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Biomolecules Mar 2023The use of iodine as antiseptic poses some issues related to its low water solubility and high volatility. Stable solid iodine-containing formulations are highly...
The use of iodine as antiseptic poses some issues related to its low water solubility and high volatility. Stable solid iodine-containing formulations are highly advisable and currently limited to the povidone-iodine complex. In this study, complexes of molecular iodine with 2-hydroxypropyl α-, β- and γ-cyclodextrins were considered water-soluble iodophors and prepared in a solid state by using three different methods (liquid-assisted grinding, co-evaporation and sealed heating). The obtained solids were evaluated for their iodine content and stability over time in different conditions using a fully validated UV method. The assessment of the actual formation of an inclusion complex in a solid state was carried out by thermal analysis, and the presence of iodine was further confirmed by SEM/EDX and XPS analyses. High levels of iodine content (8.3-10.8%) were obtained with all the tested cyclodextrins, and some influence was exerted by the employed preparation method. Potential use as solid iodophors can be envisaged for these iodine complexes, among which those with 2-hydroxypropyl-α-cyclodextrin were found the most stable, regardless of the preparation technique. The three prepared cyclodextrin-iodine complexes proved effective as bactericides against .
Topics: Iodine; Iodophors; Cyclodextrins; Povidone-Iodine; Solubility; Water; Calorimetry, Differential Scanning
PubMed: 36979409
DOI: 10.3390/biom13030474 -
Nature Communications Oct 2021Death from acute hemorrhage is a major problem in military conflicts, traffic accidents, and surgical procedures, et al. Achieving rapid effective hemostasis for...
Death from acute hemorrhage is a major problem in military conflicts, traffic accidents, and surgical procedures, et al. Achieving rapid effective hemostasis for pre-hospital care is essential to save lives in massive bleeding. An ideal hemostasis material should have those features such as safe, efficient, convenient, economical, which remains challenging and most of them cannot be achieved at the same time. In this work, we report a rapid effective nanoclay-based hemostatic membranes with nanoclay particles incorporate into polyvinylpyrrolidone (PVP) electrospun fibers. The nanoclay electrospun membrane (NEM) with 60 wt% kaolinite (KEM1.5) shows better and faster hemostatic performance in vitro and in vivo with good biocompatibility compared with most other NEMs and clay-based hemostats, benefiting from its enriched hemostatic functional sites, robust fluffy framework, and hydrophilic surface. The robust hemostatic bandages based on nanoclay electrospun membrane is an effective candidate hemostat in practical application.
Topics: Animals; Bandages; Clay; Disease Models, Animal; Hemorrhage; Hemostasis; Hemostatics; Humans; Kaolin; Liver; Male; Nanostructures; Povidone; Rats; Rats, Sprague-Dawley; Spleen; Surgical Wound
PubMed: 34635666
DOI: 10.1038/s41467-021-26237-4 -
Acta Ortopedica Mexicana 2007The jumper's knee or patellar tendonitis is a common injury in the athlete with an incidence between 14% and 16% among high-performance athletes. In addition to an... (Review)
Review
UNLABELLED
The jumper's knee or patellar tendonitis is a common injury in the athlete with an incidence between 14% and 16% among high-performance athletes. In addition to an overuse injury, there are some intrinsic factors for its development. Conservative treatment is indicated for the initial form, but when it fails, surgical treatment should be performed with an appropriate rehabilitation program.
MATERIAL AND METHODS
We retrospectively studied 18 high performance athletes in various disciplines, with an average age of 22 years, operated by arthroscopy and mini-arthrotomy scraping and application of povidone collagen sponge between March 2001 and December 2005. There after patients underwent a rehabilitation program specific for their return to their athletic activity.
RESULTS
The patients returned to their sports activity in an average of 15 weeks, with functional knees without pain, with full range of motion. We did not find postoperative fibrosis.
DISCUSSION
The results were similar and slightly better in time of return to sports activities to those reported in the world literature, with the difference in follow up. According to the clinical evaluation, treatment performed allows functional improvement with a return to athletic activity in a reasonable time.
Topics: Adolescent; Adult; Arthroscopy; Athletic Injuries; Debridement; Drug Implants; Female; Fibrosis; Gelatin Sponge, Absorbable; Humans; Knee Injuries; Male; Patellar Ligament; Povidone; Retrospective Studies; Tendinopathy; Wound Healing
PubMed: 18159910
DOI: No ID Found -
Clinical and Experimental Dental... Oct 2023This study aimed to compare and evaluate the efficacy of topical use of povidone-iodine (PVP-I) solution and chlorhexidine (CHX) gel on dental plaque regrowth after 3... (Randomized Controlled Trial)
Randomized Controlled Trial
OBJECTIVES
This study aimed to compare and evaluate the efficacy of topical use of povidone-iodine (PVP-I) solution and chlorhexidine (CHX) gel on dental plaque regrowth after 3 and 7 days in toddlers aged 24-36 months.
MATERIALS AND METHODS
A randomized controlled trial that included 45 healthy toddlers aged 24-36 months, who were randomly assigned to three groups. The first group received a placebo (distilled water (DW)) (negative control). The second group received topical CHX gel (0.2% w/v) (positive control). The third group received topical PVP-I solution (10% w/v). Plaque accumulation was measured at the baseline (t ), after 3 days (t ) and after 7 days (t ) using the Turesky-modified Quigley-Hein plaque index (TMQHPI). Oral hygiene practices were prohibited during the trial period. The trial ID is ACTRN12623000567628.
RESULTS
In the DW group, the mean of the TMQHPI score was 1.89 ± 0.67 at t and decreased to 1.45 ± 0.66 at t (p = .028). Similarly, in the CHX group, the mean of the TMQHPI score was 1.83 ± 1.06 at t and decreased to 1.02 ± 0.99 at t (p = .033). Regarding the PVP-I group, the mean of the TMQHPI score went from 1.84 ± 0.85 to 1.01 ± 0.61 at t and then increased to 1.57 ± 0.74 at t . Those changes were statistically significant (p = .001) and (p = .002), respectively. No statistically significant difference was noted between TMQHPI scores at t (p = .789). Regarding t and t , no statistically significant difference was found between the three groups (p > .05).
CONCLUSION
CHX and PVP-I efficacy lasted only for 3 days, and PVP-I was not superior to CHX in terms of plaque control in toddlers. However, further studies are needed to determine the long-term efficacy of these antiplaque agents in toddlers.
Topics: Humans; Child, Preschool; Chlorhexidine; Povidone-Iodine; Anti-Infective Agents, Local; Mouthwashes; Dental Plaque; Povidone
PubMed: 37345210
DOI: 10.1002/cre2.755 -
Theranostics 2021Acute pancreatitis (AP) is a serious acute condition affecting the abdomen and shows high morbidity and mortality rates. Its global incidence has increased in recent...
Acute pancreatitis (AP) is a serious acute condition affecting the abdomen and shows high morbidity and mortality rates. Its global incidence has increased in recent years. Inflammation and oxidative stress are potential therapeutic targets for AP. This study was conducted to investigate the intrinsic anti-oxidative and anti-inflammatory effects of Prussian blue nanozyme (PBzyme) on AP, along with its underlying mechanism. Prussian blue nanozymes were prepared by polyvinylpyrrolidone modification method. The effect of PBzyme on inhibiting inflammation and scavenging reactive oxygen species was verified at the cellular level. The efficacy and mechanism of PBzyme for prophylactically treating AP were evaluated using the following methods: serum testing , histological scoring following hematoxylin and eosin staining, terminal deoxynucleotidyl transferase dUTP nick end labeling fluorescence staining, polymerase chain reaction array, Kyoto Encyclopedia of Genes and Genomes analysis and Western blotting analysis. The synthetic PBzyme showed potent anti-oxidative and anti-inflammatory effects in reducing oxidative stress and alleviating inflammation both and in the prophylactic treatment of AP. The prophylactic therapeutic efficacy of PBzyme on AP may involve inhibition of the toll-like receptor/nuclear factor-κB signaling pathway and reactive oxygen species scavenging. The single-component, gram-level mass production, stable intrinsic biological activity, biosafety, and good therapeutic efficacy suggest the potential of PBzyme in the preventive treatment of AP. This study provides a foundation for the clinical application of PBzyme.
Topics: Animals; Apoptosis; Cell Line, Tumor; China; Cytokines; Enzyme Therapy; Enzymes; Ferricyanides; Ferrocyanides; Humans; Inflammation; Male; Mice, Inbred BALB C; NF-kappa B; Nanotechnology; Oxidative Stress; Pancreatitis; Povidone; Prussian Blue Reaction; Reactive Oxygen Species; Signal Transduction; Toll-Like Receptors; Mice
PubMed: 33537083
DOI: 10.7150/thno.52010 -
Critical Care (London, England) Sep 2020
Topics: Anti-Infective Agents, Local; Bandages; Chlorhexidine; Povidone-Iodine; Skin
PubMed: 32958012
DOI: 10.1186/s13054-020-03279-6 -
Molecular Pharmaceutics Aug 2023Phthalocyanines are ideal candidates as photosensitizers for photodynamic therapy (PDT) of cancer due to their favorable chemical and photophysical properties. However,...
Phthalocyanines are ideal candidates as photosensitizers for photodynamic therapy (PDT) of cancer due to their favorable chemical and photophysical properties. However, their tendency to form aggregates in water reduces PDT efficacy and poses challenges in obtaining efficient forms of phthalocyanines for therapeutic applications. In the current work, polyvinylpyrrolidone (PVP) and micellar formulations were compared for encapsulating and monomerizing a water-soluble zinc phthalocyanine bearing four non-peripheral triethylene glycol chains (). H NMR spectroscopy combined with UV-vis absorption and fluorescence spectroscopy revealed that exists as a mixture of regioisomers in monomeric form in dimethyl sulfoxide but forms dimers in an aqueous buffer. PVP, polyethylene glycol castor oil (Kolliphor RH40), and three different triblock copolymers with varying proportions of polyethylene and polypropylene glycol units (termed P188, P84, and F127) were tested as micellar carriers for . H NMR chemical shift analysis, diffusion-ordered spectroscopy, and 2D nuclear Overhauser enhancement spectroscopy was applied to monitor the encapsulation and localization of at the polymer interface. Kolliphor RH40 and F127 micelles exhibited the highest affinity for encapsulating in the micellar core and resulted in intense fluorescence emission as well as efficient singlet oxygen formation along with PVP. Among the triblock copolymers, efficiency in binding and dimer dissolution decreased in the order F127 > P84 > P188. PVP was a strong binder for . However, molecules are rather surface-attached and exist as monomer and dimer mixtures. The results demonstrate that NMR combined with optical spectroscopy offer powerful tools to assess parameters like drug binding, localization sites, and dynamic properties that play key roles in achieving high host-guest compatibility. With the corresponding adjustments, polymeric micelles can offer simple and easily accessible drug delivery systems optimizing phthalocyanines' properties as efficient photosensitizers.
Topics: Micelles; Povidone; Photosensitizing Agents; Polymers; Polyethylene Glycols; Magnetic Resonance Spectroscopy; Water; Photochemotherapy
PubMed: 37493236
DOI: 10.1021/acs.molpharmaceut.3c00306 -
International Journal of Nanomedicine 2022To improve the dissolution and bioavailability of the component-based Chinese medicine of leaves (GBCCM), a novel nanocrystalline solid dispersion of GBCCM (GBCCM...
BACKGROUND
To improve the dissolution and bioavailability of the component-based Chinese medicine of leaves (GBCCM), a novel nanocrystalline solid dispersion of GBCCM (GBCCM NC-SD) was first prepared.
METHODS
GBCCM mainly containing high pure flavonoid aglycones (FAs) and terpenoid lactones (TLs) was used as the model drug. PVP K30 and SDS were used as solubilizers, combined stabilizers and carriers, and GBCCM NC-SD was prepared by high-pressure homogenization combined with freeze-dryer. Morphology and crystal characteristic of GBCCM NC-SD were analyzed. The dissolution and bioavailability evaluation were performed to investigate the feasibility of GBCCM NC-SD by in vitro dissolution and in vivo integrated pharmacokinetic models.
RESULTS
After homogenizing for 30 cycles under the pressure of 650 bar and freeze-drying, GBCCM NC-SD with uniform quality would be obtained. The particle size, PDI and zeta potential were found to be 335.9 ± 32.8 nm, 0.29 ± 0.02 and -28.4 ± 0.7 mV respectively. Based on charged aerosol detector (CAD) technology, a new chromatographic method for simultaneous detection of eight components in GBCCM was developed. In vitro drug release study showed that the cumulative dissolution of FAs and TLs in GBCCM NC-SD increased from 12.77% to 52.92% (P < 0.01) and 90.91% to 99.21% (P < 0.05) respectively. In comparison with physical mixture of GBCCM and stabilizer (PM), the integrated pharmacokinetics AUC of FAs and TLs in GBCCM NC-SD were significantly increased (P < 0.05), and the T of TLs was also significantly prolonged (P < 0.05).
CONCLUSION
This study demonstrated that novel GBCCM NC-SD was prepared using Polyvinylpyrrolidone K30 (PVP K30) and Sodium dodecyl sulfate (SDS) as a synergetic stabilizer and also provided a feasible way to improve the dissolution and oral bioavailability of poorly soluble candidate antihypertensive drugs.
Topics: Excipients; Ginkgo biloba; Medicine, Chinese Traditional; Povidone; Solubility; Technology
PubMed: 36105621
DOI: 10.2147/IJN.S379736 -
Molecules (Basel, Switzerland) Nov 2012Recent developments in the synthesis of CuO nanoparticles (NPs) and their application to the [3+2] cycloaddition of azides with terminal alkynes are reviewed. With... (Review)
Review
Recent developments in the synthesis of CuO nanoparticles (NPs) and their application to the [3+2] cycloaddition of azides with terminal alkynes are reviewed. With respect to the importance of click chemistry, CuO hollow NPs, CuO hollow NPs on acetylene black, water-soluble double-hydrophilic block copolymer (DHBC) nanoreactors and ZnO–CuO hybrid NPs were synthesized. Non-conventional energy sources such as microwaves and ultrasound were also applied to these click reactions, and good catalytic activity with high regioselectivity was observed. CuO hollow NPs on acetylene black can be recycled nine times without any loss of activity, and water-soluble DHBC nanoreactors have been developed for an environmentally friendly process.
Topics: Acetylene; Alkynes; Azides; Catalysis; Click Chemistry; Copper; Cycloaddition Reaction; Green Chemistry Technology; Heterocyclic Compounds; Nanoparticles; Povidone; Soot; Thermodynamics; Zinc Oxide
PubMed: 23132140
DOI: 10.3390/molecules171113235 -
Journal of Oleo Science Mar 2021The fluoroquinolone antibiotic drug namely ciprofloxacin hydrochloride (CFH) is widely prescribed for the treatment of different bacterial infections. The interaction of...
Effect of Temperature and Additives on the Interaction of Ciprofloxacin Hydrochloride Drug with Polyvinylpyrrolidone and Bovine Serum Albumin: Spectroscopic and Molecular Docking Study.
The fluoroquinolone antibiotic drug namely ciprofloxacin hydrochloride (CFH) is widely prescribed for the treatment of different bacterial infections. The interaction of CFH with a synthetic polymer, polyvinyl pyrrolidone (PVP), and biopolymer, bovine serum albumin (BSA) was studied by UVvisible and fluorescence spectroscopic methods at different temperatures. The binding constant (K ) for the CFH-PVP complex was determined from the Benesi-Hildebrand plot. PVP of different molecular weights (MW) (such as 24,000, 40,000, 360,000, and 700,000 g. mole) were used for the interaction between CFH and PVP. The gradual increase in K value and the complexation reaction was found to be much enhanced with the augmentation of the MW of PVP. The values of K were also found to be increased with increasing temperatures as well as with the increase of electrolyte/acetic acid concentration. The Gibbs free energy of binding (∆G ) values of the interaction process was negative which indicates the complex formation is thermodynamically spontaneous. The positive values of enthalpy (∆H ) and entropy (∆S ) of binding connote that the binding force for CFH-PVP complexation is hydrophobic in nature and the complexation is entropy controlled. The negative intrinsic enthalpy (∆H ) values indicate the high stability of CFH-PVP complexes. Molecular docking calculation discloses the existence of similar binding forces between CFH and PVP obtained by the analysis of experimental data from UV-visible spectroscopic method. The binding constant between CFH and BSA (K ), quenching constant (K ), the number of binding sites (n), and the quenching rate constant (K ) for the CFH-BSA system were also calculated. The values of K , K , and n for the CFH-BSA system are lower in 0.05 mol L urea solution and higher in PVP solutions compared to those of aqueous medium.
Topics: Acetic Acid; Anti-Bacterial Agents; Biopolymers; Ciprofloxacin; Drug Interactions; Electrolytes; Molecular Docking Simulation; Molecular Weight; Povidone; Serum Albumin, Bovine; Solutions; Spectrum Analysis; Temperature; Thermodynamics
PubMed: 33583923
DOI: 10.5650/jos.ess20306