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Canadian Medical Association Journal May 1972
Topics: Adult; Aged; Female; Humans; Middle Aged; Potassium Iodide; Sporotrichosis
PubMed: 5032143
DOI: No ID Found -
British Medical Journal Oct 1980
Topics: Humans; Iodine Radioisotopes; Neoplasms, Radiation-Induced; Nuclear Reactors; Potassium Iodide; Thyroid Gland; Thyroid Neoplasms
PubMed: 7427554
DOI: 10.1136/bmj.281.6246.988 -
International Journal of Occupational... Feb 2017Lead (Pb) pollution is a serious public health problem all over the world, it especially plays severe damage role in children's health. Apart from reducing lead-induced...
OBJECTIVES
Lead (Pb) pollution is a serious public health problem all over the world, it especially plays severe damage role in children's health. Apart from reducing lead-induced damages, the decrease of lead accumulation is also critical. This study has been the first attempt to investigate effects of meso-2,3-dimercaptosuccinic acid (DMSA), potassium iodide (KI) and chlorophyll (Chl) on lead accumulation in male mice.
MATERIAL AND METHODS
Eighty healthy Kunming male mice were selected and divided randomly into 8 groups. They were treated with lead acetate (PbAc) intraperitoneally, individually and in combination with the DMSA, KI or Chl once daily for 5 days. Meanwhile, the control group was treated with normal saline during the whole exposure period. On 30th day, mice were sacrificed and lead concentrations were detected in the whole blood, livers, kidneys, and testicles of mice by means of the graphite furnace atomic absorption spectrometry.
RESULTS
In comparison with the control group, lead concentrations increased in mice treated with the PbAc and DMSA, KI and Chl diminished lead accumulation in the whole blood, livers, and kidneys. Chl had specifically the same effects on lead concentrations in the testicles of male mice.
CONCLUSIONS
Potassium iodide and Chl, as food additives, had the same effects as the DMSA to reduce lead accumulation in male mice effectively. Our results provided experimental evidence in vivo for the preventive measures of lead poisoning. Int J Occup Med Environ Health 2017;30(1):87-93.
Topics: Animals; Chelating Agents; Chlorophyll; Food Additives; Kidney; Lead; Lead Poisoning; Liver; Male; Mice; Potassium Iodide; Succimer; Testis
PubMed: 28220909
DOI: 10.13075/ijomeh.1896.00406 -
Journal of Dentistry For Children... Sep 2018The purpose of this study was to investigate the inhibitory in vitro effects of silver diamine fluoride (SDF) with and without a saturated solution of potassium iodide...
The purpose of this study was to investigate the inhibitory in vitro effects of silver diamine fluoride (SDF) with and without a saturated solution of potassium iodide (SSKI) on established biofilm. Fifty μl of an overnight culture (10 CFU per mL) in Tryptic Soy Broth (TSB) and three ml of fresh TSB supplemented with one percent sucrose (TSBS) were incubated for 24 hours to establish an biofilm in six-well tissue culture plates. Four treatments (SDF, SSKI, SDF plus SSKI, and untreated control) were used to disrupt the biofilm. The biofilm groups were each treated with reagent and washed; the biofilm was collected, diluted, and spiral-plated onto blood agar plates; and an automated counting machine was used to determine the bacterial colony forming units (CFU). The control had significantly more CFU than the SSKI, SDF, and SDF plus SSKI groups (<.0001). The SSKI group had significantly more CFU than the SDF and SDF plus SSKI groups (<.0001). The SDF group had significantly fewer CFU than the SDF plus SSKI group (=.02). The reduction from the control was more than seven-fold for SDF, four-fold for SDF plus SSKI, and two-fold for SSKI. SDF alone, SDF plus SSKI, and SSKI disrupted an established biofilm. SDF alone had the greatest overall disruption.
Topics: Biofilms; Dental Caries; Drug Combinations; Fluorides, Topical; Microbial Viability; Potassium Iodide; Quaternary Ammonium Compounds; Silver Compounds; Streptococcus mutans
PubMed: 30869588
DOI: No ID Found -
Clinical and Experimental Dental... Aug 2021Globally, has been an increase in the use of silver fluoride products to arrest carious lesions and a variety of products are available. (Randomized Controlled Trial)
Randomized Controlled Trial
BACKGROUND
Globally, has been an increase in the use of silver fluoride products to arrest carious lesions and a variety of products are available.
OBJECTIVES
To examine differences in caries arrest and lesion colour of primary tooth carious lesions.
MATERIAL AND METHODS
A four-armed, parallel-design cluster-randomised controlled trial which investigated four protocols for caries arrest at 6m and 12m. Children in Group 1 and Group 2 received Rivastar Silver Diammine Fluoride (SDF), and children in Group 3 and Group 4 received a stabilised aqueous silver fluoride solution (AgF). Children in Group 2 and Group 4 received an additional application of KI immediately after the fluoride. Differences in caries arrest and lesion appearance were examined at 6m and 12m using two level logistic regression modelling.
RESULTS
The arrest rate varied by group membership; group 1 and group 3 had higher arrest rates (77.3% and 75.3% respectively) than group 2 and group 4 (65.4% and 51.2% respectively). The use of KI was also associated with lower odds of arrest (12m OR 0.25; CI 0.19, 0.34) and higher odds of avoiding black discolouration (12m OR 6.08; 2.36, 15.67).
CONCLUSIONS
Globally, has been an increase in the use of silver fluoride products to arrest carious lesions and a variety of products are available. This study demonstrated that both AgF and SDF can effectively arrest carious lesions on primary teeth. The use of KI is associated with poorer caries control but better aesthetic outcomes.
Topics: Cariostatic Agents; Child; Dental Caries; Dental Caries Susceptibility; Fluorides; Humans; Potassium Iodide; Silver Compounds; Tooth, Deciduous
PubMed: 33370847
DOI: 10.1002/cre2.367 -
European Thyroid Journal Jul 2016Iodide transport defect (ITD) is a dyshormonogenetic congenital hypothyroidism caused by sodium/iodide symporter (NIS) gene mutations. In the lactating mammary gland,...
BACKGROUND
Iodide transport defect (ITD) is a dyshormonogenetic congenital hypothyroidism caused by sodium/iodide symporter (NIS) gene mutations. In the lactating mammary gland, iodide is concentrated by NIS, and iodine for thyroid hormone synthesis is thereby supplied to the infant in the breast milk.
CASE DESCRIPTION
A 34-year-old Japanese woman was diagnosed with ITD caused by a homozygous NIS gene mutation T354P. She had begun treatment of primary hypothyroidism with levothyroxine at the age of 5. She delivered a baby at the age of 36. The iodine concentration in her breast milk was 54 µg/l. She took a 50-mg potassium iodide tablet daily to supply iodine in the breast milk, starting on the 5th day postpartum. Her breast milk iodine concentration increased to 90 µg/l (slightly above the minimum requirement level). The patient weaned her baby and stopped taking the daily potassium iodide tablet 6 weeks postpartum, and the baby began to be fed with relatively iodine-rich formula milk. The baby's thyroid function remained normal from birth until 6 months of age.
CONCLUSION
Possible iodine deficiency in the infant breast-fed by an ITD patient should be kept in mind. Prophylactic iodine supplementation is essential for such infants in order to prevent severe iodine deficiency.
PubMed: 27493890
DOI: 10.1159/000446496 -
Dental Research Journal 2022Applying silver diamine fluoride (SDF) is recommended to arrest and prevent dental caries. However, it may jeopardize the bond of the restorative materials to the tooth....
Investigation of the effect of simultaneous use of silver diamine fluoride and potassium iodide on the shear bond strength of total etch and universal adhesive systems to dentin.
BACKGROUND
Applying silver diamine fluoride (SDF) is recommended to arrest and prevent dental caries. However, it may jeopardize the bond of the restorative materials to the tooth. The aim of the present study was to evaluate the effect of the simultaneous use of the SDF and potassium iodide (KI) on shear bond strength to the sound dentin.
MATERIALS AND METHODS
In this study, on the buccal and lingual surfaces of the 48 human third molar teeth, dentinal surfaces with a diameter of 6 mm were created by removing the enamel. Then, the specimens were divided into four groups based on applying or not applying the KI/SDF and adhesive type (etch and rinse [E and R] or universal adhesive). Afterward, cylindrical composite restoration was made on the surfaces. Half of the specimens were subjected to 1000 cycles of thermocycling. Subsequently, the shear bond strength was evaluated by Universal testing machine. Furthermore, the type of failure was determined by a stereomicroscope. Data were analyzed by -test and Chi-square at a significance level of < 0.05.
RESULTS
There were statistically significant differences in shear bond strength between Groups 1 and 3 ( < 0.05), whereas the bond strength difference between Groups 2 and 4 was not statistically significant ( = 0.609). Failures were predominantly of the mixed type in almost all groups.
CONCLUSION
Based on the results of this study, the superiority of shear bond strength of universal adhesive to the sound dentin compared to E and R adhesive was confirmed. Thus, using this type of adhesive is recommended under the condition that KI/SDF anticaries material is applied.
PubMed: 35308443
DOI: 10.4103/1735-3327.336691 -
Archives of Endocrinology and Metabolism Jun 2021To investigate the effect of iodine supplementation during gestation on the neurocognitive development of children in areas where iodine deficiency is common. (Review)
Review
OBJECTIVE
To investigate the effect of iodine supplementation during gestation on the neurocognitive development of children in areas where iodine deficiency is common.
METHODS
Based on the PRISMA methodology, we conducted the search for articles in the PubMed, LILACS and Scopus databases, between March and April 2020, without limitation of dates. We used descriptors in English, Portuguese, and Spanish, without filters. Four clinical trials and four cohort articles were included in the review.
RESULTS
The maximum supplementation was 300 μg of potassium iodide per day. The Bayley scale and Children's Communication Checklist-Short were used to assess neurodevelopment in children. There was no significant improvement in the children's mental development index and behavioural development index in the supplemented group; however, the psychomotor development index (PDI) showed improvement in the poorer gross motor skills. We found differences in the response time to sound in the supplemented group living in mild deficiency areas.
CONCLUSION
Daily supplementation with iodine can improve poor psychomotor development of children living in mild to moderate iodine deficiency areas. Thus, it is necessary to perform further studies to assess the effect of supplementation on neurodevelopment before, during and after gestation in mild to moderate iodine deficiency areas.
Topics: Child; Dietary Supplements; Female; Humans; Iodine; Pregnancy; Pregnancy Complications
PubMed: 34191411
DOI: 10.20945/2359-3997000000376 -
Sensors (Basel, Switzerland) Feb 2019The mineral content of dental hard tissues has traditionally been measured by destructive tests such as transverse microradiography. Microfocus X-ray computed tomography...
The mineral content of dental hard tissues has traditionally been measured by destructive tests such as transverse microradiography. Microfocus X-ray computed tomography (micro CT) has enabled non-destructive 3D assessment of tooth demineralization. This study compared the preventive effects of silver diammine fluoride (SDF) and potassium iodide (KI) in comparison with fluoride varnish. SDF has been known to arrest caries but darkens the tooth. KI creates a precipitate with SDF that reduces the discoloration, but its effects on SDF efficacy in terms of preventing demineralization of at-risk root dentin surfaces is unknown. Bovine root dentin blocks were randomly distributed into four groups and subjected to a pretreatment in each group (n = 8); Control: deionized water (DIW); F-Varnish: 5% sodium fluoride varnish: 38% Saforide; SDF+KI: SDF followed by saturated solution of KI in DIW. The treated dentin was subjected to 8 cycles of demineralization (pH 5) for 14 h and remineralization in artificial saliva (pH 7) for 10 h. Specimens were then scanned for 12 min using micro CT at 73 KV and 1012 µA with 8.3 μm resolution. The 3D images were analyzed in Amira software to calculate lesion depth (LD), surface layer mineral density (SL) and mineral loss (ΔZ) for each specimen. One-way ANOVA with Bonferroni posthoc showed that there was a statistically significant difference between Control and all three other groups for all parameters (P < 0.001), however, there was no statistical difference among F-Varnish, SDF and SDF+KI (P > 0.05). Single application of F-Varnish, SDF and SDF+KI showed comparable preventive effects against root dentin demineralization. Application of KI did not affect anti-demineralization properties of SDF in this study. Micro CT is a quick and effective method for objective and high-resolution characterization of dentin caries lesions.
Topics: Animals; Cattle; Dental Caries; Dentin; Fluorides, Topical; Humans; Potassium Iodide; Root Caries; Tooth Demineralization; Tooth Root; X-Ray Microtomography
PubMed: 30791530
DOI: 10.3390/s19040874 -
Internal Medicine (Tokyo, Japan) Jun 2021Objective Painless thyroiditis (PT) is characterized by transient hyperthyroidism with a low Tc uptake. We herein describe 11 cases of PT that occurred during treatment...
Objective Painless thyroiditis (PT) is characterized by transient hyperthyroidism with a low Tc uptake. We herein describe 11 cases of PT that occurred during treatment with potassium iodide (KI) for Graves' disease (GD). Methods From August 2016 to December 2018, 11 women with GD who developed PT during treatment with KI were enrolled. Of these patients, 10 discontinued antithyroid drug (ATD) because of side effects and began KI, and 1 patient switched from thiamazole to KI because she was planning a pregnancy. The mean patient age was 40.1 years old. Thyroid function tests, thyroid autoantibodies including anti thyroglobulin antibody (TgAb), anti-thyroperoxidase antibody (TPOAb), and M22-TRAb, and the Tc uptake were evaluated at the time of PT. Results All 11 women patients presented with transient thyrotoxicosis in which Tc scans revealed a low uptake of 0.34±0.15% (normal 0.70-1.02%). M22-TRAb was absent in all cases except for one (2.4 IU/L), whereas TgAb and TPOAb were present in 10 and 6 cases, respectively. Ten patients returned to a euthyroid status without passing through the post-hypothyroid phase, and one patient underwent total thyroidectomy during the euthyroid phase of PT. Only four patients require beta-blocker therapy. All patients with KI-induced PT except 1 displayed GD remission during a mean observation period of 23.3 months, and 1 patient had recurrence of GD after PT. Conclusion We encountered 11 GD patients who developed PT during treatment with KI, which was initiated after ATD had been discontinued due to side effects.
Topics: Adult; Antithyroid Agents; Autoantibodies; Female; Graves Disease; Humans; Potassium Iodide; Thyroiditis; Thyrotoxicosis
PubMed: 33431733
DOI: 10.2169/internalmedicine.6411-20