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The Journal of Thoracic and... Apr 2014
Topics: Humans; Prostheses and Implants; Prosthesis Design; Regeneration; Tissue Engineering; Trachea
PubMed: 24503324
DOI: 10.1016/j.jtcvs.2013.12.024 -
Veterinary Journal (London, England :... Sep 2018Precision medicine can be defined as the prevention, investigation and treatment of diseases taking individual variability into account. There are multiple ways in which... (Review)
Review
Precision medicine can be defined as the prevention, investigation and treatment of diseases taking individual variability into account. There are multiple ways in which the field of precision medicine may be advanced; however, recent innovations in the fields of electronics and microfabrication techniques have led to an increased interest in the use of implantable biosensors in precision medicine. Implantable biosensors are an important class of biosensors because of their ability to provide continuous data on the levels of a target analyte; this enables trends and changes in analyte levels over time to be monitored without any need for intervention from either the patient or clinician. As such, implantable biosensors have great potential in the diagnosis, monitoring, management and treatment of a variety of disease conditions. In this review, we describe precision medicine and the role implantable biosensors may have in this field, along with challenges in their clinical implementation due to the host immune responses they elicit within the body.
Topics: Animals; Biosensing Techniques; Precision Medicine; Prostheses and Implants; Veterinary Medicine
PubMed: 30197105
DOI: 10.1016/j.tvjl.2018.07.011 -
JACC. Cardiovascular Imaging Jan 2023
Topics: Humans; Transcatheter Aortic Valve Replacement; Predictive Value of Tests; Aortic Valve; Heart Valve Prosthesis Implantation; Prostheses and Implants; Heart Valve Prosthesis; Aortic Valve Stenosis; Treatment Outcome; Hemodynamics; Prosthesis Design; Risk Factors
PubMed: 36599556
DOI: 10.1016/j.jcmg.2022.10.013 -
Biomaterials Apr 2013Implants are widely used for orthopaedic applications such as fixing fractures, repairing non-unions, obtaining a joint arthrodesis, total joint arthroplasty, spinal... (Review)
Review
Implants are widely used for orthopaedic applications such as fixing fractures, repairing non-unions, obtaining a joint arthrodesis, total joint arthroplasty, spinal reconstruction, and soft tissue anchorage. Previously, orthopaedic implants were designed simply as mechanical devices; the biological aspects of the implant were a byproduct of stable internal/external fixation of the device to the surrounding bone or soft tissue. More recently, biologic coatings have been incorporated into orthopaedic implants in order to modulate the surrounding biological environment. This opinion article reviews current and potential future use of biologic coatings for orthopaedic implants to facilitate osseointegration and mitigate possible adverse tissue responses including the foreign body reaction and implant infection. While many of these coatings are still in the preclinical testing stage, bioengineers, material scientists and surgeons continue to explore surface coatings as a means of improving clinical outcome of patients undergoing orthopaedic surgery.
Topics: Coated Materials, Biocompatible; Foreign-Body Reaction; Humans; Orthopedics; Osseointegration; Prostheses and Implants; Prosthesis-Related Infections
PubMed: 23391496
DOI: 10.1016/j.biomaterials.2013.01.074 -
Arquivos Brasileiros de Oftalmologia 2012Regardless of significant progress in the field of corneal transplantation to treat corneal opacification, some cases of corneal blindness still present a poor prognosis... (Review)
Review
Regardless of significant progress in the field of corneal transplantation to treat corneal opacification, some cases of corneal blindness still present a poor prognosis for conventional penetrating keratoplasty. In patients with repeated graft failure and/or with severe ocular surface disease, the Boston type I keratoprosthesis (type I BKPro) has become a viable option. Modifications in its design and postoperative management have improved the long-term outcomes of visual acuity, retention, and postoperative infection rates. These advances made the type I BKPro be considered a safe alternative for visual rehabilitation in many patients with corneal pathologies. However, postoperative handle of chronic comorbidities, such as glaucoma, is still critical for preserving the visual gains achieved with BKPro.
Topics: Corneal Diseases; Humans; Postoperative Care; Prostheses and Implants; Prosthesis Design; Prosthesis Implantation; Visual Acuity
PubMed: 22872210
DOI: 10.1590/s0004-27492012000300016 -
BioMed Research International 20213D printing technology is widely used in the field of implantable medical device in recent decades because of its advantages in high precision, complex structure, and... (Review)
Review
3D printing technology is widely used in the field of implantable medical device in recent decades because of its advantages in high precision, complex structure, and high material utilization. Based on the characteristics of 3D printing technology, this paper reviews the manufacturing process, materials, and some typical products of 3D printing implantable medical devices and analyzes and summarizes the development trend of 3D printed implantable medical devices.
Topics: Biocompatible Materials; Blood Vessel Prosthesis; Ceramics; Humans; Joint Prosthesis; Lasers; Orthopedics; Polymers; Printing, Three-Dimensional; Prostheses and Implants; Prosthesis Design; Stents; Technology, Pharmaceutical
PubMed: 33521128
DOI: 10.1155/2021/6653967 -
Orthopadie (Heidelberg, Germany) Sep 2023More than almost any other implant, fully implantable intramedullary distraction nails have changed corrective and reconstructive bone surgery. Based on the fundamentals... (Review)
Review
More than almost any other implant, fully implantable intramedullary distraction nails have changed corrective and reconstructive bone surgery. Based on the fundamentals of callus distraction, these new apparatus developments with their novel planning strategies and minimally invasive surgical techniques have opened up a wide range of indications and made the treatment reproducible and safe. The prerequisite, however, is that standardized procedures are adhered to, which concern both the preparation for the surgery, the surgery itself and the subsequent distraction treatment. Treatment with fully implantable intramedullary distraction nails should be performed at specialized centers, so that the paradigm shift in corrective and reconstructive limb surgery, which is already recognizable, will open the door for further developments.
Topics: Nails; Internal Fixators; Fracture Fixation, Intramedullary; Prostheses and Implants; Bone Lengthening; Dioctyl Sulfosuccinic Acid; Phenolphthalein
PubMed: 37620678
DOI: 10.1007/s00132-023-04418-x -
Advanced Drug Delivery Reviews Sep 2012Many surgical procedures require the placement of an inert or tissue-derived implant deep within the body cavity. While the majority of these implants do not become... (Review)
Review
Many surgical procedures require the placement of an inert or tissue-derived implant deep within the body cavity. While the majority of these implants do not become colonized by bacteria, a small percentage develops a biofilm layer that harbors invasive microorganisms. In orthopaedic surgery, unresolved periprosthetic infections can lead to implant loosening, arthrodeses, amputations and sometimes death. The focus of this review is to describe development of an implant in which an antibiotic tethered to the metal surface is used to prevent bacterial colonization and biofilm formation. Building on well-established chemical syntheses, studies show that antibiotics can be linked to titanium through a self-assembled monolayer of siloxy amines. The stable metal-antibiotic construct resists bacterial colonization and biofilm formation while remaining amenable to osteoblastic cell adhesion and maturation. In an animal model, the antibiotic modified implant resists challenges by bacteria that are commonly present in periprosthetic infections. While the long-term efficacy and stability is still to be established, ongoing studies support the view that this novel type of bioactive surface has a real potential to mitigate or prevent the devastating consequences of orthopaedic infection.
Topics: Animals; Anti-Bacterial Agents; Biofilms; Disease Models, Animal; Drug Delivery Systems; Drug Design; Drug Implants; Humans; Orthopedic Procedures; Prostheses and Implants; Prosthesis Design; Prosthesis-Related Infections; Titanium
PubMed: 22512927
DOI: 10.1016/j.addr.2012.03.015 -
Acta Orthopaedica Feb 2015
Topics: Bone Cements; Humans; Joint Prosthesis; Medical Device Recalls; Orthopedic Procedures; Product Surveillance, Postmarketing; Prostheses and Implants; Registries
PubMed: 25583041
DOI: 10.3109/17453674.2014.1002184 -
Journal of the American College of... May 2023
Topics: Humans; Endocarditis; Pacemaker, Artificial; Prostheses and Implants; Defibrillators, Implantable; Device Removal; Prosthesis-Related Infections
PubMed: 37100489
DOI: 10.1016/j.jacc.2023.02.043