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Molecules (Basel, Switzerland) Feb 2023The -AB-corrole series was prepared starting with 5-(pentafluorophenyl)dipyrromethene, which was then reacted with respective aryl-substituted aldehyde by Gryko...
The -AB-corrole series was prepared starting with 5-(pentafluorophenyl)dipyrromethene, which was then reacted with respective aryl-substituted aldehyde by Gryko synthesis. It was further characterized by HRMS and electrochemical methods. In addition, we investigated experimental photophysical properties (absorption, emission by steady-state and time-resolved fluorescence) in several solvents and TDDFT calculations, aggregation, photostability and reactive oxygen species generation (ROS), which are relevant when selecting photosensitizers used in photodynamic therapy and many other photo-applications. In addition, we also evaluated the biomolecule-binding properties with CT-DNA and HSA by spectroscopy, viscometry and molecular docking calculations assays.
Topics: Molecular Docking Simulation; Porphyrins; Photochemotherapy; Photobiology
PubMed: 36771053
DOI: 10.3390/molecules28031385 -
Current Biology : CB Oct 2005Red light triggers asexual development and represses sexual development in the fungus Aspergillus nidulans. This response has been shown to require a phytochrome... (Review)
Review
Red light triggers asexual development and represses sexual development in the fungus Aspergillus nidulans. This response has been shown to require a phytochrome red/far-red light photoreceptor, FphA, which is cytoplasmic and binds a tetrapyrrole chromophore. FphA exhibits similarities to both plant and bacterial phytochromes.
Topics: Aspergillus nidulans; Light; Photobiology; Photoreceptor Cells; Phytochrome; Reproduction, Asexual; Sexual Maturation
PubMed: 16243020
DOI: 10.1016/j.cub.2005.10.001 -
Biophysical Reviews Aug 2022'Ecological photobiology' session of the Russian Photobiology Society 9th Congress was devoted to a wide range of problems related to the assessment of the environmental... (Review)
Review
'Ecological photobiology' session of the Russian Photobiology Society 9th Congress was devoted to a wide range of problems related to the assessment of the environmental state by photobiological methods and included oral presentations and a poster session. A short survey of these presentations is given.
PubMed: 36124263
DOI: 10.1007/s12551-022-00955-5 -
Biochimica Et Biophysica Acta Feb 2005Photogenerated short-lived radical pairs (RP) are common in biological photoprocesses such as photosynthesis and enzymatic DNA repair. They can be favorably probed by... (Review)
Review
Photogenerated short-lived radical pairs (RP) are common in biological photoprocesses such as photosynthesis and enzymatic DNA repair. They can be favorably probed by time-resolved electron paramagnetic resonance (EPR) methods with adequate time resolution. Two EPR techniques have proven to be particularly useful to extract information on the working states of photoinduced biological processes that is only difficult or sometimes even impossible to obtain by other types of spectroscopy. Firstly, transient EPR yields crucial information on the chemical nature and the geometry of the individual RP halves in a doublet-spin pair generated by a short laser pulse. This time-resolved method is applicable in all magnetic field/microwave frequency regimes that are used for continuous-wave EPR, and is nowadays routinely utilized with a time resolution reaching about 10 ns. Secondly, a pulsed EPR method named out-of-phase electron spin echo envelope modulation (OOP-ESEEM) is increasingly becoming popular. By this pulsed technique, the mutual spin-spin interaction between the RP halves in a doublet-spin pair manifests itself as an echo modulation detected as a function of the microwave-pulse spacing of a two-pulse echo sequence subsequent to a laser pulse. From the dipolar coupling, the distance between the radicals is readily derived. Since the spin-spin interaction parameters are typically not observable by transient EPR, the two techniques complement each other favorably. Both EPR methods have recently been applied to a variety of light-induced RPs in photobiology. This review summarizes the results obtained from such studies in the fields of plant and bacterial photosynthesis and DNA repair mediated by the enzyme DNA photolyase.
Topics: DNA Repair; Deoxyribodipyrimidine Photo-Lyase; Electron Spin Resonance Spectroscopy; Free Radicals; Lasers; Microwaves; Models, Chemical; Photobiology; Photosynthesis; Protein Conformation
PubMed: 15721610
DOI: 10.1016/j.bbabio.2004.03.012 -
The Journal of Investigative Dermatology Mar 2012The JID is a major resource for publishing dermatologic research. Here we document bibliometric systems that permit detailed analysis of JID's relative scientific... (Review)
Review
A review of the Journal of Investigative Dermatology's most cited publications over the past 25 years and the use of developing bibliometric methodologies to assess journal quality.
The JID is a major resource for publishing dermatologic research. Here we document bibliometric systems that permit detailed analysis of JID's relative scientific quality. We provide an overview of metrics employed by ISI Thomson Reuters Web of Knowledge and Elsevier's open-access Scopus to measure JID's comparative performance. We list JID's 50 most cited articles between 1986 and 2010 and summarize the six most cited papers published during this period. We conclude by showing how selected cited papers have influenced research in the JID subcategories of immunology/infection and photobiology during this period. JID has thrived as the strength of its editorial leadership and the quality of dermatologic science have grown apace.
Topics: Dermatology; Humans; Internet; Journal Impact Factor; Periodicals as Topic; Publishing; Search Engine
PubMed: 22330274
DOI: 10.1038/jid.2011.391 -
IUBMB Life Aug 2010This article reviews the current knowledge in photobiology and photomedicine about the influence of monochromatic, quasimonochromatic, and bread-band radiation of... (Review)
Review
This article reviews the current knowledge in photobiology and photomedicine about the influence of monochromatic, quasimonochromatic, and bread-band radiation of red-to-near infrared (IR-A) part on solar spectrum upon mammalian cells and human skin. The role of cytochrome c oxidase as the photoacceptor and photosignal transducer is underlined and its photosensitivity at certain circumstances is discussed. The role of ATP as a critical signaling molecule is discussed.
Topics: Animals; Cells; Electron Transport Complex IV; Humans; Infrared Rays
PubMed: 20681024
DOI: 10.1002/iub.359 -
Photochemistry and Photobiology Sep 2022Ultraviolet B-light (UVB) has been often used as a "physiological" UV in photobiology studies. How representative and equivalent these studies are compared to the effect...
Ultraviolet B-light (UVB) has been often used as a "physiological" UV in photobiology studies. How representative and equivalent these studies are compared to the effect of the sunlight is always of great interest. We now characterized the spectrum and intensity of two commonly used UV sources, a UVB lamp and a UVA-340 lamp which simulate the solar spectrum in the UVB/UVA range in the presence or absence of a UVB band pass filter that reduces >80% UVA from the UVA-340 lamp. The spectrum of each lamp was used in computational modeling for skin penetration. The effects of the lamps on endoplasmic reticulum (ER)-stress response and DNA damage in cultured keratinocytes HaCaT cells were analyzed. Our data show that the UVB lamp is a better inducer for both eIF2α phosphorylation and PERK modification, as well as a better reducer of ATF6 expression. The UVB lamp is also the best inducer of gamma-H2AX expression and cyclobutane pyrimidine dimers formation. However, the UVA-340 lamp is a better inducer for ATF4 expression. Our results indicate that different spectral characteristics of UV lamps can produce different results for the activation of the ER-stress responses and the differences do not always follow a defined pattern.
Topics: DNA Damage; Pyrimidine Dimers; Skin; Sunlight; Ultraviolet Rays
PubMed: 34932214
DOI: 10.1111/php.13585 -
Biomedical Optics Express Jul 2023Light can trigger electrical activity in certain types of cells, and is considered to be a better means of biological regulation than electrical stimulation in the...
Light can trigger electrical activity in certain types of cells, and is considered to be a better means of biological regulation than electrical stimulation in the future. Due to the specificity and selectivity of natural cells' photoresponse to optical signals, constructing an applicable method to explore which kinds of cells have photosensitivity and which bands of light could induce its photoresponse most effectively, is of great significance for lights' medical applications. This paper firstly proposed a universal and operable system and corresponding method to quantitatively measure and analyze photosensitivity of cells in vitro to weak pulse laser, which is constructed with Ca imaging module, adjustable laser lights module and laser positioning module. With the measurement system and method, the photosensitive effects of the natural spiral ganglion cells (SGCs) of mice are tested systemantically. Then a new photoresponse band of light (453 nm, 300 µs) is found for SGCs, and its minimum threshold is measured as 5.3 mJ/cm. The results verify that the proposed method is applicable to screen the cells with photosensitive response, as well as to measure and analyze the working optical parameters, thus is beneficial for the optical biophysics and photobiology.
PubMed: 37497496
DOI: 10.1364/BOE.494620 -
Frontiers in Plant Science 2017Rising temperatures during growing seasons coupled with altered precipitation rates presents a challenging task of improving crop productivity for overcoming such... (Review)
Review
Rising temperatures during growing seasons coupled with altered precipitation rates presents a challenging task of improving crop productivity for overcoming such altered weather patterns and cater to a growing population. Light is a critical environmental factor that exerts a powerful influence on plant growth and development ranging from seed germination to flowering and fruiting. Higher plants utilize a suite of complex photoreceptor proteins to perceive surrounding red/far-red (phytochromes), blue/UV-A (cryptochromes, phototropins, ZTL/FKF1/LKP2), and UV-B light (UVR8). While genomic studies have also shown that light induces extensive reprogramming of gene expression patterns in plants, molecular genetic studies have shown that manipulation of one or more photoreceptors can result in modification of agronomically beneficial traits. Such information can assist researchers to engineer photoreceptors via genome editing technologies to alter expression or even sensitivity thresholds of native photoreceptors for targeting aspects of plant growth that can confer superior agronomic value to the engineered crops. Here we summarize the agronomically important plant growth processes influenced by photoreceptors in crop species, alongwith the functional interactions between different photoreceptors and phytohormones in regulating these responses. We also discuss the potential utility of synthetic biology approaches in photobiology for improving agronomically beneficial traits of crop plants by engineering designer photoreceptors.
PubMed: 28744290
DOI: 10.3389/fpls.2017.01181 -
Annals of the Rheumatic Diseases Nov 1994
Topics: Humans; Lupus Erythematosus, Cutaneous; Photosensitivity Disorders
PubMed: 7826129
DOI: 10.1136/ard.53.11.705