(mononucleosis) Acute disease characterized by fever and swollen lymph nodes and an abnormal increase of mononuclear leucocytes or monocytes in the bloodstream; not highly contagious; some believe it can be transmitted by kissing.

A clinical syndrome of fever, sore throat, fatigue, and lymphadenopathy. Epstein-Barr virus is the predominant cause.

A common, acute infection usually caused by the Epstein-Barr virus (HERPESVIRUS 4, HUMAN). There is an increase in mononuclear white blood cells and other atypical lymphocytes, generalized lymphadenopathy, splenomegaly, and occasionally hepatomegaly with hepatitis.

A clinical syndrome of fever, sore throat, fatigue, and lymphadenopathy caused by infection with the Epstein-Barr virus. Subsequent physical findings may include hepatomegaly, palatal petechiae, jaundice, uvular edema, and splenomegaly.

Infectious mononucleosis (mono) is a disease caused by viruses.The most common cause is the Epstein-Barr virus (EBV). Mono is contagious, which means it can spread from person to person. It is common among teenagers and young adults, especially college students. Mono can be caused by many different viruses. But it is most often caused by the Epstein-Barr virus (EBV). EBV is found all over the world. Most people get an EBV infection at some point in their lives, but only some of them will get the symptoms of mono. EBV infections often happen during childhood or when someone is a young adult. EBV infections in children usually do not cause symptoms. And when they do, it's hard to tell the difference between the symptoms of mono and the symptoms of other common childhood illnesses such as the flu. Teens and young adults who get EBV are more likely to have symptoms that are typical of mono. EBV and the other viruses that cause mono are usually spread through body fluids, especially saliva (spit). This means that you can get it through kissing. That's why mono is sometimes called "the kissing disease." But you can also get these viruses if you share food, drinks, forks, spoons, or lip balm with someone who has mono. Other less common ways of getting an infection are through blood transfusions, organ transplants, and blood and semen during sexual contact. The symptoms of mono usually start four to six weeks after you get the infection. But they may start sooner in young children. The symptoms often develop slowly, and they may not all happen at the same time. They can include: Extreme fatigue; Fever; Sore throat; Head and body aches; Swollen lymph glands in your neck and armpits; Rash; Swollen liver, spleen, or both (these are less common symptoms). Most people get better in two to four weeks. However, some people may feel fatigued for several more weeks. Occasionally, the symptoms can last for six months or longer. Your healthcare provider may diagnose mono based on your symptoms and a physical exam. The exam will include checking to see if your lymph nodes, tonsils, liver, or spleen are swollen. In some cases, your provider might also order a mono test to confirm the diagnosis. Drinking plenty of fluids to avoid dehydration.; Getting lots of rest.; Taking over-the-counter medications for pain and fever. But don't give aspirin to children or teens because it may cause Reye syndrome. This syndrome is a rare, serious illness that can affect the brain and liver. If you have severe symptoms, your provider may suggest additional treatment based on which organs in your body are affected by the mono. Antibiotics don't treat viral infections, so they do not help with mono. Some people do get bacterial infections such as strep throat along with mono. In that case, you probably need antibiotics to treat the bacterial infection. But you should not take penicillin antibiotics like ampicillin or amoxicillin. Those antibiotics can cause a rash in people who have mono. Mono can cause an enlarged spleen, which could rupture and cause a medical emergency. To try to protect the spleen, providers recommend avoiding intense exercise and contact sports until you fully recover (about a month). There is no vaccine to protect against mono. To lower your chance of getting or spreading mono: Don't share food, drinks, forks, spoons, or lip balm with anyone, especially if you or the other person has mono.; Don't kiss someone if you or the other person has mono.; Wash your hands often with soap and water.

MedlinePlus

U.S. National Library of Medicine, 2025

Infectious mononucleosis is caused by Epstein-Barr virus (EBV, human herpesvirus type 4) and is characterized by fatigue, fever, pharyngitis, and lymphadenopathy. Fatigue may persist weeks or months. Severe complications, including airway obstruction, splenic rupture, and neurologic syndromes, occasionally occur. Diagnosis is clinical or...

Infectious mononucleosis was first described by Sprunt and Evans in the Bulletin of the Johns Hopkins Hospital in 1920. They described the clinical characteristics of Epstein-Barr virus (EBV) infectious mononucleosis.

Infectious mononucleosis (mono) is often called the kissing disease. The virus that causes mono is transmitted through saliva, so you can get it through kissing, but you can also be exposed by sharing a glass or food utensils with someone who has mono. However, mononucleosis isn't as contagious as some infections, such as the common cold.

Infectious mononucleosis (IM) is a clinical syndrome in a patient with primary Epstein Barr virus (EBV) infection; other causes of mononucleosis syndrome are much less common. The diagnosis "infectious mononucleosis" is primarily used when the syndrome is caused by EBV; "mononucleosis syndrome" should be used when the syndrome is caused...

Mononucleosis, infection in humans, caused by the Epstein-Barr virus (EBV), whose most common symptoms are fever, general malaise, and sore throat. The disease occurs predominantly in persons from 10 to 35 years old, but it is known to appear at any age. Infection of young children by the EBV...