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Neurology(R) Neuroimmunology &... Jan 2020To assess the prevalence and clinical features of neurologic involvement in patients with acute hepatitis E virus (HEV) infection in Southern Switzerland.
OBJECTIVE
To assess the prevalence and clinical features of neurologic involvement in patients with acute hepatitis E virus (HEV) infection in Southern Switzerland.
METHODS
Among 1,940 consecutive patients investigated for acute hepatitis E, we identified 141 cases of acute of HEV infection (anti-HEV immunoglobulin M and immunoglobulin G both reactive and/or HEV RNA positive) between June 2014 and September 2017. Neurologic cases were followed up for 6 months. We compared patients with and without neurologic symptoms.
RESULTS
Neurologic symptoms occurred in 43 acute HEV cases (30.4%) and consisted of neuralgic amyotrophy (NA, n = 15, 10.6%) and myalgia (n = 28, 19.8%). All NA cases were immunocompetent. Men had higher odds (OR = 5.2, CI 1.12-24.0, = 0.03) of developing NA after infection with HEV, and in 3 couples simultaneously infected with HEV, only men developed NA. Bilateral involvement of NA was predominant (2:1) and occurred only in men. Seven NA cases were viremic (all genotype 3), but HEV was undetectable in their CSF. In the acute phase of NA, 9 patients were treated with intravenous immunoglobulin and 4 with prednisone, reporting no side effects and improvement in pain and strength. Myalgia occurred both without (n = 16) or with (n = 12) concomitant elevated serum creatinine kinase. Seven cases with myalgia in the shoulder girdle did not have muscle weakness ("forme fruste" of NA).
CONCLUSIONS
Neurologic symptoms occurred in one-third of acute HEV infections and consisted of NA and myalgia. NA seems to occur more frequently in men infected by HEV and has a predominant (but not exclusive) bilateral involvement.
Topics: Acute Disease; Adult; Aged; Brachial Plexus Neuritis; Female; Follow-Up Studies; Hepatitis E; Humans; Male; Middle Aged; Myalgia; Prevalence; Switzerland
PubMed: 31806684
DOI: 10.1212/NXI.0000000000000643 -
British Medical Journal Sep 1964
Topics: Electromyography; Humans; Myalgia
PubMed: 14171089
DOI: No ID Found -
International Journal of Environmental... Jan 2022Electrotherapy is commonly used for myalgia alleviation. Low-frequency stimulation (LFS) is primarily used for controlling acute and chronic pain and is a non-invasive... (Randomized Controlled Trial)
Randomized Controlled Trial
Electrotherapy is commonly used for myalgia alleviation. Low-frequency stimulation (LFS) is primarily used for controlling acute and chronic pain and is a non-invasive therapy that can be easily performed with electric stimulation applied on the skin. However, little evidence exists regarding the pain alleviation effects of personal low-frequency stimulation device for home use. Moreover, no studies have compared myalgia alleviation effects between personal low-frequency stimulation (PLS) and physical therapy (PT), which are most commonly used for patients with myalgia in hospitals and clinics. Therefore, we aimed to investigate the pain alleviation effects of PLS in patients with myalgia and compare these effects with those of conventional PT (transcutaneous electrical nerve stimulation + ultrasound). In total, 39 patients with myalgia in the neck, shoulder, back, and waist areas were randomly assigned to the personal low-frequency stimulation group (PLSG: = 20) and physical therapy group (PTG: = 19). Both groups were treated for 3 weeks (20 min per session and 5 sessions per week). Patients were assessed for pain intensity by surface electromyography (sEMG), visual analogue scale (VAS) and a short-form McGill pain questionnaire (SF-MPQ) before and after the intervention period. Our results showed that PLSG showed a tendency of muscle relaxation with a significant decrease in sEMG in the neck ( = 0.0425), shoulder ( = 0.0425), and back ( = 0.0046) areas compared to the control group. However, there was no significant difference in waist area. Additionally, VAS scores significantly decreased between pre- and post-treatment in both PTG ( = 0.0098), and PLSG ( = 0.0304) groups, but there was no significance difference between the groups. With respect to SF-MPQ, the PLSG showed greater pain alleviation (5.23 ± 0.25) effects than the PTG (6.23 ± 0.25). Accordingly, our results suggest that PLS treatment using a home device might offer positive assistance in pain alleviation for patients with myalgia that is as equally effective as conventional PT treatment. However, further detailed studies are required considering larger samples to fully claim the effectiveness of this device.
Topics: Chronic Pain; Electric Stimulation Therapy; Humans; Myalgia; Pain Measurement; Transcutaneous Electric Nerve Stimulation; Treatment Outcome
PubMed: 35055558
DOI: 10.3390/ijerph19020735 -
Revista Paulista de Pediatria : Orgao... 2022To describe clinical and epidemiological aspects of children and adolescents infected with the SARS-CoV-2 in the Municipality of Taubaté, SP, from March to November 2020.
OBJECTIVE
To describe clinical and epidemiological aspects of children and adolescents infected with the SARS-CoV-2 in the Municipality of Taubaté, SP, from March to November 2020.
METHODS
Cross-sectional study with secondary data obtained from the Epidemiological Surveillance System about confirmed cases in city residents and from medical records of patients who were treated in hospitals in Taubaté, aged between 0 and 19 years. Chi-square and Student's t tests were used for comparisons.
RESULTS
677 cases in the studied age range were reported during the study period, corresponding to 10.1% of cases reported in the municipality. The rapid antibody test was the most used to confirm infection, followed by RT-PCR and serology. Symptoms were described in 57.7% of the cases, mainly fever and cough. Diarrhea was associated with age below 4 years, while fever, cough, headache, odynophagia, ageusia, anosmia, myalgia, and dyspnea were associated with an age ranging from 10 to 19 years. In the study period, there were no deaths from COVID-19 of residents of the municipality in the age group from 0 to 19 years.
CONCLUSIONS
The study was able to identify the proportion of involvement of COVID-19 in children and adolescents in the city, and the disease had a mild evolution. The main symptoms were fever and cough, but mainly diarrhea in younger children, and headache, odynophagia, anosmia, ageusia, and myalgia in adolescents.
Topics: Adolescent; Adult; Ageusia; Anosmia; Brazil; COVID-19; Child; Child, Preschool; Cough; Cross-Sectional Studies; Diarrhea; Fever; Headache; Humans; Infant; Infant, Newborn; Myalgia; SARS-CoV-2; Young Adult
PubMed: 35544908
DOI: 10.1590/1984-0462/2022/40/2021172IN -
Journal of Healthcare Engineering 2022To analyze the causes of muscle soreness and injury during precompetition training in university sports meet and taking the DOMS mechanism as the main line to find a...
To analyze the causes of muscle soreness and injury during precompetition training in university sports meet and taking the DOMS mechanism as the main line to find a reasonable way to deal with the muscle pain and prevent the injury, 125 college students participating in stadium games training were randomly selected. The muscle pain and injury during the training were obtained through interviews, mathematical statistics, and literature review. The information of exercise load, pain and injury type, exercise ability, pain degree, and recovery time was comprehensively analyzed to study the mechanism of pain and injury formation. Muscle pain and injury occurred in precompetition training, especially in freshmen. After heavy load, muscle soreness occurred, causing DOMS and developing into muscle injury. Affected by the external climate environment, sudden muscle soreness and injury are a gradual transformation process with DOMS as the boundary, which is the comprehensive result of exercise load, water, energy, and material metabolism; control load intensity, water supplement, and energy and material supplement can effectively prevent the occurrence of DOMS, and timely recovery after DOMS symptoms can effectively avoid the occurrence of sports injury. According to the different intensity of exercise, it is of great significance to clarify the mechanism of DOMS and explore effective prevention methods for physical education and sports training.
Topics: Exercise; Humans; Muscle, Skeletal; Myalgia; Physical Education and Training; Water
PubMed: 35035865
DOI: 10.1155/2022/9654919 -
BMJ (Clinical Research Ed.) Jun 2017
Topics: Cross-Over Studies; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Myalgia; Precision Medicine
PubMed: 28645927
DOI: 10.1136/bmj.j3030 -
Journal of Sport Rehabilitation May 2018The squat is a fundamental movement for weightlifting and sports performance. Both unilateral and bilateral squats are also used to assess transitional and dynamic... (Review)
Review
CONTEXT
The squat is a fundamental movement for weightlifting and sports performance. Both unilateral and bilateral squats are also used to assess transitional and dynamic lower-extremity control. Common lower-extremity conditions can have an influence on squat performance. Of interest are the effects of hip musculoskeletal conditions and associated factors, such as hip muscle pain, fatigue, and tightness, on squat performance. Currently, there has been no appraisal of the evidence regarding the association of these conditions and associated factors on squat performance.
OBJECTIVE
This study evaluated the current evidence regarding common hip musculoskeletal conditions and associated factors, such as hip muscle pain, fatigue, and tightness, on squat performance.
EVIDENCE ACQUISITION
A systematic review was conducted according to preferred reporting items for systematic reviews and meta-analyses guidelines. A search of PubMed, CINAHL, SPORTDiscus, ProQuest, and Google Scholar® was conducted in October, 2016 using the following keywords alone and in combination: hip, joint, arthritis, pain, range of motion (ROM), fatigue, tightness, pathology, condition, muscle, intraarticular, extraarticular, femoroacetabular impingement, single leg, bilateral, squat, performance, and technique. The grading of studies was conducted using the Physiotherapy Evidence Database scale.
EVIDENCE SYNTHESIS
The authors identified 35 citations, 15 of which met the inclusion criteria. The qualifying studies yielded a total of 542 subjects (160 men and 382 women; mean age = 29.3 (5.9) y) and measured performance with either the barbell squat, step down, bilateral, or single-leg squat. Femoroacetabular impingement and hip arthroscopy were the only hip conditions found that affected the squat. Associated factors, such as muscle pain, fatigue, and tightness, also influenced squat performance.
CONCLUSION
This review found that common hip conditions and associated factors and their effects on squat performance to be underinvestigated. Future research should focus on the association between common hip conditions and squat performance.
Topics: Arthroscopy; Athletic Performance; Biomechanical Phenomena; Femoracetabular Impingement; Hip; Humans; Muscle Fatigue; Muscle, Skeletal; Myalgia; Range of Motion, Articular
PubMed: 28290757
DOI: 10.1123/jsr.2016-0246 -
International Journal of Molecular... Mar 2021Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a persistent and unexplained pathological state characterized by exertional and severely debilitating... (Review)
Review
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a persistent and unexplained pathological state characterized by exertional and severely debilitating fatigue, with/without infectious or neuropsychiatric symptoms, and with a minimum duration of 6 consecutive months. Its pathogenesis is not fully understood. There are no firmly established diagnostic biomarkers or treatment, due to incomplete understanding of the etiology of ME/CFS and diagnostic uncertainty. Establishing a biomarker for the objective diagnosis is urgently needed to treat a lot of patients. Recently, research on ME/CFS using metabolome analysis methods has been increasing. Here, we overview recent findings concerning the metabolic features in patients with ME/CFS and the animal models which contribute to the development of diagnostic biomarkers for ME/CFS and its treatment. In addition, we discuss future perspectives of studies on ME/CFS.
Topics: Animals; Biomarkers; Disease Models, Animal; Encephalitis; Fatigue Syndrome, Chronic; Humans; Metabolome; Metabolomics; Myalgia; Rats; Rats, Sprague-Dawley; Rats, Wistar
PubMed: 33810365
DOI: 10.3390/ijms22073423 -
Scientific Reports Sep 2021Treosulfan is increasingly used as myeloablative agent in conditioning regimen prior to allogeneic hematopoietic stem cell transplantation (HSCT). In our pediatric HSCT...
Treosulfan is increasingly used as myeloablative agent in conditioning regimen prior to allogeneic hematopoietic stem cell transplantation (HSCT). In our pediatric HSCT program, myalgia was regularly observed after treosulfan-based conditioning, which is a relatively unknown side effect. Using a natural language processing and text-mining tool (CDC), we investigated whether treosulfan compared with busulfan was associated with an increased risk of myalgia. Furthermore, among treosulfan users, we studied the characteristics of given treatment of myalgia, and studied prognostic factors for developing myalgia during treosulfan use. Electronic Health Records (EHRs) until 28 days after HSCT were screened using the CDC for myalgia and 22 synonyms. Time to myalgia, location of pain, duration, severity and drug treatment were collected. Pain severity was classified according to the WHO pain relief ladder. Logistic regression was performed to assess prognostic factors. 114 patients received treosulfan and 92 busulfan. Myalgia was reported in 37 patients; 34 patients in the treosulfan group and 3 patients in the busulfan group (p = 0.01). In the treosulfan group, median time to myalgia was 7 days (0-12) and median duration of pain was 19 days (4-73). 44% of patients needed strong acting opiates and adjuvant medicines (e.g. ketamine). Hemoglobinopathy was a significant risk factor, as compared to other underlying diseases (OR 7.16 95% CI 2.09-30.03, p = 0.003). Myalgia appears to be a common adverse effect of treosulfan in pediatric HSCT, especially in hemoglobinopathy. Using the CDC, EHRs were easily screened to detect this previously unknown side effect, proving the effectiveness of the tool. Recognition of treosulfan-induced myalgia is important for adequate pain management strategies and thereby for improving the quality of hospital stay.
Topics: Adolescent; Busulfan; Child; Child, Preschool; Data Mining; Electronic Health Records; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Humans; Male; Myalgia; Pain Measurement; Retrospective Studies; Severity of Illness Index; Transplantation Conditioning
PubMed: 34580398
DOI: 10.1038/s41598-021-98669-3 -
Journal of Dental Research Sep 2022Chronic pain associated with temporomandibular disorders (TMDs) may reflect muscle mechanoreceptor afferent barrage and dysregulated sensory processing. This... (Observational Study)
Observational Study
Chronic pain associated with temporomandibular disorders (TMDs) may reflect muscle mechanoreceptor afferent barrage and dysregulated sensory processing. This observational study tested for associations between Characteristic Pain Intensity (CPI), physical symptoms (Patient Health Questionnaire-15 [PHQ-15]), and cumulative jaw muscle motor load (mV*s). In accordance with institutional review board oversight and Strengthening the Reporting of Observational Studies in Epidemiology guidelines, adult subjects gave informed consent and were identified via Diagnostic Criteria for TMD (DC-TMD) examination and research protocols. Subjects were assigned to ±Pain groups using DC-TMD criteria for myalgia. CPI scores characterized pain intensity. PHQ-15 scores were surrogate measures of dysregulated sensory processing. Laboratory tests were performed to quantify masseter and temporalis muscle activities (mV) per bite force (N) for each subject. In their natural environments, subjects recorded day- and nighttime electromyography from which cumulative jaw muscle motor loads (mV*s) were determined for activities consistent with bite forces of >1 to ≤2 and >2 to ≤5 N. Data were assessed using univariate analysis of variance, simple effects tests, K-means cluster classification, and 3-dimensional regression analyses. Of 242 individuals screened, 144 enrolled, and 125 with complete data from study protocols, there were 35 females and 15 males for +Pain and 35 females and 40 males for -Pain. Subjects produced 324 daytime and 341 nighttime recordings of average duration 6.9 ± 1.7 and 7.6 ± 1.7 h, respectively. Overall, +Pain compared to -Pain subjects had significantly higher (all ≤ 0.002) CPI and PHQ-15 scores. Cumulative jaw muscle motor loads showed significant between-subject effects for time, diagnostic group, and sex (all < 0.003), where motor loads tended to be higher for daytime versus nighttime, +Pain versus -Pain groups, and males versus females. Two clusters were identified, and regression relations showed associations of low-magnitude daytime masseter motor load, PHQ-15, and CPI scores for cluster 1 ( = 105, = 0.44) and cluster 2 ( = 18, = 0.80). Furthermore, these regression relations showed thresholds of motor load and PHQ-15 scores, above which there were nonlinear increases in reported pain.
Topics: Adult; Chronic Pain; Electromyography; Female; Humans; Male; Masseter Muscle; Myalgia; Perception; Temporal Muscle
PubMed: 35708459
DOI: 10.1177/00220345221099885