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Arquivos de Neuro-psiquiatria May 2016Approximately 1% of the general population suffers from vestibular migraine. Despite the recently published diagnostic criteria, it is still underdiagnosed condition.... (Review)
Review
Approximately 1% of the general population suffers from vestibular migraine. Despite the recently published diagnostic criteria, it is still underdiagnosed condition. The exact neural mechanisms of vestibular migraine are still unclear, but the variability of symptoms and clinical findings both during and between attacks suggests an important interaction between trigeminal and vestibular systems. Vestibular migraine often begins several years after typical migraine and has a variable clinical presentation. In vestibular migraine patients, the neurological and neurotological examination is mostly normal and the diagnosis will be based in the patient clinical history. Treatment trials that specialize on vestibular migraine are scarce and therapeutic recommendations are based on migraine guidelines. Controlled studies on the efficacy of pharmacologic interventions in the treatment of vestibular migraine should be performed.
Topics: Diagnosis, Differential; Dizziness; Humans; Migraine Disorders; Neurotransmitter Agents; Vertigo; Vestibular Diseases
PubMed: 27191239
DOI: 10.1590/0004-282X20160037 -
CMAJ : Canadian Medical Association... Jan 2023
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The Journal of Headache and Pain Jul 2013The term omics consist of three main areas of molecular biology, such as genomics, proteomics and metabolomics. The omics synergism recognise migraine as an ideal study... (Review)
Review
The term omics consist of three main areas of molecular biology, such as genomics, proteomics and metabolomics. The omics synergism recognise migraine as an ideal study model, due to its multifactorial nature. In this review, the plainly research data featuring in this complex network are reported and analyzed, as single or multiple factor in pathophysiology of migraine. The future of migraine biomolecular research shall be focused on networking among these different and hierarchical disciplines. We have to look for its Ariadne's tread, in order to see the whole painting of migraine molecular biology.
Topics: Genomics; Humans; Metabolomics; Migraine Disorders; Proteomics
PubMed: 23815568
DOI: 10.1186/1129-2377-14-55 -
Clinical Journal of Oncology Nursing Aug 2017Cannabis has been used for centuries in the treatment of medical conditions. Cannabis has been recommended for appetite, anxiety, depression, sleep, and migraines....
Cannabis has been used for centuries in the treatment of medical conditions. Cannabis has been recommended for appetite, anxiety, depression, sleep, and migraines. However, the stigma associated with cannabis as a recreational drug has created challenges to the legitimacy and social acceptance of cannabis for medical purposes in the United States.
Topics: Anxiety; Appetite; Cannabis; Depression; Guidelines as Topic; Humans; Migraine Disorders; Sleep; United States
PubMed: 28738036
DOI: 10.1188/17.CJON.409 -
BMJ (Clinical Research Ed.) Jun 2008The authors explore whether migraine affects pregnancy, how pregnancy alters migraine, and how to treat and prevent migraine in pregnancy (Review)
Review
The authors explore whether migraine affects pregnancy, how pregnancy alters migraine, and how to treat and prevent migraine in pregnancy
Topics: Acute Disease; Adult; Breast Feeding; Female; Humans; Migraine Disorders; Pregnancy; Pregnancy Complications
PubMed: 18583683
DOI: 10.1136/bmj.39559.675891.AD -
Revista de NeurologiaHeadache and dizziness are two of the most frequent symptoms that lead patients to visit neurology outpatient services. One of the most interesting associations is the... (Review)
Review
INTRODUCTION
Headache and dizziness are two of the most frequent symptoms that lead patients to visit neurology outpatient services. One of the most interesting associations is the one existing between migraine and vertigo. Different terms have been used in the literature to refer to this clinical picture, but perhaps the one that best defines this relation is that of recurring migraine-associated vertigo, which should be considered an entity in its own right.
DEVELOPMENT
Migraine and vertigo are two clinical features that tend to occur together, possibly as a result of their pathophysiology; we must be capable of recognising the type of neuro-otological disorder our patient has in order to be able to aim the diagnostic tests in the right direction and to carry out a satisfactory treatment.
CONCLUSION
New diagnostic criteria are proposed for recurring migraine-associated vertigo.
Topics: Comorbidity; Diagnosis, Differential; Humans; Migraine Disorders; Vertigo
PubMed: 17455163
DOI: No ID Found -
The Journal of Headache and Pain Jan 2024Migraine and epilepsy are two paroxysmal chronic neurological disorders affecting a high number of individuals and being responsible for a high individual and... (Review)
Review
BACKGROUND
Migraine and epilepsy are two paroxysmal chronic neurological disorders affecting a high number of individuals and being responsible for a high individual and socioeconomic burden. The link between these disorders has been of interest for decades and innovations concerning diagnosing and treatment enable new insights into their relationship.
FINDINGS
Although appearing to be distinct at first glance, both diseases exhibit a noteworthy comorbidity, shared pathophysiological pathways, and significant overlaps in characteristics like clinical manifestation or prophylactic treatment. This review aims to explore the intricate relationship between these two conditions, shedding light on shared pathophysiological foundations, genetic interdependencies, common and distinct clinical features, clinically overlapping syndromes, and therapeutic similarities. There are several shared pathophysiological mechanisms, like CSD, the likely underlying cause of migraine aura, or neurotransmitters, mainly Glutamate and GABA, which represent important roles in triggering migraine attacks and seizures. The genetic interrelations between the two disorders can be observed by taking a closer look at the group of familial hemiplegic migraines, which are caused by mutations in genes like CACNA1A, ATP1A2, or SCN1A. The intricate relationship is further underlined by the high number of shared clinical features, which can be observed over the entire course of migraine attacks and epileptic seizures. While the variety of the clinical manifestation of an epileptic seizure is naturally higher than that of a migraine attack, a distinction can indeed be difficult in some cases, e.g. in occipital lobe epilepsy. Moreover, triggering factors like sleep deprivation or alcohol consumption play an important role in both diseases. In the period after the seizure or migraine attack, symptoms like speech difficulties, tiredness, and yawning occur. While the actual attack of the disease usually lasts for a limited time, research indicates that individuals suffering from migraine and/or epilepsy are highly affected in their daily life, especially regarding cognitive and social aspects, a burden that is even worsened using antiseizure medication. This medication allows us to reveal further connections, as certain antiepileptics are proven to have beneficial effects on the frequency and severity of migraine and have been used as a preventive drug for both diseases over many years.
CONCLUSION
Migraine and epilepsy show a high number of similarities in their mechanisms and clinical presentation. A deeper understanding of the intricate relationship will positively advance patient-oriented research and clinical work.
Topics: Humans; Migraine Disorders; Epilepsy; Migraine with Aura; Anticonvulsants; Comorbidity
PubMed: 38273253
DOI: 10.1186/s10194-024-01719-0 -
Current Pain and Headache Reports Feb 2012Chronic migraine (CM) and episodic migraine (EM) are part of the spectrum of migraine disorders, but they are distinct clinical entities. Population-based studies have... (Review)
Review
Chronic migraine (CM) and episodic migraine (EM) are part of the spectrum of migraine disorders, but they are distinct clinical entities. Population-based studies have shown that those with CM demonstrate higher individual and societal burden because they are significantly more disabled than those with EM and have greater impaired quality of life both inside and outside the home. Proper diagnosis of both conditions requires clearly defined clinical criteria. Diagnosis enables the initiation of appropriate treatments and risk-factor modification, which ultimately improve functional status and quality of life for persons with migraine. Recognizing that both disorders are on the spectrum of migraine, this review serves as a guide to define the disease state of CM as distinct from EM in terms of clinical, epidemiological, sociodemographic, and comorbidity profiles.
Topics: Chronic Disease; Diagnosis, Differential; Disease Progression; Female; Humans; Male; Middle Aged; Migraine Disorders; Quality of Life; Recurrence; Risk Factors
PubMed: 22083262
DOI: 10.1007/s11916-011-0233-z -
International Dental Journal Aug 2023Migraine is a neurologic illness that produces intense throbbing pain on one side of the head and affects roughly 1 billion people worldwide. Recent research indicates a... (Review)
Review
Migraine is a neurologic illness that produces intense throbbing pain on one side of the head and affects roughly 1 billion people worldwide. Recent research indicates a relationship between periodontitis and chronic migraines. This study aimed to review the association between chronic migraines and periodontitis through a systematic literature review. Four research databases (Google Scholar, PubMed, ProQuest, and SpringerLink) were searched according to PRISMA guidelines to retrieve the studies included in this review. A search strategy was developed to answer the study question with appropriate inclusion and exclusion criteria. Out of 34 published studies, 8 studies were included in this review. Three of the studies were cross-sectional, 3 were case-control, and 2 were clinical report and medical hypothesis papers. Seven of the 8 included studies showed that there is an association between periodontal disease and chronic migraine. The elevated blood levels of some biomarkers such as leptins, ProCalcitonin (proCT), calcitonin gene-related peptides (CGRPs), Pentraxin 3 (PTX3), and Soluble Tumor Necrosis Factor-like Weak Inducer Of Apoptosis (sTWEAK) play a significant role in this association. The limitations include a small sample size, the influence of anti-inflammatory drugs, and a self-reported headache measure that is subject to misclassification bias. This systematic review reveals a supposed correlation between periodontal disease and chronic migraine, as evidenced by various biomarkers and inflammatory mediators. This suggests that periodontal disease could potentially contribute to the development of chronic migraine. However, to further assess the potential benefits of periodontal treatment in patients with chronic migraine, additional longitudinal studies with larger sample sizes and interventional studies are needed.
Topics: Humans; Periodontal Diseases; Periodontitis; Migraine Disorders; Biomarkers
PubMed: 37225630
DOI: 10.1016/j.identj.2023.04.007 -
The Journal of Clinical Investigation Jan 2009Migraine is an episodic headache disorder affecting as many as 10% of people worldwide. Familial hemiplegic migraine (FHM) is an autosomal dominant subtype of severe...
Migraine is an episodic headache disorder affecting as many as 10% of people worldwide. Familial hemiplegic migraine (FHM) is an autosomal dominant subtype of severe migraine accompanied by visual disturbances known as aura. Migrainous aura is caused by cortical spreading depression (CSD) - a slowly advancing wave of tissue depolarization in the cortex. More than half of FHM cases are caused by mutations in the CACNA1A gene, which encodes a neuronal Cav2.1 Ca2+ channel, resulting in increased Ca2+ flow into dendrites and excessive release of the excitatory neurotransmitter glutamate. In this issue of the JCI, Eikermann-Haerter et al. show that transgenic mice with FHM-associated mutations in Cacna1a have increased susceptibility to CSD compared with wild-type animals, likely due to augmentation of excitatory neurotransmission (see the related article beginning on page 99). Additional as-yet-undefined channel mutations may similarly render the migraine brain more susceptible to the initiation of CSD, with implications not only for the genesis of migraine but also for the hypoxic injury that accompanies its worst manifestation, complicated migraine.
Topics: Animals; Calcium Channels; Cortical Spreading Depression; Female; Humans; Male; Mice; Mice, Transgenic; Migraine Disorders; Neurons; Potassium
PubMed: 19104145
DOI: 10.1172/JCI38051