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Sichuan Da Xue Xue Bao. Yi Xue Ban =... May 2022To explore the surgical safety of patients with comorbid non-small cell lung cancer (NSCLC) and pneumoconiosis.
OBJECTIVE
To explore the surgical safety of patients with comorbid non-small cell lung cancer (NSCLC) and pneumoconiosis.
METHODS
In this study, the clinical data of 165 NSCLC patients treated at West China Fourth Hospital, Sichuan University from August 2019 to May 2021 were collected. Among them, 21 patients with comorbid pneumoconiosis were included in the pneumoconiosis group, and the remaining 144 patients were included in the general group. Radical resection for lung cancer was performed in both groups. The perioperative clinical data, including preoperative, intraoperative and postoperative indicators, of the two groups were compared and analyzed.
RESULTS
There was no perioperative death in either group. The proportions of male patients and patients with smoking history in the pneumoconiosis group were significantly higher than those in the general group ( <0.05). The body mass index (BMI), pulmonary ventilation function and diffusion function in the pneumoconiosis group were significantly lower than those in the general group ( <0.05). There was no significant difference in the median operative time and the median volume of intraoperative blood loss between the pneumoconiosis group and the general group. In the pneumoconiosis group, the proportion of advanced tumors (stage Ⅱ/Ⅲ), incidence of postoperative complications, median duration of postoperative intubation, and postoperative length of hospital stay were higher/longer than those of the normal group ( <0.05). Compared with the general group, the incidences of lymph node calcification, dense pleural adhesion and surgical method alteration (switching from thoracoscopic surgery to open surgery or video-assisted thoracoscopy) were also significantly higher in the pneumoconiosis group ( <0.05). Univariate analysis showed that age, smoking history, pneumoconiosis, pulmonary ventilation dysfunction, lymph node calcification, dense pleural adhesion and the volume of intraoperative blood loss were the risk factors for postoperative complications. Further multivariate regression analysis demonstrated that smoking history ( =1.37, <0.05), lymph node calcification ( =2.36, <0.05) and pulmonary ventilation dysfunction ( =5.21, <0.05) were independent risk factors for postoperative complications.
CONCLUSION
NSCLC patients with comorbid pneumoconiosis face relatively greater risks during the perioperative period when they undergo radical resection for lung cancer. Therefore, the close attention of surgeons and the nursing staff should be raised accordingly.
Topics: Blood Loss, Surgical; Carcinoma, Non-Small-Cell Lung; Humans; Lung Neoplasms; Male; Perioperative Period; Pneumoconiosis; Postoperative Complications; Thoracic Surgery, Video-Assisted
PubMed: 35642159
DOI: 10.12182/20220560108 -
International Journal of Occupational... Oct 2014To explore the rate of pneumoconiosis in dental technicians (DTP) and to evaluate the risk factors.
OBJECTIVES
To explore the rate of pneumoconiosis in dental technicians (DTP) and to evaluate the risk factors.
MATERIAL AND METHODS
Data of 893 dental technicians, who were admitted to our hospital in the period January 2007-May 2012, from 170 dental laboratories were retrospectively examined. Demographic data, respiratory symptoms, smoking status, work duration, working fields, exposure to sandblasting, physical examination findings, chest radiographs, pulmonary function tests and high-resolution computed tomography results were evaluated.
RESULTS
Dental technicians' pneumoconiosis rate was 10.1% among 893 cases. The disease was more common among males and in those exposed to sandblasting who had 77-fold higher risk of DTP. The highest profusion subcategory was 3/+ (according to the International Labour Organization (ILO) 2011 standards) and the large opacity rate was 13.3%.
CONCLUSIONS
To the best of our knowledge, it was the largest DTP case series (N = 893/90) in the literature in English. Health screenings should be performed regularly for the early diagnosis of pneumoconiosis, which is an important occupational disease for dental technicians.
Topics: Adult; Dental Materials; Dental Technicians; Female; Humans; Male; Occupational Diseases; Occupational Exposure; Pneumoconiosis; Respiratory Function Tests; Risk Factors; Turkey
PubMed: 25216818
DOI: 10.2478/s13382-014-0301-9 -
Revista Portuguesa de Pneumologia 2017
Topics: Charcoal; Dust; Humans; Male; Middle Aged; Pneumoconiosis
PubMed: 28365221
DOI: 10.1016/j.rppnen.2017.02.006 -
Medicine Jun 2024The diagnosis of pneumoconiosis is complex and subjective, leading to inevitable variability in readings. This is especially true for inexperienced doctors. To improve... (Observational Study)
Observational Study
The diagnosis of pneumoconiosis is complex and subjective, leading to inevitable variability in readings. This is especially true for inexperienced doctors. To improve accuracy, a computer-assisted diagnosis system is used for more effective pneumoconiosis diagnoses. Three models (Resnet50, Resnet101, and DenseNet) were used for pneumoconiosis classification based on 1250 chest X-ray images. Three experienced and highly qualified physicians read the collected digital radiography images and classified them from category 0 to category III in a double-blinded manner. The results of the 3 physicians in agreement were considered the relative gold standards. Subsequently, 3 models were used to train and test these images and their performance was evaluated using multi-class classification metrics. We used kappa values and accuracy to evaluate the consistency and reliability of the optimal model with clinical typing. The results showed that ResNet101 was the optimal model among the 3 convolutional neural networks. The AUC of ResNet101 was 1.0, 0.9, 0.89, and 0.94 for detecting pneumoconiosis categories 0, I, II, and III, respectively. The micro-average and macro-average mean AUC values were 0.93 and 0.94, respectively. The accuracy and Kappa values of ResNet101 were 0.72 and 0.7111 for quadruple classification and 0.98 and 0.955 for dichotomous classification, respectively, compared with the relative standard classification of the clinic. This study develops a deep learning based model for screening and staging of pneumoconiosis is using chest radiographs. The ResNet101 model performed relatively better in classifying pneumoconiosis than radiologists. The dichotomous classification displayed outstanding performance, thereby indicating the feasibility of deep learning techniques in pneumoconiosis screening.
Topics: Humans; Pneumoconiosis; Deep Learning; Radiography, Thoracic; Male; Middle Aged; Reproducibility of Results; Female; Diagnosis, Computer-Assisted; Aged; Neural Networks, Computer
PubMed: 38905434
DOI: 10.1097/MD.0000000000038478 -
Reumatismo Dec 2015Erasmus syndrome is defined as the association of silica exposure and subsequent development of systemic sclerosis. The limited number of cases reported in the...
Erasmus syndrome is defined as the association of silica exposure and subsequent development of systemic sclerosis. The limited number of cases reported in the literature mainly involves miners and only sporadically other professionals. We describe a case of Erasmus syndrome in a marble worker. A 68 year old man came to our observation complaining pelvic and scapular girdle pain, evening fever, intense weakness and emaciation for about 1 month. He also reported to have had Raynaud's phenomenon in his hands for the last 13 years. Also, his occupational history revealed a chronic exposure to silica dust. The patient presented pain in his shoulders and hips, moderate skin thickening and sclerosis in his hands and fingers extending proximally to his wrists. The diagnosis of systemic sclerosis was determined according to his clinical and medical history, the positivity of anti-Scl 70 antibodies, the nailfold capillaroscopy suggestive of an active scleroderma pattern and the detection of a mild restrictive pulmonary syndrome. The evaluation of the organbased complications excluded a gastroenterological and cardiovascular involvement, while the chest computed tomography (CT) detected multiple small nodules with a mantle distribution and enlarged lymph nodes with no signs of interstitial lung disease and fibrosis. Additional tests (positron emission tomography-CT, flexible bronchoscopy and broncho-alveolar lavage) excluded infectious diseases and cancer. However, given the pulmonary involvement, we performed a histological examination of the parenchyma and lymph nodes, which revealed a picture of pneumoconiosis. In the end, the occupational history and the findings from the diagnostic procedures led to the diagnosis of pulmonary silicosis. The precise definition of the pulmonary involvement was essential to the therapeutic approach to this patient.
Topics: Aged; Antibodies, Anti-Idiotypic; Biomarkers; Calcium Carbonate; Fever; Humans; Male; Mining; Occupational Exposure; Pelvic Pain; Pneumoconiosis; Raynaud Disease; Scleroderma, Systemic; Silicosis; Syndrome
PubMed: 26876191
DOI: 10.4081/reumatismo.2015.826 -
American Journal of Industrial Medicine Mar 2022In 2014, a federal rule reduced occupational exposure limits to coal mine dust and expanded medical surveillance eligibility beyond underground miners to surface and...
BACKGROUND
In 2014, a federal rule reduced occupational exposure limits to coal mine dust and expanded medical surveillance eligibility beyond underground miners to surface and contract coal miners. This expansion may have provided an opportunity for more American Indian and Alaska Native (AI/AN) coal miners to participate in screening, since many surface coal mines are located near AI/AN communities and may employ AI/AN miners. Therefore we sought to better understand the respiratory health of AI/AN coal miners by characterizing prevalence of coal workers' pneumoconiosis (CWP), progressive massive fibrosis (PMF), and abnormal lung function in this population.
METHODS
Descriptive analysis of 1405 chest radiographs and 627 spirometry test results for AI/AN miners who participated in the Coal Workers' Health Surveillance Program (CWHSP) during 2014-2019 was conducted.
RESULTS
Most AI/AN miners (0-25+ years of tenure) were western United States residents (82.3%) and active surface miners (76.9%) with no underground tenure. Among miners with at least 10 years of tenure, prevalence of CWP was 3.0%, and of PMF was 0.3%. Lung function abnormalities were seen in 9.0% with primarily restrictive patterns.
CONCLUSIONS
The prevalence of CWP, PMF, and lung function abnormality among active and former AI/AN coal miners was higher than seen in a larger CWHSP study of active western miners working primarily underground with 10+ years of tenure. Interventions that eliminate or control coal mine dust exposure, identify miners with CWP early, and limit respiratory disease progression and complications remain vital for eliminating the preventable adverse health effects of coal mining. Comprehensive demographic data on the coal mining workforce are needed to improve CWHSP participation assessment.
Topics: Alaska Natives; Anthracosis; Coal; Coal Mining; Dust; Humans; Pneumoconiosis; United States; American Indian or Alaska Native
PubMed: 35032040
DOI: 10.1002/ajim.23324 -
British Journal of Industrial Medicine Jul 1992A cross sectional radiological survey of workers exposed to pottery dust during the manufacture of wall tiles and bathroom fittings was conducted in a South African...
A cross sectional radiological survey of workers exposed to pottery dust during the manufacture of wall tiles and bathroom fittings was conducted in a South African factory. Roughly one third of workers with 15 or more years of service in high dust sections of the factory had pneumoconiosis. Previously undiagnosed advanced cases, including two with progressive massive fibrosis, were working in dusty occupations. A firm diagnosis of potters' pneumoconiosis was made in 11 of the 358 workers radiographed; all had served more than 10 years suggesting that radiography of workers with more than 10 years service would be a successful case finding strategy in South Africa. A combination of rounded and irregular opacities was the most common radiological finding in the workers with pneumoconiosis (55%). Three readers reported on the chest radiographs, and all found an association between small radiological opacities, which were usually irregular or a combination of irregular and rounded, and exposure to pottery dust. The occurrence of irregular radiological opacities in workers exposed to pottery dust deserves further study. The least experienced reader significantly associated age with small opacities when duration of service (years) was used to measure exposure to dust. Sex was not an important predictor of radiological changes consistent with pneumoconiosis. Breast shadows were not an important cause of false positive readings and participating women did not develop pneumoconiosis after less exposure than men.
Topics: Humans; Occupational Exposure; Pneumoconiosis; Prevalence; Radiography; South Africa
PubMed: 1637706
DOI: 10.1136/oem.49.7.465 -
MMWR. Morbidity and Mortality Weekly... Jul 2004Pneumoconioses are caused by the inhalation and deposition of mineral dusts in the lungs, resulting in pulmonary fibrosis and other parenchymal changes. Many persons...
Pneumoconioses are caused by the inhalation and deposition of mineral dusts in the lungs, resulting in pulmonary fibrosis and other parenchymal changes. Many persons with early pneumoconiosis are asymptomatic, but advanced disease often is accompanied by disability and premature death. Known pneumoconioses include coal workers' pneumoconiosis (CWP), silicosis, asbestosis, mixed dust pneumoconiosis, graphitosis, and talcosis. No effective treatment for these diseases is available. This report describes the temporal patterns of pneumoconiosis mortality during 1968-2000, which indicates an overall decrease in pneumoconiosis mortality. However, asbestosis increased steadily and is now the most frequently recorded pneumoconiosis on death certificates. Increased awareness of this trend is needed among health-care providers, employers, workers, and public health agencies.
Topics: Humans; Pneumoconiosis; United States
PubMed: 15269698
DOI: No ID Found -
Journal of UOEH Oct 2013Pneumoconiosis law describes mainly the medical examination and its treatment for health care management. The revision of the medical examination and construction of the...
Pneumoconiosis law describes mainly the medical examination and its treatment for health care management. The revision of the medical examination and construction of the law has been performed according to the times. The main revised points are 1) digital images such as CR and DR are accepted as a substitute of chest Xrays, 2) the standard values in pulmonary function test are based on values of Japanese, and 3) bronchogenic carcinoma was recognized as a complication of pneumoconiosis. It is important to maintain occupational health management in order to avoid the onset of pneumoconiosis. Furthermore, an official notice from the ministry of health, labour and welfare established guidelines for the treatment of manufactured nanomaterials. It is important to actively maintain and update occupational health management to protect against materials of unknown harmful effects.
Topics: Humans; Japan; Occupational Health; Pneumoconiosis
PubMed: 24107343
DOI: 10.7888/juoeh.35.113 -
British Medical Journal Jul 1974Circulating antinuclear antibody and rheumatoid factor have been measured in 109 coal miners with pneumoconiosis whose chest radiograph showed a range of abnormalities...
Circulating antinuclear antibody and rheumatoid factor have been measured in 109 coal miners with pneumoconiosis whose chest radiograph showed a range of abnormalities varying from simple pneumoconiosis of mild degree to advanced progressive massive fibrosis.At a screening dilution of 1/10 the overall incidence of antinuclear antibody was 17%. In almost half of the positive cases the titre was 1/40 or greater.The prevalence of antinuclear antibody was lowest in those with simple pneumoconiosis (9%) and highest in those with category C progressive massive fibrosis (27%). A similar but less striking trend was seen with rheumatoid factor, ranging from 6% in simple pneumoconiosis to 18% in category C progressive massive fibrosis. The trend of increasing frequency of autoantibodies with advancing radiographic category was most marked when the frequencies of antinuclear antibody and rheumatoid factor were combined. These autoantibodies were found in 13% of the miners with simple pneumoconiosis and 45% of those with category C progressive massive fibrosis (P for the trend=0.01).
Topics: Adult; Aged; Antibodies, Antinuclear; Arthritis, Rheumatoid; Autoantibodies; Coal; Fluorescent Antibody Technique; Humans; Latex Fixation Tests; Male; Middle Aged; Pneumoconiosis; Pulmonary Fibrosis; Radiography; Rheumatoid Factor
PubMed: 4602134
DOI: 10.1136/bmj.3.5924.145