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British Medical Journal Oct 1958
Topics: Humans; Infectious Mononucleosis
PubMed: 13572942
DOI: No ID Found -
Henry Ford Hospital Medical Bulletin Jun 1957
Topics: Humans; Infectious Mononucleosis
PubMed: 13438442
DOI: No ID Found -
Minerva Medica Jun 2021
Review
Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Female; Herpesvirus 4, Human; Humans; Infant; Infectious Mononucleosis; Male; Middle Aged; Serositis; Serous Membrane; Young Adult
PubMed: 31638357
DOI: 10.23736/S0026-4806.19.06047-6 -
British Medical Journal Sep 1973
Topics: Diagnosis, Differential; Edema; Eyelid Diseases; Humans; Infectious Mononucleosis; Lymph Nodes; Pain
PubMed: 4741621
DOI: 10.1136/bmj.3.5879.545-c -
British Medical Journal Jun 1973
Topics: Adolescent; Adult; Age Factors; Agranulocytosis; Female; Humans; Infectious Mononucleosis; Sex Factors
PubMed: 4714478
DOI: 10.1136/bmj.2.5865.547 -
British Medical Journal Mar 1952
Topics: Chloramphenicol; Humans; Infectious Mononucleosis; Skin Tests
PubMed: 14905012
DOI: 10.1136/bmj.1.4759.636-a -
British Medical Journal Jul 1973
Topics: Female; Herpesvirus 4, Human; Humans; Infectious Mononucleosis; Male
PubMed: 4352252
DOI: 10.1136/bmj.3.5871.107 -
BMC Infectious Diseases Oct 2023Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis (EBV-HLH) and infectious mononucleosis (EBV-IM) share mimic symptoms in the early stages of childhood...
BACKGROUND AND AIM
Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis (EBV-HLH) and infectious mononucleosis (EBV-IM) share mimic symptoms in the early stages of childhood development. We aimed to examine the clinical features and laboratory indices of these two diseases in children and uncover unique indicators to assist pediatricians in identifying these diseases early.
METHODS
We collected clinical data from 791 pediatric patients diagnosed with EBV-IM or EBV-HLH, compared the clinical traits and laboratory biomarkers presented in the two groups, and constructed predictive models based on them.
RESULTS
Patients with EBV-IM had greater ratios of cervical lymphadenopathy, eyelid edema, and tonsillitis, whereas individuals with EBV-HLH were more likely to have hepatomegaly and splenomegaly. When using the criteria of interleukin (IL)-10 > 89.6 pg/mL, interferon (IFN)-γ > 45.6 pg/mL, ferritin > 429 μg/L, D-dimer > 3.15 mg/L and triglycerides > 2.1 mmol/L, the sensitivity was 87.9%, 90.7%, 98.1%, 91.1% and 81.5% to predict EBV-HLH, while the specificity was 98.4%, 96.3%, 96.5%, 94.1% and 80.6%, respectively. A logistic regression model based on four parameters (IL-10, ferritin, D-dimer, and triglycerides) was established to distinguish EBV-HLH patients from EBV-IM patients, with a sensitivity of 98.0% and a specificity of 98.2%.
CONCLUSIONS
IL-10, IFN-γ, ferritin and D-dimer levels are significantly different between EBV-HLH and EBV-IM. Predictive models based on clinical signs and laboratory findings provide simple tools to distinguish the two situations.
Topics: Child; Humans; Herpesvirus 4, Human; Infectious Mononucleosis; Lymphohistiocytosis, Hemophagocytic; Epstein-Barr Virus Infections; Interleukin-10; Biomarkers; Ferritins; Triglycerides
PubMed: 37880605
DOI: 10.1186/s12879-023-08654-6 -
Antimicrobial Agents and Chemotherapy Jun 2023Present evidence suggests that the administration of antibiotics, particularly aminopenicillins, may increase the risk of rash in children with infectious mononucleosis...
Present evidence suggests that the administration of antibiotics, particularly aminopenicillins, may increase the risk of rash in children with infectious mononucleosis (IM). This retrospective, multicenter cohort study of children with IM was conducted to explore the association between antibiotic exposure in IM children and the risk of rash. A robust error generalized linear regression was performed to address the potential cluster effect, as well as confounding factors such as age and sex. A total of 767 children (aged from 0 to 18 years) with IM from 14 hospitals in Guizhou Province were included in the final analysis. The regression analysis implied that exposure to antibiotics was associated with a significantly increased incidence of overall rash in IM children (adjusted odds ratio [AOR], 1.47; 95% confidence interval [CI], ~1.04 to 2.08; = 0.029). Of 92 overall rash cases, 43 were probably related to antibiotic exposure: two cases (4.08%) in the amoxicillin-treated group and 41 (8.15%) in the group treated with other antibiotics. Regression analysis indicated that the risk of rash induced by amoxicillin in IM children was similar to that induced by other penicillins (AOR, 1.12; 95% CI, ~0.13 to 9.67), cephalosporins (AOR, 2.45; 95% CI, ~0.43 to 14.02), or macrolides (AOR, 0.91; 95% CI, ~0.15 to 5.43). Antibiotic exposure may be associated with an increased risk of overall rash in IM children, but amoxicillin was not found to be associated with any increased risk of rash during IM compared to other antibiotics. We suggest that clinicians be vigilant against the occurrence of rash in IM children receiving antibiotic therapy, rather than indiscriminately avoiding prescribing amoxicillin.
Topics: Humans; Child; Anti-Bacterial Agents; Retrospective Studies; Infectious Mononucleosis; Cohort Studies; Amoxicillin; Exanthema; Penicillins
PubMed: 37219437
DOI: 10.1128/aac.00249-23 -
The Journal of Pediatrics Jun 2019To develop a scale for the severity of mononucleosis.
OBJECTIVES
To develop a scale for the severity of mononucleosis.
STUDY DESIGN
One to 5 percent of college students develop infectious mononucleosis annually, and about 10% meet criteria for chronic fatigue syndrome (CFS) 6 months following infectious mononucleosis. We developed a severity of mononucleosis scale based on a review of the literature. College students were enrolled, generally when they were healthy. When the students developed infectious mononucleosis, an assessment was made as to the severity of their infectious mononucleosis independently by 2 physicians using the severity of mononucleosis scale. This scale was correlated with corticosteroid use and hospitalization. Six months following infectious mononucleosis, an assessment is made for recovery from infectious mononucleosis or meeting 1 or more case definitions of CFS.
RESULTS
In total, 126 severity of mononucleosis scales were analyzed. The concordance between the 2 physician reviewers was 95%. All 3 hospitalized subjects had severity of mononucleosis scores ≥2. Subjects with severity of mononucleosis scores of ≥1 were 1.83 times as likely to be given corticosteroids. Students with severity of mononucleosis scores of 0 or 1 were less likely to meet more than 1 case definition of CFS 6 months following infectious mononucleosis.
CONCLUSIONS
The severity of mononucleosis scale has interobserver, concurrent and predictive validity for hospitalization, corticosteroid use, and meeting criteria for CFS 6 months following infectious mononucleosis.
Topics: Adolescent; Female; Humans; Infectious Mononucleosis; Male; Severity of Illness Index; Young Adult
PubMed: 30853204
DOI: 10.1016/j.jpeds.2019.01.035