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American Journal of Transplantation :... Mar 2016Obesity is often associated with the development of adipose tissue (AT) inflammation, resulting in metabolic dysfunction and an increased risk for developing type 2... (Review)
Review
Obesity is often associated with the development of adipose tissue (AT) inflammation, resulting in metabolic dysfunction and an increased risk for developing type 2 diabetes. It is also associated with multiple chronic diseases, including cardiovascular, liver, and kidney disease, and thus can contribute to organ failure. Several studies have investigated whether there is a correlation between obesity and outcomes in transplantation, but there is currently very limited information on the specific role of AT inflammation in the rejection process or on the overall function of the transplanted organ. Here, we provide a brief review of the current understanding of the cellular mechanisms that control obesity-associated AT inflammation and summarize knowledge about how obesity affects clinical outcomes following solid organ or hematopoietic stem cell transplantation. We also highlight opportunities for more research to better understand how obesity affects outcomes of transplantation.
Topics: Adipose Tissue; Animals; Graft Rejection; Humans; Obesity; Organ Transplantation; Panniculitis
PubMed: 26755439
DOI: 10.1111/ajt.13578 -
European Radiology Dec 2016Systematic review to determine any association between imaging features of idiopathic mesenteric panniculitis (MP) and subsequent malignancy. (Review)
Review
OBJECTIVES
Systematic review to determine any association between imaging features of idiopathic mesenteric panniculitis (MP) and subsequent malignancy.
METHODS
Two researchers searched primary literature independently for imaging studies of MP. They extracted data focusing on methodology for unbiased patient accrual and capability to determine a link between MP and subsequent malignancy. They noted imaging features of MP. Data were accrued and meta-analysis intended.
RESULTS
Fourteen of 675 articles were eligible; 1,226 patients. Only three (21 %) accrued patients prospectively. Twelve (86 %) studies described CT features. Follow-up varied widely; 1 month to 8 years. Prevalence of MP was influenced by accrual: 0.2 % for keyword search versus 1.7 % for consecutive series. Accrual bias affected nine (64 %) studies. 458 (38 %) of 1,209 patients had malignancy at accrual but varied widely (8-89 %), preventing meta-analysis. Sixty (6.4 %) of 933 patients developed new malignancy subsequently, also varying widely (0-11 %). Of just four studies that determined the proportion of unselected, consecutive patients with MP developing subsequent malignancy, three were retrospective and the fourth excluded patients with lymphadenopathy, likely excluding patients with MP.
CONCLUSION
Studies were heterogeneous, with biased accrual. No available study can determine an association between MP and subsequent malignancy with certainty.
KEY POINTS
• Our systematic review of mesenteric panniculitis found that imaging studies were biased. • Spectrum and recruitment bias was largely due to retrospective study designs. • No study could confirm a certain link between mesenteric panniculitis and subsequent malignancy. • Excessive methodological heterogeneity precluded meaningful meta-analysis. • High-quality research linking mesenteric panniculitis imaging features and subsequent malignancy is needed.
Topics: Bias; Humans; Panniculitis, Peritoneal; Peritoneal Neoplasms; Prevalence; Retrospective Studies; Risk; Tomography, X-Ray Computed
PubMed: 27048526
DOI: 10.1007/s00330-016-4298-2 -
BMJ Case Reports Oct 2015
Topics: Abdominal Pain; Cholangiopancreatography, Magnetic Resonance; Female; Humans; Panniculitis; Retroperitoneal Space; Tomography, X-Ray Computed; Young Adult
PubMed: 26491006
DOI: 10.1136/bcr-2015-212670 -
BMJ Case Reports Jan 2015
Topics: Aged, 80 and over; Carcinoma; Female; Humans; Pancreatic Neoplasms; Panniculitis; Paraneoplastic Syndromes
PubMed: 25631757
DOI: 10.1136/bcr-2014-206980 -
Haematologica Oct 2023Germline HAVCR2 mutations are frequently detected in subcutaneous panniculitis-like T-cell lymphoma (SPTCL) patients with/without hemophagocytic lymphohistiocytosis... (Meta-Analysis)
Meta-Analysis
Germline mutations and their relation to the clinical spectrum of subcutaneous panniculitis-like T-cell lymphoma and hemophagocytic lymphohistiocytosis: results from a multicenter study and meta-analysis.
Germline HAVCR2 mutations are frequently detected in subcutaneous panniculitis-like T-cell lymphoma (SPTCL) patients with/without hemophagocytic lymphohistiocytosis (HLH) but factors associated with variable manifestations remain undetermined. To evaluate clinical variations and associated factors in SPTCL and/or HLH with/without HAVCR2 mutations, we performed direct sequencing of HAVCR2 exon 2 using DNA from patients with SPTCL or idiopathic HLH/HLH-like systemic illnesses, defined by HLH alone without secondary causes. The systematic review and individual patient data (IPD) level meta-analysis which included the present and previously published studies reporting HAVCR2 mutations in SPTCL with/without HLH populations was subsequently conducted using random-effects meta-analysis and multivariate logistic regression. Among 34 patients enrolled, ten of 28 SPTCL patients developed HLH/HLH-like systemic illnesses. Six cases with HAVCR2Y82C mutation manifested with HLH without panniculitis. Male sex (P=0.03) and age <18 years (P=0.04) were associated with HLH, corresponding to the inverse correlation between age and HLH-2004 score (r=-0.40; P=0.02). Homozygous HAVCR2Y82C mutation was more common in the presence of HLH compared with the absence (75.0% vs. 44.4%; P=0.02). Using IPD from the present and the other three eligible cohorts (N=127), male sex, heterozygous and homozygous/compound heterozygous HAVCR2 mutations were associated with HLH by the adjusted odds ratio of 2.93 (95% confidence interval [CI]: 1.22-7.06), 4.77 (95% CI: 1.05-21.63) and 8.48 (95% CI: 2.98-24.10), respectively. Patients with male sex and/or germline HAVCR2 mutations showed an increased risk of developing HLH. Younger patients tended to manifest with HLH, while older patients typically presented with SPTCL with less frequent HLH/HLH-like systemic illnesses.
Topics: Humans; Male; Adolescent; Lymphohistiocytosis, Hemophagocytic; Panniculitis; Germ-Line Mutation; Germ Cells; Hepatitis A Virus Cellular Receptor 2; Multicenter Studies as Topic
PubMed: 37051767
DOI: 10.3324/haematol.2022.282419 -
Journal of the American Veterinary... Aug 2018
Topics: Animals; Cat Diseases; Cats; Diagnosis, Differential; Escherichia coli; Escherichia coli Infections; Female; Panniculitis; Pedigree; Tail; Tinea
PubMed: 30020009
DOI: 10.2460/javma.253.3.287 -
Annals of the Rheumatic Diseases Apr 1987Two cases of Weber-Christian panniculitis with onset at 7 months and 3 years 6 months are described. Both show evidence of disturbances in immune mechanisms. The family...
Two cases of Weber-Christian panniculitis with onset at 7 months and 3 years 6 months are described. Both show evidence of disturbances in immune mechanisms. The family of the first case has a high prevalence of coeliac disease, and the mother of the first patient also suffers from alopecia areata and dermatitis herpetiformis.
Topics: Child, Preschool; Humans; Infant; Male; Panniculitis, Nodular Nonsuppurative; Pedigree
PubMed: 3592792
DOI: 10.1136/ard.46.4.339 -
Archives of Pathology & Laboratory... Oct 2014Neutrophilic panniculitis encompasses an etiologically and morphologically heterogeneous group of disorders. Correct histopathologic diagnosis is important in... (Review)
Review
CONTEXT
Neutrophilic panniculitis encompasses an etiologically and morphologically heterogeneous group of disorders. Correct histopathologic diagnosis is important in identifying certain systemic diseases and guiding appropriate treatment.
OBJECTIVE
To review the clinical and histopathologic features of different types of neutrophilic panniculitis, and to provide a diagnostic algorithm for these disorders.
DATA SOURCES
A review of the literature with emphasis on the distinguishing features of different entities was performed.
CONCLUSIONS
Evaluation for neutrophilic panniculitis entails paying close attention to the pattern of inflammation, the type of fat necrosis present, any evidence of vascular damage, and other relevant histopathologic features. An algorithmic approach integrating all histopathologic, clinical, and laboratory findings is required for correct diagnosis.
Topics: Adipose Tissue; Arthritis, Rheumatoid; Decision Trees; Diagnosis, Differential; Erythema Induratum; Erythema Nodosum; Fat Necrosis; Humans; Neutrophils; Pancreatitis; Panniculitis; Subcutaneous Fat; Sweet Syndrome; Vasculitis; alpha 1-Antitrypsin Deficiency
PubMed: 25268197
DOI: 10.5858/arpa.2014-0270-CC -
Archives of Pathology & Laboratory... Nov 2017Primary cutaneous acral CD8 T-cell lymphoma is a new provisional entity in the 2016 revision of the World Health Organization classification of lymphoid neoplasms. This... (Review)
Review
Primary cutaneous acral CD8 T-cell lymphoma is a new provisional entity in the 2016 revision of the World Health Organization classification of lymphoid neoplasms. This is a challenging diagnosis because of its rarity, as well as its morphologic and immunophenotypic overlap with other CD8 cytotoxic lymphoid proliferations. Appropriate classification of this entity is crucial because of its indolent clinical behavior compared with other CD8 T-cell lymphomas. Knowledge of the clinical setting, sites of involvement, and morphologic features can aid in correct diagnosis. Here, we review the clinical and pathologic features of primary cutaneous acral CD8 T-cell lymphoma with an emphasis on the differential diagnosis among other C8 T-cell lymphomas.
Topics: Biomarkers, Tumor; CD8-Positive T-Lymphocytes; Diagnosis, Differential; Extremities; Humans; Immunohistochemistry; Immunophenotyping; Lymphoma, T-Cell; Lymphoma, T-Cell, Cutaneous; Panniculitis; Prognosis
PubMed: 29072952
DOI: 10.5858/arpa.2017-0230-RA -
Indian Journal of Dermatology,... 2020
Review
Topics: Adult; Anti-Inflammatory Agents; Antimetabolites, Antineoplastic; Humans; Lymphoma, T-Cell; Male; Methotrexate; Panniculitis; Prednisolone; Skin Neoplasms
PubMed: 31975700
DOI: 10.4103/ijdvl.IJDVL_635_18