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British Medical Journal (Clinical... May 1988
Topics: Female; Humans; Lorazepam; Middle Aged; Pancytopenia
PubMed: 3133076
DOI: No ID Found -
Tidsskrift For Den Norske Laegeforening... Nov 2019
Topics: Female; Humans; Pancytopenia; Pregnancy; Pregnancy Complications
PubMed: 31746163
DOI: 10.4045/tidsskr.19.0022 -
Zhongguo Fei Ai Za Zhi = Chinese... Jan 2010Lymphomatoid granulomatosis (LG) is an angiocentric lymphoproliferative disease. It usually involves lung, skin, and central nervous system, but splenomegaly and...
Lymphomatoid granulomatosis (LG) is an angiocentric lymphoproliferative disease. It usually involves lung, skin, and central nervous system, but splenomegaly and pancytopenia are the rare manifestations of the disease. We report a 15-year-old boy presented with fever, dry cough and dyspnea from two months ago, after admission patient had nodular lesions on the left leg and hepatosplenomegaly. Then he manifested neurologic signs such as seizure, aphasia and right-sided hemiplegia. Chest X-ray and CT scan revealed bilateral pulmonary nodules predominantly in lower lobes and peripheral lung fields. Laboratory exams showed pancytopenia. Skin biopsy was done, and histopathological examination and immunohistochemistry evaluation confirmed lymphomatoid granulomatosis. He was treated with steroid and cyclophosphamide but succumbed by neurologic involvement.
Topics: Adolescent; Humans; Lymphomatoid Granulomatosis; Male; Pancytopenia; Radiography; Splenomegaly
PubMed: 20672711
DOI: 10.3779/j.issn.1009-3419.2010.01.17 -
The Pan African Medical Journal 2018Primary hyperoxaluria is a rare disease whose incidence is estimated at less than 1 cases/million inhabitants/year. This is a congenital abnormality of hepatic...
Primary hyperoxaluria is a rare disease whose incidence is estimated at less than 1 cases/million inhabitants/year. This is a congenital abnormality of hepatic metabolism leading to an endogenous overproduction of oxalate with excess urinary excretion. We report the case of a 43-year-old patient, was followed to end-stage renal disease hemodialysis, consulting for anemic syndrome with mucocutaneous pallor. Laboratory tests found pancytopenia with aplastic anemia. Bone marrow was difficult to achieve, bringing medullary blood hyperdilué and uninterpretable . Radiographs showed a homogeneous splenomegaly and small dedifferentiated a kidney marrow biopsy was performed. Histological examination revealed a myelofibrosis and birefringent crystals in polarized light, diagnosis retained: spinal oxalosis.
Topics: Adult; Anemia, Aplastic; Biopsy; Female; Humans; Hyperoxaluria, Primary; Kidney Failure, Chronic; Pancytopenia; Renal Dialysis; Splenomegaly
PubMed: 30100963
DOI: 10.11604/pamj.2018.29.209.14055 -
Methotrexate-induced toxidermia and pancytopenia in a patient with ectopic pregnancy: a case report.Journal of Medical Case Reports Dec 2021Methotrexate is an anticancer drug from the antimetabolite class. It is also used in gynecology and obstetrics and is the molecule of choice for the medical treatment of...
BACKGROUND
Methotrexate is an anticancer drug from the antimetabolite class. It is also used in gynecology and obstetrics and is the molecule of choice for the medical treatment of ectopic pregnancies. We report a case of toxidermia associated with severe pancytopenia induced by methotrexate for ectopic pregnancy.
CASE PRESENTATION
A 30-year-old Malagasy (African) woman was admitted to the Emergency and Intensive Care Department for probable toxidermia following injection of 75 mg of methotrexate for an ectopic pregnancy. She had developed generalized erythema, which started 48 hours after the injection. The secondary onset of phlyctenular maculopapular skin lesions, generalized purpura, and erosions of the oral mucosa in a context of febrile jaundice prompted her hospitalization. On admission, the patient presented with febrile neutropenia, pancytopenia, renal failure, and hepatic cytolysis. She received transfusions of fresh whole blood, erythromycin, and amphotericin B. The course was fatal within 2 days of hospitalization. The patient died of multiple organ failure.
CONCLUSIONS
Our case is mainly distinguished by the lack of use of granulocyte growth factors and folinic acid. In the event of severe reactions to methotrexate, the management should be multidisciplinary and as much as possible within an intensive care unit.
Topics: Adult; Female; Humans; Immunosuppressive Agents; Leucovorin; Methotrexate; Pancytopenia; Pregnancy; Pregnancy, Ectopic
PubMed: 34872594
DOI: 10.1186/s13256-021-03111-x -
Ghana Medical Journal Mar 2020The use of methotrexate in routine clinical practice is becoming more common among specialties such as rheumatology, dermatology, oncology and obstetrics. General...
UNLABELLED
The use of methotrexate in routine clinical practice is becoming more common among specialties such as rheumatology, dermatology, oncology and obstetrics. General clinicians are increasingly encountering patients on this drug. Though it has a high safety profile, there is a recognised risk of acute toxicity or long-term complications associated with its use, which can be worsened by several factors such as advanced age, moderate to severe renal impairment, low folate level and/or inadequate folate supplementation, hypoalbuminaemia, polypharmacy causing drug-drug interactions and wrongful administration. We present a case of a 45-year old woman with rheumatoid arthritis who presented with acute pancytopaenia and mucositis due to methotrexate toxicity. We highlight its peculiar dosing regimen to minimise prescribing errors.
FUNDING
None.
Topics: Arthritis, Rheumatoid; Drug Interactions; Female; Humans; Medication Errors; Methotrexate; Middle Aged; Mucositis; Pancytopenia
PubMed: 32863415
DOI: 10.4314/gmj.v54i1.10 -
The American Journal of Tropical... Jan 2020
Topics: Alopecia; Deception; Delusional Parasitosis; Humans; Pancytopenia; Self-Injurious Behavior
PubMed: 31701863
DOI: 10.4269/ajtmh.19-0755 -
Archives of Disease in Childhood Jul 1992Two young children whose presentation with necrobacillosis caused considerable diagnostic difficulty resulting in referral to an oncology unit are described. In both...
Two young children whose presentation with necrobacillosis caused considerable diagnostic difficulty resulting in referral to an oncology unit are described. In both cases their severe suppurative multisystem illness was complicated by pancytopenia. One had bone marrow infarcts and severe endocarditis in addition to pulmonary involvement and the other had osteitis which resulted in a deformed humerus.
Topics: Anti-Bacterial Agents; Bone Marrow Examination; Child, Preschool; Drug Therapy, Combination; Female; Fusobacterium Infections; Fusobacterium necrophorum; Humans; Male; Pancytopenia
PubMed: 1519964
DOI: 10.1136/adc.67.7.958 -
African Health Sciences Jun 2021Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy and is characterised by hyperproliferation of malignant lymphocytes in the bone marrow....
BACKGROUND
Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy and is characterised by hyperproliferation of malignant lymphocytes in the bone marrow. Rarely, ALL may be preceded by a period of pancytopenia and bone marrow hypoplasia which spontaneously recovers. This phenomenon, which has not before been described in T-cell ALL, is referred to as transient bone marrow hypoplasia.
CASE PRESENTATION
A 5-year-old boy who presented with high-grade fever and generalised lymphadenopathy, was found to have pancytopenia on peripheral blood count and bone marrow hypoplasia. He was observed over a one-month period during which his bone marrow and peripheral blood counts recovered spontaneously. Symptoms recurred after 4 months and he was found to have blast infiltration of the bone marrow and diagnosed with T-cell ALL.
CONCLUSION
Cases of transient bone marrow hypoplasia or overt aplastic anemia with spontaneous recovery and then followed by B-cell ALL or Acute Myeloid Leukemia have been described previously in the medical literature. This is the first case of transient bone marrow hypoplasia resulting into ALL of T-cell immunophenotype. While marrow hypoplasia preceding ALL remains poorly understood, it suggests an antecedent environmental insult to lymphoid progenitors or a germline abnormality that predisposes to lymphoid dysplasia. This may provide clues to the hitherto unknown pathophysiological process and etiological factors that precede the majority of childhood ALL cases. This case enlightens pediatricians about the existence of such rare cases so as to periodically follow up children with pancytopenia and/or bone marrow hypoplasia for prolonged periods even after apparent recovery.
Topics: Bone Marrow Cells; Child, Preschool; Humans; Male; Outcome Assessment, Health Care; Pancytopenia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; T-Lymphocytes
PubMed: 34795723
DOI: 10.4314/ahs.v21i2.25 -
Transplant Immunology Oct 2023Mutations in the DNA ligase IV (LIG4) gene cause a rare autosomal recessive disorder called LIG4 deficiency syndrome. The LIG4 deficiency is featured by severe...
BACKGROUND
Mutations in the DNA ligase IV (LIG4) gene cause a rare autosomal recessive disorder called LIG4 deficiency syndrome. The LIG4 deficiency is featured by severe disorders, including combined immunodeficiency disease, special face ("bird-head-like" face), developmental delays, pancytopenia, and radiosensitivity. Currently there are no curative treatment options except potentially by performing a hematopoietic stem cell transplantation (HSCT).
CASE PRESENTATION
Here we reported the clinical course of a 4 and 1/2-year-old Chinese female with LIG4-deficiency featured with pancytopenia, severe growth retardation (weight of 13.5 kg, < 3rd percentile), length of 100 cm (<2d percentile), head circumference of 46 cm (<3rd percentile), and mild microcephaly. Despite regular IVIG administrations (5 g, once a month), the patient's thrombocytopenia had progressed. Eventually, the patient received HSCT that successfully normalized the LIG4 syndrome associated pancytopenia and corrected the LIG4 mutation. Despite progress the patient succumbed to thrombotic microangiopathy more than 3 months after HSCT.
CONCLUSIONS
This case reports an example of partially successful HSCT as a treatment option for LIG4 syndrome. It is possible that individual factors influence the therapeutic effect of HSCT in LIG4 deficiency.
Topics: Female; Humans; Pancytopenia; Immunologic Deficiency Syndromes; Growth Disorders; Hematopoietic Stem Cell Transplantation
PubMed: 37437665
DOI: 10.1016/j.trim.2023.101897