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Polish Journal of Pathology : Official... Jun 2014Elastofibromas are slow-growing and rare soft-tissue tumors. The etiology and pathogenetic mechanisms are still controversial and there are only a few studies in the...
Elastofibromas are slow-growing and rare soft-tissue tumors. The etiology and pathogenetic mechanisms are still controversial and there are only a few studies in the literature investigating the histochemical, immunohistochemical, and genetic features to determine the pathogenesis. We investigated the cellular composition of lesions with a diagnosis of elastofibroma in 17 patients by using histochemical and immunohistochemical methods. There were 17 cases with a mean age of 53.5 years. Mean lesion diameter was 6.6 cm. The immunohistochemical method showed vimentin and factor XIIIa positivity in all cases. Four cases had focal myoglobin positivity in the spindle-shaped cells between the collagen fibers. Spindle cells were positive for CD34 in 8 cases. Smooth muscle actin, desmin, type 4 collagen and laminin were negative in all cases. The elastic nature of the abnormal fibers was shown histoch with Verhoeff elastin staining and aldehyde fuchsin staining in all cases. Our results have shown that the concurrent positivity of factor XIIIa and CD34 in the cells forming the lesion might show that the lesionoriginates from primitive dermal mesenchymal cells. In addition, the myoglobin positivity found in some cases indicates the possibility of a myofibroblastic origin of elastofibromas.
Topics: Adult; Aged; Biomarkers, Tumor; Biopsy; Cell Lineage; Female; Fibroma; Humans; Immunohistochemistry; Male; Middle Aged; Predictive Value of Tests; Retrospective Studies; Soft Tissue Neoplasms; Tumor Burden
PubMed: 25119171
DOI: 10.5114/pjp.2014.43961 -
Ugeskrift For Laeger Sep 2014Elastofibroma dorsi (ED) is a benign, slow-growing soft tissue pseudo-tumor and is regarded as rare. The aetiology is unclear and ED is often associated with only...
Elastofibroma dorsi (ED) is a benign, slow-growing soft tissue pseudo-tumor and is regarded as rare. The aetiology is unclear and ED is often associated with only distinct symptoms. This case report describes a 55-year-old woman with bilateral ED, who underwent surgical treatment with great result. Some prevalence studies suggest that ED is more common than previously assumed, and on suspicion of a low diagnostic rate the importance of sufficient primary examination is therefore emphasized, especially since surgical treatment of symptomatic ED is associated with fine results in case of symptoms, and low complication rate.
Topics: Female; Fibroma; Humans; Magnetic Resonance Imaging; Middle Aged; Scapula; Soft Tissue Neoplasms
PubMed: 25294509
DOI: No ID Found -
Einstein (Sao Paulo, Brazil) 2015Storiform collagenoma is a rare tumor, which originates from the proliferation of fibroblasts that show increased production of type-I collagen. It is usually found in...
Storiform collagenoma is a rare tumor, which originates from the proliferation of fibroblasts that show increased production of type-I collagen. It is usually found in the face, neck and extremities, but it can also appear in the trunk, scalp and, less frequently, in the oral mucosa and the nail bed. It affects both sexes, with a slight female predominance. It may be solitary or multiple, the latter being an important marker for Cowden syndrome. It presents as a painless, solid nodular tumor that is slow-growing. It must be considered in the differential diagnosis of other well-circumscribed skin lesions, such as dermatofibroma, pleomorphic fibroma, sclerotic lipoma, fibrolipoma, giant cell collagenoma, benign fibrous histiocytoma, intradermal Spitz nevus and giant cell angiohistiocytoma.
Topics: Adult; Collagen Diseases; Diagnosis, Differential; Fibroma; Hamartoma Syndrome, Multiple; Humans; Male; Skin Neoplasms; Treatment Outcome
PubMed: 25993076
DOI: 10.1590/S1679-45082015RC2907 -
The Pan African Medical Journal 2022Breast fibromatosis is a benign breast tumor of mesenchymal origin, accounting for 0.2% of breast tumors. This study reports two cases of breast fibromatosis... (Review)
Review
Breast fibromatosis is a benign breast tumor of mesenchymal origin, accounting for 0.2% of breast tumors. This study reports two cases of breast fibromatosis highlighting its diagnostic, morphological, therapeutic and evolutionary features. In both cases, this tumor clinically and radiologically mimicked a cancer. Diagnostic confirmation was based on histological examination. Breast fibromatosis was characterized by local progression and a tendency to recurrence, hence the role of surgical excision with free surgical margins in our patients. The role of locoregional treatments (radiotherapy and cryotherapy) and medical treatments, in particular anti-estrogen therapy, is not clearly defined. In conclusion, breast fibromatosis must be known as it mimicks breast cancer and is characterized by a very high recurrence rate, without ever developing metastases.
Topics: Breast Neoplasms; Female; Fibroma; Fibromatosis, Aggressive; Humans; Margins of Excision
PubMed: 35655675
DOI: 10.11604/pamj.2022.41.184.28549 -
Journal of Pediatric Hematology/oncology Apr 2024The plexiform fibromyxoma is a rare mesenchymal tumor in adults that generally originates in the antrum of stomach, being its occurrence in pediatric patients...
The plexiform fibromyxoma is a rare mesenchymal tumor in adults that generally originates in the antrum of stomach, being its occurrence in pediatric patients exceptional. It was classified as a distinct entity by World Health Organization in 2010. No recurrences and metastases have been documented in many of the reported patients to date, being the surgical treatment curative. We report the case of a 3-month-old infant who presented to the emergency department with an episode of intestinal subocclusion requiring an emergent surgery. During the surgical intervention, a mass was identified in the jejunum, causing partial occlusion of its lumen. The surgical pathology report revealed an infiltrative tumor composed of spindle-shaped cells disposed in a stroma with a plexiform pattern alternating myxoid areas. These findings and the immunohistochemical characteristics of the neoplastic cells led to classify the tumor as a plexiform fibromyxoma. A description of the immunophenotype of this tumor is made and differential diagnosis with other gastrointestinal tumors is also discussed.
Topics: Humans; Infant; Fibroma; Soft Tissue Neoplasms; Stomach Neoplasms
PubMed: 38408159
DOI: 10.1097/MPH.0000000000002833 -
Journal of Clinical Pathology Aug 1982A series of nine cases of fibroma of tendon sheath is described including details of the ultrastructural features of two cases. The series was composed of lesions from...
A series of nine cases of fibroma of tendon sheath is described including details of the ultrastructural features of two cases. The series was composed of lesions from six males and three females with a mean age of 38 yr. The most common site of involvement was the hand (including fingers) and the mean greater diameter was 19 mm. Typically the tumours were lobulated and microscopically there was a collagenous stroma with spindle and stellate cells in a moderate degree of cellularity. One recurrence was noted in the series. The lesion was distinguished from circumscribed fibromatosis, nodular fasciitis, neurofibroma, leiomyoma, scar tissue, giant cell tumour of tendon sheath (localised nodular tenosynovitis) and fibrous histiocytoma. Ultrastructural studies revealed that the large majority of cells present in the two cases studied were myofibroblasts and fibroma of tendon sheath is therefore the third instance of a benign tumour containing these cells (the other two being dermatofibroma and giant cell fibroma of the oral mucosa).
Topics: Adolescent; Adult; Aged; Female; Fibroma; Hand; Humans; Knee; Male; Microscopy, Electron; Middle Aged; Muscular Diseases; Neoplasm Recurrence, Local; Tendons
PubMed: 7107956
DOI: 10.1136/jcp.35.8.842 -
The Pan African Medical Journal 2017Elastofibroma dorsi (ED) is an uncommon benign soft tissue tumor with an uncertain pathogenesis. It mostly occurs in the infrascapular region of elderly people with a... (Review)
Review
Elastofibroma dorsi (ED) is an uncommon benign soft tissue tumor with an uncertain pathogenesis. It mostly occurs in the infrascapular region of elderly people with a female predominance. Typically bilateral, ED can also be unilateral. While many patients remain asymptomatic, ED can be responsible of a periscapular arch source of ache. The diagnosis of ED is set on magnetic resonance imaging, and the pathological study ensures the diagnosis after surgical excision and establishes the differential diagnosis with malignant neoplasic process. The prognosis is excellent with extremely rare recurrence cases. Herein we report a case of a 54-years-old woman with a bilateral painful ED. The diagnosis was based on clinical and MRI findings that revealed bilateral tumors. Surgery was decided due to the symptomatic nature of the tumors. Pathological study confirmed the diagnosis. The post operative course was uncomplicated. We update through a review of the literature aspects of the diagnostic and therapeutic care of Elastofibroma dorsi.
Topics: Diagnosis, Differential; Female; Fibroma; Humans; Magnetic Resonance Imaging; Middle Aged; Prognosis; Scapula; Soft Tissue Neoplasms
PubMed: 29158858
DOI: 10.11604/pamj.2017.28.34.13675 -
Indian Heart Journal 2012Cardiac tumours in infancy are rare and are mostly benign with rhabdomyomas, fibromas and teratomas accounting for the majority. The presentation depends on size and... (Review)
Review
Cardiac tumours in infancy are rare and are mostly benign with rhabdomyomas, fibromas and teratomas accounting for the majority. The presentation depends on size and location of the mass as they tend to cause cavity obstruction or arrhythmias. Most rhabdomyomas tend to regress spontaneously but fibromas and teratomas generally require surgical intervention for severe haemodynamic or arrhythmic complications. Other relatively rare cardiac tumours too are discussed along with an Indian perspective.
Topics: Age Factors; Cardiac Surgical Procedures; Fibroma; Heart Neoplasms; Humans; India; Infant; Infant, Newborn; Neoplasm Regression, Spontaneous; Prognosis; Rhabdomyoma; Teratoma
PubMed: 23102388
DOI: 10.1016/j.ihj.2012.05.004 -
Asian Journal of Surgery May 2024
Topics: Humans; Fibroma; Mandibular Neoplasms; Odontogenic Tumors
PubMed: 38350778
DOI: 10.1016/j.asjsur.2024.01.177 -
The Kaohsiung Journal of Medical... May 2024
Topics: Humans; Mesentery; Male; Female; Tomography, X-Ray Computed; Fibromatosis, Abdominal; Fibroma; Peritoneal Neoplasms; Middle Aged
PubMed: 38426273
DOI: 10.1002/kjm2.12817