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Anaesthesia Sep 1978A case of unilateral pulmonary oedema following "Mandrax" overdose is presented. The pulmonary oedema is believed to result from hypoxia and increased pulmonary vascular...
A case of unilateral pulmonary oedema following "Mandrax" overdose is presented. The pulmonary oedema is believed to result from hypoxia and increased pulmonary vascular permeability. A multi-factorial pathophysiology including patient posture, may have been responsible for the unusual unilateral distribution of the oedema. This report should serve to increase awareness of this interesting clinical entity.
Topics: Adult; Diphenhydramine; Drug Combinations; Humans; Male; Methaqualone; Pulmonary Edema
PubMed: 717715
DOI: 10.1111/j.1365-2044.1978.tb08468.x -
British Journal of Pharmacology Apr 19741 Injection of pentobarbitone sodium into a lateral cerebral ventricle of rats produced a loss of righting reflex. The duration of anaesthesia was dose-dependent.2 The...
A study of the factors affecting the sleeping time following intracerebroventricular administration of pentobarbitone sodium: effect of prior administration of centrally active drugs.
1 Injection of pentobarbitone sodium into a lateral cerebral ventricle of rats produced a loss of righting reflex. The duration of anaesthesia was dose-dependent.2 The optimum dose of pentobarbitone to allow study of the factors affecting the sleeping time was considered to be 650 mug injected in 25 mul water.3 In a study of the effect of age and sex on the sleeping time, the youngest rats used (88 g body weight) were found to be the most sensitive to barbiturate. Female rats were more sensitive than male animals.4 The duration of anaesthesia was not affected by induction or inhibition of hepatic drug-metabolizing enzyme activity.5 Prior administration (acute) of central nervous system depressant drugs shortened the latent period and prolonged the duration of sleep. Prior administration of stimulant drugs antagonized the effect of pentobarbitone.6 Animals withdrawn following chronic administration of a number of drugs, barbitone, barbitone/bemegride mixture, Mandrax (methaqualone: diphenhydramine; 10: 1), chlordiazepoxide, nitrazepam, chlorpromazine or ethanol, exhibited a significant tolerance to intracerebroventricularly administered pentobarbitone.7 Withdrawal of amphetamine, morphine, methyprylon or diazepam did not result in tolerance to intracerebroventricularly administered pentobarbitone.8 Chronic administration of all drugs except amphetamine and morphine induced a tolerance to intraperitoneally administered hexobarbitone (100 mg/kg).9 The usefulness of sleeping time determination following intracerebroventricular administration of pentobarbitone as an assessment of central nervous system excitability is discussed. It is concluded that this method gives a valid indication of the sensitivity of the central nervous system to barbiturate and of the level of excitability in general. The method is particularly applicable in situations where the activity of hepatic drug-metabolizing enzyme activity may be altered.
Topics: Aging; Amphetamine; Animals; Anti-Anxiety Agents; Barbiturates; Body Weight; Carbon Radioisotopes; Cerebral Ventricles; Chlorpromazine; Dose-Response Relationship, Drug; Ethanol; Female; Humans; Hypnotics and Sedatives; Injections; Liver; Male; Morphine; Pentobarbital; Proadifen; Rats; Sex Factors; Sleep; Substance Withdrawal Syndrome; Time Factors
PubMed: 4155651
DOI: 10.1111/j.1476-5381.1974.tb08583.x -
British Journal of Anaesthesia Jan 1972
Topics: Adolescent; Adult; Aged; Anesthesia, General; Anesthesia, Intravenous; Bronchoscopy; Consciousness; Ear, External; Foreign Bodies; Humans; Injections, Intravenous; Laparotomy; Methaqualone; Middle Aged; Muscles; Nitrous Oxide; Sleep; Spasm; Time Factors; Tonsillectomy
PubMed: 5058138
DOI: 10.1093/bja/44.1.83 -
British Medical Journal Jun 1975
Topics: Acute Disease; Adult; Diphenhydramine; Gout; Humans; Hypnotics and Sedatives; Male; Methaqualone
PubMed: 1148714
DOI: 10.1136/bmj.2.5970.561 -
The Journal of Biological Chemistry Sep 2000In HepG2 cells, inhibition of apolipoprotein B100 (apoB) translocation across the endoplasmic reticulum by an microsomal triglyceride transfer protein (MTP) inhibitor...
Inhibition of translocation of nascent apolipoprotein B across the endoplasmic reticulum membrane is associated with selective inhibition of the synthesis of apolipoprotein B.
In HepG2 cells, inhibition of apolipoprotein B100 (apoB) translocation across the endoplasmic reticulum by an microsomal triglyceride transfer protein (MTP) inhibitor (CP-10447) in the presence of N-acetyl-leucinyl-norleucinal, a proteasomal inhibitor, results in accumulation of newly synthesized apoB in the translocation channel. Here we demonstrated that such accumulation led to a specific reduction of apoB synthesis. ApoB mRNA levels remained unchanged, but we observed reduced rates of elongation of nascent apoB in puromycin-synchronized cells pretreated with MTP inhibitor. This observation was consistent with a longer half-ribosome transit time for the synthesis of apoB in MTP-inhibited cells. Initiation of translation of apoB mRNA was not impaired by MTP inhibition. Overall, these findings suggest that translocation arrest of apoB in the endoplasmic reticulum channel can exert a selective and negative effect on the synthesis of apoB at the stage of elongation.
Topics: Apolipoproteins B; Biological Transport; Carrier Proteins; Cell Line; Endoplasmic Reticulum; Humans; Leupeptins; Methaqualone; RNA, Messenger; Ribosomes
PubMed: 10846173
DOI: 10.1074/jbc.M000554200 -
Zhongguo Yao Li Xue Bao = Acta... Mar 1991Rage reaction was induced in mice by sc 4-aminopyridine (4-AP) 6 mg . kg-1. Mice appeared hyperreactive after 8-12 min and then squeaked and fought each other. These...
Rage reaction was induced in mice by sc 4-aminopyridine (4-AP) 6 mg . kg-1. Mice appeared hyperreactive after 8-12 min and then squeaked and fought each other. These manifestations were most distinct in 10-30 min and subsided after 40-60 min. The occurrence of rage reaction on this dose level was around 90%. At higher doses 4-AP caused convulsions and death after evocation of rage reaction. The ED50 of 4-AP for eliciting rage reaction was 4.7 +/- 0.7 mg . kg-1 sc. No significant difference in induction of rage reaction was seen between male and female mice of different body weights. Both neuroleptic drugs (chlorpromazine, haloperidol, tarden and clozapine) and anxiolytic drugs (diazepam, chlordiazepoxide, and meprobamate) inhibited 4-AP-induced rage reaction in mice. Barbiturates, Chloral hydrate, methaqualone, morphine hydrochloride, aspirin, phenytoin sodium, diphenhydramine hydrochloride, atropine sulfate, and procaine hydrochloride did not affect rage reaction. The 4-AP-induced aggressive behavior, similar to that induced by electric footshock or isolation, has the merits of convenience to deal with and time saving. Hence we recommended it as a screening method for drugs with neuroleptic and anxiolytic activities.
Topics: 4-Aminopyridine; Animals; Anti-Anxiety Agents; Antipsychotic Agents; Drug Evaluation, Preclinical; Female; Hypnotics and Sedatives; Male; Mice; Rage
PubMed: 1685615
DOI: No ID Found -
Canadian Medical Association Journal Mar 1975
Topics: Depression; Female; Humans; Leg; Methaqualone; Middle Aged; Neuritis; Paresthesia; Sleep Initiation and Maintenance Disorders
PubMed: 1122439
DOI: No ID Found -
British Journal of Anaesthesia Oct 1969
Clinical Trial Comparative Study Randomized Controlled Trial
Topics: Adult; Blood Pressure; Clinical Trials as Topic; Diphenhydramine; Female; Heart Rate; Humans; Methaqualone; Placebos; Preanesthetic Medication; Vomiting
PubMed: 4899767
DOI: 10.1093/bja/41.10.874 -
British Medical Journal May 1975
Topics: Aged; Diphenhydramine; Drug Combinations; Humans; Male; Methaqualone; Peripheral Nervous System Diseases
PubMed: 165858
DOI: 10.1136/bmj.2.5967.370-a -
The Yale Journal of Biology and Medicine 1981We recently utilized the technique of resin hemoperfusion (employing an Amberlite XAD-4 resin cartridge) to remove drug from a patient i deep coma after an estimated...
We recently utilized the technique of resin hemoperfusion (employing an Amberlite XAD-4 resin cartridge) to remove drug from a patient i deep coma after an estimated ingestion of greater than 4.5 grams of methaqualone. At plasma flow rates of 204 ml/min, the mean value for plasma clearance of methaqualone was 179 ml/min. The amount of methaqualone recovered from the cartridge at the end of the 10-hour procedure was 1,565 mg measured by gas chromatography. The patient became responsive to deep pain by the end of the procedure. The only complication encountered was a transient decrease in the formed blood elements. The present study verifies that a large, pharmacologically significance quantity of methaqualone can be removed in a short time using resin hemoperfusion.
Topics: Adult; Hemoperfusion; Humans; Male; Methaqualone; Resins, Plant
PubMed: 7269641
DOI: No ID Found