the maintenance process. Finally, the review concludes with suggestions for future research using this operationalization of maintenance including measure development, tests of latency to reach the peak maintenance process, validating constructs critical to determining maintenance, exploration of the contextual and individual moderators of maintenance formation, and the development of an omnibus dynamic model of initiation, continuation, and maintenance in PA behavior change.
PubMed: 34552537
DOI: 10.3389/fpsyg.2021.725671 -
Family Practice Management 2019
Topics: Family Practice; Humans; Maintenance; Patients
PubMed: 30645085
DOI: No ID Found