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The Journal of Investigative Dermatology Oct 2020Potassium iodide (KI), initially derived from seaweed in the early 19th century, is used for treating sporotrichosis in dermatological practice. KI has also been used to...
Potassium iodide (KI), initially derived from seaweed in the early 19th century, is used for treating sporotrichosis in dermatological practice. KI has also been used to treat several noninfectious inflammatory skin diseases. However, the mechanisms underlying the improvement in such skin diseases remain unknown, and KI is not used widely. Thus, although KI is an old drug, physicians may not prescribe it frequently because they lack knowledge about it. Although KI is very inexpensive and causes few side effects, it has been superseded by new powerful and expensive drugs, such as biological agents. We applied 3% KI topically to areas of inflammation induced by SDS in mice. The levels of IL-1 and TNF-α gene expression were reduced, whereas that of IL-10 gene expression was increased. Small interfering RNA that was designed to reduce IL-10 gene expression levels was injected into the same mice, and the anti-inflammatory effects of KI were not observed. Thus, the pharmacologic action of KI is based on its anti-inflammatory effects caused by the increase in IL-10 levels. This information would increase dermatologists' awareness of KI as an efficacious and cost-effective treatment.
Topics: Animals; Anti-Inflammatory Agents; Cytokines; Dermatitis; Female; Interleukin-10; Interleukins; Mice; Mice, Inbred BALB C; Potassium Iodide; Sodium Dodecyl Sulfate
PubMed: 32109455
DOI: 10.1016/j.jid.2020.01.028 -
Journal of Conservative Dentistry : JCD 2019Disinfection of the prepared cavity can be a crucial step in the longevity of restorations. The objective of this study was to compare the antimicrobial action (AMA) of...
Effect of silver diamine fluoride-potassium iodide and 2% chlorhexidine gluconate cavity cleansers on the bond strength and microleakage of resin-modified glass ionomer cement.
BACKGROUND
Disinfection of the prepared cavity can be a crucial step in the longevity of restorations. The objective of this study was to compare the antimicrobial action (AMA) of silver diamine fluoride-potassium iodide combination (SDF-KI) with 2% chlorhexidine gluconate (CHX) and to compare the alteration in bond strength and microleakage while using SDF-KI and CHX as cavity cleansers in resin-modified glass ionomer cement (RMGIC) restorations.
MATERIALS AND METHODS
Samples were grouped as follows: Group 1: Polyacrylic acid (PAA), Group 2: CHX, Group 3: SDF-KI, and Group 4: Distilled water (CTRL). AMA was assessed by measuring the zone of inhibition of the above-mentioned materials by dispensing them into the punch hole prepared on agar plates with an inoculum of . For assessing the effect of the cavity cleansers on the bond strength of RMGIC, they were applied to the dentinal samples prepared from freshly extracted noncarious molars. After the surface was treated, cylindrical restoration of RMGIC was placed and allowed to set. The shear bond strength was then evaluated using a universal testing machine. Rhodamine-B dye penetration was viewed under a fluorescent microscope to evaluate the microleakage of RMGIC following surface treatment of the standardized cavities prepared on the cervical third of freshly extracted noncarious premolars.
RESULTS
SDF-KI (34 ± 0.8 mm) showed potent AMA followed by CHX (23.9 ± 0.7 mm) and PAA (12.7 ± 0.8 mm). SDF-KI showed a drastic increase in the bond strength when compared to the PAA, CHX, and CTRL groups. Although the application of SDF-KI showed the least microleakage among all the groups, it was not statistically significant.
CONCLUSION
The application of SDF-KI and CHX is useful against in an study. Although SDF-KI group showed the least microleakage among the groups, it was not statistically significant. SDF-KI application has shown a drastic increase in the bond strength of RMGIC although further research is required for the suitable reasoning of the phenomenon.
PubMed: 31142994
DOI: 10.4103/JCD.JCD_485_18 -
Cold Spring Harbor Perspectives in... Nov 2014In recent years, we have seen an increase in the number of immunocompromised cohorts as a result of infections and/or medical conditions, which has resulted in an... (Review)
Review
In recent years, we have seen an increase in the number of immunocompromised cohorts as a result of infections and/or medical conditions, which has resulted in an increased incidence of fungal infections. Although rare, the incidence of infections caused by fungi belonging to basal fungal lineages is also continuously increasing. Basal fungal lineages diverged at an early point during the evolution of the fungal lineage, in which, in a simplified four-phylum fungal kingdom, Zygomycota and Chytridiomycota belong to the basal fungi, distinguishing them from Ascomycota and Basidiomycota. Currently there are no known human infections caused by fungi in Chytridiomycota; only Zygomycotan fungi are known to infect humans. Hence, infections caused by zygomycetes have been called zygomycosis, and the term "zygomycosis" is often used as a synonym for "mucormycosis." In the four-phylum fungal kingdom system, Zygomycota is classified mainly based on morphology, including the ability to form coenocytic (aseptated) hyphae and zygospores (sexual spores). In the Zygomycota, there are 10 known orders, two of which, the Mucorales and Entomophthorales, contain species that can infect humans, and the infection has historically been known as zygomycosis. However, recent multilocus sequence typing analyses (the fungal tree of life [AFTOL] project) revealed that the Zygomycota forms not a monophyletic clade but instead a polyphyletic clade, whereas Ascomycota and Basidiomycota are monophyletic. Thus, the term "zygomycosis" needed to be further specified, resulting in the terms "mucormycosis" and "entomophthoramycosis." This review covers these two different types of fungal infections.
Topics: Amphotericin B; Animals; Conidiobolus; Entomophthorales; Humans; Immunocompromised Host; Mice; Mucorales; Mucormycosis; Potassium Iodide; Randomized Controlled Trials as Topic; Zygomycosis
PubMed: 25377138
DOI: 10.1101/cshperspect.a019562 -
Clinical Toxicology (Philadelphia, Pa.) Jan 2013In March of 2011, an earthquake struck Japan causing a tsunami that resulted in a radiological release from the damaged Fukushima Daiichi nuclear power plant....
National surveillance for radiological exposures and intentional potassium iodide and iodine product ingestions in the United States associated with the 2011 Japan radiological incident.
BACKGROUND
In March of 2011, an earthquake struck Japan causing a tsunami that resulted in a radiological release from the damaged Fukushima Daiichi nuclear power plant. Surveillance for potential radiological and any iodine/iodide product exposures was initiated on the National Poison Data System (NPDS) to target public health messaging needs within the United States (US). Our objectives are to describe self-reported exposures to radiation, potassium iodide (KI) and other iodine/iodide products which occurred during the US federal response and discuss its public health impact.
METHODS
All calls to poison centers associated with the Japan incident were identified from March 11, 2011 to April 18, 2011 in NPDS. Exposure, demographic and health outcome information were collected. Calls about reported radiation exposures and KI or other iodine/iodide product ingestions were then categorized with regard to exposure likelihood based on follow-up information obtained from the PC where each call originated. Reported exposures were subsequently classified as probable exposures (high likelihood of exposure), probable non-exposures (low likelihood of exposure), and suspect exposure (unknown likelihood of exposure).
RESULTS
We identified 400 calls to PCs associated with the incident, with 340 information requests (no exposure reported) and 60 reported exposures. The majority (n = 194; 57%) of the information requests mentioned one or more substances. Radiation was inquired about most frequently (n = 88; 45%), followed by KI (n = 86; 44%) and other iodine/iodide products (n = 47; 24%). Of the 60 reported exposures, KI was reported most frequently (n = 25; 42%), followed by radiation (n = 22; 37%) and other iodine/iodide products (n = 13; 22%). Among reported KI exposures, most were classified as probable exposures (n = 24; 96%); one was a probable non-exposure. Among reported other iodine/iodide product exposures, most were probable exposures (n = 10, 77%) and the rest were suspect exposures (n = 3; 23%). The reported radiation exposures were classified as suspect exposures (n = 16, 73%) or probable non-exposures (n = 6; 27%). No radiation exposures were classified as probable exposures. A small number of the probable exposures to KI and other iodide/iodine products reported adverse signs or symptoms (n = 9; 26%). The majority of probable exposures had no adverse outcomes (n = 28; 82%). These data identified a potential public health information gap regarding KI and other iodine/iodide products which was then addressed through public health messaging activities.
CONCLUSION
During the Japan incident response, surveillance activities using NPDS identified KI and other iodine/iodide products as potential public health concerns within the US, which guided CDC's public health messaging and communication activities. Regional PCs can provide timely and additional information during a public health emergency to enhance data collected from surveillance activities, which in turn can be used to inform public health decision-making.
Topics: Centers for Disease Control and Prevention, U.S.; Environmental Exposure; Female; Follow-Up Studies; Fukushima Nuclear Accident; Health Promotion; Humans; Iodides; Iodine; Male; Patient Acceptance of Health Care; Poison Control Centers; Population Surveillance; Potassium Iodide; Radiation Dosage; Radiation Effects; Self Report; United States
PubMed: 23043524
DOI: 10.3109/15563650.2012.732701 -
Endocrine Connections May 2017Graves' disease is a common cause of hyperthyroidism. Three therapies have been used for decades: pharmacologic therapy, surgery and radioiodine. In case of adverse...
BACKGROUND
Graves' disease is a common cause of hyperthyroidism. Three therapies have been used for decades: pharmacologic therapy, surgery and radioiodine. In case of adverse events, especially agranulocytosis or hepatotoxicity, pre-treatment with Lugol's solution containing iodine/potassium iodide to induce euthyroidism before surgery could be advocated, but this has rarely been reported.
METHODS
All patients hospitalised due to uncontrolled hyperthyroidism at the Karolinska University Hospital 2005-2015 and treated with Lugol's solution were included. All electronic files were carefully reviewed manually, with focus on the cause of treatment and admission, demographic data, and effects of iodine on thyroid hormone levels and pulse frequency.
RESULTS
Twenty-seven patients were included. Lugol's solution had been chosen due to agranulocytosis in 9 (33%), hepatotoxicity in 2 (7%), other side effects in 11 (41%) and poor adherence to medication in 5 (19%). Levels of free T4, free T3 and heart rate decreased significantly after 5-9 days of iodine therapy (free T4 53-20 pmol/L, = 0.0002; free T3 20-6.5 pmol/L, = 0.04; heart rate 87-76 beats/min = 0.0007), whereas TSH remained unchanged. Side effects were noted in 4 (15%) (rash = 2, rash and vomiting = 1, swelling of fingers = 1). Thyroidectomy was performed in 26 patients (96%) and one was treated with radioiodine; all treatments were without serious complications.
CONCLUSION
Treatment of uncontrolled hyperthyroidism with Lugol's solution before definitive treatment is safe and it decreases thyroid hormone levels and heart rate. Side effects were limited. Lugol's solution could be recommended pre-operatively in Graves' disease with failed medical treatment, especially if side effects to anti-thyroid drugs have occurred.
PubMed: 28325735
DOI: 10.1530/EC-17-0025 -
American Journal of Otolaryngology 2022Second wave of COVID-19 pandemic was associated with an unprecedented rise in cases of mucormycosis, treatment of which has been challenging owing to the availability...
Adjunctive use of saturated solution of potassium iodide (SSKI) with liposomal amphotericin B (L-AMB) in mucormycosis achieves favorable response, shortened dose and duration of amphotericin: A retrospective study from a COVID-19 tertiary care center.
PURPOSE
Second wave of COVID-19 pandemic was associated with an unprecedented rise in cases of mucormycosis, treatment of which has been challenging owing to the availability and side effects associated with amphotericin.
METHODS
All patients presenting with rhino-orbital cerebral mucormycosis (ROCM) following COVID-19 infection between April 2021 to June 2021 were included in this retrospective interventional study. Primary objective was to assess the clinical response with combination of intravenous liposomal amphotericin B (4-5 mg/kg/day) and saturated solution of potassium iodide (SSKI) given orally along with surgical debridement.
RESULTS
Twenty-five patients of ROCM were treated with the regimen. Mean age and fasting blood sugar levels were 53.48 years and 239.64 mg/dL respectively. All patients had history of intake of steroids with a mean daily dose of 86.39 mg of prednisolone equivalent. 88% of patients had a "proven" diagnosis of mucormycosis. Cultures were positive in 52% of patients with Rhizopus arrhizus as the predominant species. The mean daily dose of amphotericin received was 268 mg/day with a mean duration of 9.52 days. Mean daily dose of SSKI was 2.57 g. 21 patients (84%) had stabilization of disease at week 8 and achieved cure at the end of treatment whereas the mortality rate was 16%. Factors that significantly affected outcome were eye and central nervous system (CNS) involvement on presentation.
CONCLUSION
SSKI, with its remarkably low cost and safety profile, makes it a potential adjuvant drug that may help achieve the twin benefits of shortened duration and dose of LAMB.
Topics: Amphotericin B; Antifungal Agents; COVID-19; Eye Infections, Fungal; Humans; Mucormycosis; Orbital Diseases; Pandemics; Potassium Iodide; Retrospective Studies; SARS-CoV-2; Tertiary Care Centers
PubMed: 35429848
DOI: 10.1016/j.amjoto.2022.103465 -
Indian Journal of Endocrinology and... Apr 2011The recent nuclear disaster at Japan has raised global concerns about effects of radioactive leakage in the environment, associated hazards, and how they can be...
The recent nuclear disaster at Japan has raised global concerns about effects of radioactive leakage in the environment, associated hazards, and how they can be prevented. In this article, we have tried to explain about the guidelines laid down by World Health Organization for a potassium iodide prophylaxis following a nuclear disaster, and its mechanism of action in preventing thyroid cancer. Data was collected mainly from the studies carried out during the Chernobyl disaster of Russia in 1986 and the hazardous effects especially on the thyroid gland were studied. It was seen that radioactive iodine leakage from the nuclear plants mainly affected the thyroid gland, and especially children were at a higher risk at developing the cancers. Potassium Iodide prophylaxis can be administered in order to prevent an increase in the incidence of thyroid cancers in the population of an area affected by a nuclear disaster. However, one has to be cautious while giving it, as using it without indication has its own risks.
PubMed: 21731865
DOI: 10.4103/2230-8210.81937 -
Thyroid Research Aug 2013Fenton reaction (Fe2++H2O2→Fe3++•OH+OH-) is of special significance in the thyroid gland, as both its substrates, i.e. H2O2 and Fe2+, are required for thyroid...
BACKGROUND
Fenton reaction (Fe2++H2O2→Fe3++•OH+OH-) is of special significance in the thyroid gland, as both its substrates, i.e. H2O2 and Fe2+, are required for thyroid hormone synthesis. Also iodine, an essential element supplied by the diet, is indispensable for thyroid hormone synthesis. It is well known that iodine affects red-ox balance. One of the most frequently examined oxidative processes is lipid peroxidation (LPO), which results from oxidative damage to membrane lipids. Fenton reaction is used to experimentally induce lipid peroxidation. The aim of the study was to evaluate effects of iodine, used as potassium iodide (KI) or potassium iodate (KIO3), on lipid peroxidation in porcine thyroid homogenates under basal conditions and in the presence of Fenton reaction substrates.
METHODS
Porcine thyroid homogenates were incubated in the presence of either KI (0.00005 - 500 mM) or KIO3 (0.00005 - 200 mM), without or with addition of FeSO4 (30 μM) + H2O2 (0.5 mM). Concentration of malondialdehyde + 4-hydroxyalkenals (MDA + 4-HDA) was measured spectrophotometrically, as an index of lipid peroxidation.
RESULTS
Potassium iodide, only when used in the highest concentrations (≥50 mM), increased lipid peroxidation in concentration-dependent manner. In the middle range of concentrations (5.0; 10; 25; 50 and 100 mM) KI reduced Fenton reaction-induced lipid peroxidation, with the strongest protective effect observed for the concentration of 25 mM. Potassium iodate increased lipid peroxidation in concentrations ≥2.5 mM. The damaging effect of KIO3 increased gradually from the concentration of 2.5 mM to 10 mM. The strongest damaging effect was observed at the KIO3 concentration of 10 mM, corresponding to physiological iodine concentration in the thyroid. Potassium iodate in concentrations of 5-200 mM enhanced Fenton reaction-induced lipid peroxidation with the strongest damaging effect found again for the concentration of 10 mM.
CONCLUSIONS
Potassium iodide, used in doses generally recommended in iodide prophylaxis, may prevent oxidative damage to membrane lipids in this gland. Toxic effects of iodide overload may result from its prooxidative action. Potassium iodate does not possess any direct beneficial effects on oxidative damage to membrane lipids in the thyroid, which constitutes an additional argument against its utility in iodine prophylaxis.
PubMed: 24004681
DOI: 10.1186/1756-6614-6-10 -
Nutrients Feb 2021Imbalanced maternal micronutrient status, poor placentation, and oxidative stress are associated with greater risk of pregnancy complications, which impact mother and...
Imbalanced maternal micronutrient status, poor placentation, and oxidative stress are associated with greater risk of pregnancy complications, which impact mother and offspring health. As selenium, iodine, and copper are essential micronutrients with key roles in antioxidant systems, this study investigated their potential protective effects on placenta against oxidative stress. First trimester human placenta explants were treated with different concentrations of selenium (sodium selenite), iodine (potassium iodide), their combination or copper (copper (II) sulfate). The concentrations represented deficient, physiological, or super physiological levels. Oxidative stress was induced by menadione or antimycin. Placenta explants were collected, fixed, processed, and embedded for laser ablation inductively coupled plasma-mass spectrometry (LA ICP-MS) element imaging or immunohistochemical labelling. LA ICP-MS showed that placenta could uptake selenium and copper from the media. Sodium selenite and potassium iodide reduced DNA damage and apoptosis ( < 0.05). Following oxidative stress induction, a higher concentration of sodium selenite (1.6 µM) was needed to reduce DNA damage and apoptosis while both concentrations of potassium iodide (0.5 and 1 µM) were protective ( < 0.05). A high concentration of copper (40 µM) increased apoptosis and DNA damage but this effect was no longer significant after induction of oxidative stress. Micronutrients supplementation can increase their content within the placenta and an optimal maternal micronutrient level is essential for placenta health.
Topics: Antioxidants; Apoptosis; Cell Proliferation; Copper; DNA Damage; Female; Humans; Iodine; Oxidative Stress; Placenta; Pregnancy; Pregnancy Trimester, First; Selenium; Tissue Culture Techniques
PubMed: 33671070
DOI: 10.3390/nu13030800 -
Journal of Dental Sciences Jan 2022Potassium iodide (KI) is used for reducing the degree of black staining occurred after silver diamine fluoride (SDF) application. However, the optimal KI concentration...
BACKGROUND/PURPOSE
Potassium iodide (KI) is used for reducing the degree of black staining occurred after silver diamine fluoride (SDF) application. However, the optimal KI concentration remains unknown. This study aimed to identify the optimal concentration of KI that effectively reduces black staining after SDF application.
MATERIALS AND METHODS
Twenty-four extracted teeth with similar pattern of carious lesions were assigned into 6 groups as follows: 1) SDF only, 2) SDF+7.5%KI, 3) SDF+10%KI, 4) SDF+15%KI, 5) SDF+20%KI, and 6) SDF+saturated KI. The KI solution was applied immediately after SDF application. Tooth images were obtained for color measurement at different time points as followed; before SDF application, immediately after SDF application, immediately after KI application, 1, 3, 7 and 14 days after SDF+KI application. The photographs were analyzed for mean gray value using the ImageJ program.
RESULTS
The KI groups demonstrated a dose-dependent significant immediate reduction in black staining after KI application, except the saturated KI group. The teeth in the 20% KI group had the highest Δ mean gray value compared with other groups immediately after KI application, whereas a reduction in black staining in the saturated KI group appeared 1 day after KI application. The Δ mean gray value in all groups decreased over time. After 7 and 14 days, the reduction in black staining was not clearly different between KI groups.
CONCLUSION
KI application was able to reduce the degree of black staining in a dose-dependent manner, but the subsequent color change was minimal over the period of 14 days.
PubMed: 35028051
DOI: 10.1016/j.jds.2021.03.014