-
Annals of Internal Medicine Jun 2015
Topics: Encephalomyelitis; Fatigue Syndrome, Chronic; Humans; Myalgia; Prevalence; Terminology as Topic; United States
PubMed: 26075760
DOI: 10.7326/M15-0647 -
Lipids in Health and Disease Aug 2020Whether high-intensity statin treatment provides more clinical benefits compared with standard statin regimens in acute coronary syndrome (ACS) patients remains... (Meta-Analysis)
Meta-Analysis Review
BACKGROUND
Whether high-intensity statin treatment provides more clinical benefits compared with standard statin regimens in acute coronary syndrome (ACS) patients remains controversial. This meta-analysis aimed to comparatively assess high-intensity and standard statin regimens for efficacy and safety in patients with ACS.
METHODS
The PubMed, EMBASE, and Cochrane Library databases were searched for studies assessing high-intensity vs. standard statin regimens for ACS treatment from inception to April 2020. The publication language was limited to English, and 16 randomized controlled trials were finally included in this study, with a total of 26,497 patients.
RESULTS
Compared to the standard statin regimens, the relative ratio (RR) of major adverse cardiovascular events (MACE) in ACS patients treated by high-intensity statin was 0.77 (95%CI, 0.68-0.86; P < 0.00001; prediction interval, 0.56-1.07). In subgroup analysis, high-intensity statin therapy resulted in more clinical benefits regarding MACE compared with standard statin treatment in both Asian (RR = 0.77; 95%CI, 0.61-0.98; P = 0.03) and non-Asian (RR = 0.79; 95%CI, 0.71-0.89; P < 0.0001) patients. Although adverse events were acceptable in patients with ACS administered high-intensity statin therapy, this treatment was associated with a higher rate of adverse events (4.99% vs. 2.98%), including myopathy/myalgia and elevated liver enzymes, as reflected by elevated serum aminotransferase or aminotransferase amounts.
CONCLUSION
The current findings indicated that high-intensity statin therapy might be beneficial in patients with ACS, and close monitoring for adverse effects should be performed.
Topics: Acute Coronary Syndrome; Asian People; Databases as Topic; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Muscular Diseases; Myalgia
PubMed: 32829708
DOI: 10.1186/s12944-020-01369-6 -
Revista Da Escola de Enfermagem Da U S P Nov 2018Describe the clinical-epidemiological profile of hospitalized elderly patients with arbovirus.
OBJECTIVE
Describe the clinical-epidemiological profile of hospitalized elderly patients with arbovirus.
METHOD
A documentary retrospective population-based descriptive study that used a quantitative approach with hospitalized elderly patients diagnosed with arbovirus was conducted in a teaching hospital. Data were collected from medical records and investigation forms.
RESULTS
Thirty-three elderly patients participated in this study. A prevalence of dengue was observed, with fever, myalgia, and arthralgia. Arterial hypertension and diabetes were the comorbidities. Statistically significant correlations were obtained between arbovirus and schooling, employment situation, marital status, test results, and use of analgesics; and between the site of arthralgia and Chikungunya.
CONCLUSION
The results support nursing care to hospitalized elderly patients with arbovirus, allowing the development of a proper and humanized care plan.
Topics: Aged; Aged, 80 and over; Arthralgia; Chikungunya Fever; Dengue; Female; Fever; Hospitalization; Hospitals, Teaching; Humans; Male; Middle Aged; Myalgia; Prevalence; Retrospective Studies
PubMed: 30517293
DOI: 10.1590/S1980-220X2017052103403 -
The Journal of Headache and Pain Dec 2017The aim of this study was to investigate cytokine levels in the masseter muscle, their response to experimental tooth-clenching and their relation to pain, fatigue and...
BACKGROUND
The aim of this study was to investigate cytokine levels in the masseter muscle, their response to experimental tooth-clenching and their relation to pain, fatigue and psychological distress in patients with temporomandibular disorders (TMD) myalgia.
METHODS
Forty women, 20 with TMD myalgia (Diagnostic Criteria for TMD) and 20 age-matched healthy controls participated. Intramuscular microdialysis was performed to sample masseter muscle cytokines. After 140 min (baseline), a 20-minute tooth-clenching task was performed (50% of maximal voluntary contraction force). Pain (Numeric rating scale 0-10) and fatigue (Borg's Ratings of Perceived Exertion 6-20) were assessed throughout microdialysis, while pressure-pain thresholds (PPT) were assessed before and after microdialysis. Perceived stress (PSS-10) and Trait Anxiety (STAI) were assessed before microdialysis.
RESULTS
The levels of IL-6, IL-7, IL-8 and IL-13 were higher in patients than controls (Mann Whitney U-test; P's < 0.05) during the entire microdialysis. IL-6, IL-8 and IL-13 changed during microdialysis in both groups (Friedman; P's < 0.05), while IL-1β, IL-7 and GM-CSF changed only in patients (P's < 0.01). IL-6 and IL-8 increased in response to tooth-clenching in both groups (Wilcoxon test; P's < 0.05), while IL-7, IL-13 and TNF increased only in patients (P's < 0.05). Patients had higher pain and fatigue than controls before and after tooth-clenching (P < 0.001), and lower PPTs before and after microdialysis (P < 0.05). There were no correlations between cytokine levels, pain or fatigue. Also, there were no differences in stress or anxiety levels between groups.
CONCLUSIONS
In conclusion, the masseter levels of IL-6, IL-7, IL-8 and IL-13 were elevated in patients with TMD myalgia and increased in response to tooth-clenching. Tooth-clenching increased jaw muscle pain and fatigue, but without correlations to cytokine levels. This implies that subclinical muscle inflammation may be involved in TMD myalgia pathophysiology, but that there is no direct cause-relation between inflammation and pain.
Topics: Adult; Bruxism; Cytokines; Facial Pain; Female; Humans; Inflammation; Masseter Muscle; Microdialysis; Myalgia; Temporomandibular Joint Disorders
PubMed: 28243900
DOI: 10.1186/s10194-017-0737-y -
BMC Musculoskeletal Disorders Mar 2014Shoulder pain is common in the general population. Reports on specific diagnoses in general populations are scarce and only from primary care. The diagnostic...
BACKGROUND
Shoulder pain is common in the general population. Reports on specific diagnoses in general populations are scarce and only from primary care. The diagnostic distribution of shoulder disorders in secondary care is not reported. Most of the clinical research in the shoulder field is done in hospital settings. The aim of this study was to identify the diagnoses in a 1-year cohort in a hospital-based outpatient clinic using standardized diagnostic criteria and to compare the results with previous studies.
METHODS
A diagnostic routine was conducted among patients referred to our physical medicine outpatient clinic at Oslo University Hospital. Diagnostic criteria were derived from the literature and supplemented with research criteria.
RESULTS
Of 766 patients diagnosed, 55% were women and the mean age was 49 years (range 19-93, SD ± 14). The most common diagnoses were subacromial pain (36%), myalgia (17%) and adhesive capsulitis (11%). Subacromial pain and adhesive capsulitis were most frequent in persons aged 40-60 years. Shoulder myalgia was most frequent in age groups under 40. Labral tears and instability problems (8%) were most frequent in young patients and not present after age 50. Full-thickness rotator cuff tears (8%) and glenohumeral osteoarthritis (4%) were more prevalent after the age of 60. Few differences were observed between sexes. We identified three studies reporting shoulder diagnoses in primary care.
CONCLUSION
Subacromial pain syndrome, myalgia and adhesive capsulitis were the most prevalent diagnoses in our study. However, large differences in prevalence between different studies were found, most likely arising from different use of diagnostic criteria and a difference in populations between primary and secondary care. Of the diagnoses in our cohort, 20% were not reported by the studies from primary care (glenohumeral osteoarthritis, full thickness rotator cuff tears, labral tears and instabilities).
Topics: Acromioclavicular Joint; Adolescent; Adult; Age Distribution; Aged; Aged, 80 and over; Bursitis; Female; Humans; International Classification of Diseases; Male; Middle Aged; Myalgia; Norway; Osteoarthritis; Outpatient Clinics, Hospital; Prevalence; Prospective Studies; Rotator Cuff Injuries; Secondary Care; Sex Distribution; Shoulder Impingement Syndrome; Shoulder Joint; Shoulder Pain; Young Adult
PubMed: 24642168
DOI: 10.1186/1471-2474-15-89 -
The New England Journal of Medicine Jun 2017A 22-year-old man presented to the emergency department on Christmas Day with a 5-day history of myalgias, cough, dyspnea, nonbilious emesis, and nonbloody diarrhea....
A 22-year-old man presented to the emergency department on Christmas Day with a 5-day history of myalgias, cough, dyspnea, nonbilious emesis, and nonbloody diarrhea. Although he had been ill for several days, he ultimately sought treatment because of intractable vomiting. He reported feeling feverish, although he had not measured his temperature, and noted one episode of hemoptysis.
Topics: Anti-Bacterial Agents; Diagnosis, Differential; Diarrhea; Humans; Jaundice, Obstructive; Leptospira interrogans; Leptospirosis; Lipase; Lung; Lung Diseases; Male; Myalgia; Radiography; Tomography, X-Ray Computed; Young Adult
PubMed: 28564558
DOI: 10.1056/NEJMcps1610072 -
International Journal of Environmental... Mar 2020This study investigates the types and degrees of physical and psychological discomfort experienced by hematopoietic stem cell donors before, during, and after the...
This study investigates the types and degrees of physical and psychological discomfort experienced by hematopoietic stem cell donors before, during, and after the donation process in order to provide helpful information for developing education programs that can help donors to cope with their discomforts. One hundred and thirty-one individuals who donated hematopoietic stem cells from 2017 to 2019 were asked to self-report the types and degrees of physical and psychological discomfort they felt in the process, and the results were analyzed using SPSS. All participants donated peripheral blood stem cells; the most commonly reported physical discomfort was myalgia (72.5%), followed by bone pain (62.6%), fatigue (60.3%), and headache (55.0%). Of the donors, 88.5% responded that they experienced psychological discomforts, including fear (44.3%), anxiety (44.3%), stress (39.7%), depression (31.3%), loneliness (31.3%), regret (29.8%), and ambivalence (23.7%). In particular, female donors experienced more discomfort than males in rash (Z = -2.123, = 0.034), fear (Z = -2.851, = 0.004), and anxiety (Z = -1.861, = 0.044). Therefore, it is necessary for healthcare providers and experts to make efforts to educate and help donors to prepare and mitigate their discomfort throughout the donation process, and to strategically manage donors' well-being by monitoring and evaluating their discomfort levels and providing interventions if necessary.
Topics: Adult; Anxiety; Fatigue; Fear; Female; Hematopoietic Stem Cell Transplantation; Humans; Male; Middle Aged; Myalgia; Tissue Donors; Young Adult
PubMed: 32235487
DOI: 10.3390/ijerph17072316 -
Exercise and Sport Sciences Reviews Jul 2017Work-related physical activity (PA), in terms of peak loads and sustained and/or repetitive contractions, presents risk factors for the development of muscular pain and... (Review)
Review
Work-related physical activity (PA), in terms of peak loads and sustained and/or repetitive contractions, presents risk factors for the development of muscular pain and disorders. However, PA as a training tailored to the employee's work exposure, health, and physical capacity offers prevention and rehabilitation. We suggest the concept of "Intelligent Physical Exercise Training" relying on evidence-based sports science training principles.
Topics: Exercise; Exercise Therapy; Humans; Musculoskeletal Diseases; Myalgia; Occupational Diseases; Physical Conditioning, Human; Risk Factors; Workplace
PubMed: 28418998
DOI: 10.1249/JES.0000000000000112 -
Exercise and Sport Sciences Reviews Oct 2020The prolonged impairment in muscle strength, power, and fatigue resistance after eccentric exercise has been ascribed to a plethora of mechanisms, including delayed... (Review)
Review
The prolonged impairment in muscle strength, power, and fatigue resistance after eccentric exercise has been ascribed to a plethora of mechanisms, including delayed muscle refueling and microvascular and mitochondrial dysfunction. This review explores the hypothesis that local heat therapy hastens functional recovery after strenuous eccentric exercise by facilitating glycogen resynthesis, reversing vascular derangements, augmenting mitochondrial function, and stimulating muscle protein synthesis.
Topics: Adaptation, Physiological; Animals; Exercise; Glycogen; Hot Temperature; Humans; Microcirculation; Mitochondria, Muscle; Muscle Fatigue; Muscle Proteins; Muscle Strength; Muscle, Skeletal; Myalgia
PubMed: 32658042
DOI: 10.1249/JES.0000000000000230 -
Journal of the American Medical... Jan 2023We examined the impact of loss of skeletal muscle mass in post-acute sequelae of SARS-CoV-2 infection, hospital readmission rate, self-perception of health, and health... (Observational Study)
Observational Study
OBJECTIVE
We examined the impact of loss of skeletal muscle mass in post-acute sequelae of SARS-CoV-2 infection, hospital readmission rate, self-perception of health, and health care costs in a cohort of COVID-19 survivors.
DESIGN
Prospective observational study.
SETTING AND PARTICIPANTS
Tertiary Clinical Hospital. Eighty COVID-19 survivors age 59 ± 14 years were prospectively assessed.
METHODS
Handgrip strength and vastus lateralis muscle cross-sectional area were evaluated at hospital admission, discharge, and 6 months after discharge. Post-acute sequelae of SARS-CoV-2 were evaluated 6 months after discharge (main outcome). Also, health care costs, hospital readmission rate, and self-perception of health were evaluated 2 and 6 months after hospital discharge. To examine whether the magnitude of muscle mass loss impacts the outcomes, we ranked patients according to relative vastus lateralis muscle cross-sectional area reduction during hospital stay into either "high muscle loss" (-18 ± 11%) or "low muscle loss" (-4 ± 2%) group, based on median values.
RESULTS
High muscle loss group showed greater prevalence of fatigue (76% vs 46%, P = .0337) and myalgia (66% vs 36%, P = .0388), and lower muscle mass (-8% vs 3%, P < .0001) than low muscle loss group 6 months after discharge. No between-group difference was observed for hospital readmission and self-perceived health (P > .05). High muscle loss group demonstrated greater total COVID-19-related health care costs 2 ($77,283.87 vs. $3057.14, P = .0223, respectively) and 6 months ($90,001.35 vs $12, 913.27, P = .0210, respectively) after discharge vs low muscle loss group. Muscle mass loss was shown to be a predictor of total COVID-19-related health care costs at 2 (adjusted β = $10, 070.81, P < .0001) and 6 months after discharge (adjusted β = $9885.63, P < .0001).
CONCLUSIONS AND IMPLICATIONS
COVID-19 survivors experiencing high muscle mass loss during hospital stay fail to fully recover muscle health. In addition, greater muscle loss was associated with a higher frequency of post-acute sequelae of SARS-CoV-2 and greater total COVID-19-related health care costs 2 and 6 months after discharge. Altogether, these data suggest that the loss of muscle mass resulting from COVID-19 hospitalization may incur in an economical burden to health care systems.
Topics: Humans; Middle Aged; Aged; COVID-19; SARS-CoV-2; Myalgia; Hand Strength; Post-Acute COVID-19 Syndrome; Hospitalization; Health Care Costs; Survivors; Muscles; Fatigue
PubMed: 36493804
DOI: 10.1016/j.jamda.2022.11.013