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European Journal of Immunology Apr 2023Recurrent respiratory papillomatosis (RRP), a rare chronic disease caused primarily by human papillomavirus types 6 and 11, consists of repeated growth of premalignant...
Recurrent respiratory papillomatosis (RRP), a rare chronic disease caused primarily by human papillomavirus types 6 and 11, consists of repeated growth of premalignant papillomas in the airway. RRP is characterized by multiple abnormalities in innate and adaptive immunity. Natural killer (NK) cells play important roles in immune surveillance and are part of the innate immune responses that help prevent tumor growth. We identified that papillomas lack classical class I MHC and retain nonclassical class I MHC expression. Moreover, in this study, we have identified and characterized the mechanism that blocks NK cell targeting of papilloma cells. Here, we show for the first time that the PGE secreted by papilloma cells directly inhibits NK cells activation/degranulation principally through the PGE receptor EP2, and to a lesser extent through EP4 signaling. Thus, papilloma cells have a potent mechanism to block NK cell function that likely supports papilloma cell growth.
Topics: Humans; Dinoprostone; Papillomavirus Infections; Respiratory Tract Infections; Killer Cells, Natural; Papilloma
PubMed: 36608264
DOI: 10.1002/eji.202250036 -
European Annals of Otorhinolaryngology,... Jun 2018The objectives of this study were to describe the epidemiological, clinical and therapeutic characteristics of laryngeal papillomatosis in the Fann teaching hospital ENT...
OBJECTIVES
The objectives of this study were to describe the epidemiological, clinical and therapeutic characteristics of laryngeal papillomatosis in the Fann teaching hospital ENT department in Dakar, Senegal.
PATIENTS AND METHODS
We retrospectively reviewed all cases of laryngeal papillomatosis managed in the Fann teaching hospital ENT department between 1st January 2006 and 31st December 2015. Epidemiological, clinical and therapeutic characteristics of laryngeal papillomatosis were studied. Statistical analysis was performed with SPSS 18 software.
RESULTS
The median age at diagnosis was 11 years and the sex ratio was 1.88. The mean time to consultation was 4.5 years. The predominant symptom was dysphonia, present in all cases, followed by laryngeal dyspnoea in 64.6% of cases. The glottic area was involved in all patients. Tracheostomy was performed in 20.8% of cases. All patients in our study underwent endoscopic excision of the lesions.
CONCLUSION
Laryngeal papillomatosis is the most common benign tumor in children, but it can also occur in adults. Treatment has been revolutionized by progress in endoscopy and antiviral therapy. However, tracheostomy still occupies an important place in our practice.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Female; Humans; Laryngeal Neoplasms; Male; Middle Aged; Papilloma; Retrospective Studies; Senegal; Young Adult
PubMed: 29396224
DOI: 10.1016/j.anorl.2018.01.002 -
The Pan African Medical Journal 2018Limb lymphedemas are due to a malfunction of the lymphatic system responsible for lymph stasis in the interstitial tissue and secondarily to an increase in the volume of...
Limb lymphedemas are due to a malfunction of the lymphatic system responsible for lymph stasis in the interstitial tissue and secondarily to an increase in the volume of the affected limb. They are divided into primary lymphedema (PL) and secondary lymphedema (SL). SLs develop most frequently in lower limbs after breast cancer treatment while lymphedemas are either secondary (iatrogenic or infectious) or primitive, most often sporadic, sometimes familial or they can be part of syndromes resulting in malformations and/or more complex genetics in upper limbs. The diagnosis of lymphedema is essentially based on clinical examination. Erysipelas are the main complication of lymphedema. Other abnormalities are often visible: yellowish skin and nails, lymphangiectasias, keratotic papules with papillomatosis, lichenified plaques. The main differential diagnosis in patients with limb lymphedema is lipoedema, defined as body fat distribution from the hips up to the ankles and affecting almost exclusively obese women. We report the case of a 30 year old man with left lower limb lymphedema occurred at puberty complicated by verrucous papillomatosis. It is a late-revelation congenital lymphedema.
Topics: Adult; Diagnosis, Differential; Erysipelas; Humans; Lower Extremity; Lymphedema; Male; Papilloma
PubMed: 31448007
DOI: 10.11604/pamj.2018.31.251.16166 -
Current Biology : CB Oct 2004Recent years have seen an inexplicable increase in the frequency of an appalling disease in sea turtles: fibropapillomatosis, which is likely caused by a herpesvirus and... (Review)
Review
Recent years have seen an inexplicable increase in the frequency of an appalling disease in sea turtles: fibropapillomatosis, which is likely caused by a herpesvirus and causes tumors to grow throughout the turtle's body. New research has led to the disturbing conclusion that recent, human-induced environmental changes are responsible.
Topics: Animals; Environment; Herpesviridae; Papilloma; Phylogeny; Seawater; Turtles
PubMed: 15458663
DOI: 10.1016/j.cub.2004.09.038 -
Tuberkuloz Ve Toraks Sep 2023Endobronchial solitary papillomas are extremely rare lung neoplasms originating from the bronchial surface epithelium. They often present with cough or recurrent...
Endobronchial solitary papillomas are extremely rare lung neoplasms originating from the bronchial surface epithelium. They often present with cough or recurrent hemoptysis. These tumors are benign, but they should be followed closely because they may even have a low probability of malignant transformation features. It should be kept in mind that malignancy may develop especially if the patient is a smoker. Although the etiology is not known for certain, it is thought to be caused by human papillomavirus in some cases. A 43-year-old male patient was admitted with a complaint of chronic cough. Rigid bronchoscopy was performed for diagnostic and therapeutic purposes after imaging techniques revealed a lesion obstructing the lumen of the right main bronchus. The pathology result was reported as mixed bronchial papilloma. We aimed to present our case because of its rarity and to indicate that chronic cough must be further evaluated.
Topics: Male; Humans; Adult; Cough; Bronchial Neoplasms; Bronchi; Bronchoscopy; Papilloma
PubMed: 37740634
DOI: 10.5578/tt.20239712 -
The British Journal of Ophthalmology Jul 2001To examine conjunctival papillomas for the presence of human papillomavirus (HPV) and koilocytosis.
AIM
To examine conjunctival papillomas for the presence of human papillomavirus (HPV) and koilocytosis.
METHODS
Archival paraffin embedded tissue from 55 conjunctival papillomas was analysed for the presence of HPV by polymerase chain reaction and subsequent filter hybridisation. Histological sections of the 55 papillomas were evaluated for the presence of koilocytosis.
RESULTS
HPV was present in 48 of 52 (92%) beta globin positive papillomas. HPV type 6/11 were found in 40 of 47 investigated papillomas and a double infection with HPV 6/11 and 16 was identified in a single papilloma. In six papillomas the HPV type could not be identified. Koilocytosis was present in 22 of 55 papillomas (40%).
CONCLUSION
There is a strong association between HPV and conjunctival papillomas. HPV type 6/11 is the most common HPV type in conjunctival papilloma. The sensitivity of koilocytosis as an indicator of HPV in conjunctival papilloma is low.
Topics: Adult; Aged; Aged, 80 and over; Conjunctiva; Conjunctival Neoplasms; DNA, Viral; Female; Humans; Male; Middle Aged; Papilloma; Papillomaviridae; Polymerase Chain Reaction; Retrospective Studies
PubMed: 11423448
DOI: 10.1136/bjo.85.7.785 -
Scientific Reports Dec 2020Recent advances in the field of biomedical research allow for elucidation of the transcriptional signature of rare tumors such as conjunctival squamous cell carcinoma... (Comparative Study)
Comparative Study
Recent advances in the field of biomedical research allow for elucidation of the transcriptional signature of rare tumors such as conjunctival squamous cell carcinoma (SCC). In this study we compare its expression profile to conjunctival papilloma (Pap) and healthy conjunctival tissue (Ctrl) and develop a classification tool to differentiate these entities. Seven conjunctival SCC, seven Pap and ten Ctrl were formalin-fixed and paraffin-embedded (FFPE) and analyzed using Massive Analysis of cDNA Ends (MACE) RNA sequencing. Differentially expressed genes (DEG) and gene ontology (GO) clusters were explored and the abundance of involved cell types was quantified by xCell. Finally, a classification model was developed to distinguish SCC from Pap and Ctrl. Among the most prominent DEG in SCC a plethora of keratins were upregulated when compared to Pap and Ctrl. xCell analysis revealed an enrichment of immune cells, including activated dendritic cells and T-helper type 1 cells (Th1), in SCC when compared to Ctrl. The generated classification model could reliably discriminate between the three entities according to the expression pattern of 30 factors. This study provides a transcriptome-wide gene expression profile of rare conjunctival SCC. The analysis identifies distinct keratins, as well as dendritic and Th1 cells as important mediators in SCC. Finally, the provided gene expression classifier may become an aid to the conventional histological classification of conjunctival tumors in uncertain cases.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Carcinoma, Squamous Cell; Case-Control Studies; Conjunctival Neoplasms; Female; Gene Expression Profiling; Humans; Male; Middle Aged; Papilloma; Sequence Analysis, RNA; Transcriptome; Young Adult
PubMed: 33277602
DOI: 10.1038/s41598-020-78339-6 -
The Tokai Journal of Experimental and... Apr 2021Most maxillary sinus papillomas are confirmed when they have extended beyond the nasal cavity and are rarely found while localized in the maxillary sinus. We experienced...
Most maxillary sinus papillomas are confirmed when they have extended beyond the nasal cavity and are rarely found while localized in the maxillary sinus. We experienced two cases of localized papilloma in the maxillary sinus. Case 1 was a 69-year-old man with a localized left maxillary sinus lesion detected during a routine imaging examination. As the lesion was likely to be papilloma, we recommended that the patient undergo diagnostic surgery, which he refused. He experienced bloody rhinorrhea 1 year and 9 months after the first visit, and computed tomography (CT) showed increased lesions and bone destruction. Histological examinations revealed squamous cell carcinoma ex inverted papilloma. He died 5 years after the first visit. Case 2 was a 46-year-old woman in whom positron emission tomography/CT showed a localized right maxillary sinus lesion. Tissue biopsy results indicated oncocytic papilloma. Endoscopic resection was performed later. On an imaging examination, sinonasal papilloma was determined accidentally to be a localized lesion of the maxillary sinus. A detailed interpretation of the CT scan was useful in estimating sinonasal papilloma. Tissue biopsy or diagnostic surgery should be performed when sinonasal papilloma is suspected during appropriate image evaluation.
Topics: Aged; Biopsy; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Fatal Outcome; Female; Humans; Incidental Findings; Male; Maxillary Sinus Neoplasms; Middle Aged; Papilloma; Tomography, X-Ray Computed; Treatment Outcome; Treatment Refusal
PubMed: 33835470
DOI: No ID Found -
Clinical Nuclear Medicine Oct 2020Biliary papillomatosis is a rare disease with high malignant potential. A 64-year-old woman underwent FDG PET/CT, which showed an intense FDG uptake in the location of...
Biliary papillomatosis is a rare disease with high malignant potential. A 64-year-old woman underwent FDG PET/CT, which showed an intense FDG uptake in the location of an aggregated biliary papillomatosis with high-grade intraepithelial neoplasia/carcinoma in situ but did not show FDG uptake in the sporadic, small biliary papilloma. FDG PET/CT may be an effective method to identify the components of the malignant transformation of biliary papillomatosis.
Topics: Bile Duct Neoplasms; Fluorodeoxyglucose F18; Humans; Male; Middle Aged; Neoplasm Grading; Papilloma; Positron Emission Tomography Computed Tomography
PubMed: 32804763
DOI: 10.1097/RLU.0000000000003243 -
Ceska a Slovenska Oftalmologie :... 2018The etiology of papilloma formation is multifactorial. There is a strong association between human papillomavirus (HPV) and the development of these conjunctival...
UNLABELLED
The etiology of papilloma formation is multifactorial. There is a strong association between human papillomavirus (HPV) and the development of these conjunctival lesions. HPV is tumorigenic and commonly produces benign tumors with low malignant potential. Papillomas rarely go through malignant transformation.
MATERIAL AND METHODS
Retrospective study of patients with a diagnosis of conjunctival papilloma or squamous cell carcinoma.
RESULTS
From a collection of 125 patients with conjunctival non-pigmented tumours in the period from 2007 to 2017, in 119 (95.2%) patients histological examination confirmed papilloma and in 6 (4.8%) patients it confirmed carcinoma. Of the total number of patients, 39 were women (31.2%) and 86 men (68.8%). The mean age of patients was 68.4 years (range 20-94 years). Localization of lesions: bulbar conjunctiva - 65 (52.0%), upper eyelid tarsal conjunctiva + fornix - 6 (4.8%), lower eyelid + fornix - 27 (21.6%), caruncle - 20 (16.0%) and plica semilunaris - 7 (5.6%) patients. In the patient cohort we recorded 2 papillomas that were transformed into squamous cell carcinoma. HPV16 was positive in these patients, the carcinomas were from the area of the bulbar conjunctiva, and the surgical solution was associated with the perioperative administration of Mitomycin C. In one case, the inverted papilloma developed into orbital carcinoma within 2 years of primary excision, and the patient underwent radical surgical procedure (partial exenteration of the orbit) followed by radiotherapy.
CONCLUSION
Transformation of the papilloma into the carcinoma is rare, but it must always be taken into consideration in case of a recurrence of the disease. HPV can infect the conjunctiva. The ophthalmologist, in collaboration with a pathologist, may recommend appropriate laboratory tests to confirm the diagnosis. Long-term outpatient follow-up of patients after excision of the conjunctival papilloma is also necessary. Key words: epibulbar tumors, conjunctival tumors, papilloma, carcinoma.
Topics: Adult; Aged; Aged, 80 and over; Carcinoma, Squamous Cell; Conjunctival Neoplasms; Female; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Papilloma; Papillomavirus Infections; Retrospective Studies; Young Adult
PubMed: 30650971
DOI: 10.31348/2018/1/2-3-2018