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BMJ Case Reports Sep 2021Subcutaneous panniculitis-like T cell lymphoma (SPTCL) is a rare cutaneous T cell malignancy of cytotoxic T cell origin. It is frequently associated with autoimmune... (Review)
Review
Subcutaneous panniculitis-like T cell lymphoma (SPTCL) is a rare cutaneous T cell malignancy of cytotoxic T cell origin. It is frequently associated with autoimmune diseases. It is known to preferentially involve subcutaneous adipose tissue and histologically resembles lupus panniculitis. The aetiology and risk factors of SPTCL are unclear and there are limited studies available since this entity was initially described in 2001. There are even fewer case reports describing the association between SPTCL and chronic lymphocytic leukemia (CLL). In this article, we present a case of SPTCL arising during treatment for CLL. We conducted an extensive review of literature to delve into the possible risk factors for SPTCL development in association with CLL, including pre-existing haematological malignancies, autoimmune conditions, immunomodulation and immunosuppressive chemotherapy.
Topics: Humans; Immunosuppressive Agents; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, T-Cell; Panniculitis; Panniculitis, Lupus Erythematosus
PubMed: 34580127
DOI: 10.1136/bcr-2021-243490 -
Indian Journal of Dermatology,... 2010
Topics: Adult; Antirheumatic Agents; Diagnosis, Differential; Female; Glucocorticoids; Humans; Hydroxychloroquine; Panniculitis, Lupus Erythematosus; Prednisolone
PubMed: 20657144
DOI: 10.4103/0378-6323.66612 -
The Journal of Clinical Investigation Apr 2018Obesity is a major risk factor for insulin resistance and type 2 diabetes. In adipose tissue, obesity-mediated insulin resistance correlates with the accumulation of...
Obesity is a major risk factor for insulin resistance and type 2 diabetes. In adipose tissue, obesity-mediated insulin resistance correlates with the accumulation of proinflammatory macrophages and inflammation. However, the causal relationship of these events is unclear. Here, we report that obesity-induced insulin resistance in mice precedes macrophage accumulation and inflammation in adipose tissue. Using a mouse model that combines genetically induced, adipose-specific insulin resistance (mTORC2-knockout) and diet-induced obesity, we found that insulin resistance causes local accumulation of proinflammatory macrophages. Mechanistically, insulin resistance in adipocytes results in production of the chemokine monocyte chemoattractant protein 1 (MCP1), which recruits monocytes and activates proinflammatory macrophages. Finally, insulin resistance (high homeostatic model assessment of insulin resistance [HOMA-IR]) correlated with reduced insulin/mTORC2 signaling and elevated MCP1 production in visceral adipose tissue from obese human subjects. Our findings suggest that insulin resistance in adipose tissue leads to inflammation rather than vice versa.
Topics: 3T3-L1 Cells; Animals; Chemokine CCL2; Diabetes Mellitus, Type 2; Humans; Inflammation; Insulin Resistance; Intra-Abdominal Fat; Macrophages; Mechanistic Target of Rapamycin Complex 2; Mice; Mice, Knockout; Obesity; Panniculitis; Signal Transduction
PubMed: 29528335
DOI: 10.1172/JCI96139 -
Journal of Postgraduate Medicine 2023Pancreatic panniculitis is a rare disease characterized by subcutaneous fat necrosis. It could be the result of an associated pancreatic tumor. Herein, we reported a...
Pancreatic panniculitis is a rare disease characterized by subcutaneous fat necrosis. It could be the result of an associated pancreatic tumor. Herein, we reported a 63-year-old man who presented with progressive bilateral lower limb edema accompanied with nodule-like lesions for 1 month. His serum lipase was 3,927 U/L (normal, 0-160 U/L). Histopathology of the skin specimen revealed lobular panniculitis, favoring a diagnosis of pancreatic panniculitis. Abdominal computed tomography (CT) scan with contrast showed a huge mass in his left upper quadrant. Endoscopic ultrasound showed a mixed echoic tumor, measuring 11.9 × 7.8 cm in dimensions, originating from the pancreatic tail. Biopsy performed via an endoscopic ultrasound showed a poorly differentiated acinar cell carcinoma. Because of the unresectable status of the tumor, the patient underwent chemotherapy with paclitaxel and gemcitabine. After chemotherapy, his skin lesions improved progressively. It is important to treat pancreatic panniculitis with its underlying pancreatic disease.
Topics: Male; Humans; Middle Aged; Panniculitis; Pancreatic Neoplasms; Skin Diseases; Biopsy; Necrosis
PubMed: 36537394
DOI: 10.4103/jpgm.jpgm_136_22 -
Chinese Medical Journal Aug 2020
Topics: Humans; Lupus Erythematosus, Systemic; Panniculitis; Panniculitis, Lupus Erythematosus; Scalp; Scalp Dermatoses
PubMed: 32769493
DOI: 10.1097/CM9.0000000000000959 -
Internal Medicine (Tokyo, Japan) Mar 1999
Review
Topics: Antineoplastic Combined Chemotherapy Protocols; Drug Therapy, Combination; Histiocytes; Histiocytosis; Humans; Immunosuppressive Agents; Panniculitis; Treatment Outcome
PubMed: 10337930
DOI: 10.2169/internalmedicine.38.224 -
The Pan African Medical Journal 2019Weber christian's disease or idiopathic panniculitis is a rare condition characterized by an inflammation of the subcutaneous adipose tissue; it is a non-specific...
Weber christian's disease or idiopathic panniculitis is a rare condition characterized by an inflammation of the subcutaneous adipose tissue; it is a non-specific pathological condition that remains a central issue of debate and whose outcome is unpredictable. We here report the case of a 9-month-old female infant admitted in the hospital with sepsis preceded by respiratory symptoms and followed by the occurrence of small, hard, susceptible, asymmetrical erythematous subcutaneous nodes located in the arms and lower limbs. Cutaneous biopsy showed lobular hypodermitis with polymorphonuclear neutrophil infiltrations. The diagnosis of Weber Christian's disease was retained after eliminating other differential diagnoses. The patient was treated with prednisone with good outcome; during the follow-up period and during disease regression the diagnosis of B-cell acute lymphoblastic leukemia was made; this uncommon outcome has never been described in the literature. The aim of this study is to discuss any similar situation where another diagnosis was made in patients initially treated for idiopathic lobular panniculitis. This highlights the need for exhaustive etiological investigations and prolonged monitoring in order to search for a possible associated disorder.
Topics: Anti-Inflammatory Agents; Biopsy; Diagnosis, Differential; Female; Follow-Up Studies; Humans; Infant; Panniculitis, Nodular Nonsuppurative; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Sepsis; Subcutaneous Fat; Treatment Outcome
PubMed: 31223415
DOI: 10.11604/pamj.2019.32.127.16106 -
Arteriosclerosis, Thrombosis, and... Jan 2021Smooth muscle cells and pericytes display remarkable plasticity during injury and disease progression. Here, we tested the hypothesis that perivascular cells give rise...
OBJECTIVE
Smooth muscle cells and pericytes display remarkable plasticity during injury and disease progression. Here, we tested the hypothesis that perivascular cells give rise to -dependent macrophage-like cells that augment adipose tissue (AT) inflammation and metabolic dysfunction associated with diet-induced obesity (DIO). Approach and Results: Using eYFP (enhanced yellow fluorescent protein) mice and flow cytometry of the stromovascular fraction of epididymal AT, we observed a large fraction of smooth muscle cells and pericytes lineage traced eYFP cells expressing macrophage markers. Subsequent single-cell RNA sequencing, however, showed that the majority of these cells had no detectable eYFP transcript. Further exploration revealed that intraperitoneal injection of tamoxifen in peanut oil, used for generating conditional knockout or reporter mice in thousands of previous studies, resulted in large increase in the autofluorescence and false identification of macrophages within epididymal AT as being eYFP; and unintended proinflammatory consequences. Using newly generated tdTomato mice given oral tamoxifen, we virtually eliminated the problem with autofluorescence and identified 8 perivascular cell dominated clusters, half of which were altered upon DIO. Given that perivascular cell KLF4 (kruppel-like factor 4) can have beneficial or detrimental effects, we tested its role in obesity-associated AT inflammation. While smooth muscle cells and pericytes-specific knockout (smooth muscle cells and pericytes ) mice were not protected from DIO, they displayed improved glucose tolerance upon DIO, and showed marked decreases in proinflammatory macrophages and increases in LYVE1 lymphatic endothelial cells in the epididymal AT.
CONCLUSIONS
Perivascular cells within the AT microvasculature dynamically respond to DIO and modulate tissue inflammation and metabolism in a KLF4-dependent manner.
Topics: Adipose Tissue; Animals; Blood Glucose; Cell Lineage; Cell Plasticity; Diet, High-Fat; Disease Models, Animal; Endothelial Cells; Inflammation Mediators; Insulin Resistance; Kruppel-Like Factor 4; Kruppel-Like Transcription Factors; Macrophages; Male; Mice, Knockout; Myocytes, Smooth Muscle; Obesity; Panniculitis; Pericytes; Mice
PubMed: 33054397
DOI: 10.1161/ATVBAHA.120.314703 -
Actas Dermo-sifiliograficas Nov 2020
Topics: Adult; Biopsy; COVID-19; Eosinophilia; Female; Humans; Panniculitis; SARS-CoV-2; Skin
PubMed: 32450058
DOI: 10.1016/j.ad.2020.05.003 -
Anais Brasileiros de Dermatologia 2022Pseudomonas aeruginosa is a Gram-negative bacillus that frequently causes septicemia, abscesses and infections in skin wounds. Panniculitis caused by this microorganism... (Review)
Review
Pseudomonas aeruginosa is a Gram-negative bacillus that frequently causes septicemia, abscesses and infections in skin wounds. Panniculitis caused by this microorganism is unusual and there are few well-documented cases, none of them in a patient with systemic lupus erythematosus. The present report describes an immunosuppressed patient with systemic lupus erythematosus who developed panniculitis caused by Pseudomonas aeruginosa, with a review of the literature on this rare presentation.
Topics: Humans; Immunocompromised Host; Lupus Erythematosus, Systemic; Panniculitis; Pseudomonas aeruginosa; Skin Diseases, Infectious
PubMed: 35272923
DOI: 10.1016/j.abd.2020.09.018